Amino acid dipepetide frequency for Thiomonas intermedia (strain K12) (Thiobacillus intermedius)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.776AlaAla: 18.776 ± 0.213	1.235AlaCys: 1.235 ± 0.034	6.576AlaAsp: 6.576 ± 0.092	6.683AlaGlu: 6.683 ± 0.103	3.874AlaPhe: 3.874 ± 0.062	9.338AlaGly: 9.338 ± 0.101	2.913AlaHis: 2.913 ± 0.064	5.069AlaIle: 5.069 ± 0.072	3.543AlaLys: 3.543 ± 0.072	16.616AlaLeu: 16.616 ± 0.176	3.259AlaMet: 3.259 ± 0.07	2.593AlaAsn: 2.593 ± 0.066	6.573AlaPro: 6.573 ± 0.101	7.884AlaGln: 7.884 ± 0.132	8.806AlaArg: 8.806 ± 0.103	6.594AlaSer: 6.594 ± 0.093	5.689AlaThr: 5.689 ± 0.082	9.17AlaVal: 9.17 ± 0.11	1.908AlaTrp: 1.908 ± 0.049	2.663AlaTyr: 2.663 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.239CysAla: 1.239 ± 0.034	0.113CysCys: 0.113 ± 0.01	0.528CysAsp: 0.528 ± 0.025	0.453CysGlu: 0.453 ± 0.02	0.24CysPhe: 0.24 ± 0.016	1.033CysGly: 1.033 ± 0.037	0.3CysHis: 0.3 ± 0.021	0.405CysIle: 0.405 ± 0.023	0.226CysLys: 0.226 ± 0.015	0.743CysLeu: 0.743 ± 0.031	0.178CysMet: 0.178 ± 0.014	0.252CysAsn: 0.252 ± 0.016	0.574CysPro: 0.574 ± 0.026	0.24CysGln: 0.24 ± 0.015	0.517CysArg: 0.517 ± 0.026	0.506CysSer: 0.506 ± 0.023	0.465CysThr: 0.465 ± 0.023	0.652CysVal: 0.652 ± 0.029	0.116CysTrp: 0.116 ± 0.012	0.168CysTyr: 0.168 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.317AspAla: 7.317 ± 0.104	0.502AspCys: 0.502 ± 0.024	2.69AspAsp: 2.69 ± 0.054	2.613AspGlu: 2.613 ± 0.055	2.071AspPhe: 2.071 ± 0.047	3.999AspGly: 3.999 ± 0.069	1.186AspHis: 1.186 ± 0.033	2.349AspIle: 2.349 ± 0.049	1.679AspLys: 1.679 ± 0.042	5.901AspLeu: 5.901 ± 0.088	1.179AspMet: 1.179 ± 0.036	1.187AspAsn: 1.187 ± 0.042	2.969AspPro: 2.969 ± 0.065	1.756AspGln: 1.756 ± 0.041	3.05AspArg: 3.05 ± 0.059	2.268AspSer: 2.268 ± 0.044	2.466AspThr: 2.466 ± 0.056	3.61AspVal: 3.61 ± 0.064	1.065AspTrp: 1.065 ± 0.037	1.412AspTyr: 1.412 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.177GluAla: 6.177 ± 0.095	0.333GluCys: 0.333 ± 0.019	1.968GluAsp: 1.968 ± 0.049	2.141GluGlu: 2.141 ± 0.056	1.684GluPhe: 1.684 ± 0.046	3.4GluGly: 3.4 ± 0.054	1.348GluHis: 1.348 ± 0.037	2.488GluIle: 2.488 ± 0.059	1.615GluLys: 1.615 ± 0.048	5.366GluLeu: 5.366 ± 0.078	1.152GluMet: 1.152 ± 0.035	1.152GluAsn: 1.152 ± 0.029	2.37GluPro: 2.37 ± 0.056	3.073GluGln: 3.073 ± 0.071	4.119GluArg: 4.119 ± 0.08	2.293GluSer: 2.293 ± 0.048	2.377GluThr: 2.377 ± 0.056	3.636GluVal: 3.636 ± 0.07	0.673GluTrp: 0.673 ± 0.031	0.845GluTyr: 0.845 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.279PheAla: 4.279 ± 0.065	0.367PheCys: 0.367 ± 0.019	2.408PheAsp: 2.408 ± 0.054	1.826PheGlu: 1.826 ± 0.044	1.345PhePhe: 1.345 ± 0.045	3.302PheGly: 3.302 ± 0.062	0.793PheHis: 0.793 ± 0.029	1.614PheIle: 1.614 ± 0.038	1.074PheLys: 1.074 ± 0.032	3.052PheLeu: 3.052 ± 0.062	0.753PheMet: 0.753 ± 0.028	1.134PheAsn: 1.134 ± 0.037	1.457PhePro: 1.457 ± 0.036	1.079PheGln: 1.079 ± 0.033	1.679PheArg: 1.679 ± 0.044	2.159PheSer: 2.159 ± 0.052	1.966PheThr: 1.966 ± 0.042	2.576PheVal: 2.576 ± 0.055	0.557PheTrp: 0.557 ± 0.026	0.956PheTyr: 0.956 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.079GlyAla: 9.079 ± 0.117	0.858GlyCys: 0.858 ± 0.027	3.708GlyAsp: 3.708 ± 0.073	3.922GlyGlu: 3.922 ± 0.078	3.061GlyPhe: 3.061 ± 0.062	6.683GlyGly: 6.683 ± 0.114	1.874GlyHis: 1.874 ± 0.042	3.75GlyIle: 3.75 ± 0.076	3.221GlyLys: 3.221 ± 0.063	9.392GlyLeu: 9.392 ± 0.115	2.34GlyMet: 2.34 ± 0.051	2.111GlyAsn: 2.111 ± 0.046	2.97GlyPro: 2.97 ± 0.058	3.753GlyGln: 3.753 ± 0.064	4.999GlyArg: 4.999 ± 0.074	4.216GlySer: 4.216 ± 0.075	3.761GlyThr: 3.761 ± 0.071	6.527GlyVal: 6.527 ± 0.095	1.481GlyTrp: 1.481 ± 0.045	2.206GlyTyr: 2.206 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	3.146HisAla: 3.146 ± 0.064	0.305HisCys: 0.305 ± 0.019	1.301HisAsp: 1.301 ± 0.032	0.956HisGlu: 0.956 ± 0.032	0.899HisPhe: 0.899 ± 0.03	2.111HisGly: 2.111 ± 0.045	0.728HisHis: 0.728 ± 0.03	1.057HisIle: 1.057 ± 0.033	0.594HisLys: 0.594 ± 0.023	2.616HisLeu: 2.616 ± 0.058	0.506HisMet: 0.506 ± 0.022	0.573HisAsn: 0.573 ± 0.026	1.726HisPro: 1.726 ± 0.049	0.887HisGln: 0.887 ± 0.032	1.55HisArg: 1.55 ± 0.037	1.128HisSer: 1.128 ± 0.032	1.208HisThr: 1.208 ± 0.035	1.497HisVal: 1.497 ± 0.035	0.484HisTrp: 0.484 ± 0.022	0.656HisTyr: 0.656 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.473IleAla: 6.473 ± 0.081	0.378IleCys: 0.378 ± 0.02	3.219IleAsp: 3.219 ± 0.058	2.733IleGlu: 2.733 ± 0.056	1.267IlePhe: 1.267 ± 0.04	4.234IleGly: 4.234 ± 0.079	0.917IleHis: 0.917 ± 0.031	1.63IleIle: 1.63 ± 0.046	1.371IleLys: 1.371 ± 0.039	3.654IleLeu: 3.654 ± 0.073	0.735IleMet: 0.735 ± 0.028	1.38IleAsn: 1.38 ± 0.044	2.113IlePro: 2.113 ± 0.051	1.31IleGln: 1.31 ± 0.037	2.561IleArg: 2.561 ± 0.05	2.391IleSer: 2.391 ± 0.056	2.488IleThr: 2.488 ± 0.057	3.323IleVal: 3.323 ± 0.061	0.529IleTrp: 0.529 ± 0.027	1.049IleTyr: 1.049 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.721LysAla: 3.721 ± 0.069	0.131LysCys: 0.131 ± 0.011	1.392LysAsp: 1.392 ± 0.039	1.256LysGlu: 1.256 ± 0.038	0.834LysPhe: 0.834 ± 0.035	2.19LysGly: 2.19 ± 0.047	0.604LysHis: 0.604 ± 0.026	1.366LysIle: 1.366 ± 0.042	1.139LysLys: 1.139 ± 0.043	3.343LysLeu: 3.343 ± 0.058	0.755LysMet: 0.755 ± 0.03	0.884LysAsn: 0.884 ± 0.033	2.27LysPro: 2.27 ± 0.052	1.353LysGln: 1.353 ± 0.043	2.172LysArg: 2.172 ± 0.057	1.731LysSer: 1.731 ± 0.042	2.02LysThr: 2.02 ± 0.048	2.179LysVal: 2.179 ± 0.054	0.319LysTrp: 0.319 ± 0.018	0.596LysTyr: 0.596 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.6LeuAla: 14.6 ± 0.155	0.98LeuCys: 0.98 ± 0.03	6.268LeuAsp: 6.268 ± 0.089	4.89LeuGlu: 4.89 ± 0.076	3.86LeuPhe: 3.86 ± 0.073	9.036LeuGly: 9.036 ± 0.119	2.956LeuHis: 2.956 ± 0.055	4.799LeuIle: 4.799 ± 0.082	3.28LeuLys: 3.28 ± 0.06	12.926LeuLeu: 12.926 ± 0.184	2.488LeuMet: 2.488 ± 0.054	2.695LeuAsn: 2.695 ± 0.053	6.812LeuPro: 6.812 ± 0.089	5.826LeuGln: 5.826 ± 0.089	8.755LeuArg: 8.755 ± 0.11	6.748LeuSer: 6.748 ± 0.081	5.557LeuThr: 5.557 ± 0.077	7.398LeuVal: 7.398 ± 0.106	1.638LeuTrp: 1.638 ± 0.049	2.226LeuTyr: 2.226 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.837MetAla: 2.837 ± 0.06	0.154MetCys: 0.154 ± 0.013	1.062MetAsp: 1.062 ± 0.036	1.019MetGlu: 1.019 ± 0.031	0.687MetPhe: 0.687 ± 0.029	1.774MetGly: 1.774 ± 0.05	0.592MetHis: 0.592 ± 0.024	0.917MetIle: 0.917 ± 0.033	0.827MetLys: 0.827 ± 0.029	2.533MetLeu: 2.533 ± 0.059	0.535MetMet: 0.535 ± 0.024	0.88MetAsn: 0.88 ± 0.03	1.557MetPro: 1.557 ± 0.038	1.387MetGln: 1.387 ± 0.042	1.762MetArg: 1.762 ± 0.041	1.551MetSer: 1.551 ± 0.038	1.511MetThr: 1.511 ± 0.041	1.473MetVal: 1.473 ± 0.046	0.21MetTrp: 0.21 ± 0.017	0.336MetTyr: 0.336 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.338AsnAla: 3.338 ± 0.064	0.253AsnCys: 0.253 ± 0.016	1.159AsnAsp: 1.159 ± 0.036	0.971AsnGlu: 0.971 ± 0.03	0.872AsnPhe: 0.872 ± 0.034	2.165AsnGly: 2.165 ± 0.056	0.549AsnHis: 0.549 ± 0.023	1.147AsnIle: 1.147 ± 0.042	0.79AsnLys: 0.79 ± 0.03	2.822AsnLeu: 2.822 ± 0.062	0.583AsnMet: 0.583 ± 0.024	0.741AsnAsn: 0.741 ± 0.038	2.078AsnPro: 2.078 ± 0.054	0.951AsnGln: 0.951 ± 0.037	1.607AsnArg: 1.607 ± 0.041	1.189AsnSer: 1.189 ± 0.039	1.486AsnThr: 1.486 ± 0.042	1.761AsnVal: 1.761 ± 0.045	0.46AsnTrp: 0.46 ± 0.02	0.663AsnTyr: 0.663 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	7.126ProAla: 7.126 ± 0.105	0.359ProCys: 0.359 ± 0.017	3.274ProAsp: 3.274 ± 0.068	3.266ProGlu: 3.266 ± 0.067	1.683ProPhe: 1.683 ± 0.046	4.704ProGly: 4.704 ± 0.077	1.271ProHis: 1.271 ± 0.039	1.997ProIle: 1.997 ± 0.04	1.663ProLys: 1.663 ± 0.046	5.832ProLeu: 5.832 ± 0.075	1.307ProMet: 1.307 ± 0.035	1.398ProAsn: 1.398 ± 0.035	3.145ProPro: 3.145 ± 0.068	3.121ProGln: 3.121 ± 0.058	3.053ProArg: 3.053 ± 0.064	3.067ProSer: 3.067 ± 0.059	2.816ProThr: 2.816 ± 0.054	4.146ProVal: 4.146 ± 0.073	0.861ProTrp: 0.861 ± 0.033	1.198ProTyr: 1.198 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	7.049GlnAla: 7.049 ± 0.11	0.339GlnCys: 0.339 ± 0.018	1.797GlnAsp: 1.797 ± 0.044	1.728GlnGlu: 1.728 ± 0.048	1.605GlnPhe: 1.605 ± 0.043	3.641GlnGly: 3.641 ± 0.064	1.199GlnHis: 1.199 ± 0.032	2.356GlnIle: 2.356 ± 0.048	1.178GlnLys: 1.178 ± 0.04	4.723GlnLeu: 4.723 ± 0.091	1.142GlnMet: 1.142 ± 0.03	1.119GlnAsn: 1.119 ± 0.037	2.884GlnPro: 2.884 ± 0.059	2.855GlnGln: 2.855 ± 0.071	4.108GlnArg: 4.108 ± 0.07	2.622GlnSer: 2.622 ± 0.058	3.122GlnThr: 3.122 ± 0.062	3.308GlnVal: 3.308 ± 0.061	0.805GlnTrp: 0.805 ± 0.032	0.917GlnTyr: 0.917 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.962ArgAla: 7.962 ± 0.108	0.617ArgCys: 0.617 ± 0.028	3.642ArgAsp: 3.642 ± 0.067	3.979ArgGlu: 3.979 ± 0.067	2.617ArgPhe: 2.617 ± 0.056	4.501ArgGly: 4.501 ± 0.068	1.854ArgHis: 1.854 ± 0.047	3.524ArgIle: 3.524 ± 0.068	2.159ArgLys: 2.159 ± 0.05	8.201ArgLeu: 8.201 ± 0.105	1.753ArgMet: 1.753 ± 0.041	1.751ArgAsn: 1.751 ± 0.043	3.226ArgPro: 3.226 ± 0.065	3.237ArgGln: 3.237 ± 0.063	4.873ArgArg: 4.873 ± 0.083	3.349ArgSer: 3.349 ± 0.053	3.099ArgThr: 3.099 ± 0.057	4.762ArgVal: 4.762 ± 0.069	1.228ArgTrp: 1.228 ± 0.042	1.776ArgTyr: 1.776 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.266SerAla: 7.266 ± 0.1	0.439SerCys: 0.439 ± 0.026	2.405SerAsp: 2.405 ± 0.058	2.3SerGlu: 2.3 ± 0.051	1.804SerPhe: 1.804 ± 0.045	5.175SerGly: 5.175 ± 0.077	1.131SerHis: 1.131 ± 0.031	2.3SerIle: 2.3 ± 0.055	1.526SerLys: 1.526 ± 0.044	5.84SerLeu: 5.84 ± 0.087	1.334SerMet: 1.334 ± 0.038	1.506SerAsn: 1.506 ± 0.046	3.168SerPro: 3.168 ± 0.058	2.151SerGln: 2.151 ± 0.048	3.369SerArg: 3.369 ± 0.06	3.11SerSer: 3.11 ± 0.072	2.944SerThr: 2.944 ± 0.068	3.835SerVal: 3.835 ± 0.058	0.741SerTrp: 0.741 ± 0.028	1.17SerTyr: 1.17 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.39ThrAla: 6.39 ± 0.1	0.447ThrCys: 0.447 ± 0.021	2.508ThrAsp: 2.508 ± 0.056	2.315ThrGlu: 2.315 ± 0.051	1.662ThrPhe: 1.662 ± 0.042	4.315ThrGly: 4.315 ± 0.076	1.238ThrHis: 1.238 ± 0.034	1.921ThrIle: 1.921 ± 0.052	1.083ThrLys: 1.083 ± 0.038	6.927ThrLeu: 6.927 ± 0.095	0.881ThrMet: 0.881 ± 0.029	1.111ThrAsn: 1.111 ± 0.037	3.813ThrPro: 3.813 ± 0.067	2.399ThrGln: 2.399 ± 0.056	3.236ThrArg: 3.236 ± 0.053	2.605ThrSer: 2.605 ± 0.049	2.677ThrThr: 2.677 ± 0.057	3.995ThrVal: 3.995 ± 0.069	0.648ThrTrp: 0.648 ± 0.026	1.083ThrTyr: 1.083 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.432ValAla: 8.432 ± 0.113	0.718ValCys: 0.718 ± 0.028	3.735ValAsp: 3.735 ± 0.065	3.691ValGlu: 3.691 ± 0.063	2.774ValPhe: 2.774 ± 0.056	5.214ValGly: 5.214 ± 0.09	1.647ValHis: 1.647 ± 0.039	3.475ValIle: 3.475 ± 0.065	2.108ValLys: 2.108 ± 0.057	8.596ValLeu: 8.596 ± 0.098	1.794ValMet: 1.794 ± 0.047	2.059ValAsn: 2.059 ± 0.055	3.624ValPro: 3.624 ± 0.065	3.5ValGln: 3.5 ± 0.066	4.953ValArg: 4.953 ± 0.078	4.039ValSer: 4.039 ± 0.067	3.524ValThr: 3.524 ± 0.058	5.738ValVal: 5.738 ± 0.105	1.129ValTrp: 1.129 ± 0.034	1.464ValTyr: 1.464 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.6TrpAla: 1.6 ± 0.051	0.166TrpCys: 0.166 ± 0.012	0.587TrpAsp: 0.587 ± 0.021	0.578TrpGlu: 0.578 ± 0.03	0.577TrpPhe: 0.577 ± 0.024	1.028TrpGly: 1.028 ± 0.034	0.361TrpHis: 0.361 ± 0.017	0.737TrpIle: 0.737 ± 0.029	0.507TrpLys: 0.507 ± 0.024	2.23TrpLeu: 2.23 ± 0.068	0.508TrpMet: 0.508 ± 0.024	0.45TrpAsn: 0.45 ± 0.022	0.768TrpPro: 0.768 ± 0.03	0.87TrpGln: 0.87 ± 0.033	1.333TrpArg: 1.333 ± 0.044	0.801TrpSer: 0.801 ± 0.029	0.734TrpThr: 0.734 ± 0.03	1.099TrpVal: 1.099 ± 0.039	0.302TrpTrp: 0.302 ± 0.019	0.289TrpTyr: 0.289 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.955TyrAla: 2.955 ± 0.051	0.254TyrCys: 0.254 ± 0.015	1.04TyrAsp: 1.04 ± 0.033	0.891TyrGlu: 0.891 ± 0.03	0.961TyrPhe: 0.961 ± 0.03	2.07TyrGly: 2.07 ± 0.057	0.467TyrHis: 0.467 ± 0.021	0.852TyrIle: 0.852 ± 0.031	0.67TyrLys: 0.67 ± 0.029	2.423TyrLeu: 2.423 ± 0.048	0.421TyrMet: 0.421 ± 0.023	0.611TyrAsn: 0.611 ± 0.032	1.191TyrPro: 1.191 ± 0.041	0.864TyrGln: 0.864 ± 0.029	1.61TyrArg: 1.61 ± 0.04	1.149TyrSer: 1.149 ± 0.042	1.344TyrThr: 1.344 ± 0.043	1.531TyrVal: 1.531 ± 0.043	0.372TyrTrp: 0.372 ± 0.021	0.579TyrTyr: 0.579 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3134 proteins (1016059 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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