Amino acid dipepetide frequency for Halioglobus sp. HI00S01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.618AlaAla: 12.618 ± 0.124	1.161AlaCys: 1.161 ± 0.027	6.455AlaAsp: 6.455 ± 0.077	7.187AlaGlu: 7.187 ± 0.091	3.519AlaPhe: 3.519 ± 0.052	8.808AlaGly: 8.808 ± 0.095	1.981AlaHis: 1.981 ± 0.046	5.442AlaIle: 5.442 ± 0.069	3.171AlaLys: 3.171 ± 0.066	11.581AlaLeu: 11.581 ± 0.114	3.184AlaMet: 3.184 ± 0.046	3.199AlaAsn: 3.199 ± 0.048	4.523AlaPro: 4.523 ± 0.069	4.203AlaGln: 4.203 ± 0.068	6.446AlaArg: 6.446 ± 0.079	6.235AlaSer: 6.235 ± 0.07	5.273AlaThr: 5.273 ± 0.065	7.43AlaVal: 7.43 ± 0.09	1.456AlaTrp: 1.456 ± 0.035	2.732AlaTyr: 2.732 ± 0.056	0.007AlaXaa: 0.007 ± 0.002
Cys	1.04CysAla: 1.04 ± 0.032	0.145CysCys: 0.145 ± 0.011	0.698CysAsp: 0.698 ± 0.023	0.67CysGlu: 0.67 ± 0.024	0.365CysPhe: 0.365 ± 0.017	0.974CysGly: 0.974 ± 0.031	0.291CysHis: 0.291 ± 0.018	0.503CysIle: 0.503 ± 0.019	0.299CysLys: 0.299 ± 0.015	1.033CysLeu: 1.033 ± 0.027	0.213CysMet: 0.213 ± 0.014	0.298CysAsn: 0.298 ± 0.016	0.521CysPro: 0.521 ± 0.02	0.381CysGln: 0.381 ± 0.016	0.618CysArg: 0.618 ± 0.024	0.689CysSer: 0.689 ± 0.023	0.521CysThr: 0.521 ± 0.025	0.614CysVal: 0.614 ± 0.023	0.136CysTrp: 0.136 ± 0.011	0.3CysTyr: 0.3 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.215AspAla: 6.215 ± 0.077	0.651AspCys: 0.651 ± 0.027	3.715AspAsp: 3.715 ± 0.062	4.29AspGlu: 4.29 ± 0.069	2.505AspPhe: 2.505 ± 0.044	4.821AspGly: 4.821 ± 0.071	1.263AspHis: 1.263 ± 0.031	3.806AspIle: 3.806 ± 0.057	2.03AspLys: 2.03 ± 0.046	5.919AspLeu: 5.919 ± 0.073	1.67AspMet: 1.67 ± 0.04	2.132AspAsn: 2.132 ± 0.051	2.979AspPro: 2.979 ± 0.053	2.187AspGln: 2.187 ± 0.041	3.34AspArg: 3.34 ± 0.051	3.518AspSer: 3.518 ± 0.054	3.186AspThr: 3.186 ± 0.058	4.231AspVal: 4.231 ± 0.058	1.043AspTrp: 1.043 ± 0.031	2.152AspTyr: 2.152 ± 0.042	0.006AspXaa: 0.006 ± 0.002
Glu	6.962GluAla: 6.962 ± 0.093	0.502GluCys: 0.502 ± 0.019	3.628GluAsp: 3.628 ± 0.049	4.38GluGlu: 4.38 ± 0.082	2.357GluPhe: 2.357 ± 0.042	4.737GluGly: 4.737 ± 0.059	1.658GluHis: 1.658 ± 0.04	3.523GluIle: 3.523 ± 0.048	2.308GluLys: 2.308 ± 0.045	7.297GluLeu: 7.297 ± 0.085	1.591GluMet: 1.591 ± 0.036	2.049GluAsn: 2.049 ± 0.043	2.643GluPro: 2.643 ± 0.05	3.587GluGln: 3.587 ± 0.058	4.523GluArg: 4.523 ± 0.069	3.565GluSer: 3.565 ± 0.055	3.174GluThr: 3.174 ± 0.05	4.781GluVal: 4.781 ± 0.072	0.845GluTrp: 0.845 ± 0.025	1.813GluTyr: 1.813 ± 0.039	0.007GluXaa: 0.007 ± 0.002
Phe	3.747PheAla: 3.747 ± 0.055	0.467PheCys: 0.467 ± 0.018	2.764PheAsp: 2.764 ± 0.049	2.238PheGlu: 2.238 ± 0.041	1.462PhePhe: 1.462 ± 0.042	3.196PheGly: 3.196 ± 0.055	0.813PheHis: 0.813 ± 0.024	1.851PheIle: 1.851 ± 0.039	1.153PheLys: 1.153 ± 0.03	3.243PheLeu: 3.243 ± 0.056	0.935PheMet: 0.935 ± 0.024	1.44PheAsn: 1.44 ± 0.032	1.477PhePro: 1.477 ± 0.032	1.182PheGln: 1.182 ± 0.03	1.863PheArg: 1.863 ± 0.034	2.644PheSer: 2.644 ± 0.044	2.1PheThr: 2.1 ± 0.04	2.497PheVal: 2.497 ± 0.045	0.485PheTrp: 0.485 ± 0.021	1.201PheTyr: 1.201 ± 0.033	0.004PheXaa: 0.004 ± 0.002
Gly	7.524GlyAla: 7.524 ± 0.087	0.886GlyCys: 0.886 ± 0.03	4.899GlyAsp: 4.899 ± 0.075	5.515GlyGlu: 5.515 ± 0.07	3.3GlyPhe: 3.3 ± 0.049	6.304GlyGly: 6.304 ± 0.096	1.792GlyHis: 1.792 ± 0.039	4.39GlyIle: 4.39 ± 0.063	3.097GlyLys: 3.097 ± 0.051	7.96GlyLeu: 7.96 ± 0.089	2.343GlyMet: 2.343 ± 0.047	2.596GlyAsn: 2.596 ± 0.052	2.668GlyPro: 2.668 ± 0.053	2.996GlyGln: 2.996 ± 0.053	4.483GlyArg: 4.483 ± 0.06	4.732GlySer: 4.732 ± 0.072	4.107GlyThr: 4.107 ± 0.061	5.941GlyVal: 5.941 ± 0.07	1.23GlyTrp: 1.23 ± 0.031	2.556GlyTyr: 2.556 ± 0.04	0.007GlyXaa: 0.007 ± 0.002
His	1.919HisAla: 1.919 ± 0.036	0.353HisCys: 0.353 ± 0.019	1.135HisAsp: 1.135 ± 0.035	1.154HisGlu: 1.154 ± 0.032	0.914HisPhe: 0.914 ± 0.029	1.777HisGly: 1.777 ± 0.036	0.659HisHis: 0.659 ± 0.027	1.139HisIle: 1.139 ± 0.028	0.642HisLys: 0.642 ± 0.023	2.248HisLeu: 2.248 ± 0.045	0.538HisMet: 0.538 ± 0.02	0.682HisAsn: 0.682 ± 0.025	1.339HisPro: 1.339 ± 0.034	0.865HisGln: 0.865 ± 0.026	1.473HisArg: 1.473 ± 0.034	1.323HisSer: 1.323 ± 0.033	1.111HisThr: 1.111 ± 0.03	1.316HisVal: 1.316 ± 0.036	0.412HisTrp: 0.412 ± 0.018	0.847HisTyr: 0.847 ± 0.026	0.001HisXaa: 0.001 ± 0.001
Ile	6.076IleAla: 6.076 ± 0.083	0.55IleCys: 0.55 ± 0.016	3.912IleAsp: 3.912 ± 0.053	3.824IleGlu: 3.824 ± 0.064	1.633IlePhe: 1.633 ± 0.038	4.158IleGly: 4.158 ± 0.059	1.077IleHis: 1.077 ± 0.031	2.264IleIle: 2.264 ± 0.045	1.636IleLys: 1.636 ± 0.04	4.208IleLeu: 4.208 ± 0.058	1.079IleMet: 1.079 ± 0.03	2.006IleAsn: 2.006 ± 0.036	2.413IlePro: 2.413 ± 0.047	1.543IleGln: 1.543 ± 0.037	2.793IleArg: 2.793 ± 0.052	3.342IleSer: 3.342 ± 0.059	2.944IleThr: 2.944 ± 0.045	3.578IleVal: 3.578 ± 0.056	0.543IleTrp: 0.543 ± 0.022	1.404IleTyr: 1.404 ± 0.036	0.007IleXaa: 0.007 ± 0.002
Lys	3.476LysAla: 3.476 ± 0.062	0.238LysCys: 0.238 ± 0.015	1.623LysAsp: 1.623 ± 0.035	1.709LysGlu: 1.709 ± 0.037	0.977LysPhe: 0.977 ± 0.027	2.35LysGly: 2.35 ± 0.04	0.741LysHis: 0.741 ± 0.024	1.655LysIle: 1.655 ± 0.043	1.409LysLys: 1.409 ± 0.057	3.393LysLeu: 3.393 ± 0.053	0.832LysMet: 0.832 ± 0.027	1.05LysAsn: 1.05 ± 0.032	1.726LysPro: 1.726 ± 0.039	1.402LysGln: 1.402 ± 0.039	2.232LysArg: 2.232 ± 0.048	1.869LysSer: 1.869 ± 0.038	1.759LysThr: 1.759 ± 0.038	2.419LysVal: 2.419 ± 0.051	0.399LysTrp: 0.399 ± 0.022	0.859LysTyr: 0.859 ± 0.026	0.005LysXaa: 0.005 ± 0.002
Leu	11.992LeuAla: 11.992 ± 0.113	1.095LeuCys: 1.095 ± 0.028	6.436LeuAsp: 6.436 ± 0.076	6.749LeuGlu: 6.749 ± 0.079	3.568LeuPhe: 3.568 ± 0.064	8.01LeuGly: 8.01 ± 0.085	2.088LeuHis: 2.088 ± 0.039	4.605LeuIle: 4.605 ± 0.064	3.415LeuLys: 3.415 ± 0.05	10.543LeuLeu: 10.543 ± 0.138	2.526LeuMet: 2.526 ± 0.037	3.25LeuAsn: 3.25 ± 0.052	5.253LeuPro: 5.253 ± 0.072	4.175LeuGln: 4.175 ± 0.065	6.264LeuArg: 6.264 ± 0.072	6.413LeuSer: 6.413 ± 0.084	5.269LeuThr: 5.269 ± 0.064	7.411LeuVal: 7.411 ± 0.085	1.225LeuTrp: 1.225 ± 0.035	2.536LeuTyr: 2.536 ± 0.043	0.014LeuXaa: 0.014 ± 0.003
Met	2.931MetAla: 2.931 ± 0.057	0.189MetCys: 0.189 ± 0.012	1.456MetAsp: 1.456 ± 0.031	1.487MetGlu: 1.487 ± 0.035	0.847MetPhe: 0.847 ± 0.024	2.028MetGly: 2.028 ± 0.045	0.567MetHis: 0.567 ± 0.021	1.244MetIle: 1.244 ± 0.031	0.934MetLys: 0.934 ± 0.027	2.578MetLeu: 2.578 ± 0.05	0.644MetMet: 0.644 ± 0.025	0.936MetAsn: 0.936 ± 0.027	1.337MetPro: 1.337 ± 0.03	1.08MetGln: 1.08 ± 0.028	1.574MetArg: 1.574 ± 0.037	1.879MetSer: 1.879 ± 0.036	1.482MetThr: 1.482 ± 0.035	1.795MetVal: 1.795 ± 0.039	0.247MetTrp: 0.247 ± 0.015	0.512MetTyr: 0.512 ± 0.019	0.005MetXaa: 0.005 ± 0.002
Asn	3.333AsnAla: 3.333 ± 0.047	0.374AsnCys: 0.374 ± 0.02	1.792AsnAsp: 1.792 ± 0.042	1.807AsnGlu: 1.807 ± 0.035	1.223AsnPhe: 1.223 ± 0.034	2.481AsnGly: 2.481 ± 0.056	0.7AsnHis: 0.7 ± 0.02	1.857AsnIle: 1.857 ± 0.04	1.031AsnLys: 1.031 ± 0.025	3.228AsnLeu: 3.228 ± 0.055	0.796AsnMet: 0.796 ± 0.025	1.127AsnAsn: 1.127 ± 0.033	2.049AsnPro: 2.049 ± 0.044	1.179AsnGln: 1.179 ± 0.026	1.964AsnArg: 1.964 ± 0.04	1.871AsnSer: 1.871 ± 0.045	1.942AsnThr: 1.942 ± 0.045	2.235AsnVal: 2.235 ± 0.042	0.542AsnTrp: 0.542 ± 0.022	1.034AsnTyr: 1.034 ± 0.032	0.001AsnXaa: 0.001 ± 0.001
Pro	5.105ProAla: 5.105 ± 0.068	0.342ProCys: 0.342 ± 0.014	3.229ProAsp: 3.229 ± 0.056	4.017ProGlu: 4.017 ± 0.057	1.624ProPhe: 1.624 ± 0.033	4.172ProGly: 4.172 ± 0.064	0.959ProHis: 0.959 ± 0.024	1.993ProIle: 1.993 ± 0.041	1.249ProLys: 1.249 ± 0.032	4.585ProLeu: 4.585 ± 0.063	1.182ProMet: 1.182 ± 0.033	1.376ProAsn: 1.376 ± 0.034	1.913ProPro: 1.913 ± 0.048	1.714ProGln: 1.714 ± 0.035	2.388ProArg: 2.388 ± 0.043	2.519ProSer: 2.519 ± 0.045	2.258ProThr: 2.258 ± 0.044	3.779ProVal: 3.779 ± 0.055	0.701ProTrp: 0.701 ± 0.023	1.238ProTyr: 1.238 ± 0.031	0.002ProXaa: 0.002 ± 0.001
Gln	4.63GlnAla: 4.63 ± 0.067	0.37GlnCys: 0.37 ± 0.017	1.866GlnAsp: 1.866 ± 0.039	2.118GlnGlu: 2.118 ± 0.043	1.395GlnPhe: 1.395 ± 0.031	2.949GlnGly: 2.949 ± 0.052	0.953GlnHis: 0.953 ± 0.024	1.85GlnIle: 1.85 ± 0.033	1.114GlnLys: 1.114 ± 0.032	4.656GlnLeu: 4.656 ± 0.07	1.008GlnMet: 1.008 ± 0.031	0.997GlnAsn: 0.997 ± 0.03	1.834GlnPro: 1.834 ± 0.036	2.145GlnGln: 2.145 ± 0.047	3.04GlnArg: 3.04 ± 0.06	2.121GlnSer: 2.121 ± 0.041	1.789GlnThr: 1.789 ± 0.042	3.012GlnVal: 3.012 ± 0.047	0.649GlnTrp: 0.649 ± 0.022	1.081GlnTyr: 1.081 ± 0.029	0.008GlnXaa: 0.008 ± 0.002
Arg	5.707ArgAla: 5.707 ± 0.069	0.648ArgCys: 0.648 ± 0.025	3.913ArgAsp: 3.913 ± 0.053	4.579ArgGlu: 4.579 ± 0.076	2.454ArgPhe: 2.454 ± 0.044	4.191ArgGly: 4.191 ± 0.065	1.44ArgHis: 1.44 ± 0.033	3.233ArgIle: 3.233 ± 0.046	2.214ArgLys: 2.214 ± 0.043	6.371ArgLeu: 6.371 ± 0.081	1.612ArgMet: 1.612 ± 0.039	2.116ArgAsn: 2.116 ± 0.041	2.471ArgPro: 2.471 ± 0.044	2.604ArgGln: 2.604 ± 0.044	3.888ArgArg: 3.888 ± 0.067	3.411ArgSer: 3.411 ± 0.051	2.724ArgThr: 2.724 ± 0.046	4.048ArgVal: 4.048 ± 0.052	0.985ArgTrp: 0.985 ± 0.027	2.091ArgTyr: 2.091 ± 0.043	0.008ArgXaa: 0.008 ± 0.003
Ser	6.206SerAla: 6.206 ± 0.07	0.562SerCys: 0.562 ± 0.021	3.693SerAsp: 3.693 ± 0.059	3.923SerGlu: 3.923 ± 0.053	2.259SerPhe: 2.259 ± 0.043	5.405SerGly: 5.405 ± 0.077	1.263SerHis: 1.263 ± 0.031	3.146SerIle: 3.146 ± 0.049	1.778SerLys: 1.778 ± 0.039	6.362SerLeu: 6.362 ± 0.071	1.633SerMet: 1.633 ± 0.037	1.888SerAsn: 1.888 ± 0.042	2.802SerPro: 2.802 ± 0.049	2.217SerGln: 2.217 ± 0.044	3.644SerArg: 3.644 ± 0.063	3.662SerSer: 3.662 ± 0.065	3.086SerThr: 3.086 ± 0.056	4.203SerVal: 4.203 ± 0.062	0.815SerTrp: 0.815 ± 0.025	1.726SerTyr: 1.726 ± 0.037	0.004SerXaa: 0.004 ± 0.002
Thr	5.415ThrAla: 5.415 ± 0.06	0.488ThrCys: 0.488 ± 0.021	3.127ThrAsp: 3.127 ± 0.055	3.046ThrGlu: 3.046 ± 0.053	1.875ThrPhe: 1.875 ± 0.04	4.649ThrGly: 4.649 ± 0.065	1.078ThrHis: 1.078 ± 0.026	2.6ThrIle: 2.6 ± 0.042	1.178ThrLys: 1.178 ± 0.034	5.917ThrLeu: 5.917 ± 0.066	1.136ThrMet: 1.136 ± 0.034	1.506ThrAsn: 1.506 ± 0.036	3.069ThrPro: 3.069 ± 0.048	1.706ThrGln: 1.706 ± 0.036	3.023ThrArg: 3.023 ± 0.046	3.114ThrSer: 3.114 ± 0.061	2.779ThrThr: 2.779 ± 0.052	3.986ThrVal: 3.986 ± 0.062	0.727ThrTrp: 0.727 ± 0.022	1.455ThrTyr: 1.455 ± 0.036	0.002ThrXaa: 0.002 ± 0.001
Val	7.961ValAla: 7.961 ± 0.08	0.772ValCys: 0.772 ± 0.029	4.745ValAsp: 4.745 ± 0.068	4.792ValGlu: 4.792 ± 0.061	2.702ValPhe: 2.702 ± 0.05	5.173ValGly: 5.173 ± 0.06	1.474ValHis: 1.474 ± 0.035	4.024ValIle: 4.024 ± 0.058	2.226ValLys: 2.226 ± 0.041	6.914ValLeu: 6.914 ± 0.08	1.77ValMet: 1.77 ± 0.038	2.554ValAsn: 2.554 ± 0.046	3.333ValPro: 3.333 ± 0.056	2.322ValGln: 2.322 ± 0.04	3.87ValArg: 3.87 ± 0.057	4.676ValSer: 4.676 ± 0.06	4.141ValThr: 4.141 ± 0.061	5.638ValVal: 5.638 ± 0.088	0.81ValTrp: 0.81 ± 0.028	1.832ValTyr: 1.832 ± 0.04	0.004ValXaa: 0.004 ± 0.001
Trp	1.139TrpAla: 1.139 ± 0.025	0.164TrpCys: 0.164 ± 0.012	0.825TrpAsp: 0.825 ± 0.026	0.783TrpGlu: 0.783 ± 0.025	0.545TrpPhe: 0.545 ± 0.022	0.952TrpGly: 0.952 ± 0.028	0.364TrpHis: 0.364 ± 0.018	0.604TrpIle: 0.604 ± 0.023	0.418TrpLys: 0.418 ± 0.018	1.716TrpLeu: 1.716 ± 0.04	0.381TrpMet: 0.381 ± 0.018	0.424TrpAsn: 0.424 ± 0.021	0.594TrpPro: 0.594 ± 0.023	0.792TrpGln: 0.792 ± 0.024	1.042TrpArg: 1.042 ± 0.032	0.873TrpSer: 0.873 ± 0.03	0.673TrpThr: 0.673 ± 0.029	0.976TrpVal: 0.976 ± 0.028	0.232TrpTrp: 0.232 ± 0.014	0.426TrpTyr: 0.426 ± 0.019	0.004TrpXaa: 0.004 ± 0.002
Tyr	2.606TyrAla: 2.606 ± 0.045	0.351TyrCys: 0.351 ± 0.017	1.746TyrAsp: 1.746 ± 0.043	1.659TyrGlu: 1.659 ± 0.036	1.232TyrPhe: 1.232 ± 0.032	2.184TyrGly: 2.184 ± 0.04	0.684TyrHis: 0.684 ± 0.023	1.26TyrIle: 1.26 ± 0.033	0.82TyrLys: 0.82 ± 0.026	3.071TyrLeu: 3.071 ± 0.053	0.673TyrMet: 0.673 ± 0.023	0.936TyrAsn: 0.936 ± 0.03	1.389TyrPro: 1.389 ± 0.035	1.3TyrGln: 1.3 ± 0.028	2.233TyrArg: 2.233 ± 0.042	1.814TyrSer: 1.814 ± 0.039	1.555TyrThr: 1.555 ± 0.031	1.835TyrVal: 1.835 ± 0.037	0.446TyrTrp: 0.446 ± 0.019	0.936TyrTyr: 0.936 ± 0.032	0.004TyrXaa: 0.004 ± 0.002
Xaa	0.01XaaAla: 0.01 ± 0.002	0.002XaaCys: 0.002 ± 0.001	0.003XaaAsp: 0.003 ± 0.002	0.003XaaGlu: 0.003 ± 0.001	0.004XaaPhe: 0.004 ± 0.002	0.009XaaGly: 0.009 ± 0.002	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.014XaaLeu: 0.014 ± 0.003	0.002XaaMet: 0.002 ± 0.001	0.005XaaAsn: 0.005 ± 0.002	0.014XaaPro: 0.014 ± 0.003	0.004XaaGln: 0.004 ± 0.002	0.008XaaArg: 0.008 ± 0.002	0.006XaaSer: 0.006 ± 0.002	0.003XaaThr: 0.003 ± 0.001	0.006XaaVal: 0.006 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 4067 proteins (1321789 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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