Amino acid dipepetide frequency for Dechloromonas denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.992AlaAla: 15.992 ± 0.179	1.338AlaCys: 1.338 ± 0.036	6.269AlaAsp: 6.269 ± 0.078	7.937AlaGlu: 7.937 ± 0.089	3.916AlaPhe: 3.916 ± 0.05	10.458AlaGly: 10.458 ± 0.11	2.313AlaHis: 2.313 ± 0.047	6.032AlaIle: 6.032 ± 0.069	4.416AlaLys: 4.416 ± 0.071	13.635AlaLeu: 13.635 ± 0.142	3.309AlaMet: 3.309 ± 0.055	3.358AlaAsn: 3.358 ± 0.062	4.672AlaPro: 4.672 ± 0.066	4.455AlaGln: 4.455 ± 0.066	7.404AlaArg: 7.404 ± 0.095	6.223AlaSer: 6.223 ± 0.081	5.266AlaThr: 5.266 ± 0.077	8.306AlaVal: 8.306 ± 0.09	1.643AlaTrp: 1.643 ± 0.042	2.53AlaTyr: 2.53 ± 0.051	0.002AlaXaa: 0.002 ± 0.001
Cys	1.053CysAla: 1.053 ± 0.03	0.156CysCys: 0.156 ± 0.011	0.516CysAsp: 0.516 ± 0.02	0.526CysGlu: 0.526 ± 0.018	0.381CysPhe: 0.381 ± 0.02	1.037CysGly: 1.037 ± 0.033	0.333CysHis: 0.333 ± 0.016	0.423CysIle: 0.423 ± 0.017	0.297CysLys: 0.297 ± 0.017	1.026CysLeu: 1.026 ± 0.03	0.184CysMet: 0.184 ± 0.011	0.285CysAsn: 0.285 ± 0.016	0.602CysPro: 0.602 ± 0.024	0.349CysGln: 0.349 ± 0.018	0.689CysArg: 0.689 ± 0.021	0.576CysSer: 0.576 ± 0.022	0.461CysThr: 0.461 ± 0.019	0.645CysVal: 0.645 ± 0.025	0.145CysTrp: 0.145 ± 0.012	0.245CysTyr: 0.245 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.696AspAla: 5.696 ± 0.066	0.542AspCys: 0.542 ± 0.021	2.827AspAsp: 2.827 ± 0.064	3.555AspGlu: 3.555 ± 0.06	2.329AspPhe: 2.329 ± 0.041	4.561AspGly: 4.561 ± 0.084	1.069AspHis: 1.069 ± 0.032	3.003AspIle: 3.003 ± 0.057	2.05AspLys: 2.05 ± 0.04	5.59AspLeu: 5.59 ± 0.071	1.185AspMet: 1.185 ± 0.03	1.514AspAsn: 1.514 ± 0.041	2.596AspPro: 2.596 ± 0.046	1.805AspGln: 1.805 ± 0.043	3.094AspArg: 3.094 ± 0.05	2.721AspSer: 2.721 ± 0.056	2.386AspThr: 2.386 ± 0.066	3.353AspVal: 3.353 ± 0.055	0.972AspTrp: 0.972 ± 0.031	1.518AspTyr: 1.518 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.5GluAla: 7.5 ± 0.085	0.473GluCys: 0.473 ± 0.022	2.325GluAsp: 2.325 ± 0.051	3.219GluGlu: 3.219 ± 0.063	2.129GluPhe: 2.129 ± 0.04	3.773GluGly: 3.773 ± 0.05	1.45GluHis: 1.45 ± 0.035	3.897GluIle: 3.897 ± 0.066	2.952GluLys: 2.952 ± 0.063	6.512GluLeu: 6.512 ± 0.084	1.66GluMet: 1.66 ± 0.044	1.815GluAsn: 1.815 ± 0.042	2.284GluPro: 2.284 ± 0.051	2.948GluGln: 2.948 ± 0.057	4.686GluArg: 4.686 ± 0.068	3.071GluSer: 3.071 ± 0.049	3.066GluThr: 3.066 ± 0.054	4.228GluVal: 4.228 ± 0.068	0.791GluTrp: 0.791 ± 0.024	1.227GluTyr: 1.227 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.565PheAla: 4.565 ± 0.06	0.449PheCys: 0.449 ± 0.02	2.432PheAsp: 2.432 ± 0.043	2.117PheGlu: 2.117 ± 0.039	1.562PhePhe: 1.562 ± 0.045	3.456PheGly: 3.456 ± 0.058	0.737PheHis: 0.737 ± 0.024	1.858PheIle: 1.858 ± 0.043	1.32PheLys: 1.32 ± 0.034	3.424PheLeu: 3.424 ± 0.06	0.873PheMet: 0.873 ± 0.025	1.226PheAsn: 1.226 ± 0.032	1.611PhePro: 1.611 ± 0.038	1.079PheGln: 1.079 ± 0.031	2.062PheArg: 2.062 ± 0.044	2.467PheSer: 2.467 ± 0.05	1.788PheThr: 1.788 ± 0.04	2.798PheVal: 2.798 ± 0.044	0.531PheTrp: 0.531 ± 0.02	0.984PheTyr: 0.984 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.587GlyAla: 7.587 ± 0.108	0.983GlyCys: 0.983 ± 0.032	4.102GlyAsp: 4.102 ± 0.083	5.151GlyGlu: 5.151 ± 0.064	3.313GlyPhe: 3.313 ± 0.057	6.384GlyGly: 6.384 ± 0.114	1.885GlyHis: 1.885 ± 0.037	4.679GlyIle: 4.679 ± 0.063	4.126GlyLys: 4.126 ± 0.062	9.037GlyLeu: 9.037 ± 0.088	2.292GlyMet: 2.292 ± 0.049	2.593GlyAsn: 2.593 ± 0.085	2.563GlyPro: 2.563 ± 0.047	3.448GlyGln: 3.448 ± 0.059	5.148GlyArg: 5.148 ± 0.07	4.364GlySer: 4.364 ± 0.057	3.72GlyThr: 3.72 ± 0.069	5.74GlyVal: 5.74 ± 0.073	1.318GlyTrp: 1.318 ± 0.037	2.299GlyTyr: 2.299 ± 0.045	0.001GlyXaa: 0.001 ± 0.001
His	2.401HisAla: 2.401 ± 0.044	0.295HisCys: 0.295 ± 0.015	1.218HisAsp: 1.218 ± 0.03	1.184HisGlu: 1.184 ± 0.034	1.025HisPhe: 1.025 ± 0.025	1.985HisGly: 1.985 ± 0.042	0.638HisHis: 0.638 ± 0.025	1.047HisIle: 1.047 ± 0.031	0.615HisLys: 0.615 ± 0.021	2.529HisLeu: 2.529 ± 0.046	0.437HisMet: 0.437 ± 0.019	0.575HisAsn: 0.575 ± 0.021	1.374HisPro: 1.374 ± 0.037	0.816HisGln: 0.816 ± 0.027	1.382HisArg: 1.382 ± 0.033	1.073HisSer: 1.073 ± 0.031	0.901HisThr: 0.901 ± 0.024	1.375HisVal: 1.375 ± 0.033	0.375HisTrp: 0.375 ± 0.018	0.68HisTyr: 0.68 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.648IleAla: 6.648 ± 0.085	0.496IleCys: 0.496 ± 0.016	3.4IleAsp: 3.4 ± 0.059	3.666IleGlu: 3.666 ± 0.058	1.786IlePhe: 1.786 ± 0.048	4.683IleGly: 4.683 ± 0.077	1.031IleHis: 1.031 ± 0.029	2.311IleIle: 2.311 ± 0.053	1.991IleLys: 1.991 ± 0.041	4.559IleLeu: 4.559 ± 0.059	0.891IleMet: 0.891 ± 0.029	1.733IleAsn: 1.733 ± 0.041	2.438IlePro: 2.438 ± 0.047	1.526IleGln: 1.526 ± 0.035	3.218IleArg: 3.218 ± 0.06	3.162IleSer: 3.162 ± 0.049	2.486IleThr: 2.486 ± 0.042	3.851IleVal: 3.851 ± 0.057	0.526IleTrp: 0.526 ± 0.02	1.203IleTyr: 1.203 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.581LysAla: 4.581 ± 0.076	0.239LysCys: 0.239 ± 0.014	1.853LysAsp: 1.853 ± 0.043	2.156LysGlu: 2.156 ± 0.046	1.146LysPhe: 1.146 ± 0.029	2.682LysGly: 2.682 ± 0.049	0.849LysHis: 0.849 ± 0.028	2.103LysIle: 2.103 ± 0.045	2.008LysLys: 2.008 ± 0.046	4.371LysLeu: 4.371 ± 0.065	1.093LysMet: 1.093 ± 0.03	1.306LysAsn: 1.306 ± 0.034	2.313LysPro: 2.313 ± 0.048	1.589LysGln: 1.589 ± 0.039	2.456LysArg: 2.456 ± 0.045	2.059LysSer: 2.059 ± 0.045	2.15LysThr: 2.15 ± 0.04	2.823LysVal: 2.823 ± 0.049	0.379LysTrp: 0.379 ± 0.017	0.843LysTyr: 0.843 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.416LeuAla: 15.416 ± 0.133	1.091LeuCys: 1.091 ± 0.031	6.038LeuAsp: 6.038 ± 0.076	6.126LeuGlu: 6.126 ± 0.076	3.966LeuPhe: 3.966 ± 0.065	8.983LeuGly: 8.983 ± 0.092	2.323LeuHis: 2.323 ± 0.041	5.434LeuIle: 5.434 ± 0.066	4.335LeuLys: 4.335 ± 0.065	12.761LeuLeu: 12.761 ± 0.159	2.332LeuMet: 2.332 ± 0.047	3.275LeuAsn: 3.275 ± 0.054	6.397LeuPro: 6.397 ± 0.078	3.983LeuGln: 3.983 ± 0.056	7.052LeuArg: 7.052 ± 0.087	6.524LeuSer: 6.524 ± 0.075	5.487LeuThr: 5.487 ± 0.076	7.309LeuVal: 7.309 ± 0.085	1.258LeuTrp: 1.258 ± 0.034	2.194LeuTyr: 2.194 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.897MetAla: 2.897 ± 0.047	0.155MetCys: 0.155 ± 0.012	1.105MetAsp: 1.105 ± 0.031	1.156MetGlu: 1.156 ± 0.034	0.723MetPhe: 0.723 ± 0.023	1.587MetGly: 1.587 ± 0.037	0.551MetHis: 0.551 ± 0.023	1.118MetIle: 1.118 ± 0.033	1.14MetLys: 1.14 ± 0.03	2.758MetLeu: 2.758 ± 0.049	0.574MetMet: 0.574 ± 0.023	0.919MetAsn: 0.919 ± 0.023	1.526MetPro: 1.526 ± 0.036	1.082MetGln: 1.082 ± 0.03	1.556MetArg: 1.556 ± 0.034	1.595MetSer: 1.595 ± 0.032	1.391MetThr: 1.391 ± 0.036	1.585MetVal: 1.585 ± 0.043	0.209MetTrp: 0.209 ± 0.014	0.366MetTyr: 0.366 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.333AsnAla: 3.333 ± 0.057	0.355AsnCys: 0.355 ± 0.017	1.629AsnAsp: 1.629 ± 0.067	1.593AsnGlu: 1.593 ± 0.036	1.144AsnPhe: 1.144 ± 0.035	2.593AsnGly: 2.593 ± 0.053	0.6AsnHis: 0.6 ± 0.019	1.579AsnIle: 1.579 ± 0.038	1.066AsnLys: 1.066 ± 0.037	3.232AsnLeu: 3.232 ± 0.048	0.669AsnMet: 0.669 ± 0.022	0.926AsnAsn: 0.926 ± 0.029	2.015AsnPro: 2.015 ± 0.041	1.075AsnGln: 1.075 ± 0.031	1.937AsnArg: 1.937 ± 0.037	1.514AsnSer: 1.514 ± 0.036	1.406AsnThr: 1.406 ± 0.039	1.965AsnVal: 1.965 ± 0.046	0.487AsnTrp: 0.487 ± 0.023	0.824AsnTyr: 0.824 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.272ProAla: 6.272 ± 0.085	0.412ProCys: 0.412 ± 0.018	2.816ProAsp: 2.816 ± 0.044	3.835ProGlu: 3.835 ± 0.054	1.72ProPhe: 1.72 ± 0.04	4.101ProGly: 4.101 ± 0.062	0.991ProHis: 0.991 ± 0.032	2.079ProIle: 2.079 ± 0.04	1.738ProLys: 1.738 ± 0.039	5.252ProLeu: 5.252 ± 0.074	1.111ProMet: 1.111 ± 0.029	1.396ProAsn: 1.396 ± 0.034	2.375ProPro: 2.375 ± 0.055	1.778ProGln: 1.778 ± 0.038	2.352ProArg: 2.352 ± 0.044	2.356ProSer: 2.356 ± 0.05	2.14ProThr: 2.14 ± 0.039	3.972ProVal: 3.972 ± 0.067	0.661ProTrp: 0.661 ± 0.023	1.143ProTyr: 1.143 ± 0.027	0.001ProXaa: 0.001 ± 0.001
Gln	5.201GlnAla: 5.201 ± 0.086	0.267GlnCys: 0.267 ± 0.015	1.43GlnAsp: 1.43 ± 0.03	1.915GlnGlu: 1.915 ± 0.041	1.317GlnPhe: 1.317 ± 0.029	2.753GlnGly: 2.753 ± 0.048	0.978GlnHis: 0.978 ± 0.03	2.018GlnIle: 2.018 ± 0.038	1.468GlnLys: 1.468 ± 0.035	4.535GlnLeu: 4.535 ± 0.074	1.037GlnMet: 1.037 ± 0.028	1.067GlnAsn: 1.067 ± 0.029	2.199GlnPro: 2.199 ± 0.047	1.996GlnGln: 1.996 ± 0.05	3.06GlnArg: 3.06 ± 0.055	1.992GlnSer: 1.992 ± 0.037	1.885GlnThr: 1.885 ± 0.044	2.769GlnVal: 2.769 ± 0.045	0.522GlnTrp: 0.522 ± 0.02	0.782GlnTyr: 0.782 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.278ArgAla: 6.278 ± 0.068	0.606ArgCys: 0.606 ± 0.026	3.396ArgAsp: 3.396 ± 0.059	4.029ArgGlu: 4.029 ± 0.066	2.76ArgPhe: 2.76 ± 0.05	3.901ArgGly: 3.901 ± 0.057	1.735ArgHis: 1.735 ± 0.04	3.672ArgIle: 3.672 ± 0.057	2.211ArgLys: 2.211 ± 0.045	8.379ArgLeu: 8.379 ± 0.107	1.591ArgMet: 1.591 ± 0.039	2.011ArgAsn: 2.011 ± 0.037	2.852ArgPro: 2.852 ± 0.059	3.437ArgGln: 3.437 ± 0.05	4.64ArgArg: 4.64 ± 0.067	3.204ArgSer: 3.204 ± 0.054	2.64ArgThr: 2.64 ± 0.043	4.06ArgVal: 4.06 ± 0.071	0.964ArgTrp: 0.964 ± 0.032	1.913ArgTyr: 1.913 ± 0.038	0.001ArgXaa: 0.001 ± 0.001
Ser	6.111SerAla: 6.111 ± 0.079	0.509SerCys: 0.509 ± 0.02	2.677SerAsp: 2.677 ± 0.049	3.069SerGlu: 3.069 ± 0.053	2.139SerPhe: 2.139 ± 0.041	5.215SerGly: 5.215 ± 0.062	1.201SerHis: 1.201 ± 0.03	2.772SerIle: 2.772 ± 0.045	1.891SerLys: 1.891 ± 0.036	6.287SerLeu: 6.287 ± 0.084	1.265SerMet: 1.265 ± 0.032	1.584SerAsn: 1.584 ± 0.037	2.602SerPro: 2.602 ± 0.047	2.03SerGln: 2.03 ± 0.041	3.557SerArg: 3.557 ± 0.055	3.05SerSer: 3.05 ± 0.061	2.757SerThr: 2.757 ± 0.056	3.698SerVal: 3.698 ± 0.064	0.708SerTrp: 0.708 ± 0.027	1.244SerTyr: 1.244 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.634ThrAla: 5.634 ± 0.077	0.426ThrCys: 0.426 ± 0.018	2.33ThrAsp: 2.33 ± 0.05	2.58ThrGlu: 2.58 ± 0.049	1.633ThrPhe: 1.633 ± 0.04	4.271ThrGly: 4.271 ± 0.076	1.073ThrHis: 1.073 ± 0.031	2.192ThrIle: 2.192 ± 0.046	1.395ThrLys: 1.395 ± 0.033	6.036ThrLeu: 6.036 ± 0.077	0.941ThrMet: 0.941 ± 0.027	1.232ThrAsn: 1.232 ± 0.037	3.06ThrPro: 3.06 ± 0.055	1.734ThrGln: 1.734 ± 0.042	2.793ThrArg: 2.793 ± 0.047	2.332ThrSer: 2.332 ± 0.043	2.567ThrThr: 2.567 ± 0.056	3.738ThrVal: 3.738 ± 0.062	0.615ThrTrp: 0.615 ± 0.026	1.126ThrTyr: 1.126 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.594ValAla: 8.594 ± 0.092	0.708ValCys: 0.708 ± 0.028	4.205ValAsp: 4.205 ± 0.057	4.323ValGlu: 4.323 ± 0.058	2.737ValPhe: 2.737 ± 0.054	5.43ValGly: 5.43 ± 0.073	1.34ValHis: 1.34 ± 0.032	3.808ValIle: 3.808 ± 0.056	2.656ValLys: 2.656 ± 0.055	7.514ValLeu: 7.514 ± 0.093	1.81ValMet: 1.81 ± 0.046	2.051ValAsn: 2.051 ± 0.044	3.194ValPro: 3.194 ± 0.053	2.187ValGln: 2.187 ± 0.04	4.281ValArg: 4.281 ± 0.057	4.085ValSer: 4.085 ± 0.06	3.516ValThr: 3.516 ± 0.062	5.682ValVal: 5.682 ± 0.072	0.832ValTrp: 0.832 ± 0.026	1.395ValTyr: 1.395 ± 0.04	0.001ValXaa: 0.001 ± 0.001
Trp	1.194TrpAla: 1.194 ± 0.034	0.147TrpCys: 0.147 ± 0.01	0.519TrpAsp: 0.519 ± 0.023	0.657TrpGlu: 0.657 ± 0.021	0.541TrpPhe: 0.541 ± 0.019	0.834TrpGly: 0.834 ± 0.027	0.32TrpHis: 0.32 ± 0.018	0.63TrpIle: 0.63 ± 0.022	0.515TrpLys: 0.515 ± 0.023	2.188TrpLeu: 2.188 ± 0.052	0.309TrpMet: 0.309 ± 0.016	0.413TrpAsn: 0.413 ± 0.02	0.637TrpPro: 0.637 ± 0.021	0.881TrpGln: 0.881 ± 0.029	1.076TrpArg: 1.076 ± 0.03	0.736TrpSer: 0.736 ± 0.025	0.555TrpThr: 0.555 ± 0.02	0.866TrpVal: 0.866 ± 0.03	0.229TrpTrp: 0.229 ± 0.016	0.289TrpTyr: 0.289 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.521TyrAla: 2.521 ± 0.045	0.281TyrCys: 0.281 ± 0.015	1.282TyrAsp: 1.282 ± 0.037	1.214TyrGlu: 1.214 ± 0.032	1.071TyrPhe: 1.071 ± 0.031	2.044TyrGly: 2.044 ± 0.046	0.507TyrHis: 0.507 ± 0.022	0.952TyrIle: 0.952 ± 0.03	0.807TyrLys: 0.807 ± 0.03	2.66TyrLeu: 2.66 ± 0.05	0.43TyrMet: 0.43 ± 0.022	0.661TyrAsn: 0.661 ± 0.027	1.191TyrPro: 1.191 ± 0.031	0.991TyrGln: 0.991 ± 0.027	1.838TyrArg: 1.838 ± 0.042	1.261TyrSer: 1.261 ± 0.033	1.142TyrThr: 1.142 ± 0.034	1.583TyrVal: 1.583 ± 0.041	0.367TyrTrp: 0.367 ± 0.016	0.657TyrTyr: 0.657 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.011XaaXaa: 0.011 ± 0.004

Statistics based on 3886 proteins (1254878 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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