Amino acid dipepetide frequency for Candidatus Filomicrobium marinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.859AlaAla: 14.859 ± 0.176	1.095AlaCys: 1.095 ± 0.032	6.328AlaAsp: 6.328 ± 0.079	7.212AlaGlu: 7.212 ± 0.093	4.157AlaPhe: 4.157 ± 0.055	9.229AlaGly: 9.229 ± 0.101	2.309AlaHis: 2.309 ± 0.048	6.401AlaIle: 6.401 ± 0.09	4.456AlaLys: 4.456 ± 0.079	11.898AlaLeu: 11.898 ± 0.124	3.052AlaMet: 3.052 ± 0.058	3.211AlaAsn: 3.211 ± 0.054	5.078AlaPro: 5.078 ± 0.083	4.053AlaGln: 4.053 ± 0.073	7.941AlaArg: 7.941 ± 0.103	6.774AlaSer: 6.774 ± 0.094	5.927AlaThr: 5.927 ± 0.075	8.11AlaVal: 8.11 ± 0.086	1.367AlaTrp: 1.367 ± 0.033	2.539AlaTyr: 2.539 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.029	0.144CysCys: 0.144 ± 0.011	0.514CysAsp: 0.514 ± 0.024	0.517CysGlu: 0.517 ± 0.023	0.35CysPhe: 0.35 ± 0.019	1.005CysGly: 1.005 ± 0.032	0.28CysHis: 0.28 ± 0.018	0.398CysIle: 0.398 ± 0.018	0.26CysLys: 0.26 ± 0.014	0.875CysLeu: 0.875 ± 0.028	0.178CysMet: 0.178 ± 0.012	0.244CysAsn: 0.244 ± 0.017	0.466CysPro: 0.466 ± 0.025	0.275CysGln: 0.275 ± 0.015	0.711CysArg: 0.711 ± 0.024	0.586CysSer: 0.586 ± 0.023	0.438CysThr: 0.438 ± 0.021	0.706CysVal: 0.706 ± 0.026	0.135CysTrp: 0.135 ± 0.01	0.211CysTyr: 0.211 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.255AspAla: 6.255 ± 0.077	0.529AspCys: 0.529 ± 0.022	3.212AspAsp: 3.212 ± 0.068	3.551AspGlu: 3.551 ± 0.053	2.036AspPhe: 2.036 ± 0.043	4.902AspGly: 4.902 ± 0.081	1.182AspHis: 1.182 ± 0.032	3.092AspIle: 3.092 ± 0.052	1.988AspLys: 1.988 ± 0.049	5.648AspLeu: 5.648 ± 0.068	1.22AspMet: 1.22 ± 0.033	1.47AspAsn: 1.47 ± 0.038	3.08AspPro: 3.08 ± 0.05	1.714AspGln: 1.714 ± 0.037	3.932AspArg: 3.932 ± 0.067	2.248AspSer: 2.248 ± 0.045	2.748AspThr: 2.748 ± 0.057	4.535AspVal: 4.535 ± 0.071	0.956AspTrp: 0.956 ± 0.027	1.381AspTyr: 1.381 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.303GluAla: 7.303 ± 0.114	0.372GluCys: 0.372 ± 0.019	2.96GluAsp: 2.96 ± 0.053	3.382GluGlu: 3.382 ± 0.068	1.951GluPhe: 1.951 ± 0.04	4.259GluGly: 4.259 ± 0.054	1.29GluHis: 1.29 ± 0.035	3.714GluIle: 3.714 ± 0.064	2.574GluLys: 2.574 ± 0.055	5.95GluLeu: 5.95 ± 0.079	1.521GluMet: 1.521 ± 0.038	1.794GluAsn: 1.794 ± 0.041	2.93GluPro: 2.93 ± 0.056	2.131GluGln: 2.131 ± 0.046	5.01GluArg: 5.01 ± 0.072	2.507GluSer: 2.507 ± 0.054	3.577GluThr: 3.577 ± 0.053	4.102GluVal: 4.102 ± 0.061	0.731GluTrp: 0.731 ± 0.024	1.072GluTyr: 1.072 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.456PheAla: 4.456 ± 0.061	0.386PheCys: 0.386 ± 0.018	2.417PheAsp: 2.417 ± 0.045	2.344PheGlu: 2.344 ± 0.051	1.484PhePhe: 1.484 ± 0.044	3.441PheGly: 3.441 ± 0.058	0.749PheHis: 0.749 ± 0.025	1.808PheIle: 1.808 ± 0.045	1.258PheLys: 1.258 ± 0.031	3.465PheLeu: 3.465 ± 0.062	0.852PheMet: 0.852 ± 0.027	1.171PheAsn: 1.171 ± 0.039	1.551PhePro: 1.551 ± 0.036	1.012PheGln: 1.012 ± 0.03	2.204PheArg: 2.204 ± 0.045	2.354PheSer: 2.354 ± 0.046	1.978PheThr: 1.978 ± 0.035	2.805PheVal: 2.805 ± 0.053	0.568PheTrp: 0.568 ± 0.024	0.886PheTyr: 0.886 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.332GlyAla: 8.332 ± 0.097	0.907GlyCys: 0.907 ± 0.029	4.261GlyAsp: 4.261 ± 0.081	4.59GlyGlu: 4.59 ± 0.062	3.457GlyPhe: 3.457 ± 0.061	6.967GlyGly: 6.967 ± 0.201	1.866GlyHis: 1.866 ± 0.044	4.394GlyIle: 4.394 ± 0.072	3.256GlyLys: 3.256 ± 0.063	8.632GlyLeu: 8.632 ± 0.121	1.959GlyMet: 1.959 ± 0.046	2.224GlyAsn: 2.224 ± 0.082	3.448GlyPro: 3.448 ± 0.052	2.774GlyGln: 2.774 ± 0.049	5.794GlyArg: 5.794 ± 0.084	4.951GlySer: 4.951 ± 0.084	4.482GlyThr: 4.482 ± 0.07	5.872GlyVal: 5.872 ± 0.077	1.272GlyTrp: 1.272 ± 0.036	2.308GlyTyr: 2.308 ± 0.045	0.001GlyXaa: 0.001 ± 0.001
His	2.267HisAla: 2.267 ± 0.048	0.257HisCys: 0.257 ± 0.015	1.181HisAsp: 1.181 ± 0.031	1.167HisGlu: 1.167 ± 0.033	0.855HisPhe: 0.855 ± 0.028	1.856HisGly: 1.856 ± 0.044	0.635HisHis: 0.635 ± 0.031	1.089HisIle: 1.089 ± 0.029	0.635HisLys: 0.635 ± 0.021	1.972HisLeu: 1.972 ± 0.046	0.521HisMet: 0.521 ± 0.022	0.558HisAsn: 0.558 ± 0.024	1.283HisPro: 1.283 ± 0.035	0.629HisGln: 0.629 ± 0.025	1.474HisArg: 1.474 ± 0.042	1.086HisSer: 1.086 ± 0.032	0.928HisThr: 0.928 ± 0.029	1.561HisVal: 1.561 ± 0.036	0.341HisTrp: 0.341 ± 0.018	0.613HisTyr: 0.613 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.266IleAla: 7.266 ± 0.093	0.58IleCys: 0.58 ± 0.024	3.648IleAsp: 3.648 ± 0.053	3.705IleGlu: 3.705 ± 0.056	1.901IlePhe: 1.901 ± 0.047	4.934IleGly: 4.934 ± 0.077	0.902IleHis: 0.902 ± 0.026	2.767IleIle: 2.767 ± 0.049	1.853IleLys: 1.853 ± 0.044	4.749IleLeu: 4.749 ± 0.063	1.06IleMet: 1.06 ± 0.03	1.58IleAsn: 1.58 ± 0.042	2.522IlePro: 2.522 ± 0.05	1.253IleGln: 1.253 ± 0.035	3.199IleArg: 3.199 ± 0.046	3.569IleSer: 3.569 ± 0.055	2.808IleThr: 2.808 ± 0.049	4.52IleVal: 4.52 ± 0.071	0.632IleTrp: 0.632 ± 0.027	1.174IleTyr: 1.174 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.286LysAla: 4.286 ± 0.07	0.264LysCys: 0.264 ± 0.016	1.927LysAsp: 1.927 ± 0.044	1.992LysGlu: 1.992 ± 0.05	1.142LysPhe: 1.142 ± 0.029	2.76LysGly: 2.76 ± 0.051	0.732LysHis: 0.732 ± 0.027	2.05LysIle: 2.05 ± 0.042	1.675LysLys: 1.675 ± 0.054	3.746LysLeu: 3.746 ± 0.057	0.821LysMet: 0.821 ± 0.025	1.084LysAsn: 1.084 ± 0.034	2.347LysPro: 2.347 ± 0.048	1.152LysGln: 1.152 ± 0.032	2.815LysArg: 2.815 ± 0.056	2.477LysSer: 2.477 ± 0.051	2.226LysThr: 2.226 ± 0.046	2.601LysVal: 2.601 ± 0.053	0.423LysTrp: 0.423 ± 0.018	0.722LysTyr: 0.722 ± 0.023	0.001LysXaa: 0.001 ± 0.001
Leu	12.443LeuAla: 12.443 ± 0.13	0.885LeuCys: 0.885 ± 0.026	5.481LeuAsp: 5.481 ± 0.07	5.61LeuGlu: 5.61 ± 0.067	3.583LeuPhe: 3.583 ± 0.067	7.783LeuGly: 7.783 ± 0.095	1.791LeuHis: 1.791 ± 0.039	5.5LeuIle: 5.5 ± 0.081	4.09LeuLys: 4.09 ± 0.061	8.95LeuLeu: 8.95 ± 0.139	2.387LeuMet: 2.387 ± 0.043	2.923LeuAsn: 2.923 ± 0.046	5.177LeuPro: 5.177 ± 0.077	2.815LeuGln: 2.815 ± 0.049	6.548LeuArg: 6.548 ± 0.087	6.909LeuSer: 6.909 ± 0.082	5.644LeuThr: 5.644 ± 0.074	7.092LeuVal: 7.092 ± 0.079	1.123LeuTrp: 1.123 ± 0.034	1.99LeuTyr: 1.99 ± 0.04	0.001LeuXaa: 0.001 ± 0.001
Met	2.724MetAla: 2.724 ± 0.051	0.18MetCys: 0.18 ± 0.014	1.023MetAsp: 1.023 ± 0.028	1.059MetGlu: 1.059 ± 0.029	0.771MetPhe: 0.771 ± 0.027	1.746MetGly: 1.746 ± 0.036	0.523MetHis: 0.523 ± 0.021	1.272MetIle: 1.272 ± 0.032	0.984MetLys: 0.984 ± 0.032	2.367MetLeu: 2.367 ± 0.047	0.593MetMet: 0.593 ± 0.024	0.727MetAsn: 0.727 ± 0.026	1.397MetPro: 1.397 ± 0.036	0.85MetGln: 0.85 ± 0.025	1.924MetArg: 1.924 ± 0.042	1.796MetSer: 1.796 ± 0.039	1.739MetThr: 1.739 ± 0.042	1.559MetVal: 1.559 ± 0.039	0.234MetTrp: 0.234 ± 0.014	0.326MetTyr: 0.326 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.344AsnAla: 3.344 ± 0.054	0.324AsnCys: 0.324 ± 0.018	1.535AsnAsp: 1.535 ± 0.04	1.547AsnGlu: 1.547 ± 0.035	1.019AsnPhe: 1.019 ± 0.034	2.604AsnGly: 2.604 ± 0.07	0.549AsnHis: 0.549 ± 0.021	1.497AsnIle: 1.497 ± 0.036	0.907AsnLys: 0.907 ± 0.029	2.821AsnLeu: 2.821 ± 0.055	0.627AsnMet: 0.627 ± 0.023	0.795AsnAsn: 0.795 ± 0.04	1.856AsnPro: 1.856 ± 0.042	0.862AsnGln: 0.862 ± 0.036	1.883AsnArg: 1.883 ± 0.042	1.474AsnSer: 1.474 ± 0.042	1.477AsnThr: 1.477 ± 0.042	2.296AsnVal: 2.296 ± 0.05	0.476AsnTrp: 0.476 ± 0.019	0.724AsnTyr: 0.724 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.374ProAla: 5.374 ± 0.086	0.348ProCys: 0.348 ± 0.02	3.431ProAsp: 3.431 ± 0.061	3.697ProGlu: 3.697 ± 0.058	1.956ProPhe: 1.956 ± 0.044	4.139ProGly: 4.139 ± 0.064	1.057ProHis: 1.057 ± 0.028	2.64ProIle: 2.64 ± 0.053	2.003ProLys: 2.003 ± 0.041	4.445ProLeu: 4.445 ± 0.063	1.146ProMet: 1.146 ± 0.026	1.609ProAsn: 1.609 ± 0.036	2.715ProPro: 2.715 ± 0.07	1.746ProGln: 1.746 ± 0.039	2.919ProArg: 2.919 ± 0.051	3.204ProSer: 3.204 ± 0.06	2.699ProThr: 2.699 ± 0.049	3.879ProVal: 3.879 ± 0.056	0.635ProTrp: 0.635 ± 0.023	1.185ProTyr: 1.185 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.704GlnAla: 3.704 ± 0.061	0.243GlnCys: 0.243 ± 0.014	1.518GlnAsp: 1.518 ± 0.04	1.61GlnGlu: 1.61 ± 0.036	1.179GlnPhe: 1.179 ± 0.034	2.093GlnGly: 2.093 ± 0.048	0.717GlnHis: 0.717 ± 0.024	1.93GlnIle: 1.93 ± 0.042	1.267GlnLys: 1.267 ± 0.033	3.228GlnLeu: 3.228 ± 0.061	0.871GlnMet: 0.871 ± 0.03	1.0GlnAsn: 1.0 ± 0.029	1.744GlnPro: 1.744 ± 0.038	1.265GlnGln: 1.265 ± 0.036	2.678GlnArg: 2.678 ± 0.055	2.16GlnSer: 2.16 ± 0.044	1.846GlnThr: 1.846 ± 0.043	2.127GlnVal: 2.127 ± 0.045	0.38GlnTrp: 0.38 ± 0.017	0.605GlnTyr: 0.605 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.305ArgAla: 7.305 ± 0.085	0.608ArgCys: 0.608 ± 0.027	3.88ArgAsp: 3.88 ± 0.06	4.295ArgGlu: 4.295 ± 0.064	2.731ArgPhe: 2.731 ± 0.057	4.663ArgGly: 4.663 ± 0.07	1.738ArgHis: 1.738 ± 0.039	4.153ArgIle: 4.153 ± 0.064	2.454ArgLys: 2.454 ± 0.049	7.472ArgLeu: 7.472 ± 0.106	1.765ArgMet: 1.765 ± 0.035	2.042ArgAsn: 2.042 ± 0.042	3.415ArgPro: 3.415 ± 0.06	2.626ArgGln: 2.626 ± 0.058	5.625ArgArg: 5.625 ± 0.085	4.095ArgSer: 4.095 ± 0.061	3.442ArgThr: 3.442 ± 0.055	4.811ArgVal: 4.811 ± 0.057	0.967ArgTrp: 0.967 ± 0.027	1.808ArgTyr: 1.808 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.574SerAla: 6.574 ± 0.076	0.537SerCys: 0.537 ± 0.024	3.467SerAsp: 3.467 ± 0.06	3.583SerGlu: 3.583 ± 0.063	2.208SerPhe: 2.208 ± 0.036	5.902SerGly: 5.902 ± 0.102	1.246SerHis: 1.246 ± 0.034	3.142SerIle: 3.142 ± 0.066	2.149SerLys: 2.149 ± 0.042	5.692SerLeu: 5.692 ± 0.066	1.44SerMet: 1.44 ± 0.034	1.663SerAsn: 1.663 ± 0.038	3.085SerPro: 3.085 ± 0.059	2.011SerGln: 2.011 ± 0.042	4.008SerArg: 4.008 ± 0.062	3.735SerSer: 3.735 ± 0.078	3.02SerThr: 3.02 ± 0.057	4.314SerVal: 4.314 ± 0.073	0.814SerTrp: 0.814 ± 0.027	1.446SerTyr: 1.446 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.04ThrAla: 6.04 ± 0.08	0.506ThrCys: 0.506 ± 0.022	2.798ThrAsp: 2.798 ± 0.045	2.874ThrGlu: 2.874 ± 0.052	2.181ThrPhe: 2.181 ± 0.042	4.885ThrGly: 4.885 ± 0.078	1.126ThrHis: 1.126 ± 0.035	2.943ThrIle: 2.943 ± 0.05	1.769ThrLys: 1.769 ± 0.036	5.515ThrLeu: 5.515 ± 0.067	1.201ThrMet: 1.201 ± 0.036	1.546ThrAsn: 1.546 ± 0.044	3.21ThrPro: 3.21 ± 0.064	1.661ThrGln: 1.661 ± 0.039	3.324ThrArg: 3.324 ± 0.053	3.315ThrSer: 3.315 ± 0.07	3.021ThrThr: 3.021 ± 0.069	4.278ThrVal: 4.278 ± 0.068	0.757ThrTrp: 0.757 ± 0.026	1.307ThrTyr: 1.307 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.77ValAla: 8.77 ± 0.093	0.747ValCys: 0.747 ± 0.025	4.013ValAsp: 4.013 ± 0.061	4.479ValGlu: 4.479 ± 0.074	2.778ValPhe: 2.778 ± 0.056	5.594ValGly: 5.594 ± 0.09	1.366ValHis: 1.366 ± 0.033	4.15ValIle: 4.15 ± 0.075	2.506ValLys: 2.506 ± 0.048	7.263ValLeu: 7.263 ± 0.089	1.787ValMet: 1.787 ± 0.043	1.959ValAsn: 1.959 ± 0.044	3.769ValPro: 3.769 ± 0.058	2.025ValGln: 2.025 ± 0.044	4.949ValArg: 4.949 ± 0.062	4.737ValSer: 4.737 ± 0.062	4.458ValThr: 4.458 ± 0.07	5.919ValVal: 5.919 ± 0.08	0.957ValTrp: 0.957 ± 0.028	1.476ValTyr: 1.476 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.181TrpAla: 1.181 ± 0.034	0.138TrpCys: 0.138 ± 0.011	0.604TrpAsp: 0.604 ± 0.022	0.586TrpGlu: 0.586 ± 0.023	0.514TrpPhe: 0.514 ± 0.021	0.973TrpGly: 0.973 ± 0.036	0.36TrpHis: 0.36 ± 0.018	0.711TrpIle: 0.711 ± 0.026	0.455TrpLys: 0.455 ± 0.021	1.687TrpLeu: 1.687 ± 0.041	0.319TrpMet: 0.319 ± 0.017	0.409TrpAsn: 0.409 ± 0.02	0.711TrpPro: 0.711 ± 0.026	0.599TrpGln: 0.599 ± 0.025	1.192TrpArg: 1.192 ± 0.031	0.847TrpSer: 0.847 ± 0.028	0.741TrpThr: 0.741 ± 0.026	0.857TrpVal: 0.857 ± 0.034	0.244TrpTrp: 0.244 ± 0.017	0.303TrpTyr: 0.303 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.471TyrAla: 2.471 ± 0.041	0.285TyrCys: 0.285 ± 0.015	1.479TyrAsp: 1.479 ± 0.036	1.33TyrGlu: 1.33 ± 0.035	0.94TyrPhe: 0.94 ± 0.028	2.012TyrGly: 2.012 ± 0.048	0.488TyrHis: 0.488 ± 0.02	0.972TyrIle: 0.972 ± 0.028	0.702TyrLys: 0.702 ± 0.025	2.351TyrLeu: 2.351 ± 0.048	0.472TyrMet: 0.472 ± 0.021	0.607TyrAsn: 0.607 ± 0.026	1.044TyrPro: 1.044 ± 0.03	0.712TyrGln: 0.712 ± 0.026	1.765TyrArg: 1.765 ± 0.035	1.21TyrSer: 1.21 ± 0.034	1.06TyrThr: 1.06 ± 0.031	1.76TyrVal: 1.76 ± 0.039	0.42TyrTrp: 0.42 ± 0.019	0.62TyrTyr: 0.62 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4045 proteins (1183516 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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