Amino acid dipepetide frequency for Flavobacterium branchiophilum (strain FL-15)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.388AlaAla: 4.388 ± 0.091	0.565AlaCys: 0.565 ± 0.028	3.092AlaAsp: 3.092 ± 0.066	3.295AlaGlu: 3.295 ± 0.066	3.411AlaPhe: 3.411 ± 0.061	3.861AlaGly: 3.861 ± 0.087	1.221AlaHis: 1.221 ± 0.039	5.655AlaIle: 5.655 ± 0.09	4.749AlaLys: 4.749 ± 0.083	6.099AlaLeu: 6.099 ± 0.086	1.382AlaMet: 1.382 ± 0.043	3.765AlaAsn: 3.765 ± 0.068	1.946AlaPro: 1.946 ± 0.053	3.02AlaGln: 3.02 ± 0.061	1.725AlaArg: 1.725 ± 0.048	4.001AlaSer: 4.001 ± 0.088	4.501AlaThr: 4.501 ± 0.128	3.837AlaVal: 3.837 ± 0.076	0.569AlaTrp: 0.569 ± 0.025	2.308AlaTyr: 2.308 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.448CysAla: 0.448 ± 0.023	0.134CysCys: 0.134 ± 0.014	0.45CysAsp: 0.45 ± 0.028	0.446CysGlu: 0.446 ± 0.025	0.51CysPhe: 0.51 ± 0.024	0.645CysGly: 0.645 ± 0.032	0.228CysHis: 0.228 ± 0.016	0.766CysIle: 0.766 ± 0.032	0.576CysLys: 0.576 ± 0.024	0.795CysLeu: 0.795 ± 0.027	0.181CysMet: 0.181 ± 0.014	0.559CysAsn: 0.559 ± 0.025	0.383CysPro: 0.383 ± 0.027	0.319CysGln: 0.319 ± 0.019	0.197CysArg: 0.197 ± 0.014	0.598CysSer: 0.598 ± 0.025	0.47CysThr: 0.47 ± 0.026	0.437CysVal: 0.437 ± 0.023	0.07CysTrp: 0.07 ± 0.009	0.369CysTyr: 0.369 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.485AspAla: 3.485 ± 0.068	0.439AspCys: 0.439 ± 0.022	2.498AspAsp: 2.498 ± 0.057	3.229AspGlu: 3.229 ± 0.074	3.852AspPhe: 3.852 ± 0.072	3.197AspGly: 3.197 ± 0.076	0.861AspHis: 0.861 ± 0.028	4.108AspIle: 4.108 ± 0.066	4.053AspLys: 4.053 ± 0.084	5.122AspLeu: 5.122 ± 0.083	1.018AspMet: 1.018 ± 0.03	3.144AspAsn: 3.144 ± 0.069	1.378AspPro: 1.378 ± 0.042	1.671AspGln: 1.671 ± 0.048	1.548AspArg: 1.548 ± 0.036	2.536AspSer: 2.536 ± 0.053	2.535AspThr: 2.535 ± 0.047	3.291AspVal: 3.291 ± 0.058	0.661AspTrp: 0.661 ± 0.026	2.817AspTyr: 2.817 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.171GluAla: 4.171 ± 0.074	0.356GluCys: 0.356 ± 0.021	2.595GluAsp: 2.595 ± 0.062	3.535GluGlu: 3.535 ± 0.093	2.617GluPhe: 2.617 ± 0.055	3.083GluGly: 3.083 ± 0.061	1.105GluHis: 1.105 ± 0.037	5.638GluIle: 5.638 ± 0.109	6.204GluLys: 6.204 ± 0.112	5.229GluLeu: 5.229 ± 0.095	1.592GluMet: 1.592 ± 0.043	5.035GluAsn: 5.035 ± 0.076	1.37GluPro: 1.37 ± 0.04	2.425GluGln: 2.425 ± 0.053	1.963GluArg: 1.963 ± 0.051	3.01GluSer: 3.01 ± 0.061	3.361GluThr: 3.361 ± 0.057	3.697GluVal: 3.697 ± 0.064	0.6GluTrp: 0.6 ± 0.024	2.16GluTyr: 2.16 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.05PheAla: 3.05 ± 0.057	0.54PheCys: 0.54 ± 0.023	3.713PheAsp: 3.713 ± 0.072	4.131PheGlu: 4.131 ± 0.08	2.99PhePhe: 2.99 ± 0.067	3.774PheGly: 3.774 ± 0.069	0.943PheHis: 0.943 ± 0.034	4.347PheIle: 4.347 ± 0.083	3.925PheLys: 3.925 ± 0.074	4.919PheLeu: 4.919 ± 0.102	1.143PheMet: 1.143 ± 0.037	3.348PheAsn: 3.348 ± 0.067	1.654PhePro: 1.654 ± 0.04	1.974PheGln: 1.974 ± 0.05	1.547PheArg: 1.547 ± 0.041	4.069PheSer: 4.069 ± 0.077	2.927PheThr: 2.927 ± 0.062	3.401PheVal: 3.401 ± 0.067	0.664PheTrp: 0.664 ± 0.03	2.334PheTyr: 2.334 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	3.839GlyAla: 3.839 ± 0.085	0.645GlyCys: 0.645 ± 0.039	2.687GlyAsp: 2.687 ± 0.06	2.711GlyGlu: 2.711 ± 0.056	3.674GlyPhe: 3.674 ± 0.079	4.033GlyGly: 4.033 ± 0.085	1.191GlyHis: 1.191 ± 0.036	5.393GlyIle: 5.393 ± 0.085	4.701GlyLys: 4.701 ± 0.08	5.28GlyLeu: 5.28 ± 0.085	1.475GlyMet: 1.475 ± 0.04	3.686GlyAsn: 3.686 ± 0.076	1.135GlyPro: 1.135 ± 0.038	2.154GlyGln: 2.154 ± 0.053	1.692GlyArg: 1.692 ± 0.049	3.645GlySer: 3.645 ± 0.08	4.146GlyThr: 4.146 ± 0.124	3.814GlyVal: 3.814 ± 0.07	0.67GlyTrp: 0.67 ± 0.031	2.637GlyTyr: 2.637 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.04HisAla: 1.04 ± 0.037	0.214HisCys: 0.214 ± 0.015	0.905HisAsp: 0.905 ± 0.03	0.986HisGlu: 0.986 ± 0.034	1.562HisPhe: 1.562 ± 0.045	1.028HisGly: 1.028 ± 0.036	0.564HisHis: 0.564 ± 0.027	1.494HisIle: 1.494 ± 0.045	1.131HisLys: 1.131 ± 0.036	2.236HisLeu: 2.236 ± 0.058	0.197HisMet: 0.197 ± 0.014	1.025HisAsn: 1.025 ± 0.033	0.836HisPro: 0.836 ± 0.031	1.127HisGln: 1.127 ± 0.034	0.567HisArg: 0.567 ± 0.024	0.977HisSer: 0.977 ± 0.034	0.944HisThr: 0.944 ± 0.032	0.947HisVal: 0.947 ± 0.032	0.211HisTrp: 0.211 ± 0.015	0.958HisTyr: 0.958 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.973IleAla: 5.973 ± 0.075	0.838IleCys: 0.838 ± 0.03	5.031IleAsp: 5.031 ± 0.079	5.643IleGlu: 5.643 ± 0.104	4.13IlePhe: 4.13 ± 0.084	5.143IleGly: 5.143 ± 0.084	1.516IleHis: 1.516 ± 0.04	7.091IleIle: 7.091 ± 0.121	6.781IleLys: 6.781 ± 0.103	7.669IleLeu: 7.669 ± 0.111	1.559IleMet: 1.559 ± 0.039	5.536IleAsn: 5.536 ± 0.097	3.229IlePro: 3.229 ± 0.059	3.48IleGln: 3.48 ± 0.062	2.433IleArg: 2.433 ± 0.043	5.674IleSer: 5.674 ± 0.089	4.901IleThr: 4.901 ± 0.08	5.121IleVal: 5.121 ± 0.09	0.731IleTrp: 0.731 ± 0.029	3.125IleTyr: 3.125 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.872LysAla: 4.872 ± 0.08	0.469LysCys: 0.469 ± 0.022	4.15LysAsp: 4.15 ± 0.085	5.268LysGlu: 5.268 ± 0.106	3.164LysPhe: 3.164 ± 0.062	4.299LysGly: 4.299 ± 0.078	1.393LysHis: 1.393 ± 0.042	7.893LysIle: 7.893 ± 0.104	7.481LysLys: 7.481 ± 0.122	6.831LysLeu: 6.831 ± 0.105	2.401LysMet: 2.401 ± 0.056	6.68LysAsn: 6.68 ± 0.106	2.65LysPro: 2.65 ± 0.059	3.071LysGln: 3.071 ± 0.058	2.301LysArg: 2.301 ± 0.053	4.693LysSer: 4.693 ± 0.078	5.117LysThr: 5.117 ± 0.085	4.402LysVal: 4.402 ± 0.074	0.905LysTrp: 0.905 ± 0.035	3.315LysTyr: 3.315 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.723LeuAla: 5.723 ± 0.083	0.725LeuCys: 0.725 ± 0.028	5.088LeuAsp: 5.088 ± 0.083	6.027LeuGlu: 6.027 ± 0.091	5.189LeuPhe: 5.189 ± 0.102	5.275LeuGly: 5.275 ± 0.087	1.796LeuHis: 1.796 ± 0.048	7.339LeuIle: 7.339 ± 0.133	7.822LeuLys: 7.822 ± 0.121	8.656LeuLeu: 8.656 ± 0.133	2.193LeuMet: 2.193 ± 0.052	5.891LeuAsn: 5.891 ± 0.093	3.539LeuPro: 3.539 ± 0.07	3.78LeuGln: 3.78 ± 0.083	2.517LeuArg: 2.517 ± 0.053	6.342LeuSer: 6.342 ± 0.082	5.114LeuThr: 5.114 ± 0.093	4.864LeuVal: 4.864 ± 0.079	0.8LeuTrp: 0.8 ± 0.03	3.445LeuTyr: 3.445 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.672MetAla: 1.672 ± 0.051	0.167MetCys: 0.167 ± 0.012	1.027MetAsp: 1.027 ± 0.034	1.34MetGlu: 1.34 ± 0.042	0.89MetPhe: 0.89 ± 0.03	1.397MetGly: 1.397 ± 0.047	0.353MetHis: 0.353 ± 0.019	1.688MetIle: 1.688 ± 0.043	2.152MetLys: 2.152 ± 0.051	1.878MetLeu: 1.878 ± 0.042	0.62MetMet: 0.62 ± 0.029	1.511MetAsn: 1.511 ± 0.039	0.881MetPro: 0.881 ± 0.032	0.95MetGln: 0.95 ± 0.029	0.718MetArg: 0.718 ± 0.026	1.393MetSer: 1.393 ± 0.042	1.236MetThr: 1.236 ± 0.038	1.299MetVal: 1.299 ± 0.036	0.147MetTrp: 0.147 ± 0.012	0.751MetTyr: 0.751 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	4.249AsnAla: 4.249 ± 0.085	0.584AsnCys: 0.584 ± 0.025	3.515AsnAsp: 3.515 ± 0.06	4.06AsnGlu: 4.06 ± 0.07	3.451AsnPhe: 3.451 ± 0.062	4.193AsnGly: 4.193 ± 0.101	1.365AsnHis: 1.365 ± 0.035	5.745AsnIle: 5.745 ± 0.096	5.117AsnLys: 5.117 ± 0.082	6.018AsnLeu: 6.018 ± 0.085	1.305AsnMet: 1.305 ± 0.034	4.771AsnAsn: 4.771 ± 0.09	3.134AsnPro: 3.134 ± 0.069	3.346AsnGln: 3.346 ± 0.071	1.993AsnArg: 1.993 ± 0.055	4.086AsnSer: 4.086 ± 0.087	4.055AsnThr: 4.055 ± 0.088	3.666AsnVal: 3.666 ± 0.062	0.874AsnTrp: 0.874 ± 0.033	3.197AsnTyr: 3.197 ± 0.068	0.0AsnXaa: 0.0 ± 0.0
Pro	1.879ProAla: 1.879 ± 0.053	0.24ProCys: 0.24 ± 0.015	1.673ProAsp: 1.673 ± 0.042	2.327ProGlu: 2.327 ± 0.056	2.088ProPhe: 2.088 ± 0.045	1.481ProGly: 1.481 ± 0.05	0.626ProHis: 0.626 ± 0.025	3.014ProIle: 3.014 ± 0.066	2.732ProLys: 2.732 ± 0.059	2.922ProLeu: 2.922 ± 0.064	0.745ProMet: 0.745 ± 0.027	2.665ProAsn: 2.665 ± 0.074	0.75ProPro: 0.75 ± 0.034	1.223ProGln: 1.223 ± 0.036	0.749ProArg: 0.749 ± 0.031	2.154ProSer: 2.154 ± 0.05	2.132ProThr: 2.132 ± 0.062	1.973ProVal: 1.973 ± 0.054	0.289ProTrp: 0.289 ± 0.019	1.393ProTyr: 1.393 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.237GlnAla: 2.237 ± 0.055	0.253GlnCys: 0.253 ± 0.015	1.737GlnAsp: 1.737 ± 0.045	2.298GlnGlu: 2.298 ± 0.058	2.069GlnPhe: 2.069 ± 0.049	1.75GlnGly: 1.75 ± 0.043	0.838GlnHis: 0.838 ± 0.033	3.534GlnIle: 3.534 ± 0.068	3.967GlnLys: 3.967 ± 0.072	3.993GlnLeu: 3.993 ± 0.08	0.994GlnMet: 0.994 ± 0.03	3.553GlnAsn: 3.553 ± 0.075	1.114GlnPro: 1.114 ± 0.035	1.796GlnGln: 1.796 ± 0.055	1.09GlnArg: 1.09 ± 0.036	2.335GlnSer: 2.335 ± 0.053	2.507GlnThr: 2.507 ± 0.057	2.136GlnVal: 2.136 ± 0.052	0.413GlnTrp: 0.413 ± 0.021	1.772GlnTyr: 1.772 ± 0.052	0.0GlnXaa: 0.0 ± 0.0
Arg	1.729ArgAla: 1.729 ± 0.042	0.197ArgCys: 0.197 ± 0.013	1.336ArgAsp: 1.336 ± 0.039	1.632ArgGlu: 1.632 ± 0.045	1.748ArgPhe: 1.748 ± 0.042	1.552ArgGly: 1.552 ± 0.041	0.532ArgHis: 0.532 ± 0.031	2.602ArgIle: 2.602 ± 0.05	2.382ArgLys: 2.382 ± 0.056	2.691ArgLeu: 2.691 ± 0.059	0.785ArgMet: 0.785 ± 0.029	1.904ArgAsn: 1.904 ± 0.042	0.898ArgPro: 0.898 ± 0.031	1.037ArgGln: 1.037 ± 0.037	0.949ArgArg: 0.949 ± 0.034	1.446ArgSer: 1.446 ± 0.041	1.58ArgThr: 1.58 ± 0.049	1.716ArgVal: 1.716 ± 0.044	0.346ArgTrp: 0.346 ± 0.02	1.285ArgTyr: 1.285 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.275SerAla: 3.275 ± 0.076	0.655SerCys: 0.655 ± 0.028	3.219SerAsp: 3.219 ± 0.06	3.659SerGlu: 3.659 ± 0.064	3.741SerPhe: 3.741 ± 0.075	4.225SerGly: 4.225 ± 0.089	1.088SerHis: 1.088 ± 0.035	5.367SerIle: 5.367 ± 0.077	5.381SerLys: 5.381 ± 0.079	5.475SerLeu: 5.475 ± 0.081	1.23SerMet: 1.23 ± 0.037	4.411SerAsn: 4.411 ± 0.095	1.893SerPro: 1.893 ± 0.044	2.28SerGln: 2.28 ± 0.047	1.728SerArg: 1.728 ± 0.042	3.769SerSer: 3.769 ± 0.092	3.479SerThr: 3.479 ± 0.109	3.507SerVal: 3.507 ± 0.063	0.649SerTrp: 0.649 ± 0.026	2.607SerTyr: 2.607 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	3.987ThrAla: 3.987 ± 0.118	0.436ThrCys: 0.436 ± 0.026	3.1ThrAsp: 3.1 ± 0.062	3.07ThrGlu: 3.07 ± 0.061	3.4ThrPhe: 3.4 ± 0.075	3.835ThrGly: 3.835 ± 0.123	1.101ThrHis: 1.101 ± 0.034	5.509ThrIle: 5.509 ± 0.097	4.2ThrLys: 4.2 ± 0.065	5.486ThrLeu: 5.486 ± 0.092	0.959ThrMet: 0.959 ± 0.033	4.121ThrAsn: 4.121 ± 0.099	2.557ThrPro: 2.557 ± 0.072	2.23ThrGln: 2.23 ± 0.052	1.351ThrArg: 1.351 ± 0.034	3.7ThrSer: 3.7 ± 0.1	4.243ThrThr: 4.243 ± 0.141	3.457ThrVal: 3.457 ± 0.092	0.56ThrTrp: 0.56 ± 0.028	2.348ThrTyr: 2.348 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.5ValAla: 4.5 ± 0.08	0.586ValCys: 0.586 ± 0.029	2.902ValAsp: 2.902 ± 0.058	3.241ValGlu: 3.241 ± 0.064	3.474ValPhe: 3.474 ± 0.059	3.42ValGly: 3.42 ± 0.067	0.976ValHis: 0.976 ± 0.038	4.389ValIle: 4.389 ± 0.069	4.033ValLys: 4.033 ± 0.065	5.904ValLeu: 5.904 ± 0.079	1.277ValMet: 1.277 ± 0.034	3.465ValAsn: 3.465 ± 0.062	2.036ValPro: 2.036 ± 0.05	2.001ValGln: 2.001 ± 0.05	1.681ValArg: 1.681 ± 0.038	4.091ValSer: 4.091 ± 0.08	3.325ValThr: 3.325 ± 0.089	4.057ValVal: 4.057 ± 0.072	0.622ValTrp: 0.622 ± 0.03	2.352ValTyr: 2.352 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.613TrpAla: 0.613 ± 0.027	0.106TrpCys: 0.106 ± 0.01	0.563TrpAsp: 0.563 ± 0.027	0.58TrpGlu: 0.58 ± 0.026	0.587TrpPhe: 0.587 ± 0.026	0.618TrpGly: 0.618 ± 0.028	0.28TrpHis: 0.28 ± 0.02	0.805TrpIle: 0.805 ± 0.029	0.799TrpLys: 0.799 ± 0.029	0.931TrpLeu: 0.931 ± 0.031	0.266TrpMet: 0.266 ± 0.016	0.787TrpAsn: 0.787 ± 0.032	0.195TrpPro: 0.195 ± 0.017	0.507TrpGln: 0.507 ± 0.023	0.3TrpArg: 0.3 ± 0.018	0.617TrpSer: 0.617 ± 0.029	0.63TrpThr: 0.63 ± 0.025	0.63TrpVal: 0.63 ± 0.024	0.127TrpTrp: 0.127 ± 0.011	0.419TrpTyr: 0.419 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.261TyrAla: 2.261 ± 0.058	0.431TyrCys: 0.431 ± 0.021	2.16TyrAsp: 2.16 ± 0.051	2.268TyrGlu: 2.268 ± 0.051	2.845TyrPhe: 2.845 ± 0.064	2.4TyrGly: 2.4 ± 0.049	0.976TyrHis: 0.976 ± 0.032	3.228TyrIle: 3.228 ± 0.067	3.167TyrLys: 3.167 ± 0.06	3.99TyrLeu: 3.99 ± 0.07	0.745TyrMet: 0.745 ± 0.027	2.867TyrAsn: 2.867 ± 0.062	1.473TyrPro: 1.473 ± 0.038	1.997TyrGln: 1.997 ± 0.047	1.3TyrArg: 1.3 ± 0.036	2.503TyrSer: 2.503 ± 0.053	2.447TyrThr: 2.447 ± 0.061	2.082TyrVal: 2.082 ± 0.049	0.453TyrTrp: 0.453 ± 0.021	2.049TyrTyr: 2.049 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2848 proteins (975703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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