Amino acid dipepetide frequency for Acinetobacter phage vB_AbaM_phiAbaA1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.275AlaAla: 4.275 ± 0.528
0.665AlaCys: 0.665 ± 0.147
3.673AlaAsp: 3.673 ± 0.555
4.116AlaGlu: 4.116 ± 0.319
2.723AlaPhe: 2.723 ± 0.345
3.863AlaGly: 3.863 ± 0.637
0.95AlaHis: 0.95 ± 0.188
5.224AlaIle: 5.224 ± 0.432
5.858AlaLys: 5.858 ± 0.474
5.826AlaLeu: 5.826 ± 0.566
1.9AlaMet: 1.9 ± 0.265
3.293AlaAsn: 3.293 ± 0.675
1.9AlaPro: 1.9 ± 0.297
2.47AlaGln: 2.47 ± 0.347
2.47AlaArg: 2.47 ± 0.259
4.148AlaSer: 4.148 ± 0.454
4.781AlaThr: 4.781 ± 0.716
3.831AlaVal: 3.831 ± 0.449
0.728AlaTrp: 0.728 ± 0.13
2.596AlaTyr: 2.596 ± 0.323
0.0AlaXaa: 0.0 ± 0.0
Cys
0.57CysAla: 0.57 ± 0.127
0.222CysCys: 0.222 ± 0.085
0.76CysAsp: 0.76 ± 0.18
0.823CysGlu: 0.823 ± 0.166
0.57CysPhe: 0.57 ± 0.147
1.267CysGly: 1.267 ± 0.25
0.443CysHis: 0.443 ± 0.138
0.633CysIle: 0.633 ± 0.162
1.045CysLys: 1.045 ± 0.228
0.728CysLeu: 0.728 ± 0.162
0.222CysMet: 0.222 ± 0.091
0.633CysAsn: 0.633 ± 0.144
0.475CysPro: 0.475 ± 0.132
0.38CysGln: 0.38 ± 0.101
0.538CysArg: 0.538 ± 0.137
0.475CysSer: 0.475 ± 0.119
0.57CysThr: 0.57 ± 0.132
0.728CysVal: 0.728 ± 0.171
0.19CysTrp: 0.19 ± 0.077
0.443CysTyr: 0.443 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
4.021AspAla: 4.021 ± 0.404
0.633AspCys: 0.633 ± 0.146
4.781AspAsp: 4.781 ± 0.504
4.876AspGlu: 4.876 ± 0.618
3.293AspPhe: 3.293 ± 0.28
4.496AspGly: 4.496 ± 0.376
0.665AspHis: 0.665 ± 0.138
4.75AspIle: 4.75 ± 0.421
4.528AspLys: 4.528 ± 0.467
6.079AspLeu: 6.079 ± 0.487
1.741AspMet: 1.741 ± 0.247
2.723AspAsn: 2.723 ± 0.341
2.248AspPro: 2.248 ± 0.288
1.583AspGln: 1.583 ± 0.204
2.121AspArg: 2.121 ± 0.301
4.116AspSer: 4.116 ± 0.335
3.293AspThr: 3.293 ± 0.344
5.319AspVal: 5.319 ± 0.339
1.298AspTrp: 1.298 ± 0.197
2.628AspTyr: 2.628 ± 0.313
0.0AspXaa: 0.0 ± 0.0
Glu
5.541GluAla: 5.541 ± 0.42
0.982GluCys: 0.982 ± 0.211
5.003GluAsp: 5.003 ± 0.635
5.066GluGlu: 5.066 ± 0.618
3.546GluPhe: 3.546 ± 0.375
4.781GluGly: 4.781 ± 0.427
1.552GluHis: 1.552 ± 0.226
4.211GluIle: 4.211 ± 0.34
4.401GluLys: 4.401 ± 0.342
5.921GluLeu: 5.921 ± 0.493
2.343GluMet: 2.343 ± 0.28
3.325GluAsn: 3.325 ± 0.346
1.362GluPro: 1.362 ± 0.21
2.501GluGln: 2.501 ± 0.262
3.071GluArg: 3.071 ± 0.317
3.736GluSer: 3.736 ± 0.326
3.42GluThr: 3.42 ± 0.291
5.288GluVal: 5.288 ± 0.435
1.235GluTrp: 1.235 ± 0.187
2.945GluTyr: 2.945 ± 0.356
0.0GluXaa: 0.0 ± 0.0
Phe
2.311PheAla: 2.311 ± 0.315
0.538PheCys: 0.538 ± 0.123
3.578PheAsp: 3.578 ± 0.39
3.451PheGlu: 3.451 ± 0.308
1.235PhePhe: 1.235 ± 0.214
3.23PheGly: 3.23 ± 0.328
0.602PheHis: 0.602 ± 0.145
3.103PheIle: 3.103 ± 0.364
3.958PheLys: 3.958 ± 0.354
2.913PheLeu: 2.913 ± 0.285
1.362PheMet: 1.362 ± 0.261
2.85PheAsn: 2.85 ± 0.29
1.267PhePro: 1.267 ± 0.192
1.267PheGln: 1.267 ± 0.222
1.71PheArg: 1.71 ± 0.196
2.818PheSer: 2.818 ± 0.287
2.66PheThr: 2.66 ± 0.293
2.185PheVal: 2.185 ± 0.276
0.507PheTrp: 0.507 ± 0.119
1.868PheTyr: 1.868 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
3.736GlyAla: 3.736 ± 0.427
0.918GlyCys: 0.918 ± 0.18
4.433GlyAsp: 4.433 ± 0.426
4.433GlyGlu: 4.433 ± 0.423
2.913GlyPhe: 2.913 ± 0.315
4.971GlyGly: 4.971 ± 0.417
1.077GlyHis: 1.077 ± 0.22
4.908GlyIle: 4.908 ± 0.317
5.478GlyLys: 5.478 ± 0.526
5.509GlyLeu: 5.509 ± 0.449
1.71GlyMet: 1.71 ± 0.224
3.705GlyAsn: 3.705 ± 0.335
0.792GlyPro: 0.792 ± 0.145
2.09GlyGln: 2.09 ± 0.244
2.881GlyArg: 2.881 ± 0.289
4.148GlySer: 4.148 ± 0.319
4.528GlyThr: 4.528 ± 0.606
5.035GlyVal: 5.035 ± 0.432
1.203GlyTrp: 1.203 ± 0.191
3.198GlyTyr: 3.198 ± 0.293
0.0GlyXaa: 0.0 ± 0.0
His
0.918HisAla: 0.918 ± 0.176
0.253HisCys: 0.253 ± 0.101
1.33HisAsp: 1.33 ± 0.295
1.108HisGlu: 1.108 ± 0.22
0.887HisPhe: 0.887 ± 0.175
1.045HisGly: 1.045 ± 0.186
0.412HisHis: 0.412 ± 0.14
1.108HisIle: 1.108 ± 0.194
1.203HisLys: 1.203 ± 0.221
1.552HisLeu: 1.552 ± 0.287
0.507HisMet: 0.507 ± 0.124
1.108HisAsn: 1.108 ± 0.22
0.823HisPro: 0.823 ± 0.139
0.57HisGln: 0.57 ± 0.143
1.013HisArg: 1.013 ± 0.207
0.982HisSer: 0.982 ± 0.133
1.045HisThr: 1.045 ± 0.163
1.393HisVal: 1.393 ± 0.27
0.317HisTrp: 0.317 ± 0.086
0.665HisTyr: 0.665 ± 0.151
0.0HisXaa: 0.0 ± 0.0
Ile
4.845IleAla: 4.845 ± 0.384
0.57IleCys: 0.57 ± 0.127
5.288IleAsp: 5.288 ± 0.469
5.035IleGlu: 5.035 ± 0.513
2.375IlePhe: 2.375 ± 0.372
4.116IleGly: 4.116 ± 0.395
1.235IleHis: 1.235 ± 0.208
3.863IleIle: 3.863 ± 0.347
5.288IleLys: 5.288 ± 0.426
4.781IleLeu: 4.781 ± 0.487
1.552IleMet: 1.552 ± 0.206
3.673IleAsn: 3.673 ± 0.292
2.406IlePro: 2.406 ± 0.255
2.596IleGln: 2.596 ± 0.298
2.786IleArg: 2.786 ± 0.322
4.528IleSer: 4.528 ± 0.411
4.275IleThr: 4.275 ± 0.676
4.306IleVal: 4.306 ± 0.366
0.665IleTrp: 0.665 ± 0.127
2.375IleTyr: 2.375 ± 0.285
0.0IleXaa: 0.0 ± 0.0
Lys
6.016LysAla: 6.016 ± 0.755
0.823LysCys: 0.823 ± 0.177
4.908LysAsp: 4.908 ± 0.394
5.858LysGlu: 5.858 ± 0.553
3.356LysPhe: 3.356 ± 0.426
5.066LysGly: 5.066 ± 0.443
1.868LysHis: 1.868 ± 0.29
5.319LysIle: 5.319 ± 0.381
5.889LysLys: 5.889 ± 0.747
6.554LysLeu: 6.554 ± 0.582
1.963LysMet: 1.963 ± 0.317
3.546LysAsn: 3.546 ± 0.315
2.026LysPro: 2.026 ± 0.355
2.375LysGln: 2.375 ± 0.251
3.325LysArg: 3.325 ± 0.311
5.035LysSer: 5.035 ± 0.442
4.053LysThr: 4.053 ± 0.423
5.953LysVal: 5.953 ± 0.445
1.14LysTrp: 1.14 ± 0.165
3.483LysTyr: 3.483 ± 0.403
0.0LysXaa: 0.0 ± 0.0
Leu
5.161LeuAla: 5.161 ± 0.549
1.235LeuCys: 1.235 ± 0.197
4.971LeuAsp: 4.971 ± 0.375
6.871LeuGlu: 6.871 ± 0.441
2.786LeuPhe: 2.786 ± 0.296
4.94LeuGly: 4.94 ± 0.376
1.488LeuHis: 1.488 ± 0.225
4.845LeuIle: 4.845 ± 0.446
6.903LeuLys: 6.903 ± 0.536
5.794LeuLeu: 5.794 ± 0.454
1.963LeuMet: 1.963 ± 0.299
5.098LeuAsn: 5.098 ± 0.39
1.9LeuPro: 1.9 ± 0.264
2.375LeuGln: 2.375 ± 0.356
3.325LeuArg: 3.325 ± 0.441
5.193LeuSer: 5.193 ± 0.352
5.066LeuThr: 5.066 ± 0.391
5.224LeuVal: 5.224 ± 0.521
0.887LeuTrp: 0.887 ± 0.177
2.596LeuTyr: 2.596 ± 0.276
0.0LeuXaa: 0.0 ± 0.0
Met
1.552MetAla: 1.552 ± 0.254
0.285MetCys: 0.285 ± 0.113
1.457MetAsp: 1.457 ± 0.207
1.868MetGlu: 1.868 ± 0.244
1.203MetPhe: 1.203 ± 0.196
1.52MetGly: 1.52 ± 0.239
0.285MetHis: 0.285 ± 0.091
2.058MetIle: 2.058 ± 0.287
2.66MetLys: 2.66 ± 0.367
2.058MetLeu: 2.058 ± 0.257
0.665MetMet: 0.665 ± 0.16
1.298MetAsn: 1.298 ± 0.206
0.665MetPro: 0.665 ± 0.138
0.887MetGln: 0.887 ± 0.189
1.393MetArg: 1.393 ± 0.191
2.501MetSer: 2.501 ± 0.304
1.615MetThr: 1.615 ± 0.211
1.583MetVal: 1.583 ± 0.24
0.253MetTrp: 0.253 ± 0.08
0.918MetTyr: 0.918 ± 0.175
0.0MetXaa: 0.0 ± 0.0
Asn
3.705AsnAla: 3.705 ± 0.651
0.412AsnCys: 0.412 ± 0.111
3.23AsnAsp: 3.23 ± 0.296
3.135AsnGlu: 3.135 ± 0.371
2.501AsnPhe: 2.501 ± 0.271
4.623AsnGly: 4.623 ± 0.373
0.887AsnHis: 0.887 ± 0.198
3.61AsnIle: 3.61 ± 0.314
3.483AsnLys: 3.483 ± 0.342
3.768AsnLeu: 3.768 ± 0.469
1.71AsnMet: 1.71 ± 0.238
2.121AsnAsn: 2.121 ± 0.366
1.995AsnPro: 1.995 ± 0.245
1.71AsnGln: 1.71 ± 0.215
2.28AsnArg: 2.28 ± 0.255
3.23AsnSer: 3.23 ± 0.421
3.293AsnThr: 3.293 ± 0.447
3.863AsnVal: 3.863 ± 0.349
0.57AsnTrp: 0.57 ± 0.141
1.678AsnTyr: 1.678 ± 0.224
0.0AsnXaa: 0.0 ± 0.0
Pro
1.583ProAla: 1.583 ± 0.296
0.348ProCys: 0.348 ± 0.112
2.185ProAsp: 2.185 ± 0.282
2.786ProGlu: 2.786 ± 0.403
1.14ProPhe: 1.14 ± 0.158
0.0ProGly: 0.0 ± 0.0
0.57ProHis: 0.57 ± 0.114
1.931ProIle: 1.931 ± 0.239
2.565ProLys: 2.565 ± 0.399
2.185ProLeu: 2.185 ± 0.323
0.887ProMet: 0.887 ± 0.146
1.931ProAsn: 1.931 ± 0.306
0.823ProPro: 0.823 ± 0.137
0.855ProGln: 0.855 ± 0.16
1.33ProArg: 1.33 ± 0.207
2.216ProSer: 2.216 ± 0.274
1.457ProThr: 1.457 ± 0.199
1.995ProVal: 1.995 ± 0.235
0.253ProTrp: 0.253 ± 0.094
1.393ProTyr: 1.393 ± 0.194
0.0ProXaa: 0.0 ± 0.0
Gln
3.04GlnAla: 3.04 ± 0.489
0.475GlnCys: 0.475 ± 0.122
1.805GlnAsp: 1.805 ± 0.195
1.9GlnGlu: 1.9 ± 0.245
1.457GlnPhe: 1.457 ± 0.178
3.04GlnGly: 3.04 ± 0.497
0.633GlnHis: 0.633 ± 0.169
2.438GlnIle: 2.438 ± 0.232
2.121GlnLys: 2.121 ± 0.216
2.786GlnLeu: 2.786 ± 0.316
1.362GlnMet: 1.362 ± 0.252
1.583GlnAsn: 1.583 ± 0.231
0.855GlnPro: 0.855 ± 0.136
1.108GlnGln: 1.108 ± 0.209
1.868GlnArg: 1.868 ± 0.246
1.647GlnSer: 1.647 ± 0.258
1.678GlnThr: 1.678 ± 0.269
1.836GlnVal: 1.836 ± 0.25
0.443GlnTrp: 0.443 ± 0.117
1.425GlnTyr: 1.425 ± 0.185
0.0GlnXaa: 0.0 ± 0.0
Arg
2.216ArgAla: 2.216 ± 0.232
0.443ArgCys: 0.443 ± 0.134
2.438ArgAsp: 2.438 ± 0.269
3.261ArgGlu: 3.261 ± 0.375
2.438ArgPhe: 2.438 ± 0.358
2.913ArgGly: 2.913 ± 0.313
1.045ArgHis: 1.045 ± 0.212
3.483ArgIle: 3.483 ± 0.3
3.261ArgLys: 3.261 ± 0.389
3.261ArgLeu: 3.261 ± 0.414
1.045ArgMet: 1.045 ± 0.175
2.28ArgAsn: 2.28 ± 0.3
1.077ArgPro: 1.077 ± 0.19
1.267ArgGln: 1.267 ± 0.157
2.343ArgArg: 2.343 ± 0.284
2.85ArgSer: 2.85 ± 0.306
2.153ArgThr: 2.153 ± 0.291
3.673ArgVal: 3.673 ± 0.391
0.475ArgTrp: 0.475 ± 0.112
1.995ArgTyr: 1.995 ± 0.276
0.0ArgXaa: 0.0 ± 0.0
Ser
3.863SerAla: 3.863 ± 0.614
0.728SerCys: 0.728 ± 0.159
3.293SerAsp: 3.293 ± 0.297
3.515SerGlu: 3.515 ± 0.303
3.103SerPhe: 3.103 ± 0.337
5.541SerGly: 5.541 ± 0.436
1.298SerHis: 1.298 ± 0.186
3.8SerIle: 3.8 ± 0.34
4.876SerLys: 4.876 ± 0.394
4.433SerLeu: 4.433 ± 0.407
1.203SerMet: 1.203 ± 0.234
3.578SerAsn: 3.578 ± 0.312
1.868SerPro: 1.868 ± 0.303
2.881SerGln: 2.881 ± 0.26
3.008SerArg: 3.008 ± 0.347
3.863SerSer: 3.863 ± 0.507
3.895SerThr: 3.895 ± 0.533
4.845SerVal: 4.845 ± 0.41
0.697SerTrp: 0.697 ± 0.135
2.945SerTyr: 2.945 ± 0.272
0.0SerXaa: 0.0 ± 0.0
Thr
4.686ThrAla: 4.686 ± 1.003
0.602ThrCys: 0.602 ± 0.126
3.388ThrAsp: 3.388 ± 0.417
3.198ThrGlu: 3.198 ± 0.272
2.818ThrPhe: 2.818 ± 0.308
4.813ThrGly: 4.813 ± 0.536
1.172ThrHis: 1.172 ± 0.225
3.451ThrIle: 3.451 ± 0.29
4.686ThrLys: 4.686 ± 0.384
5.193ThrLeu: 5.193 ± 0.449
1.235ThrMet: 1.235 ± 0.198
2.501ThrAsn: 2.501 ± 0.395
2.311ThrPro: 2.311 ± 0.297
2.058ThrGln: 2.058 ± 0.352
2.438ThrArg: 2.438 ± 0.281
3.705ThrSer: 3.705 ± 0.523
3.8ThrThr: 3.8 ± 0.66
4.591ThrVal: 4.591 ± 0.556
0.823ThrTrp: 0.823 ± 0.176
2.185ThrTyr: 2.185 ± 0.258
0.0ThrXaa: 0.0 ± 0.0
Val
4.718ValAla: 4.718 ± 0.536
0.792ValCys: 0.792 ± 0.171
5.003ValAsp: 5.003 ± 0.405
5.446ValGlu: 5.446 ± 0.434
2.818ValPhe: 2.818 ± 0.322
4.465ValGly: 4.465 ± 0.37
0.918ValHis: 0.918 ± 0.195
4.243ValIle: 4.243 ± 0.484
5.889ValLys: 5.889 ± 0.445
5.288ValLeu: 5.288 ± 0.443
1.71ValMet: 1.71 ± 0.244
3.831ValAsn: 3.831 ± 0.341
2.09ValPro: 2.09 ± 0.288
2.28ValGln: 2.28 ± 0.399
3.451ValArg: 3.451 ± 0.349
4.116ValSer: 4.116 ± 0.322
4.37ValThr: 4.37 ± 0.536
6.206ValVal: 6.206 ± 0.584
1.013ValTrp: 1.013 ± 0.161
3.451ValTyr: 3.451 ± 0.365
0.0ValXaa: 0.0 ± 0.0
Trp
0.633TrpAla: 0.633 ± 0.14
0.253TrpCys: 0.253 ± 0.082
0.823TrpAsp: 0.823 ± 0.176
0.982TrpGlu: 0.982 ± 0.194
0.697TrpPhe: 0.697 ± 0.158
0.475TrpGly: 0.475 ± 0.112
0.285TrpHis: 0.285 ± 0.103
1.172TrpIle: 1.172 ± 0.192
0.95TrpLys: 0.95 ± 0.187
1.013TrpLeu: 1.013 ± 0.182
0.443TrpMet: 0.443 ± 0.103
0.76TrpAsn: 0.76 ± 0.13
0.095TrpPro: 0.095 ± 0.057
0.412TrpGln: 0.412 ± 0.109
0.538TrpArg: 0.538 ± 0.128
0.982TrpSer: 0.982 ± 0.17
0.982TrpThr: 0.982 ± 0.172
1.235TrpVal: 1.235 ± 0.197
0.158TrpTrp: 0.158 ± 0.065
0.855TrpTyr: 0.855 ± 0.208
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.9TyrAla: 1.9 ± 0.275
0.538TyrCys: 0.538 ± 0.145
2.85TyrAsp: 2.85 ± 0.311
2.501TyrGlu: 2.501 ± 0.289
1.552TyrPhe: 1.552 ± 0.196
2.501TyrGly: 2.501 ± 0.23
0.855TyrHis: 0.855 ± 0.203
2.438TyrIle: 2.438 ± 0.313
3.515TyrLys: 3.515 ± 0.288
2.976TyrLeu: 2.976 ± 0.299
1.172TyrMet: 1.172 ± 0.21
1.963TyrAsn: 1.963 ± 0.215
1.457TyrPro: 1.457 ± 0.189
1.836TyrGln: 1.836 ± 0.277
2.026TyrArg: 2.026 ± 0.272
2.945TyrSer: 2.945 ± 0.407
2.723TyrThr: 2.723 ± 0.292
3.008TyrVal: 3.008 ± 0.335
0.887TyrTrp: 0.887 ± 0.173
1.773TyrTyr: 1.773 ± 0.278
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 165 proteins (31583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski