Amino acid dipepetide frequency for Streptococcus satellite phage Javan16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.957AlaAla: 3.957 ± 0.853
1.079AlaCys: 1.079 ± 0.597
3.957AlaAsp: 3.957 ± 1.025
3.597AlaGlu: 3.597 ± 0.773
2.878AlaPhe: 2.878 ± 1.153
3.957AlaGly: 3.957 ± 1.113
0.36AlaHis: 0.36 ± 0.37
2.878AlaIle: 2.878 ± 0.915
4.676AlaLys: 4.676 ± 1.191
3.597AlaLeu: 3.597 ± 1.065
1.799AlaMet: 1.799 ± 0.841
3.237AlaAsn: 3.237 ± 1.61
0.0AlaPro: 0.0 ± 0.0
1.439AlaGln: 1.439 ± 0.617
3.597AlaArg: 3.597 ± 1.084
2.518AlaSer: 2.518 ± 0.941
4.317AlaThr: 4.317 ± 1.362
2.518AlaVal: 2.518 ± 0.934
0.719AlaTrp: 0.719 ± 0.496
2.158AlaTyr: 2.158 ± 0.837
0.0AlaXaa: 0.0 ± 0.0
Cys
0.36CysAla: 0.36 ± 0.346
0.0CysCys: 0.0 ± 0.0
0.36CysAsp: 0.36 ± 0.317
0.36CysGlu: 0.36 ± 0.412
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.36CysIle: 0.36 ± 0.344
0.719CysLys: 0.719 ± 0.528
0.36CysLeu: 0.36 ± 0.395
0.0CysMet: 0.0 ± 0.0
0.36CysAsn: 0.36 ± 0.308
1.079CysPro: 1.079 ± 0.727
0.36CysGln: 0.36 ± 0.339
0.719CysArg: 0.719 ± 0.475
0.0CysSer: 0.0 ± 0.0
0.36CysThr: 0.36 ± 0.343
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.878AspAla: 2.878 ± 0.921
0.0AspCys: 0.0 ± 0.0
4.317AspAsp: 4.317 ± 1.405
2.878AspGlu: 2.878 ± 0.914
4.676AspPhe: 4.676 ± 1.37
3.597AspGly: 3.597 ± 0.975
0.0AspHis: 0.0 ± 0.0
6.475AspIle: 6.475 ± 1.557
5.755AspLys: 5.755 ± 1.136
5.396AspLeu: 5.396 ± 1.218
1.799AspMet: 1.799 ± 0.799
5.396AspAsn: 5.396 ± 1.091
0.0AspPro: 0.0 ± 0.0
1.079AspGln: 1.079 ± 0.666
1.799AspArg: 1.799 ± 0.84
3.957AspSer: 3.957 ± 1.192
2.518AspThr: 2.518 ± 0.7
5.396AspVal: 5.396 ± 1.134
0.719AspTrp: 0.719 ± 0.424
2.878AspTyr: 2.878 ± 0.907
0.0AspXaa: 0.0 ± 0.0
Glu
3.597GluAla: 3.597 ± 1.186
0.0GluCys: 0.0 ± 0.0
4.676GluAsp: 4.676 ± 1.376
5.755GluGlu: 5.755 ± 1.498
3.597GluPhe: 3.597 ± 1.447
2.878GluGly: 2.878 ± 0.769
2.158GluHis: 2.158 ± 0.81
3.597GluIle: 3.597 ± 1.437
8.633GluLys: 8.633 ± 1.797
12.23GluLeu: 12.23 ± 2.516
2.878GluMet: 2.878 ± 1.112
4.676GluAsn: 4.676 ± 1.346
2.158GluPro: 2.158 ± 0.634
4.676GluGln: 4.676 ± 1.238
2.878GluArg: 2.878 ± 1.042
3.237GluSer: 3.237 ± 1.133
4.676GluThr: 4.676 ± 1.336
3.957GluVal: 3.957 ± 0.973
1.439GluTrp: 1.439 ± 0.714
1.439GluTyr: 1.439 ± 0.823
0.0GluXaa: 0.0 ± 0.0
Phe
2.158PheAla: 2.158 ± 0.79
0.36PheCys: 0.36 ± 0.346
3.237PheAsp: 3.237 ± 1.184
3.237PheGlu: 3.237 ± 1.121
1.439PhePhe: 1.439 ± 0.602
1.439PheGly: 1.439 ± 0.569
0.719PheHis: 0.719 ± 0.475
5.396PheIle: 5.396 ± 1.786
2.878PheLys: 2.878 ± 1.123
2.878PheLeu: 2.878 ± 1.129
0.719PheMet: 0.719 ± 0.46
2.158PheAsn: 2.158 ± 0.792
0.36PhePro: 0.36 ± 0.326
0.36PheGln: 0.36 ± 0.326
1.439PheArg: 1.439 ± 0.63
4.317PheSer: 4.317 ± 1.112
2.158PheThr: 2.158 ± 0.785
2.158PheVal: 2.158 ± 0.866
0.36PheTrp: 0.36 ± 0.316
1.439PheTyr: 1.439 ± 1.023
0.0PheXaa: 0.0 ± 0.0
Gly
1.799GlyAla: 1.799 ± 0.521
0.719GlyCys: 0.719 ± 0.449
0.719GlyAsp: 0.719 ± 0.462
3.237GlyGlu: 3.237 ± 1.123
0.719GlyPhe: 0.719 ± 0.449
0.36GlyGly: 0.36 ± 0.344
0.36GlyHis: 0.36 ± 0.412
4.676GlyIle: 4.676 ± 1.195
3.237GlyLys: 3.237 ± 1.631
4.676GlyLeu: 4.676 ± 1.615
1.439GlyMet: 1.439 ± 0.786
5.755GlyAsn: 5.755 ± 1.6
0.0GlyPro: 0.0 ± 0.0
3.237GlyGln: 3.237 ± 0.874
1.079GlyArg: 1.079 ± 0.637
0.719GlySer: 0.719 ± 0.522
1.799GlyThr: 1.799 ± 0.693
5.036GlyVal: 5.036 ± 1.128
0.36GlyTrp: 0.36 ± 0.378
1.799GlyTyr: 1.799 ± 0.719
0.0GlyXaa: 0.0 ± 0.0
His
0.36HisAla: 0.36 ± 0.37
0.36HisCys: 0.36 ± 0.384
0.0HisAsp: 0.0 ± 0.0
2.158HisGlu: 2.158 ± 0.788
0.719HisPhe: 0.719 ± 0.54
1.439HisGly: 1.439 ± 0.621
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.079HisLys: 1.079 ± 0.693
2.158HisLeu: 2.158 ± 0.845
0.36HisMet: 0.36 ± 0.339
1.079HisAsn: 1.079 ± 0.557
0.0HisPro: 0.0 ± 0.0
1.079HisGln: 1.079 ± 0.533
0.719HisArg: 0.719 ± 0.484
0.36HisSer: 0.36 ± 0.348
2.878HisThr: 2.878 ± 0.981
0.36HisVal: 0.36 ± 0.378
0.36HisTrp: 0.36 ± 0.384
0.719HisTyr: 0.719 ± 0.555
0.0HisXaa: 0.0 ± 0.0
Ile
5.396IleAla: 5.396 ± 1.567
0.36IleCys: 0.36 ± 0.384
6.115IleAsp: 6.115 ± 1.104
5.396IleGlu: 5.396 ± 1.476
1.079IlePhe: 1.079 ± 0.577
2.158IleGly: 2.158 ± 0.971
1.439IleHis: 1.439 ± 0.628
6.835IleIle: 6.835 ± 1.852
6.115IleLys: 6.115 ± 1.891
8.273IleLeu: 8.273 ± 2.13
1.799IleMet: 1.799 ± 0.702
3.597IleAsn: 3.597 ± 0.998
2.518IlePro: 2.518 ± 0.857
2.518IleGln: 2.518 ± 0.831
3.597IleArg: 3.597 ± 0.94
5.755IleSer: 5.755 ± 1.605
3.237IleThr: 3.237 ± 0.789
3.597IleVal: 3.597 ± 0.965
0.36IleTrp: 0.36 ± 0.37
2.878IleTyr: 2.878 ± 1.279
0.0IleXaa: 0.0 ± 0.0
Lys
6.475LysAla: 6.475 ± 1.849
0.719LysCys: 0.719 ± 0.458
5.036LysAsp: 5.036 ± 1.278
8.633LysGlu: 8.633 ± 1.457
1.439LysPhe: 1.439 ± 0.613
2.518LysGly: 2.518 ± 0.958
1.799LysHis: 1.799 ± 0.594
5.396LysIle: 5.396 ± 1.597
7.554LysLys: 7.554 ± 1.872
7.554LysLeu: 7.554 ± 2.102
1.799LysMet: 1.799 ± 0.878
6.115LysAsn: 6.115 ± 1.618
2.878LysPro: 2.878 ± 0.924
6.115LysGln: 6.115 ± 0.956
3.957LysArg: 3.957 ± 1.127
4.676LysSer: 4.676 ± 1.113
6.475LysThr: 6.475 ± 1.274
6.115LysVal: 6.115 ± 1.316
1.439LysTrp: 1.439 ± 0.738
4.317LysTyr: 4.317 ± 0.972
0.0LysXaa: 0.0 ± 0.0
Leu
4.317LeuAla: 4.317 ± 1.105
0.36LeuCys: 0.36 ± 0.343
10.072LeuAsp: 10.072 ± 1.949
10.432LeuGlu: 10.432 ± 1.939
3.597LeuPhe: 3.597 ± 1.046
4.317LeuGly: 4.317 ± 0.998
1.079LeuHis: 1.079 ± 0.605
4.317LeuIle: 4.317 ± 1.024
9.353LeuLys: 9.353 ± 2.016
8.993LeuLeu: 8.993 ± 1.503
1.799LeuMet: 1.799 ± 1.036
5.036LeuAsn: 5.036 ± 1.083
3.237LeuPro: 3.237 ± 1.051
1.799LeuGln: 1.799 ± 0.779
3.957LeuArg: 3.957 ± 1.03
7.194LeuSer: 7.194 ± 1.768
5.755LeuThr: 5.755 ± 1.154
6.115LeuVal: 6.115 ± 1.745
0.36LeuTrp: 0.36 ± 0.339
5.755LeuTyr: 5.755 ± 0.998
0.0LeuXaa: 0.0 ± 0.0
Met
2.158MetAla: 2.158 ± 0.891
0.0MetCys: 0.0 ± 0.0
1.439MetAsp: 1.439 ± 0.963
1.079MetGlu: 1.079 ± 0.53
1.439MetPhe: 1.439 ± 0.742
0.719MetGly: 0.719 ± 0.438
0.0MetHis: 0.0 ± 0.0
1.799MetIle: 1.799 ± 0.825
1.079MetLys: 1.079 ± 0.597
4.676MetLeu: 4.676 ± 1.124
1.439MetMet: 1.439 ± 0.965
2.878MetAsn: 2.878 ± 0.801
0.0MetPro: 0.0 ± 0.0
1.439MetGln: 1.439 ± 0.499
1.799MetArg: 1.799 ± 0.705
0.36MetSer: 0.36 ± 0.347
2.518MetThr: 2.518 ± 0.891
1.079MetVal: 1.079 ± 0.673
0.0MetTrp: 0.0 ± 0.0
0.36MetTyr: 0.36 ± 0.378
0.0MetXaa: 0.0 ± 0.0
Asn
3.237AsnAla: 3.237 ± 1.113
0.36AsnCys: 0.36 ± 0.317
3.237AsnAsp: 3.237 ± 1.083
4.676AsnGlu: 4.676 ± 1.446
2.158AsnPhe: 2.158 ± 0.658
4.317AsnGly: 4.317 ± 1.002
1.079AsnHis: 1.079 ± 0.573
4.317AsnIle: 4.317 ± 1.327
5.396AsnLys: 5.396 ± 1.479
6.835AsnLeu: 6.835 ± 1.441
1.439AsnMet: 1.439 ± 0.824
2.878AsnAsn: 2.878 ± 0.95
3.597AsnPro: 3.597 ± 1.056
4.317AsnGln: 4.317 ± 1.056
2.518AsnArg: 2.518 ± 0.723
3.237AsnSer: 3.237 ± 1.075
3.237AsnThr: 3.237 ± 1.058
1.799AsnVal: 1.799 ± 0.704
0.719AsnTrp: 0.719 ± 0.553
2.878AsnTyr: 2.878 ± 1.081
0.0AsnXaa: 0.0 ± 0.0
Pro
0.719ProAla: 0.719 ± 0.394
0.0ProCys: 0.0 ± 0.0
0.36ProAsp: 0.36 ± 0.356
0.719ProGlu: 0.719 ± 0.496
2.158ProPhe: 2.158 ± 0.744
0.36ProGly: 0.36 ± 0.348
0.0ProHis: 0.0 ± 0.0
1.799ProIle: 1.799 ± 0.851
3.957ProLys: 3.957 ± 0.713
2.878ProLeu: 2.878 ± 0.682
0.719ProMet: 0.719 ± 0.493
2.518ProAsn: 2.518 ± 0.748
0.719ProPro: 0.719 ± 0.689
1.439ProGln: 1.439 ± 0.611
1.439ProArg: 1.439 ± 0.552
2.158ProSer: 2.158 ± 0.805
3.237ProThr: 3.237 ± 1.077
1.439ProVal: 1.439 ± 0.602
0.0ProTrp: 0.0 ± 0.0
0.719ProTyr: 0.719 ± 0.511
0.0ProXaa: 0.0 ± 0.0
Gln
2.158GlnAla: 2.158 ± 0.541
0.0GlnCys: 0.0 ± 0.0
2.518GlnAsp: 2.518 ± 0.79
2.518GlnGlu: 2.518 ± 1.145
1.079GlnPhe: 1.079 ± 0.601
2.878GlnGly: 2.878 ± 1.023
0.719GlnHis: 0.719 ± 0.515
4.317GlnIle: 4.317 ± 1.132
4.676GlnLys: 4.676 ± 1.24
3.597GlnLeu: 3.597 ± 1.133
1.079GlnMet: 1.079 ± 0.577
1.799GlnAsn: 1.799 ± 1.034
1.439GlnPro: 1.439 ± 0.728
5.396GlnGln: 5.396 ± 1.914
1.439GlnArg: 1.439 ± 0.599
3.597GlnSer: 3.597 ± 0.85
3.237GlnThr: 3.237 ± 1.028
3.237GlnVal: 3.237 ± 1.004
0.719GlnTrp: 0.719 ± 0.429
1.799GlnTyr: 1.799 ± 0.689
0.0GlnXaa: 0.0 ± 0.0
Arg
2.158ArgAla: 2.158 ± 0.798
0.0ArgCys: 0.0 ± 0.0
3.597ArgAsp: 3.597 ± 0.83
4.317ArgGlu: 4.317 ± 1.372
0.719ArgPhe: 0.719 ± 0.465
1.079ArgGly: 1.079 ± 0.597
1.079ArgHis: 1.079 ± 0.569
4.676ArgIle: 4.676 ± 1.236
4.317ArgLys: 4.317 ± 0.925
2.518ArgLeu: 2.518 ± 0.868
2.158ArgMet: 2.158 ± 0.833
1.439ArgAsn: 1.439 ± 0.651
0.36ArgPro: 0.36 ± 0.384
1.799ArgGln: 1.799 ± 0.754
1.079ArgArg: 1.079 ± 0.755
1.799ArgSer: 1.799 ± 0.68
2.878ArgThr: 2.878 ± 1.002
3.597ArgVal: 3.597 ± 1.112
0.719ArgTrp: 0.719 ± 0.472
1.439ArgTyr: 1.439 ± 0.65
0.0ArgXaa: 0.0 ± 0.0
Ser
3.237SerAla: 3.237 ± 0.849
0.36SerCys: 0.36 ± 0.308
4.317SerAsp: 4.317 ± 1.05
4.676SerGlu: 4.676 ± 0.965
2.518SerPhe: 2.518 ± 1.146
1.079SerGly: 1.079 ± 0.606
1.079SerHis: 1.079 ± 0.64
4.676SerIle: 4.676 ± 1.041
5.755SerLys: 5.755 ± 1.515
5.396SerLeu: 5.396 ± 1.73
1.079SerMet: 1.079 ± 0.479
3.957SerAsn: 3.957 ± 0.872
4.317SerPro: 4.317 ± 1.11
2.518SerGln: 2.518 ± 1.225
1.799SerArg: 1.799 ± 0.796
3.597SerSer: 3.597 ± 0.984
2.158SerThr: 2.158 ± 0.768
4.317SerVal: 4.317 ± 1.192
1.079SerTrp: 1.079 ± 0.645
2.878SerTyr: 2.878 ± 0.784
0.0SerXaa: 0.0 ± 0.0
Thr
2.878ThrAla: 2.878 ± 0.822
0.36ThrCys: 0.36 ± 0.346
1.799ThrAsp: 1.799 ± 0.838
5.396ThrGlu: 5.396 ± 1.248
1.439ThrPhe: 1.439 ± 0.672
5.036ThrGly: 5.036 ± 1.196
1.799ThrHis: 1.799 ± 0.681
3.597ThrIle: 3.597 ± 0.927
6.835ThrLys: 6.835 ± 1.587
5.755ThrLeu: 5.755 ± 1.057
1.439ThrMet: 1.439 ± 0.689
2.518ThrAsn: 2.518 ± 0.702
2.158ThrPro: 2.158 ± 0.886
3.237ThrGln: 3.237 ± 1.3
2.158ThrArg: 2.158 ± 1.164
1.799ThrSer: 1.799 ± 0.842
6.115ThrThr: 6.115 ± 1.438
3.237ThrVal: 3.237 ± 0.971
0.36ThrTrp: 0.36 ± 0.36
3.597ThrTyr: 3.597 ± 1.126
0.0ThrXaa: 0.0 ± 0.0
Val
1.439ValAla: 1.439 ± 0.616
0.36ValCys: 0.36 ± 0.395
2.878ValAsp: 2.878 ± 0.809
6.115ValGlu: 6.115 ± 1.793
3.237ValPhe: 3.237 ± 1.163
2.518ValGly: 2.518 ± 0.801
0.36ValHis: 0.36 ± 0.308
6.475ValIle: 6.475 ± 1.448
4.317ValLys: 4.317 ± 1.337
4.676ValLeu: 4.676 ± 1.079
1.079ValMet: 1.079 ± 0.598
4.317ValAsn: 4.317 ± 1.14
2.518ValPro: 2.518 ± 0.711
1.799ValGln: 1.799 ± 0.666
2.518ValArg: 2.518 ± 0.899
6.835ValSer: 6.835 ± 1.497
2.158ValThr: 2.158 ± 0.863
4.676ValVal: 4.676 ± 0.918
0.0ValTrp: 0.0 ± 0.0
3.237ValTyr: 3.237 ± 1.365
0.0ValXaa: 0.0 ± 0.0
Trp
1.079TrpAla: 1.079 ± 0.538
0.0TrpCys: 0.0 ± 0.0
1.079TrpAsp: 1.079 ± 0.646
0.36TrpGlu: 0.36 ± 0.346
0.36TrpPhe: 0.36 ± 0.339
0.36TrpGly: 0.36 ± 0.348
0.36TrpHis: 0.36 ± 0.308
0.36TrpIle: 0.36 ± 0.378
0.36TrpLys: 0.36 ± 0.344
2.158TrpLeu: 2.158 ± 0.923
0.719TrpMet: 0.719 ± 0.523
0.36TrpAsn: 0.36 ± 0.316
0.0TrpPro: 0.0 ± 0.0
0.719TrpGln: 0.719 ± 0.428
0.719TrpArg: 0.719 ± 0.74
0.719TrpSer: 0.719 ± 0.449
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.36TrpTrp: 0.36 ± 0.308
0.36TrpTyr: 0.36 ± 0.339
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.878TyrAla: 2.878 ± 0.91
0.0TyrCys: 0.0 ± 0.0
1.799TyrAsp: 1.799 ± 0.76
3.597TyrGlu: 3.597 ± 1.002
3.957TyrPhe: 3.957 ± 1.202
0.719TyrGly: 0.719 ± 0.426
1.799TyrHis: 1.799 ± 0.794
1.079TyrIle: 1.079 ± 0.529
4.317TyrLys: 4.317 ± 1.445
3.237TyrLeu: 3.237 ± 1.156
0.36TyrMet: 0.36 ± 0.344
2.518TyrAsn: 2.518 ± 0.972
0.0TyrPro: 0.0 ± 0.0
2.878TyrGln: 2.878 ± 0.747
2.518TyrArg: 2.518 ± 0.849
3.957TyrSer: 3.957 ± 1.221
1.799TyrThr: 1.799 ± 0.595
2.878TyrVal: 2.878 ± 0.843
0.36TyrTrp: 0.36 ± 0.308
1.079TyrTyr: 1.079 ± 0.536
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (2781 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski