Amino acid dipepetide frequency for Planococcus sp. Y42

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.343AlaAla: 9.343 ± 0.123	0.621AlaCys: 0.621 ± 0.022	5.14AlaAsp: 5.14 ± 0.076	7.178AlaGlu: 7.178 ± 0.089	3.897AlaPhe: 3.897 ± 0.065	7.407AlaGly: 7.407 ± 0.092	1.578AlaHis: 1.578 ± 0.036	6.056AlaIle: 6.056 ± 0.082	4.284AlaLys: 4.284 ± 0.07	8.486AlaLeu: 8.486 ± 0.109	2.323AlaMet: 2.323 ± 0.049	2.666AlaAsn: 2.666 ± 0.051	2.565AlaPro: 2.565 ± 0.055	2.571AlaGln: 2.571 ± 0.048	3.523AlaArg: 3.523 ± 0.052	4.434AlaSer: 4.434 ± 0.064	3.801AlaThr: 3.801 ± 0.066	7.238AlaVal: 7.238 ± 0.098	0.737AlaTrp: 0.737 ± 0.028	2.706AlaTyr: 2.706 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.448CysAla: 0.448 ± 0.024	0.087CysCys: 0.087 ± 0.01	0.32CysAsp: 0.32 ± 0.018	0.412CysGlu: 0.412 ± 0.017	0.26CysPhe: 0.26 ± 0.016	0.642CysGly: 0.642 ± 0.027	0.164CysHis: 0.164 ± 0.012	0.372CysIle: 0.372 ± 0.02	0.217CysLys: 0.217 ± 0.013	0.569CysLeu: 0.569 ± 0.022	0.139CysMet: 0.139 ± 0.01	0.204CysAsn: 0.204 ± 0.013	0.328CysPro: 0.328 ± 0.017	0.201CysGln: 0.201 ± 0.014	0.397CysArg: 0.397 ± 0.018	0.442CysSer: 0.442 ± 0.019	0.384CysThr: 0.384 ± 0.021	0.359CysVal: 0.359 ± 0.018	0.055CysTrp: 0.055 ± 0.007	0.199CysTyr: 0.199 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.237AspAla: 4.237 ± 0.065	0.354AspCys: 0.354 ± 0.02	2.463AspAsp: 2.463 ± 0.059	4.734AspGlu: 4.734 ± 0.076	2.579AspPhe: 2.579 ± 0.05	3.838AspGly: 3.838 ± 0.067	1.142AspHis: 1.142 ± 0.03	3.693AspIle: 3.693 ± 0.064	2.473AspLys: 2.473 ± 0.053	5.042AspLeu: 5.042 ± 0.074	1.475AspMet: 1.475 ± 0.037	1.63AspAsn: 1.63 ± 0.038	2.333AspPro: 2.333 ± 0.055	1.886AspGln: 1.886 ± 0.043	3.152AspArg: 3.152 ± 0.056	2.728AspSer: 2.728 ± 0.053	2.573AspThr: 2.573 ± 0.05	3.994AspVal: 3.994 ± 0.06	0.776AspTrp: 0.776 ± 0.029	2.095AspTyr: 2.095 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	7.106GluAla: 7.106 ± 0.084	0.302GluCys: 0.302 ± 0.018	4.134GluAsp: 4.134 ± 0.064	8.382GluGlu: 8.382 ± 0.118	2.805GluPhe: 2.805 ± 0.048	4.893GluGly: 4.893 ± 0.072	1.487GluHis: 1.487 ± 0.036	4.817GluIle: 4.817 ± 0.073	5.04GluLys: 5.04 ± 0.074	7.989GluLeu: 7.989 ± 0.099	2.276GluMet: 2.276 ± 0.047	3.151GluAsn: 3.151 ± 0.055	2.609GluPro: 2.609 ± 0.06	4.157GluGln: 4.157 ± 0.068	4.344GluArg: 4.344 ± 0.079	3.591GluSer: 3.591 ± 0.061	4.82GluThr: 4.82 ± 0.071	5.553GluVal: 5.553 ± 0.071	0.939GluTrp: 0.939 ± 0.03	2.01GluTyr: 2.01 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.536PheAla: 3.536 ± 0.065	0.3PheCys: 0.3 ± 0.019	2.524PheAsp: 2.524 ± 0.053	2.883PheGlu: 2.883 ± 0.051	2.319PhePhe: 2.319 ± 0.067	3.498PheGly: 3.498 ± 0.06	0.965PheHis: 0.965 ± 0.029	3.428PheIle: 3.428 ± 0.062	1.894PheLys: 1.894 ± 0.04	4.55PheLeu: 4.55 ± 0.083	1.154PheMet: 1.154 ± 0.034	1.728PheAsn: 1.728 ± 0.04	1.727PhePro: 1.727 ± 0.04	1.473PheGln: 1.473 ± 0.033	2.077PheArg: 2.077 ± 0.052	3.03PheSer: 3.03 ± 0.055	2.645PheThr: 2.645 ± 0.05	3.016PheVal: 3.016 ± 0.056	0.463PheTrp: 0.463 ± 0.022	1.602PheTyr: 1.602 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.73GlyAla: 5.73 ± 0.085	0.58GlyCys: 0.58 ± 0.026	3.586GlyAsp: 3.586 ± 0.068	5.185GlyGlu: 5.185 ± 0.086	3.606GlyPhe: 3.606 ± 0.062	5.207GlyGly: 5.207 ± 0.084	1.539GlyHis: 1.539 ± 0.04	5.691GlyIle: 5.691 ± 0.07	4.483GlyLys: 4.483 ± 0.071	7.059GlyLeu: 7.059 ± 0.078	2.255GlyMet: 2.255 ± 0.045	2.58GlyAsn: 2.58 ± 0.046	1.947GlyPro: 1.947 ± 0.041	2.547GlyGln: 2.547 ± 0.048	3.345GlyArg: 3.345 ± 0.061	4.156GlySer: 4.156 ± 0.067	4.475GlyThr: 4.475 ± 0.07	5.084GlyVal: 5.084 ± 0.076	0.883GlyTrp: 0.883 ± 0.03	2.728GlyTyr: 2.728 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.644HisAla: 1.644 ± 0.046	0.185HisCys: 0.185 ± 0.013	1.062HisAsp: 1.062 ± 0.033	1.49HisGlu: 1.49 ± 0.037	0.961HisPhe: 0.961 ± 0.033	1.499HisGly: 1.499 ± 0.038	0.557HisHis: 0.557 ± 0.023	1.319HisIle: 1.319 ± 0.035	0.892HisLys: 0.892 ± 0.028	2.016HisLeu: 2.016 ± 0.045	0.508HisMet: 0.508 ± 0.019	0.646HisAsn: 0.646 ± 0.024	1.24HisPro: 1.24 ± 0.037	0.765HisGln: 0.765 ± 0.024	1.045HisArg: 1.045 ± 0.027	1.18HisSer: 1.18 ± 0.036	1.075HisThr: 1.075 ± 0.029	1.437HisVal: 1.437 ± 0.037	0.231HisTrp: 0.231 ± 0.013	0.75HisTyr: 0.75 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.311IleAla: 6.311 ± 0.09	0.467IleCys: 0.467 ± 0.02	3.957IleAsp: 3.957 ± 0.059	5.114IleGlu: 5.114 ± 0.069	2.644IlePhe: 2.644 ± 0.056	5.75IleGly: 5.75 ± 0.091	1.483IleHis: 1.483 ± 0.041	4.398IleIle: 4.398 ± 0.071	2.809IleLys: 2.809 ± 0.057	5.845IleLeu: 5.845 ± 0.079	1.467IleMet: 1.467 ± 0.035	2.297IleAsn: 2.297 ± 0.051	3.042IlePro: 3.042 ± 0.068	2.563IleGln: 2.563 ± 0.045	3.813IleArg: 3.813 ± 0.058	4.192IleSer: 4.192 ± 0.067	3.742IleThr: 3.742 ± 0.054	4.654IleVal: 4.654 ± 0.071	0.586IleTrp: 0.586 ± 0.024	2.009IleTyr: 2.009 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.47LysAla: 4.47 ± 0.074	0.23LysCys: 0.23 ± 0.014	2.68LysAsp: 2.68 ± 0.063	5.234LysGlu: 5.234 ± 0.079	1.724LysPhe: 1.724 ± 0.038	3.594LysGly: 3.594 ± 0.059	1.005LysHis: 1.005 ± 0.031	3.147LysIle: 3.147 ± 0.061	4.307LysLys: 4.307 ± 0.082	4.828LysLeu: 4.828 ± 0.08	1.732LysMet: 1.732 ± 0.035	2.246LysAsn: 2.246 ± 0.055	2.08LysPro: 2.08 ± 0.046	2.417LysGln: 2.417 ± 0.051	3.205LysArg: 3.205 ± 0.052	2.743LysSer: 2.743 ± 0.045	3.237LysThr: 3.237 ± 0.065	3.509LysVal: 3.509 ± 0.057	0.708LysTrp: 0.708 ± 0.025	1.529LysTyr: 1.529 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	8.993LeuAla: 8.993 ± 0.11	0.527LeuCys: 0.527 ± 0.023	4.954LeuAsp: 4.954 ± 0.072	7.03LeuGlu: 7.03 ± 0.093	4.753LeuPhe: 4.753 ± 0.089	6.316LeuGly: 6.316 ± 0.089	1.993LeuHis: 1.993 ± 0.05	6.632LeuIle: 6.632 ± 0.09	5.666LeuLys: 5.666 ± 0.089	10.78LeuLeu: 10.78 ± 0.141	2.473LeuMet: 2.473 ± 0.053	3.82LeuAsn: 3.82 ± 0.058	4.373LeuPro: 4.373 ± 0.07	3.778LeuGln: 3.778 ± 0.066	4.234LeuArg: 4.234 ± 0.066	6.221LeuSer: 6.221 ± 0.071	6.076LeuThr: 6.076 ± 0.079	6.292LeuVal: 6.292 ± 0.093	0.906LeuTrp: 0.906 ± 0.032	3.144LeuTyr: 3.144 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.389MetAla: 2.389 ± 0.054	0.123MetCys: 0.123 ± 0.011	1.529MetAsp: 1.529 ± 0.037	2.174MetGlu: 2.174 ± 0.042	0.905MetPhe: 0.905 ± 0.028	1.695MetGly: 1.695 ± 0.047	0.462MetHis: 0.462 ± 0.02	1.7MetIle: 1.7 ± 0.04	2.172MetLys: 2.172 ± 0.043	2.436MetLeu: 2.436 ± 0.046	0.775MetMet: 0.775 ± 0.033	1.374MetAsn: 1.374 ± 0.032	1.113MetPro: 1.113 ± 0.031	1.026MetGln: 1.026 ± 0.031	1.264MetArg: 1.264 ± 0.038	1.416MetSer: 1.416 ± 0.033	1.849MetThr: 1.849 ± 0.045	1.56MetVal: 1.56 ± 0.032	0.189MetTrp: 0.189 ± 0.014	0.673MetTyr: 0.673 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.989AsnAla: 2.989 ± 0.051	0.254AsnCys: 0.254 ± 0.015	1.803AsnAsp: 1.803 ± 0.044	2.852AsnGlu: 2.852 ± 0.054	1.517AsnPhe: 1.517 ± 0.035	3.074AsnGly: 3.074 ± 0.057	0.801AsnHis: 0.801 ± 0.025	2.34AsnIle: 2.34 ± 0.045	1.789AsnLys: 1.789 ± 0.043	3.217AsnLeu: 3.217 ± 0.059	0.948AsnMet: 0.948 ± 0.029	1.281AsnAsn: 1.281 ± 0.044	2.035AsnPro: 2.035 ± 0.047	1.381AsnGln: 1.381 ± 0.037	2.188AsnArg: 2.188 ± 0.049	1.917AsnSer: 1.917 ± 0.044	1.878AsnThr: 1.878 ± 0.045	2.596AsnVal: 2.596 ± 0.048	0.461AsnTrp: 0.461 ± 0.019	1.25AsnTyr: 1.25 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.749ProAla: 3.749 ± 0.058	0.186ProCys: 0.186 ± 0.014	2.613ProAsp: 2.613 ± 0.05	3.901ProGlu: 3.901 ± 0.06	2.038ProPhe: 2.038 ± 0.043	2.78ProGly: 2.78 ± 0.054	0.857ProHis: 0.857 ± 0.026	2.406ProIle: 2.406 ± 0.044	1.891ProLys: 1.891 ± 0.04	3.823ProLeu: 3.823 ± 0.057	0.829ProMet: 0.829 ± 0.026	1.381ProAsn: 1.381 ± 0.036	1.203ProPro: 1.203 ± 0.032	1.186ProGln: 1.186 ± 0.035	1.274ProArg: 1.274 ± 0.032	2.091ProSer: 2.091 ± 0.045	1.777ProThr: 1.777 ± 0.039	3.596ProVal: 3.596 ± 0.06	0.37ProTrp: 0.37 ± 0.022	1.381ProTyr: 1.381 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.37GlnAla: 3.37 ± 0.067	0.181GlnCys: 0.181 ± 0.012	1.757GlnAsp: 1.757 ± 0.044	3.383GlnGlu: 3.383 ± 0.062	1.547GlnPhe: 1.547 ± 0.038	2.229GlnGly: 2.229 ± 0.047	0.827GlnHis: 0.827 ± 0.027	2.053GlnIle: 2.053 ± 0.037	2.164GlnLys: 2.164 ± 0.05	4.375GlnLeu: 4.375 ± 0.083	1.039GlnMet: 1.039 ± 0.031	1.381GlnAsn: 1.381 ± 0.035	1.485GlnPro: 1.485 ± 0.038	2.049GlnGln: 2.049 ± 0.058	1.821GlnArg: 1.821 ± 0.04	1.977GlnSer: 1.977 ± 0.045	2.023GlnThr: 2.023 ± 0.043	2.499GlnVal: 2.499 ± 0.054	0.41GlnTrp: 0.41 ± 0.019	1.139GlnTyr: 1.139 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.222ArgAla: 3.222 ± 0.048	0.29ArgCys: 0.29 ± 0.016	2.498ArgAsp: 2.498 ± 0.049	4.001ArgGlu: 4.001 ± 0.064	2.322ArgPhe: 2.322 ± 0.049	2.845ArgGly: 2.845 ± 0.053	1.117ArgHis: 1.117 ± 0.033	3.415ArgIle: 3.415 ± 0.059	3.365ArgLys: 3.365 ± 0.063	5.111ArgLeu: 5.111 ± 0.082	1.514ArgMet: 1.514 ± 0.034	2.032ArgAsn: 2.032 ± 0.038	1.728ArgPro: 1.728 ± 0.039	2.258ArgGln: 2.258 ± 0.041	2.58ArgArg: 2.58 ± 0.06	2.624ArgSer: 2.624 ± 0.046	2.712ArgThr: 2.712 ± 0.049	3.017ArgVal: 3.017 ± 0.058	0.523ArgTrp: 0.523 ± 0.022	1.745ArgTyr: 1.745 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.611SerAla: 4.611 ± 0.078	0.334SerCys: 0.334 ± 0.017	2.896SerAsp: 2.896 ± 0.051	3.837SerGlu: 3.837 ± 0.059	2.905SerPhe: 2.905 ± 0.051	4.845SerGly: 4.845 ± 0.071	1.124SerHis: 1.124 ± 0.028	3.873SerIle: 3.873 ± 0.054	2.717SerLys: 2.717 ± 0.052	5.512SerLeu: 5.512 ± 0.067	1.585SerMet: 1.585 ± 0.039	1.936SerAsn: 1.936 ± 0.041	2.255SerPro: 2.255 ± 0.044	1.785SerGln: 1.785 ± 0.041	2.81SerArg: 2.81 ± 0.052	3.4SerSer: 3.4 ± 0.072	2.716SerThr: 2.716 ± 0.057	4.278SerVal: 4.278 ± 0.063	0.609SerTrp: 0.609 ± 0.026	1.953SerTyr: 1.953 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.576ThrAla: 5.576 ± 0.075	0.362ThrCys: 0.362 ± 0.021	3.461ThrAsp: 3.461 ± 0.058	4.548ThrGlu: 4.548 ± 0.081	2.477ThrPhe: 2.477 ± 0.052	4.968ThrGly: 4.968 ± 0.061	1.054ThrHis: 1.054 ± 0.032	3.745ThrIle: 3.745 ± 0.058	2.536ThrLys: 2.536 ± 0.045	5.103ThrLeu: 5.103 ± 0.07	1.248ThrMet: 1.248 ± 0.031	1.861ThrAsn: 1.861 ± 0.043	2.353ThrPro: 2.353 ± 0.052	1.451ThrGln: 1.451 ± 0.038	2.117ThrArg: 2.117 ± 0.044	2.861ThrSer: 2.861 ± 0.056	2.635ThrThr: 2.635 ± 0.055	4.779ThrVal: 4.779 ± 0.075	0.538ThrTrp: 0.538 ± 0.025	1.893ThrTyr: 1.893 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.623ValAla: 5.623 ± 0.076	0.533ValCys: 0.533 ± 0.024	3.501ValAsp: 3.501 ± 0.061	4.882ValGlu: 4.882 ± 0.074	3.427ValPhe: 3.427 ± 0.06	4.342ValGly: 4.342 ± 0.074	1.467ValHis: 1.467 ± 0.038	5.252ValIle: 5.252 ± 0.077	3.829ValLys: 3.829 ± 0.066	7.718ValLeu: 7.718 ± 0.092	1.909ValMet: 1.909 ± 0.043	2.733ValAsn: 2.733 ± 0.046	3.146ValPro: 3.146 ± 0.054	2.51ValGln: 2.51 ± 0.049	3.353ValArg: 3.353 ± 0.054	4.429ValSer: 4.429 ± 0.063	4.622ValThr: 4.622 ± 0.067	4.667ValVal: 4.667 ± 0.082	0.691ValTrp: 0.691 ± 0.027	2.245ValTyr: 2.245 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.745TrpAla: 0.745 ± 0.025	0.052TrpCys: 0.052 ± 0.006	0.473TrpAsp: 0.473 ± 0.02	0.665TrpGlu: 0.665 ± 0.03	0.535TrpPhe: 0.535 ± 0.023	0.684TrpGly: 0.684 ± 0.027	0.225TrpHis: 0.225 ± 0.013	0.799TrpIle: 0.799 ± 0.028	0.602TrpLys: 0.602 ± 0.026	1.292TrpLeu: 1.292 ± 0.039	0.363TrpMet: 0.363 ± 0.018	0.517TrpAsn: 0.517 ± 0.023	0.296TrpPro: 0.296 ± 0.017	0.484TrpGln: 0.484 ± 0.022	0.498TrpArg: 0.498 ± 0.019	0.599TrpSer: 0.599 ± 0.027	0.664TrpThr: 0.664 ± 0.023	0.676TrpVal: 0.676 ± 0.028	0.14TrpTrp: 0.14 ± 0.01	0.311TrpTyr: 0.311 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.463TyrAla: 2.463 ± 0.05	0.233TyrCys: 0.233 ± 0.016	1.843TyrAsp: 1.843 ± 0.042	2.52TyrGlu: 2.52 ± 0.05	1.592TyrPhe: 1.592 ± 0.041	2.559TyrGly: 2.559 ± 0.042	0.656TyrHis: 0.656 ± 0.024	2.01TyrIle: 2.01 ± 0.043	1.492TyrLys: 1.492 ± 0.041	3.21TyrLeu: 3.21 ± 0.063	0.811TyrMet: 0.811 ± 0.03	1.105TyrAsn: 1.105 ± 0.033	1.475TyrPro: 1.475 ± 0.036	1.22TyrGln: 1.22 ± 0.033	1.877TyrArg: 1.877 ± 0.045	1.949TyrSer: 1.949 ± 0.042	1.861TyrThr: 1.861 ± 0.037	2.077TyrVal: 2.077 ± 0.039	0.408TyrTrp: 0.408 ± 0.021	1.169TyrTyr: 1.169 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3921 proteins (1117653 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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