Amino acid dipepetide frequency for Streptomyces sp. DvalAA-43

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.016AlaAla: 21.016 ± 0.145
1.063AlaCys: 1.063 ± 0.022
8.379AlaAsp: 8.379 ± 0.064
8.67AlaGlu: 8.67 ± 0.078
3.5AlaPhe: 3.5 ± 0.04
13.088AlaGly: 13.088 ± 0.081
2.872AlaHis: 2.872 ± 0.035
3.406AlaIle: 3.406 ± 0.043
2.704AlaLys: 2.704 ± 0.041
14.368AlaLeu: 14.368 ± 0.094
2.552AlaMet: 2.552 ± 0.029
1.857AlaAsn: 1.857 ± 0.026
7.444AlaPro: 7.444 ± 0.067
3.649AlaGln: 3.649 ± 0.046
10.322AlaArg: 10.322 ± 0.089
5.879AlaSer: 5.879 ± 0.051
7.08AlaThr: 7.08 ± 0.062
12.2AlaVal: 12.2 ± 0.082
1.828AlaTrp: 1.828 ± 0.027
2.77AlaTyr: 2.77 ± 0.03
0.0AlaXaa: 0.0 ± 0.0
Cys
1.101CysAla: 1.101 ± 0.022
0.096CysCys: 0.096 ± 0.007
0.485CysAsp: 0.485 ± 0.014
0.411CysGlu: 0.411 ± 0.015
0.227CysPhe: 0.227 ± 0.009
0.974CysGly: 0.974 ± 0.02
0.199CysHis: 0.199 ± 0.008
0.17CysIle: 0.17 ± 0.008
0.116CysLys: 0.116 ± 0.007
0.729CysLeu: 0.729 ± 0.017
0.134CysMet: 0.134 ± 0.008
0.135CysAsn: 0.135 ± 0.006
0.518CysPro: 0.518 ± 0.016
0.173CysGln: 0.173 ± 0.007
0.657CysArg: 0.657 ± 0.015
0.444CysSer: 0.444 ± 0.012
0.527CysThr: 0.527 ± 0.015
0.647CysVal: 0.647 ± 0.015
0.13CysTrp: 0.13 ± 0.007
0.151CysTyr: 0.151 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.658AspAla: 7.658 ± 0.064
0.441AspCys: 0.441 ± 0.013
3.612AspAsp: 3.612 ± 0.04
3.939AspGlu: 3.939 ± 0.039
1.616AspPhe: 1.616 ± 0.025
6.598AspGly: 6.598 ± 0.061
1.459AspHis: 1.459 ± 0.024
2.039AspIle: 2.039 ± 0.034
1.156AspLys: 1.156 ± 0.027
6.067AspLeu: 6.067 ± 0.046
0.826AspMet: 0.826 ± 0.017
0.993AspAsn: 0.993 ± 0.02
4.591AspPro: 4.591 ± 0.051
1.53AspGln: 1.53 ± 0.027
5.275AspArg: 5.275 ± 0.048
2.666AspSer: 2.666 ± 0.028
3.338AspThr: 3.338 ± 0.037
4.432AspVal: 4.432 ± 0.044
1.046AspTrp: 1.046 ± 0.017
1.077AspTyr: 1.077 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
7.182GluAla: 7.182 ± 0.063
0.381GluCys: 0.381 ± 0.012
2.741GluAsp: 2.741 ± 0.037
3.432GluGlu: 3.432 ± 0.043
1.467GluPhe: 1.467 ± 0.023
4.19GluGly: 4.19 ± 0.044
1.534GluHis: 1.534 ± 0.024
2.253GluIle: 2.253 ± 0.031
1.405GluLys: 1.405 ± 0.027
6.863GluLeu: 6.863 ± 0.064
0.871GluMet: 0.871 ± 0.02
1.079GluAsn: 1.079 ± 0.02
3.385GluPro: 3.385 ± 0.043
2.265GluGln: 2.265 ± 0.033
5.397GluArg: 5.397 ± 0.052
2.68GluSer: 2.68 ± 0.035
2.912GluThr: 2.912 ± 0.035
4.248GluVal: 4.248 ± 0.044
0.761GluTrp: 0.761 ± 0.018
1.104GluTyr: 1.104 ± 0.021
0.0GluXaa: 0.0 ± 0.0
Phe
3.661PheAla: 3.661 ± 0.042
0.27PheCys: 0.27 ± 0.01
2.0PheAsp: 2.0 ± 0.029
1.394PheGlu: 1.394 ± 0.022
0.882PhePhe: 0.882 ± 0.019
3.007PheGly: 3.007 ± 0.037
0.633PheHis: 0.633 ± 0.016
0.756PheIle: 0.756 ± 0.018
0.494PheLys: 0.494 ± 0.015
2.551PheLeu: 2.551 ± 0.035
0.396PheMet: 0.396 ± 0.011
0.551PheAsn: 0.551 ± 0.016
1.424PhePro: 1.424 ± 0.029
0.668PheGln: 0.668 ± 0.016
1.873PheArg: 1.873 ± 0.028
1.46PheSer: 1.46 ± 0.021
2.017PheThr: 2.017 ± 0.03
2.144PheVal: 2.144 ± 0.029
0.422PheTrp: 0.422 ± 0.012
0.555PheTyr: 0.555 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
11.341GlyAla: 11.341 ± 0.081
0.84GlyCys: 0.84 ± 0.017
5.192GlyAsp: 5.192 ± 0.047
5.08GlyGlu: 5.08 ± 0.047
2.831GlyPhe: 2.831 ± 0.034
8.906GlyGly: 8.906 ± 0.077
2.39GlyHis: 2.39 ± 0.035
3.618GlyIle: 3.618 ± 0.039
2.496GlyLys: 2.496 ± 0.041
9.541GlyLeu: 9.541 ± 0.07
2.042GlyMet: 2.042 ± 0.03
1.826GlyAsn: 1.826 ± 0.031
5.485GlyPro: 5.485 ± 0.06
2.648GlyGln: 2.648 ± 0.036
7.94GlyArg: 7.94 ± 0.063
5.63GlySer: 5.63 ± 0.045
6.608GlyThr: 6.608 ± 0.051
7.224GlyVal: 7.224 ± 0.051
1.692GlyTrp: 1.692 ± 0.027
2.293GlyTyr: 2.293 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
2.636HisAla: 2.636 ± 0.035
0.215HisCys: 0.215 ± 0.009
1.417HisAsp: 1.417 ± 0.025
1.234HisGlu: 1.234 ± 0.021
0.636HisPhe: 0.636 ± 0.017
2.501HisGly: 2.501 ± 0.029
0.768HisHis: 0.768 ± 0.019
0.737HisIle: 0.737 ± 0.018
0.351HisLys: 0.351 ± 0.013
2.427HisLeu: 2.427 ± 0.034
0.337HisMet: 0.337 ± 0.012
0.383HisAsn: 0.383 ± 0.012
1.875HisPro: 1.875 ± 0.03
0.675HisGln: 0.675 ± 0.017
2.245HisArg: 2.245 ± 0.035
1.057HisSer: 1.057 ± 0.02
1.389HisThr: 1.389 ± 0.027
1.6HisVal: 1.6 ± 0.026
0.397HisTrp: 0.397 ± 0.01
0.476HisTyr: 0.476 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
4.811IleAla: 4.811 ± 0.048
0.314IleCys: 0.314 ± 0.01
2.409IleAsp: 2.409 ± 0.032
2.058IleGlu: 2.058 ± 0.03
0.704IlePhe: 0.704 ± 0.015
3.833IleGly: 3.833 ± 0.04
0.666IleHis: 0.666 ± 0.017
0.865IleIle: 0.865 ± 0.019
0.748IleLys: 0.748 ± 0.019
2.396IleLeu: 2.396 ± 0.033
0.438IleMet: 0.438 ± 0.014
0.692IleAsn: 0.692 ± 0.018
1.832IlePro: 1.832 ± 0.032
0.733IleGln: 0.733 ± 0.017
2.341IleArg: 2.341 ± 0.028
1.748IleSer: 1.748 ± 0.027
2.28IleThr: 2.28 ± 0.035
2.734IleVal: 2.734 ± 0.035
0.395IleTrp: 0.395 ± 0.014
0.518IleTyr: 0.518 ± 0.011
0.0IleXaa: 0.0 ± 0.0
Lys
2.805LysAla: 2.805 ± 0.046
0.109LysCys: 0.109 ± 0.006
1.375LysAsp: 1.375 ± 0.026
1.171LysGlu: 1.171 ± 0.027
0.45LysPhe: 0.45 ± 0.015
1.867LysGly: 1.867 ± 0.032
0.453LysHis: 0.453 ± 0.012
0.829LysIle: 0.829 ± 0.024
0.891LysLys: 0.891 ± 0.028
2.006LysLeu: 2.006 ± 0.029
0.376LysMet: 0.376 ± 0.014
0.564LysAsn: 0.564 ± 0.017
1.364LysPro: 1.364 ± 0.032
0.726LysGln: 0.726 ± 0.017
1.432LysArg: 1.432 ± 0.025
1.173LysSer: 1.173 ± 0.027
1.248LysThr: 1.248 ± 0.026
1.807LysVal: 1.807 ± 0.029
0.262LysTrp: 0.262 ± 0.009
0.447LysTyr: 0.447 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
14.83LeuAla: 14.83 ± 0.094
0.846LeuCys: 0.846 ± 0.018
6.839LeuAsp: 6.839 ± 0.051
4.453LeuGlu: 4.453 ± 0.047
2.608LeuPhe: 2.608 ± 0.034
9.31LeuGly: 9.31 ± 0.071
2.347LeuHis: 2.347 ± 0.033
3.415LeuIle: 3.415 ± 0.04
1.991LeuLys: 1.991 ± 0.031
11.245LeuLeu: 11.245 ± 0.098
1.657LeuMet: 1.657 ± 0.025
1.7LeuAsn: 1.7 ± 0.031
6.57LeuPro: 6.57 ± 0.054
2.087LeuGln: 2.087 ± 0.03
8.671LeuArg: 8.671 ± 0.069
5.385LeuSer: 5.385 ± 0.038
6.81LeuThr: 6.81 ± 0.055
8.625LeuVal: 8.625 ± 0.066
1.304LeuTrp: 1.304 ± 0.023
1.835LeuTyr: 1.835 ± 0.027
0.0LeuXaa: 0.0 ± 0.0
Met
2.271MetAla: 2.271 ± 0.029
0.144MetCys: 0.144 ± 0.008
0.922MetAsp: 0.922 ± 0.017
0.759MetGlu: 0.759 ± 0.017
0.461MetPhe: 0.461 ± 0.011
1.312MetGly: 1.312 ± 0.026
0.361MetHis: 0.361 ± 0.01
0.671MetIle: 0.671 ± 0.017
0.432MetLys: 0.432 ± 0.012
1.696MetLeu: 1.696 ± 0.027
0.31MetMet: 0.31 ± 0.012
0.45MetAsn: 0.45 ± 0.013
1.095MetPro: 1.095 ± 0.019
0.447MetGln: 0.447 ± 0.013
1.457MetArg: 1.457 ± 0.023
1.346MetSer: 1.346 ± 0.022
1.585MetThr: 1.585 ± 0.023
1.316MetVal: 1.316 ± 0.023
0.214MetTrp: 0.214 ± 0.009
0.337MetTyr: 0.337 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.175AsnAla: 2.175 ± 0.032
0.165AsnCys: 0.165 ± 0.008
0.979AsnAsp: 0.979 ± 0.021
0.799AsnGlu: 0.799 ± 0.017
0.479AsnPhe: 0.479 ± 0.015
1.976AsnGly: 1.976 ± 0.031
0.409AsnHis: 0.409 ± 0.013
0.646AsnIle: 0.646 ± 0.015
0.418AsnLys: 0.418 ± 0.014
1.598AsnLeu: 1.598 ± 0.027
0.306AsnMet: 0.306 ± 0.011
0.435AsnAsn: 0.435 ± 0.015
1.364AsnPro: 1.364 ± 0.026
0.503AsnGln: 0.503 ± 0.014
1.334AsnArg: 1.334 ± 0.025
0.965AsnSer: 0.965 ± 0.019
1.171AsnThr: 1.171 ± 0.027
1.313AsnVal: 1.313 ± 0.023
0.279AsnTrp: 0.279 ± 0.012
0.397AsnTyr: 0.397 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
8.854ProAla: 8.854 ± 0.071
0.37ProCys: 0.37 ± 0.012
4.686ProAsp: 4.686 ± 0.045
4.379ProGlu: 4.379 ± 0.05
1.556ProPhe: 1.556 ± 0.028
6.957ProGly: 6.957 ± 0.064
1.428ProHis: 1.428 ± 0.022
1.245ProIle: 1.245 ± 0.021
1.194ProLys: 1.194 ± 0.023
5.391ProLeu: 5.391 ± 0.048
1.04ProMet: 1.04 ± 0.02
0.877ProAsn: 0.877 ± 0.022
3.617ProPro: 3.617 ± 0.056
1.754ProGln: 1.754 ± 0.034
4.134ProArg: 4.134 ± 0.045
3.274ProSer: 3.274 ± 0.038
3.144ProThr: 3.144 ± 0.038
5.836ProVal: 5.836 ± 0.052
0.888ProTrp: 0.888 ± 0.018
1.443ProTyr: 1.443 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.496GlnAla: 3.496 ± 0.051
0.182GlnCys: 0.182 ± 0.009
1.421GlnAsp: 1.421 ± 0.022
1.496GlnGlu: 1.496 ± 0.026
0.668GlnPhe: 0.668 ± 0.016
2.278GlnGly: 2.278 ± 0.034
0.677GlnHis: 0.677 ± 0.02
1.065GlnIle: 1.065 ± 0.022
0.613GlnLys: 0.613 ± 0.017
3.025GlnLeu: 3.025 ± 0.033
0.493GlnMet: 0.493 ± 0.016
0.514GlnAsn: 0.514 ± 0.014
1.706GlnPro: 1.706 ± 0.036
1.271GlnGln: 1.271 ± 0.03
2.349GlnArg: 2.349 ± 0.036
1.278GlnSer: 1.278 ± 0.025
1.305GlnThr: 1.305 ± 0.024
2.254GlnVal: 2.254 ± 0.03
0.471GlnTrp: 0.471 ± 0.013
0.612GlnTyr: 0.612 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
9.947ArgAla: 9.947 ± 0.086
0.647ArgCys: 0.647 ± 0.018
4.277ArgAsp: 4.277 ± 0.039
4.635ArgGlu: 4.635 ± 0.049
2.357ArgPhe: 2.357 ± 0.032
5.857ArgGly: 5.857 ± 0.053
2.111ArgHis: 2.111 ± 0.028
3.556ArgIle: 3.556 ± 0.034
1.676ArgLys: 1.676 ± 0.029
8.726ArgLeu: 8.726 ± 0.071
1.785ArgMet: 1.785 ± 0.026
1.439ArgAsn: 1.439 ± 0.024
5.121ArgPro: 5.121 ± 0.059
2.283ArgGln: 2.283 ± 0.033
7.697ArgArg: 7.697 ± 0.073
4.334ArgSer: 4.334 ± 0.047
5.951ArgThr: 5.951 ± 0.05
5.69ArgVal: 5.69 ± 0.052
1.366ArgTrp: 1.366 ± 0.023
1.757ArgTyr: 1.757 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
6.864SerAla: 6.864 ± 0.059
0.434SerCys: 0.434 ± 0.013
2.772SerAsp: 2.772 ± 0.034
2.376SerGlu: 2.376 ± 0.033
1.568SerPhe: 1.568 ± 0.025
6.241SerGly: 6.241 ± 0.057
1.072SerHis: 1.072 ± 0.022
1.512SerIle: 1.512 ± 0.027
1.052SerLys: 1.052 ± 0.022
4.879SerLeu: 4.879 ± 0.045
1.113SerMet: 1.113 ± 0.02
0.863SerAsn: 0.863 ± 0.019
3.19SerPro: 3.19 ± 0.036
1.209SerGln: 1.209 ± 0.025
3.746SerArg: 3.746 ± 0.037
2.916SerSer: 2.916 ± 0.045
3.223SerThr: 3.223 ± 0.041
4.428SerVal: 4.428 ± 0.048
0.944SerTrp: 0.944 ± 0.021
1.224SerTyr: 1.224 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
9.165ThrAla: 9.165 ± 0.063
0.412ThrCys: 0.412 ± 0.014
3.756ThrAsp: 3.756 ± 0.04
3.408ThrGlu: 3.408 ± 0.036
1.615ThrPhe: 1.615 ± 0.025
7.163ThrGly: 7.163 ± 0.054
1.267ThrHis: 1.267 ± 0.023
1.753ThrIle: 1.753 ± 0.029
1.165ThrLys: 1.165 ± 0.026
5.687ThrLeu: 5.687 ± 0.053
0.938ThrMet: 0.938 ± 0.019
0.982ThrAsn: 0.982 ± 0.021
4.195ThrPro: 4.195 ± 0.045
1.255ThrGln: 1.255 ± 0.021
3.947ThrArg: 3.947 ± 0.039
3.19ThrSer: 3.19 ± 0.041
4.008ThrThr: 4.008 ± 0.048
6.183ThrVal: 6.183 ± 0.055
0.87ThrTrp: 0.87 ± 0.021
1.34ThrTyr: 1.34 ± 0.024
0.0ThrXaa: 0.0 ± 0.0
Val
10.397ValAla: 10.397 ± 0.072
0.753ValCys: 0.753 ± 0.018
4.839ValAsp: 4.839 ± 0.043
4.519ValGlu: 4.519 ± 0.043
2.399ValPhe: 2.399 ± 0.028
6.306ValGly: 6.306 ± 0.06
1.941ValHis: 1.941 ± 0.027
2.892ValIle: 2.892 ± 0.035
1.707ValLys: 1.707 ± 0.033
9.468ValLeu: 9.468 ± 0.068
1.419ValMet: 1.419 ± 0.027
1.556ValAsn: 1.556 ± 0.029
5.422ValPro: 5.422 ± 0.049
2.078ValGln: 2.078 ± 0.031
7.204ValArg: 7.204 ± 0.059
4.301ValSer: 4.301 ± 0.041
5.453ValThr: 5.453 ± 0.054
7.717ValVal: 7.717 ± 0.063
1.077ValTrp: 1.077 ± 0.022
1.511ValTyr: 1.511 ± 0.024
0.0ValXaa: 0.0 ± 0.0
Trp
1.67TrpAla: 1.67 ± 0.029
0.162TrpCys: 0.162 ± 0.008
0.824TrpAsp: 0.824 ± 0.017
0.726TrpGlu: 0.726 ± 0.016
0.5TrpPhe: 0.5 ± 0.013
1.002TrpGly: 1.002 ± 0.019
0.377TrpHis: 0.377 ± 0.013
0.574TrpIle: 0.574 ± 0.014
0.368TrpLys: 0.368 ± 0.011
1.757TrpLeu: 1.757 ± 0.027
0.294TrpMet: 0.294 ± 0.011
0.411TrpAsn: 0.411 ± 0.011
0.774TrpPro: 0.774 ± 0.015
0.635TrpGln: 0.635 ± 0.016
1.313TrpArg: 1.313 ± 0.025
0.97TrpSer: 0.97 ± 0.02
1.014TrpThr: 1.014 ± 0.02
0.974TrpVal: 0.974 ± 0.022
0.335TrpTrp: 0.335 ± 0.01
0.349TrpTyr: 0.349 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.769TyrAla: 2.769 ± 0.033
0.18TyrCys: 0.18 ± 0.008
1.432TyrAsp: 1.432 ± 0.03
1.214TyrGlu: 1.214 ± 0.021
0.631TyrPhe: 0.631 ± 0.018
2.256TyrGly: 2.256 ± 0.031
0.391TyrHis: 0.391 ± 0.013
0.512TyrIle: 0.512 ± 0.015
0.378TyrLys: 0.378 ± 0.013
2.111TyrLeu: 2.111 ± 0.029
0.256TyrMet: 0.256 ± 0.01
0.404TyrAsn: 0.404 ± 0.012
1.095TyrPro: 1.095 ± 0.021
0.586TyrGln: 0.586 ± 0.016
1.876TyrArg: 1.876 ± 0.029
0.931TyrSer: 0.931 ± 0.022
1.237TyrThr: 1.237 ± 0.023
1.588TyrVal: 1.588 ± 0.024
0.348TyrTrp: 0.348 ± 0.013
0.427TyrTyr: 0.427 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8159 proteins (2715702 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski