Amino acid dipepetide frequency for Phytoactinopolyspora alkaliphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.785AlaAla: 18.785 ± 0.162	0.934AlaCys: 0.934 ± 0.024	8.517AlaAsp: 8.517 ± 0.101	8.661AlaGlu: 8.661 ± 0.092	3.511AlaPhe: 3.511 ± 0.054	12.789AlaGly: 12.789 ± 0.103	2.573AlaHis: 2.573 ± 0.041	4.594AlaIle: 4.594 ± 0.058	2.099AlaLys: 2.099 ± 0.042	12.618AlaLeu: 12.618 ± 0.104	2.805AlaMet: 2.805 ± 0.044	2.092AlaAsn: 2.092 ± 0.035	5.561AlaPro: 5.561 ± 0.073	3.485AlaGln: 3.485 ± 0.051	9.391AlaArg: 9.391 ± 0.093	6.631AlaSer: 6.631 ± 0.062	6.813AlaThr: 6.813 ± 0.066	11.7AlaVal: 11.7 ± 0.109	1.927AlaTrp: 1.927 ± 0.035	2.484AlaTyr: 2.484 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.782CysAla: 0.782 ± 0.023	0.081CysCys: 0.081 ± 0.007	0.473CysAsp: 0.473 ± 0.02	0.401CysGlu: 0.401 ± 0.017	0.195CysPhe: 0.195 ± 0.01	0.823CysGly: 0.823 ± 0.023	0.212CysHis: 0.212 ± 0.011	0.179CysIle: 0.179 ± 0.011	0.083CysLys: 0.083 ± 0.006	0.602CysLeu: 0.602 ± 0.021	0.099CysMet: 0.099 ± 0.008	0.116CysAsn: 0.116 ± 0.009	0.402CysPro: 0.402 ± 0.02	0.157CysGln: 0.157 ± 0.01	0.523CysArg: 0.523 ± 0.021	0.392CysSer: 0.392 ± 0.015	0.43CysThr: 0.43 ± 0.018	0.578CysVal: 0.578 ± 0.019	0.099CysTrp: 0.099 ± 0.008	0.139CysTyr: 0.139 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.432AspAla: 8.432 ± 0.091	0.318AspCys: 0.318 ± 0.016	5.315AspAsp: 5.315 ± 0.07	5.021AspGlu: 5.021 ± 0.069	1.499AspPhe: 1.499 ± 0.031	6.887AspGly: 6.887 ± 0.079	1.522AspHis: 1.522 ± 0.033	2.332AspIle: 2.332 ± 0.039	0.807AspLys: 0.807 ± 0.024	6.408AspLeu: 6.408 ± 0.067	0.901AspMet: 0.901 ± 0.024	1.01AspAsn: 1.01 ± 0.027	4.613AspPro: 4.613 ± 0.055	1.859AspGln: 1.859 ± 0.037	4.7AspArg: 4.7 ± 0.057	2.672AspSer: 2.672 ± 0.046	3.103AspThr: 3.103 ± 0.047	6.635AspVal: 6.635 ± 0.075	0.94AspTrp: 0.94 ± 0.026	1.23AspTyr: 1.23 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.275GluAla: 7.275 ± 0.076	0.358GluCys: 0.358 ± 0.017	3.079GluAsp: 3.079 ± 0.043	3.321GluGlu: 3.321 ± 0.053	1.811GluPhe: 1.811 ± 0.037	3.944GluGly: 3.944 ± 0.055	1.786GluHis: 1.786 ± 0.036	2.786GluIle: 2.786 ± 0.044	1.13GluLys: 1.13 ± 0.025	7.158GluLeu: 7.158 ± 0.072	1.127GluMet: 1.127 ± 0.023	1.294GluAsn: 1.294 ± 0.03	3.931GluPro: 3.931 ± 0.06	2.276GluGln: 2.276 ± 0.037	5.507GluArg: 5.507 ± 0.07	3.169GluSer: 3.169 ± 0.048	3.04GluThr: 3.04 ± 0.043	4.732GluVal: 4.732 ± 0.062	0.915GluTrp: 0.915 ± 0.022	1.277GluTyr: 1.277 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.587PheAla: 3.587 ± 0.053	0.231PheCys: 0.231 ± 0.013	2.272PheAsp: 2.272 ± 0.037	1.609PheGlu: 1.609 ± 0.031	0.905PhePhe: 0.905 ± 0.027	3.086PheGly: 3.086 ± 0.051	0.651PheHis: 0.651 ± 0.021	1.013PheIle: 1.013 ± 0.026	0.381PheLys: 0.381 ± 0.015	2.609PheLeu: 2.609 ± 0.046	0.471PheMet: 0.471 ± 0.018	0.629PheAsn: 0.629 ± 0.02	1.371PhePro: 1.371 ± 0.033	0.699PheGln: 0.699 ± 0.02	1.894PheArg: 1.894 ± 0.037	1.699PheSer: 1.699 ± 0.035	2.02PheThr: 2.02 ± 0.04	2.534PheVal: 2.534 ± 0.039	0.455PheTrp: 0.455 ± 0.018	0.642PheTyr: 0.642 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	9.97GlyAla: 9.97 ± 0.092	0.763GlyCys: 0.763 ± 0.024	5.785GlyAsp: 5.785 ± 0.072	5.503GlyGlu: 5.503 ± 0.066	2.923GlyPhe: 2.923 ± 0.045	7.988GlyGly: 7.988 ± 0.089	2.215GlyHis: 2.215 ± 0.044	3.811GlyIle: 3.811 ± 0.053	1.84GlyLys: 1.84 ± 0.038	8.959GlyLeu: 8.959 ± 0.089	2.154GlyMet: 2.154 ± 0.039	1.803GlyAsn: 1.803 ± 0.039	4.472GlyPro: 4.472 ± 0.047	2.715GlyGln: 2.715 ± 0.039	7.113GlyArg: 7.113 ± 0.079	5.459GlySer: 5.459 ± 0.067	5.693GlyThr: 5.693 ± 0.064	7.949GlyVal: 7.949 ± 0.083	1.734GlyTrp: 1.734 ± 0.036	2.285GlyTyr: 2.285 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.707HisAla: 2.707 ± 0.043	0.166HisCys: 0.166 ± 0.01	1.544HisAsp: 1.544 ± 0.035	1.321HisGlu: 1.321 ± 0.028	0.573HisPhe: 0.573 ± 0.019	2.339HisGly: 2.339 ± 0.042	0.684HisHis: 0.684 ± 0.022	0.704HisIle: 0.704 ± 0.021	0.292HisLys: 0.292 ± 0.013	2.289HisLeu: 2.289 ± 0.038	0.351HisMet: 0.351 ± 0.015	0.393HisAsn: 0.393 ± 0.017	1.657HisPro: 1.657 ± 0.032	0.698HisGln: 0.698 ± 0.021	1.981HisArg: 1.981 ± 0.035	0.978HisSer: 0.978 ± 0.026	1.16HisThr: 1.16 ± 0.027	2.096HisVal: 2.096 ± 0.036	0.361HisTrp: 0.361 ± 0.015	0.517HisTyr: 0.517 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.383IleAla: 5.383 ± 0.054	0.293IleCys: 0.293 ± 0.014	3.013IleAsp: 3.013 ± 0.043	2.552IleGlu: 2.552 ± 0.043	1.036IlePhe: 1.036 ± 0.028	4.026IleGly: 4.026 ± 0.058	0.709IleHis: 0.709 ± 0.024	1.361IleIle: 1.361 ± 0.034	0.636IleLys: 0.636 ± 0.02	3.09IleLeu: 3.09 ± 0.043	0.631IleMet: 0.631 ± 0.017	0.765IleAsn: 0.765 ± 0.025	2.145IlePro: 2.145 ± 0.041	0.895IleGln: 0.895 ± 0.022	2.751IleArg: 2.751 ± 0.044	2.175IleSer: 2.175 ± 0.036	2.539IleThr: 2.539 ± 0.05	3.471IleVal: 3.471 ± 0.046	0.485IleTrp: 0.485 ± 0.021	0.709IleTyr: 0.709 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.038LysAla: 2.038 ± 0.042	0.065LysCys: 0.065 ± 0.007	0.895LysAsp: 0.895 ± 0.025	0.812LysGlu: 0.812 ± 0.022	0.36LysPhe: 0.36 ± 0.014	1.248LysGly: 1.248 ± 0.027	0.42LysHis: 0.42 ± 0.017	0.73LysIle: 0.73 ± 0.021	0.462LysLys: 0.462 ± 0.027	1.644LysLeu: 1.644 ± 0.033	0.291LysMet: 0.291 ± 0.015	0.387LysAsn: 0.387 ± 0.015	1.111LysPro: 1.111 ± 0.031	0.531LysGln: 0.531 ± 0.019	1.289LysArg: 1.289 ± 0.031	0.92LysSer: 0.92 ± 0.024	1.021LysThr: 1.021 ± 0.026	1.477LysVal: 1.477 ± 0.034	0.179LysTrp: 0.179 ± 0.009	0.337LysTyr: 0.337 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.232LeuAla: 14.232 ± 0.123	0.623LeuCys: 0.623 ± 0.018	7.058LeuAsp: 7.058 ± 0.077	5.132LeuGlu: 5.132 ± 0.064	2.619LeuPhe: 2.619 ± 0.046	8.935LeuGly: 8.935 ± 0.091	2.047LeuHis: 2.047 ± 0.034	3.782LeuIle: 3.782 ± 0.055	1.425LeuLys: 1.425 ± 0.032	9.757LeuLeu: 9.757 ± 0.116	1.716LeuMet: 1.716 ± 0.032	1.865LeuAsn: 1.865 ± 0.035	5.662LeuPro: 5.662 ± 0.068	2.2LeuGln: 2.2 ± 0.035	8.018LeuArg: 8.018 ± 0.078	5.614LeuSer: 5.614 ± 0.052	6.174LeuThr: 6.174 ± 0.06	8.919LeuVal: 8.919 ± 0.087	1.185LeuTrp: 1.185 ± 0.028	1.715LeuTyr: 1.715 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.495MetAla: 2.495 ± 0.04	0.137MetCys: 0.137 ± 0.008	0.929MetAsp: 0.929 ± 0.021	0.783MetGlu: 0.783 ± 0.024	0.579MetPhe: 0.579 ± 0.021	1.375MetGly: 1.375 ± 0.026	0.398MetHis: 0.398 ± 0.017	0.879MetIle: 0.879 ± 0.023	0.382MetLys: 0.382 ± 0.016	2.041MetLeu: 2.041 ± 0.039	0.34MetMet: 0.34 ± 0.014	0.499MetAsn: 0.499 ± 0.02	1.183MetPro: 1.183 ± 0.024	0.473MetGln: 0.473 ± 0.018	1.62MetArg: 1.62 ± 0.032	1.441MetSer: 1.441 ± 0.028	1.665MetThr: 1.665 ± 0.031	1.593MetVal: 1.593 ± 0.03	0.253MetTrp: 0.253 ± 0.012	0.363MetTyr: 0.363 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.275AsnAla: 2.275 ± 0.037	0.127AsnCys: 0.127 ± 0.009	1.241AsnAsp: 1.241 ± 0.027	1.001AsnGlu: 1.001 ± 0.024	0.52AsnPhe: 0.52 ± 0.019	1.89AsnGly: 1.89 ± 0.043	0.429AsnHis: 0.429 ± 0.016	0.76AsnIle: 0.76 ± 0.026	0.296AsnLys: 0.296 ± 0.014	1.75AsnLeu: 1.75 ± 0.037	0.311AsnMet: 0.311 ± 0.014	0.456AsnAsn: 0.456 ± 0.02	1.533AsnPro: 1.533 ± 0.037	0.574AsnGln: 0.574 ± 0.023	1.358AsnArg: 1.358 ± 0.032	0.997AsnSer: 0.997 ± 0.032	1.156AsnThr: 1.156 ± 0.03	1.702AsnVal: 1.702 ± 0.036	0.289AsnTrp: 0.289 ± 0.013	0.457AsnTyr: 0.457 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.375ProAla: 7.375 ± 0.086	0.278ProCys: 0.278 ± 0.014	4.687ProAsp: 4.687 ± 0.062	4.234ProGlu: 4.234 ± 0.054	1.602ProPhe: 1.602 ± 0.029	5.973ProGly: 5.973 ± 0.068	1.313ProHis: 1.313 ± 0.027	1.741ProIle: 1.741 ± 0.035	0.812ProLys: 0.812 ± 0.026	4.648ProLeu: 4.648 ± 0.054	1.115ProMet: 1.115 ± 0.027	1.038ProAsn: 1.038 ± 0.025	3.261ProPro: 3.261 ± 0.057	1.426ProGln: 1.426 ± 0.03	3.589ProArg: 3.589 ± 0.059	3.266ProSer: 3.266 ± 0.051	3.047ProThr: 3.047 ± 0.05	5.221ProVal: 5.221 ± 0.063	0.922ProTrp: 0.922 ± 0.027	1.223ProTyr: 1.223 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.696GlnAla: 3.696 ± 0.051	0.174GlnCys: 0.174 ± 0.011	1.343GlnAsp: 1.343 ± 0.025	1.402GlnGlu: 1.402 ± 0.031	0.818GlnPhe: 0.818 ± 0.019	1.955GlnGly: 1.955 ± 0.034	0.683GlnHis: 0.683 ± 0.021	1.281GlnIle: 1.281 ± 0.032	0.442GlnLys: 0.442 ± 0.018	3.07GlnLeu: 3.07 ± 0.048	0.574GlnMet: 0.574 ± 0.022	0.541GlnAsn: 0.541 ± 0.02	1.696GlnPro: 1.696 ± 0.033	1.01GlnGln: 1.01 ± 0.03	2.656GlnArg: 2.656 ± 0.046	1.374GlnSer: 1.374 ± 0.031	1.377GlnThr: 1.377 ± 0.032	2.545GlnVal: 2.545 ± 0.037	0.461GlnTrp: 0.461 ± 0.018	0.59GlnTyr: 0.59 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.957ArgAla: 8.957 ± 0.099	0.547ArgCys: 0.547 ± 0.019	4.62ArgAsp: 4.62 ± 0.058	4.6ArgGlu: 4.6 ± 0.063	2.393ArgPhe: 2.393 ± 0.044	5.532ArgGly: 5.532 ± 0.056	2.081ArgHis: 2.081 ± 0.039	3.439ArgIle: 3.439 ± 0.047	1.396ArgLys: 1.396 ± 0.034	8.247ArgLeu: 8.247 ± 0.092	1.819ArgMet: 1.819 ± 0.033	1.427ArgAsn: 1.427 ± 0.033	4.299ArgPro: 4.299 ± 0.056	2.499ArgGln: 2.499 ± 0.037	7.752ArgArg: 7.752 ± 0.1	4.384ArgSer: 4.384 ± 0.054	4.472ArgThr: 4.472 ± 0.052	6.189ArgVal: 6.189 ± 0.065	1.46ArgTrp: 1.46 ± 0.03	1.903ArgTyr: 1.903 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.951SerAla: 6.951 ± 0.062	0.355SerCys: 0.355 ± 0.015	3.187SerAsp: 3.187 ± 0.049	2.89SerGlu: 2.89 ± 0.043	1.728SerPhe: 1.728 ± 0.035	6.217SerGly: 6.217 ± 0.072	1.1SerHis: 1.1 ± 0.026	2.081SerIle: 2.081 ± 0.04	0.874SerLys: 0.874 ± 0.028	5.013SerLeu: 5.013 ± 0.055	1.288SerMet: 1.288 ± 0.03	0.977SerAsn: 0.977 ± 0.023	3.194SerPro: 3.194 ± 0.038	1.422SerGln: 1.422 ± 0.03	4.101SerArg: 4.101 ± 0.051	3.496SerSer: 3.496 ± 0.066	3.452SerThr: 3.452 ± 0.057	4.803SerVal: 4.803 ± 0.054	1.042SerTrp: 1.042 ± 0.024	1.23SerTyr: 1.23 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.392ThrAla: 7.392 ± 0.067	0.383ThrCys: 0.383 ± 0.017	3.563ThrAsp: 3.563 ± 0.051	3.208ThrGlu: 3.208 ± 0.049	1.893ThrPhe: 1.893 ± 0.035	6.002ThrGly: 6.002 ± 0.059	1.19ThrHis: 1.19 ± 0.03	2.222ThrIle: 2.222 ± 0.044	0.874ThrLys: 0.874 ± 0.026	5.575ThrLeu: 5.575 ± 0.069	1.196ThrMet: 1.196 ± 0.029	1.086ThrAsn: 1.086 ± 0.028	3.615ThrPro: 3.615 ± 0.05	1.396ThrGln: 1.396 ± 0.029	3.758ThrArg: 3.758 ± 0.046	3.509ThrSer: 3.509 ± 0.052	3.803ThrThr: 3.803 ± 0.056	6.0ThrVal: 6.0 ± 0.071	1.026ThrTrp: 1.026 ± 0.026	1.393ThrTyr: 1.393 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	11.511ValAla: 11.511 ± 0.109	0.646ValCys: 0.646 ± 0.024	6.304ValAsp: 6.304 ± 0.075	5.464ValGlu: 5.464 ± 0.058	2.614ValPhe: 2.614 ± 0.041	7.103ValGly: 7.103 ± 0.079	1.984ValHis: 1.984 ± 0.035	3.703ValIle: 3.703 ± 0.054	1.398ValLys: 1.398 ± 0.032	9.239ValLeu: 9.239 ± 0.093	1.608ValMet: 1.608 ± 0.031	1.856ValAsn: 1.856 ± 0.039	5.028ValPro: 5.028 ± 0.059	2.113ValGln: 2.113 ± 0.034	6.775ValArg: 6.775 ± 0.069	5.1ValSer: 5.1 ± 0.064	5.913ValThr: 5.913 ± 0.073	9.494ValVal: 9.494 ± 0.092	1.167ValTrp: 1.167 ± 0.026	1.656ValTyr: 1.656 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.617TrpAla: 1.617 ± 0.035	0.141TrpCys: 0.141 ± 0.01	0.892TrpAsp: 0.892 ± 0.027	0.762TrpGlu: 0.762 ± 0.023	0.542TrpPhe: 0.542 ± 0.019	0.974TrpGly: 0.974 ± 0.024	0.382TrpHis: 0.382 ± 0.015	0.647TrpIle: 0.647 ± 0.022	0.303TrpLys: 0.303 ± 0.014	1.792TrpLeu: 1.792 ± 0.04	0.352TrpMet: 0.352 ± 0.015	0.475TrpAsn: 0.475 ± 0.019	0.876TrpPro: 0.876 ± 0.027	0.57TrpGln: 0.57 ± 0.018	1.378TrpArg: 1.378 ± 0.031	1.057TrpSer: 1.057 ± 0.026	1.036TrpThr: 1.036 ± 0.026	1.127TrpVal: 1.127 ± 0.024	0.409TrpTrp: 0.409 ± 0.017	0.342TrpTyr: 0.342 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.04	0.145TyrCys: 0.145 ± 0.008	1.486TyrAsp: 1.486 ± 0.044	1.24TyrGlu: 1.24 ± 0.032	0.637TyrPhe: 0.637 ± 0.019	2.047TyrGly: 2.047 ± 0.038	0.437TyrHis: 0.437 ± 0.018	0.619TyrIle: 0.619 ± 0.019	0.288TyrLys: 0.288 ± 0.013	2.169TyrLeu: 2.169 ± 0.036	0.278TyrMet: 0.278 ± 0.012	0.415TyrAsn: 0.415 ± 0.018	1.161TyrPro: 1.161 ± 0.027	0.688TyrGln: 0.688 ± 0.022	1.861TyrArg: 1.861 ± 0.034	1.068TyrSer: 1.068 ± 0.024	1.17TyrThr: 1.17 ± 0.033	1.908TyrVal: 1.908 ± 0.035	0.363TyrTrp: 0.363 ± 0.017	0.529TyrTyr: 0.529 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4852 proteins (1624139 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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