Amino acid dipepetide frequency for Thauera sp. (strain MZ1T)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.456AlaAla: 19.456 ± 0.201
1.486AlaCys: 1.486 ± 0.038
7.203AlaAsp: 7.203 ± 0.087
8.408AlaGlu: 8.408 ± 0.108
4.3AlaPhe: 4.3 ± 0.057
11.789AlaGly: 11.789 ± 0.122
2.9AlaHis: 2.9 ± 0.051
5.546AlaIle: 5.546 ± 0.083
3.166AlaLys: 3.166 ± 0.056
16.025AlaLeu: 16.025 ± 0.157
3.207AlaMet: 3.207 ± 0.046
2.68AlaAsn: 2.68 ± 0.051
6.214AlaPro: 6.214 ± 0.08
4.56AlaGln: 4.56 ± 0.06
11.264AlaArg: 11.264 ± 0.111
6.187AlaSer: 6.187 ± 0.083
5.737AlaThr: 5.737 ± 0.069
9.037AlaVal: 9.037 ± 0.098
1.984AlaTrp: 1.984 ± 0.04
2.317AlaTyr: 2.317 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.376CysAla: 1.376 ± 0.036
0.138CysCys: 0.138 ± 0.011
0.543CysAsp: 0.543 ± 0.022
0.556CysGlu: 0.556 ± 0.02
0.342CysPhe: 0.342 ± 0.017
1.073CysGly: 1.073 ± 0.033
0.306CysHis: 0.306 ± 0.02
0.396CysIle: 0.396 ± 0.018
0.209CysLys: 0.209 ± 0.012
0.868CysLeu: 0.868 ± 0.026
0.19CysMet: 0.19 ± 0.013
0.24CysAsn: 0.24 ± 0.014
0.556CysPro: 0.556 ± 0.025
0.222CysGln: 0.222 ± 0.012
0.738CysArg: 0.738 ± 0.024
0.502CysSer: 0.502 ± 0.022
0.466CysThr: 0.466 ± 0.017
0.724CysVal: 0.724 ± 0.024
0.124CysTrp: 0.124 ± 0.01
0.224CysTyr: 0.224 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.514AspAla: 7.514 ± 0.092
0.53AspCys: 0.53 ± 0.02
2.987AspAsp: 2.987 ± 0.063
3.924AspGlu: 3.924 ± 0.068
2.26AspPhe: 2.26 ± 0.044
4.808AspGly: 4.808 ± 0.075
1.177AspHis: 1.177 ± 0.032
2.374AspIle: 2.374 ± 0.045
1.648AspLys: 1.648 ± 0.04
5.542AspLeu: 5.542 ± 0.073
1.095AspMet: 1.095 ± 0.03
1.173AspAsn: 1.173 ± 0.03
3.285AspPro: 3.285 ± 0.054
1.341AspGln: 1.341 ± 0.033
3.865AspArg: 3.865 ± 0.061
2.186AspSer: 2.186 ± 0.044
2.619AspThr: 2.619 ± 0.043
3.729AspVal: 3.729 ± 0.058
1.053AspTrp: 1.053 ± 0.029
1.452AspTyr: 1.452 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.235GluAla: 8.235 ± 0.11
0.456GluCys: 0.456 ± 0.02
2.92GluAsp: 2.92 ± 0.049
3.076GluGlu: 3.076 ± 0.054
1.85GluPhe: 1.85 ± 0.037
4.489GluGly: 4.489 ± 0.057
1.626GluHis: 1.626 ± 0.033
3.189GluIle: 3.189 ± 0.051
1.82GluLys: 1.82 ± 0.046
7.101GluLeu: 7.101 ± 0.087
1.267GluMet: 1.267 ± 0.032
1.302GluAsn: 1.302 ± 0.033
2.736GluPro: 2.736 ± 0.051
2.413GluGln: 2.413 ± 0.044
6.148GluArg: 6.148 ± 0.086
2.602GluSer: 2.602 ± 0.045
2.835GluThr: 2.835 ± 0.047
4.524GluVal: 4.524 ± 0.064
0.848GluTrp: 0.848 ± 0.026
1.168GluTyr: 1.168 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.692PheAla: 4.692 ± 0.065
0.415PheCys: 0.415 ± 0.019
2.491PheAsp: 2.491 ± 0.045
2.306PheGlu: 2.306 ± 0.04
1.347PhePhe: 1.347 ± 0.036
3.483PheGly: 3.483 ± 0.049
0.799PheHis: 0.799 ± 0.026
1.55PheIle: 1.55 ± 0.039
0.927PheLys: 0.927 ± 0.029
3.276PheLeu: 3.276 ± 0.061
0.724PheMet: 0.724 ± 0.021
0.99PheAsn: 0.99 ± 0.028
1.523PhePro: 1.523 ± 0.034
0.9PheGln: 0.9 ± 0.025
2.296PheArg: 2.296 ± 0.043
1.945PheSer: 1.945 ± 0.035
1.694PheThr: 1.694 ± 0.04
2.939PheVal: 2.939 ± 0.051
0.494PheTrp: 0.494 ± 0.017
0.791PheTyr: 0.791 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.696GlyAla: 9.696 ± 0.107
1.014GlyCys: 1.014 ± 0.03
4.195GlyAsp: 4.195 ± 0.066
5.625GlyGlu: 5.625 ± 0.076
3.452GlyPhe: 3.452 ± 0.058
7.408GlyGly: 7.408 ± 0.109
1.901GlyHis: 1.901 ± 0.036
4.03GlyIle: 4.03 ± 0.058
3.065GlyLys: 3.065 ± 0.054
9.431GlyLeu: 9.431 ± 0.097
2.403GlyMet: 2.403 ± 0.048
1.923GlyAsn: 1.923 ± 0.039
2.839GlyPro: 2.839 ± 0.046
2.624GlyGln: 2.624 ± 0.048
6.723GlyArg: 6.723 ± 0.079
4.215GlySer: 4.215 ± 0.075
4.041GlyThr: 4.041 ± 0.063
6.638GlyVal: 6.638 ± 0.093
1.403GlyTrp: 1.403 ± 0.035
2.109GlyTyr: 2.109 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
3.012HisAla: 3.012 ± 0.049
0.266HisCys: 0.266 ± 0.013
1.356HisAsp: 1.356 ± 0.033
1.243HisGlu: 1.243 ± 0.034
0.948HisPhe: 0.948 ± 0.024
2.196HisGly: 2.196 ± 0.045
0.677HisHis: 0.677 ± 0.026
0.88HisIle: 0.88 ± 0.024
0.573HisLys: 0.573 ± 0.021
2.42HisLeu: 2.42 ± 0.045
0.464HisMet: 0.464 ± 0.02
0.464HisAsn: 0.464 ± 0.017
1.639HisPro: 1.639 ± 0.043
0.648HisGln: 0.648 ± 0.024
1.726HisArg: 1.726 ± 0.037
0.918HisSer: 0.918 ± 0.026
1.031HisThr: 1.031 ± 0.024
1.552HisVal: 1.552 ± 0.036
0.397HisTrp: 0.397 ± 0.018
0.661HisTyr: 0.661 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.322IleAla: 6.322 ± 0.087
0.397IleCys: 0.397 ± 0.018
3.301IleAsp: 3.301 ± 0.051
3.48IleGlu: 3.48 ± 0.055
1.337IlePhe: 1.337 ± 0.035
4.363IleGly: 4.363 ± 0.075
0.972IleHis: 0.972 ± 0.027
1.467IleIle: 1.467 ± 0.037
1.252IleLys: 1.252 ± 0.034
3.753IleLeu: 3.753 ± 0.063
0.701IleMet: 0.701 ± 0.022
1.214IleAsn: 1.214 ± 0.033
2.112IlePro: 2.112 ± 0.045
1.13IleGln: 1.13 ± 0.029
3.148IleArg: 3.148 ± 0.047
2.024IleSer: 2.024 ± 0.034
2.229IleThr: 2.229 ± 0.047
3.581IleVal: 3.581 ± 0.056
0.443IleTrp: 0.443 ± 0.019
0.907IleTyr: 0.907 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.523LysAla: 3.523 ± 0.062
0.189LysCys: 0.189 ± 0.013
1.507LysAsp: 1.507 ± 0.039
1.472LysGlu: 1.472 ± 0.04
0.81LysPhe: 0.81 ± 0.027
2.114LysGly: 2.114 ± 0.044
0.612LysHis: 0.612 ± 0.022
1.304LysIle: 1.304 ± 0.04
1.15LysLys: 1.15 ± 0.035
3.224LysLeu: 3.224 ± 0.053
0.659LysMet: 0.659 ± 0.024
0.769LysAsn: 0.769 ± 0.027
1.696LysPro: 1.696 ± 0.041
0.966LysGln: 0.966 ± 0.034
2.148LysArg: 2.148 ± 0.044
1.403LysSer: 1.403 ± 0.037
1.487LysThr: 1.487 ± 0.04
2.32LysVal: 2.32 ± 0.048
0.326LysTrp: 0.326 ± 0.019
0.615LysTyr: 0.615 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
16.869LeuAla: 16.869 ± 0.154
1.037LeuCys: 1.037 ± 0.03
6.604LeuAsp: 6.604 ± 0.08
6.425LeuGlu: 6.425 ± 0.074
3.714LeuPhe: 3.714 ± 0.064
9.205LeuGly: 9.205 ± 0.1
2.511LeuHis: 2.511 ± 0.04
4.57LeuIle: 4.57 ± 0.057
2.978LeuLys: 2.978 ± 0.059
11.849LeuLeu: 11.849 ± 0.135
2.352LeuMet: 2.352 ± 0.043
2.295LeuAsn: 2.295 ± 0.046
6.375LeuPro: 6.375 ± 0.09
3.632LeuGln: 3.632 ± 0.066
9.081LeuArg: 9.081 ± 0.096
5.554LeuSer: 5.554 ± 0.066
4.691LeuThr: 4.691 ± 0.058
8.196LeuVal: 8.196 ± 0.098
1.275LeuTrp: 1.275 ± 0.033
2.142LeuTyr: 2.142 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.603MetAla: 2.603 ± 0.048
0.165MetCys: 0.165 ± 0.012
1.095MetAsp: 1.095 ± 0.028
1.125MetGlu: 1.125 ± 0.03
0.678MetPhe: 0.678 ± 0.023
1.645MetGly: 1.645 ± 0.042
0.492MetHis: 0.492 ± 0.02
1.006MetIle: 1.006 ± 0.028
0.982MetLys: 0.982 ± 0.031
2.585MetLeu: 2.585 ± 0.05
0.573MetMet: 0.573 ± 0.022
0.848MetAsn: 0.848 ± 0.026
1.346MetPro: 1.346 ± 0.038
0.891MetGln: 0.891 ± 0.025
1.761MetArg: 1.761 ± 0.033
1.616MetSer: 1.616 ± 0.038
1.283MetThr: 1.283 ± 0.034
1.613MetVal: 1.613 ± 0.038
0.189MetTrp: 0.189 ± 0.012
0.32MetTyr: 0.32 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.858AsnAla: 2.858 ± 0.052
0.249AsnCys: 0.249 ± 0.013
1.09AsnAsp: 1.09 ± 0.03
1.137AsnGlu: 1.137 ± 0.03
0.842AsnPhe: 0.842 ± 0.028
1.844AsnGly: 1.844 ± 0.04
0.467AsnHis: 0.467 ± 0.017
1.038AsnIle: 1.038 ± 0.033
0.656AsnLys: 0.656 ± 0.027
2.645AsnLeu: 2.645 ± 0.045
0.505AsnMet: 0.505 ± 0.021
0.589AsnAsn: 0.589 ± 0.025
1.751AsnPro: 1.751 ± 0.04
0.71AsnGln: 0.71 ± 0.024
1.747AsnArg: 1.747 ± 0.031
0.895AsnSer: 0.895 ± 0.026
1.225AsnThr: 1.225 ± 0.03
1.654AsnVal: 1.654 ± 0.033
0.355AsnTrp: 0.355 ± 0.017
0.58AsnTyr: 0.58 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.878ProAla: 7.878 ± 0.107
0.426ProCys: 0.426 ± 0.02
3.143ProAsp: 3.143 ± 0.049
3.665ProGlu: 3.665 ± 0.052
1.771ProPhe: 1.771 ± 0.036
4.7ProGly: 4.7 ± 0.06
1.083ProHis: 1.083 ± 0.032
1.972ProIle: 1.972 ± 0.048
1.263ProLys: 1.263 ± 0.038
5.249ProLeu: 5.249 ± 0.071
1.132ProMet: 1.132 ± 0.025
1.103ProAsn: 1.103 ± 0.031
2.877ProPro: 2.877 ± 0.063
1.797ProGln: 1.797 ± 0.041
3.398ProArg: 3.398 ± 0.053
2.401ProSer: 2.401 ± 0.044
2.276ProThr: 2.276 ± 0.044
4.125ProVal: 4.125 ± 0.065
0.755ProTrp: 0.755 ± 0.025
1.053ProTyr: 1.053 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.692GlnAla: 4.692 ± 0.068
0.263GlnCys: 0.263 ± 0.014
1.422GlnAsp: 1.422 ± 0.034
1.508GlnGlu: 1.508 ± 0.037
0.979GlnPhe: 0.979 ± 0.034
2.544GlnGly: 2.544 ± 0.043
0.749GlnHis: 0.749 ± 0.023
1.514GlnIle: 1.514 ± 0.036
0.891GlnLys: 0.891 ± 0.03
3.422GlnLeu: 3.422 ± 0.056
0.78GlnMet: 0.78 ± 0.023
0.679GlnAsn: 0.679 ± 0.023
1.906GlnPro: 1.906 ± 0.037
1.395GlnGln: 1.395 ± 0.037
2.998GlnArg: 2.998 ± 0.057
1.487GlnSer: 1.487 ± 0.034
1.43GlnThr: 1.43 ± 0.032
2.547GlnVal: 2.547 ± 0.05
0.471GlnTrp: 0.471 ± 0.018
0.657GlnTyr: 0.657 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
9.521ArgAla: 9.521 ± 0.103
0.74ArgCys: 0.74 ± 0.022
4.094ArgAsp: 4.094 ± 0.058
5.145ArgGlu: 5.145 ± 0.062
3.292ArgPhe: 3.292 ± 0.046
5.37ArgGly: 5.37 ± 0.069
2.196ArgHis: 2.196 ± 0.042
4.361ArgIle: 4.361 ± 0.057
2.212ArgLys: 2.212 ± 0.046
9.616ArgLeu: 9.616 ± 0.101
2.09ArgMet: 2.09 ± 0.038
1.861ArgAsn: 1.861 ± 0.041
3.85ArgPro: 3.85 ± 0.058
2.762ArgGln: 2.762 ± 0.049
6.624ArgArg: 6.624 ± 0.104
3.809ArgSer: 3.809 ± 0.06
3.339ArgThr: 3.339 ± 0.054
5.614ArgVal: 5.614 ± 0.065
1.183ArgTrp: 1.183 ± 0.036
1.984ArgTyr: 1.984 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.375SerAla: 6.375 ± 0.09
0.465SerCys: 0.465 ± 0.02
2.315SerAsp: 2.315 ± 0.05
2.412SerGlu: 2.412 ± 0.052
1.897SerPhe: 1.897 ± 0.036
4.841SerGly: 4.841 ± 0.068
1.058SerHis: 1.058 ± 0.029
2.226SerIle: 2.226 ± 0.044
1.204SerLys: 1.204 ± 0.034
5.158SerLeu: 5.158 ± 0.066
1.18SerMet: 1.18 ± 0.029
1.15SerAsn: 1.15 ± 0.032
2.641SerPro: 2.641 ± 0.046
1.352SerGln: 1.352 ± 0.038
3.457SerArg: 3.457 ± 0.056
2.424SerSer: 2.424 ± 0.048
2.433SerThr: 2.433 ± 0.048
3.577SerVal: 3.577 ± 0.057
0.662SerTrp: 0.662 ± 0.024
1.112SerTyr: 1.112 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.468ThrAla: 5.468 ± 0.074
0.398ThrCys: 0.398 ± 0.017
2.38ThrAsp: 2.38 ± 0.047
2.417ThrGlu: 2.417 ± 0.045
1.451ThrPhe: 1.451 ± 0.034
4.219ThrGly: 4.219 ± 0.069
1.094ThrHis: 1.094 ± 0.031
1.967ThrIle: 1.967 ± 0.045
1.034ThrLys: 1.034 ± 0.035
6.038ThrLeu: 6.038 ± 0.075
0.957ThrMet: 0.957 ± 0.027
1.028ThrAsn: 1.028 ± 0.029
3.13ThrPro: 3.13 ± 0.052
1.39ThrGln: 1.39 ± 0.036
3.566ThrArg: 3.566 ± 0.043
2.049ThrSer: 2.049 ± 0.042
2.386ThrThr: 2.386 ± 0.055
3.826ThrVal: 3.826 ± 0.061
0.629ThrTrp: 0.629 ± 0.025
0.884ThrTyr: 0.884 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
9.627ValAla: 9.627 ± 0.103
0.775ValCys: 0.775 ± 0.027
4.113ValAsp: 4.113 ± 0.049
4.925ValGlu: 4.925 ± 0.062
2.925ValPhe: 2.925 ± 0.051
5.885ValGly: 5.885 ± 0.097
1.627ValHis: 1.627 ± 0.037
3.311ValIle: 3.311 ± 0.058
2.176ValLys: 2.176 ± 0.045
8.607ValLeu: 8.607 ± 0.098
1.764ValMet: 1.764 ± 0.047
1.61ValAsn: 1.61 ± 0.039
3.808ValPro: 3.808 ± 0.054
2.215ValGln: 2.215 ± 0.044
5.781ValArg: 5.781 ± 0.067
3.927ValSer: 3.927 ± 0.061
3.424ValThr: 3.424 ± 0.052
6.43ValVal: 6.43 ± 0.093
0.917ValTrp: 0.917 ± 0.03
1.315ValTyr: 1.315 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.252TrpAla: 1.252 ± 0.032
0.147TrpCys: 0.147 ± 0.011
0.613TrpAsp: 0.613 ± 0.022
0.628TrpGlu: 0.628 ± 0.021
0.543TrpPhe: 0.543 ± 0.018
0.887TrpGly: 0.887 ± 0.027
0.365TrpHis: 0.365 ± 0.017
0.681TrpIle: 0.681 ± 0.023
0.476TrpLys: 0.476 ± 0.016
2.124TrpLeu: 2.124 ± 0.048
0.415TrpMet: 0.415 ± 0.016
0.42TrpAsn: 0.42 ± 0.014
0.686TrpPro: 0.686 ± 0.024
0.658TrpGln: 0.658 ± 0.024
1.272TrpArg: 1.272 ± 0.036
0.773TrpSer: 0.773 ± 0.028
0.638TrpThr: 0.638 ± 0.022
0.987TrpVal: 0.987 ± 0.029
0.257TrpTrp: 0.257 ± 0.013
0.288TrpTyr: 0.288 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.498TyrAla: 2.498 ± 0.045
0.232TyrCys: 0.232 ± 0.014
1.189TyrAsp: 1.189 ± 0.032
1.131TyrGlu: 1.131 ± 0.034
0.844TyrPhe: 0.844 ± 0.028
1.872TyrGly: 1.872 ± 0.037
0.462TyrHis: 0.462 ± 0.019
0.749TyrIle: 0.749 ± 0.023
0.61TyrLys: 0.61 ± 0.026
2.421TyrLeu: 2.421 ± 0.045
0.359TyrMet: 0.359 ± 0.017
0.502TyrAsn: 0.502 ± 0.02
1.097TyrPro: 1.097 ± 0.028
0.729TyrGln: 0.729 ± 0.025
1.923TyrArg: 1.923 ± 0.038
1.021TyrSer: 1.021 ± 0.026
1.046TyrThr: 1.046 ± 0.028
1.549TyrVal: 1.549 ± 0.033
0.346TyrTrp: 0.346 ± 0.017
0.586TyrTyr: 0.586 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3927 proteins (1335952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski