Amino acid dipepetide frequency for Umboniibacter marinipuniceus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.519AlaAla: 10.519 ± 0.143	0.955AlaCys: 0.955 ± 0.037	5.622AlaAsp: 5.622 ± 0.081	7.078AlaGlu: 7.078 ± 0.121	3.575AlaPhe: 3.575 ± 0.077	7.182AlaGly: 7.182 ± 0.122	1.909AlaHis: 1.909 ± 0.048	6.16AlaIle: 6.16 ± 0.084	4.65AlaLys: 4.65 ± 0.085	10.882AlaLeu: 10.882 ± 0.129	2.878AlaMet: 2.878 ± 0.059	4.068AlaAsn: 4.068 ± 0.075	3.495AlaPro: 3.495 ± 0.08	4.302AlaGln: 4.302 ± 0.078	4.709AlaArg: 4.709 ± 0.079	6.364AlaSer: 6.364 ± 0.096	5.383AlaThr: 5.383 ± 0.078	7.07AlaVal: 7.07 ± 0.106	1.178AlaTrp: 1.178 ± 0.037	2.552AlaTyr: 2.552 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.884CysAla: 0.884 ± 0.035	0.139CysCys: 0.139 ± 0.015	0.583CysAsp: 0.583 ± 0.027	0.673CysGlu: 0.673 ± 0.031	0.439CysPhe: 0.439 ± 0.02	0.852CysGly: 0.852 ± 0.038	0.302CysHis: 0.302 ± 0.021	0.54CysIle: 0.54 ± 0.027	0.291CysLys: 0.291 ± 0.022	0.925CysLeu: 0.925 ± 0.037	0.169CysMet: 0.169 ± 0.017	0.323CysAsn: 0.323 ± 0.021	0.433CysPro: 0.433 ± 0.026	0.369CysGln: 0.369 ± 0.022	0.466CysArg: 0.466 ± 0.024	0.704CysSer: 0.704 ± 0.029	0.453CysThr: 0.453 ± 0.027	0.646CysVal: 0.646 ± 0.029	0.144CysTrp: 0.144 ± 0.013	0.348CysTyr: 0.348 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.265AspAla: 5.265 ± 0.086	0.54AspCys: 0.54 ± 0.025	3.43AspAsp: 3.43 ± 0.08	4.388AspGlu: 4.388 ± 0.081	2.511AspPhe: 2.511 ± 0.064	4.408AspGly: 4.408 ± 0.099	1.285AspHis: 1.285 ± 0.043	3.767AspIle: 3.767 ± 0.072	1.958AspLys: 1.958 ± 0.054	5.454AspLeu: 5.454 ± 0.08	1.302AspMet: 1.302 ± 0.038	2.047AspAsn: 2.047 ± 0.053	2.361AspPro: 2.361 ± 0.059	2.474AspGln: 2.474 ± 0.054	3.019AspArg: 3.019 ± 0.065	3.583AspSer: 3.583 ± 0.084	2.776AspThr: 2.776 ± 0.062	4.238AspVal: 4.238 ± 0.08	0.933AspTrp: 0.933 ± 0.035	2.055AspTyr: 2.055 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	7.005GluAla: 7.005 ± 0.114	0.488GluCys: 0.488 ± 0.029	3.157GluAsp: 3.157 ± 0.061	3.633GluGlu: 3.633 ± 0.1	2.597GluPhe: 2.597 ± 0.06	4.032GluGly: 4.032 ± 0.078	1.415GluHis: 1.415 ± 0.042	3.665GluIle: 3.665 ± 0.071	2.366GluLys: 2.366 ± 0.062	7.721GluLeu: 7.721 ± 0.111	1.6GluMet: 1.6 ± 0.049	2.163GluAsn: 2.163 ± 0.056	2.185GluPro: 2.185 ± 0.055	3.471GluGln: 3.471 ± 0.074	4.131GluArg: 4.131 ± 0.077	3.951GluSer: 3.951 ± 0.088	3.087GluThr: 3.087 ± 0.061	5.068GluVal: 5.068 ± 0.097	0.862GluTrp: 0.862 ± 0.035	1.767GluTyr: 1.767 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.791PheAla: 3.791 ± 0.078	0.489PheCys: 0.489 ± 0.022	2.978PheAsp: 2.978 ± 0.063	2.641PheGlu: 2.641 ± 0.058	1.612PhePhe: 1.612 ± 0.048	3.281PheGly: 3.281 ± 0.073	0.816PheHis: 0.816 ± 0.03	2.307PheIle: 2.307 ± 0.061	1.493PheLys: 1.493 ± 0.045	3.294PheLeu: 3.294 ± 0.07	0.927PheMet: 0.927 ± 0.037	1.867PheAsn: 1.867 ± 0.048	1.396PhePro: 1.396 ± 0.045	1.277PheGln: 1.277 ± 0.039	1.78PheArg: 1.78 ± 0.046	3.285PheSer: 3.285 ± 0.057	2.044PheThr: 2.044 ± 0.053	2.838PheVal: 2.838 ± 0.062	0.494PheTrp: 0.494 ± 0.025	1.257PheTyr: 1.257 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	6.474GlyAla: 6.474 ± 0.109	0.909GlyCys: 0.909 ± 0.036	4.28GlyAsp: 4.28 ± 0.078	4.837GlyGlu: 4.837 ± 0.077	3.396GlyPhe: 3.396 ± 0.077	5.504GlyGly: 5.504 ± 0.11	1.598GlyHis: 1.598 ± 0.048	4.333GlyIle: 4.333 ± 0.075	3.03GlyLys: 3.03 ± 0.064	7.286GlyLeu: 7.286 ± 0.098	1.889GlyMet: 1.889 ± 0.056	2.512GlyAsn: 2.512 ± 0.07	2.061GlyPro: 2.061 ± 0.051	2.698GlyGln: 2.698 ± 0.062	3.653GlyArg: 3.653 ± 0.083	4.685GlySer: 4.685 ± 0.081	3.716GlyThr: 3.716 ± 0.091	5.999GlyVal: 5.999 ± 0.096	1.076GlyTrp: 1.076 ± 0.037	2.571GlyTyr: 2.571 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.713HisAla: 1.713 ± 0.045	0.34HisCys: 0.34 ± 0.02	1.047HisAsp: 1.047 ± 0.038	1.189HisGlu: 1.189 ± 0.043	1.075HisPhe: 1.075 ± 0.036	1.596HisGly: 1.596 ± 0.044	0.688HisHis: 0.688 ± 0.04	1.169HisIle: 1.169 ± 0.042	0.626HisLys: 0.626 ± 0.029	2.162HisLeu: 2.162 ± 0.056	0.404HisMet: 0.404 ± 0.023	0.764HisAsn: 0.764 ± 0.03	1.167HisPro: 1.167 ± 0.041	1.065HisGln: 1.065 ± 0.036	1.434HisArg: 1.434 ± 0.038	1.434HisSer: 1.434 ± 0.042	0.97HisThr: 0.97 ± 0.036	1.262HisVal: 1.262 ± 0.042	0.369HisTrp: 0.369 ± 0.022	0.811HisTyr: 0.811 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.598IleAla: 6.598 ± 0.096	0.583IleCys: 0.583 ± 0.029	4.32IleAsp: 4.32 ± 0.078	4.43IleGlu: 4.43 ± 0.083	1.955IlePhe: 1.955 ± 0.057	4.447IleGly: 4.447 ± 0.074	1.152IleHis: 1.152 ± 0.037	3.234IleIle: 3.234 ± 0.071	2.29IleLys: 2.29 ± 0.063	4.618IleLeu: 4.618 ± 0.09	1.087IleMet: 1.087 ± 0.038	2.633IleAsn: 2.633 ± 0.053	2.448IlePro: 2.448 ± 0.057	2.095IleGln: 2.095 ± 0.053	3.078IleArg: 3.078 ± 0.062	4.123IleSer: 4.123 ± 0.066	3.104IleThr: 3.104 ± 0.073	3.991IleVal: 3.991 ± 0.071	0.596IleTrp: 0.596 ± 0.026	1.438IleTyr: 1.438 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.068LysAla: 4.068 ± 0.077	0.249LysCys: 0.249 ± 0.018	1.925LysAsp: 1.925 ± 0.056	1.94LysGlu: 1.94 ± 0.05	1.219LysPhe: 1.219 ± 0.04	2.399LysGly: 2.399 ± 0.06	0.899LysHis: 0.899 ± 0.035	2.007LysIle: 2.007 ± 0.05	1.738LysLys: 1.738 ± 0.058	4.468LysLeu: 4.468 ± 0.081	0.979LysMet: 0.979 ± 0.041	1.184LysAsn: 1.184 ± 0.039	1.883LysPro: 1.883 ± 0.054	1.869LysGln: 1.869 ± 0.048	2.655LysArg: 2.655 ± 0.06	2.447LysSer: 2.447 ± 0.063	2.022LysThr: 2.022 ± 0.051	2.854LysVal: 2.854 ± 0.068	0.449LysTrp: 0.449 ± 0.021	0.928LysTyr: 0.928 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	11.96LeuAla: 11.96 ± 0.135	0.991LeuCys: 0.991 ± 0.032	5.905LeuAsp: 5.905 ± 0.09	6.046LeuGlu: 6.046 ± 0.11	3.797LeuPhe: 3.797 ± 0.076	7.173LeuGly: 7.173 ± 0.107	1.868LeuHis: 1.868 ± 0.051	6.026LeuIle: 6.026 ± 0.107	4.218LeuLys: 4.218 ± 0.079	10.282LeuLeu: 10.282 ± 0.158	2.393LeuMet: 2.393 ± 0.058	4.317LeuAsn: 4.317 ± 0.07	4.509LeuPro: 4.509 ± 0.077	3.668LeuGln: 3.668 ± 0.079	5.396LeuArg: 5.396 ± 0.093	8.376LeuSer: 8.376 ± 0.121	5.499LeuThr: 5.499 ± 0.079	7.499LeuVal: 7.499 ± 0.107	1.131LeuTrp: 1.131 ± 0.038	2.299LeuTyr: 2.299 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.636MetAla: 2.636 ± 0.062	0.155MetCys: 0.155 ± 0.012	1.147MetAsp: 1.147 ± 0.035	1.162MetGlu: 1.162 ± 0.038	0.698MetPhe: 0.698 ± 0.034	1.794MetGly: 1.794 ± 0.055	0.418MetHis: 0.418 ± 0.024	1.418MetIle: 1.418 ± 0.043	1.164MetLys: 1.164 ± 0.04	2.317MetLeu: 2.317 ± 0.058	0.682MetMet: 0.682 ± 0.032	0.988MetAsn: 0.988 ± 0.034	1.1MetPro: 1.1 ± 0.039	0.934MetGln: 0.934 ± 0.032	1.19MetArg: 1.19 ± 0.039	2.004MetSer: 2.004 ± 0.05	1.549MetThr: 1.549 ± 0.047	1.648MetVal: 1.648 ± 0.047	0.216MetTrp: 0.216 ± 0.016	0.473MetTyr: 0.473 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.634AsnAla: 3.634 ± 0.06	0.391AsnCys: 0.391 ± 0.025	2.279AsnAsp: 2.279 ± 0.053	2.432AsnGlu: 2.432 ± 0.059	1.593AsnPhe: 1.593 ± 0.044	2.96AsnGly: 2.96 ± 0.079	0.84AsnHis: 0.84 ± 0.03	2.158AsnIle: 2.158 ± 0.056	1.289AsnLys: 1.289 ± 0.036	3.377AsnLeu: 3.377 ± 0.076	0.789AsnMet: 0.789 ± 0.033	1.512AsnAsn: 1.512 ± 0.046	2.049AsnPro: 2.049 ± 0.055	1.582AsnGln: 1.582 ± 0.039	2.142AsnArg: 2.142 ± 0.054	2.459AsnSer: 2.459 ± 0.061	2.193AsnThr: 2.193 ± 0.053	2.427AsnVal: 2.427 ± 0.06	0.66AsnTrp: 0.66 ± 0.026	1.333AsnTyr: 1.333 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	3.751ProAla: 3.751 ± 0.071	0.307ProCys: 0.307 ± 0.018	2.313ProAsp: 2.313 ± 0.062	3.213ProGlu: 3.213 ± 0.067	1.6ProPhe: 1.6 ± 0.048	2.734ProGly: 2.734 ± 0.058	0.84ProHis: 0.84 ± 0.035	2.392ProIle: 2.392 ± 0.053	1.644ProLys: 1.644 ± 0.05	4.024ProLeu: 4.024 ± 0.076	0.986ProMet: 0.986 ± 0.034	1.797ProAsn: 1.797 ± 0.045	1.312ProPro: 1.312 ± 0.05	1.496ProGln: 1.496 ± 0.042	1.684ProArg: 1.684 ± 0.049	3.029ProSer: 3.029 ± 0.061	2.294ProThr: 2.294 ± 0.054	3.141ProVal: 3.141 ± 0.068	0.575ProTrp: 0.575 ± 0.029	1.098ProTyr: 1.098 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.158GlnAla: 4.158 ± 0.077	0.342GlnCys: 0.342 ± 0.023	1.632GlnAsp: 1.632 ± 0.043	1.843GlnGlu: 1.843 ± 0.052	1.711GlnPhe: 1.711 ± 0.044	2.688GlnGly: 2.688 ± 0.051	1.057GlnHis: 1.057 ± 0.039	2.201GlnIle: 2.201 ± 0.052	1.262GlnLys: 1.262 ± 0.043	5.759GlnLeu: 5.759 ± 0.104	0.943GlnMet: 0.943 ± 0.031	1.154GlnAsn: 1.154 ± 0.037	1.787GlnPro: 1.787 ± 0.052	2.586GlnGln: 2.586 ± 0.072	3.197GlnArg: 3.197 ± 0.064	2.838GlnSer: 2.838 ± 0.063	1.963GlnThr: 1.963 ± 0.055	2.899GlnVal: 2.899 ± 0.064	0.644GlnTrp: 0.644 ± 0.031	1.128GlnTyr: 1.128 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	4.889ArgAla: 4.889 ± 0.082	0.544ArgCys: 0.544 ± 0.028	3.085ArgAsp: 3.085 ± 0.064	3.697ArgGlu: 3.697 ± 0.078	2.586ArgPhe: 2.586 ± 0.056	3.547ArgGly: 3.547 ± 0.075	1.272ArgHis: 1.272 ± 0.038	3.287ArgIle: 3.287 ± 0.061	1.981ArgLys: 1.981 ± 0.053	5.79ArgLeu: 5.79 ± 0.089	1.287ArgMet: 1.287 ± 0.041	1.905ArgAsn: 1.905 ± 0.045	1.886ArgPro: 1.886 ± 0.051	2.348ArgGln: 2.348 ± 0.057	3.136ArgArg: 3.136 ± 0.078	3.357ArgSer: 3.357 ± 0.069	2.34ArgThr: 2.34 ± 0.052	3.993ArgVal: 3.993 ± 0.073	0.903ArgTrp: 0.903 ± 0.034	2.0ArgTyr: 2.0 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	6.944SerAla: 6.944 ± 0.094	0.67SerCys: 0.67 ± 0.035	3.993SerAsp: 3.993 ± 0.091	4.53SerGlu: 4.53 ± 0.088	3.004SerPhe: 3.004 ± 0.068	5.514SerGly: 5.514 ± 0.108	1.449SerHis: 1.449 ± 0.043	3.697SerIle: 3.697 ± 0.069	2.44SerLys: 2.44 ± 0.055	7.29SerLeu: 7.29 ± 0.097	1.618SerMet: 1.618 ± 0.043	2.468SerAsn: 2.468 ± 0.063	2.816SerPro: 2.816 ± 0.059	2.743SerGln: 2.743 ± 0.062	3.323SerArg: 3.323 ± 0.064	4.892SerSer: 4.892 ± 0.089	3.483SerThr: 3.483 ± 0.068	5.087SerVal: 5.087 ± 0.086	0.978SerTrp: 0.978 ± 0.035	2.21SerTyr: 2.21 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	5.164ThrAla: 5.164 ± 0.09	0.376ThrCys: 0.376 ± 0.025	2.862ThrAsp: 2.862 ± 0.08	3.15ThrGlu: 3.15 ± 0.066	1.805ThrPhe: 1.805 ± 0.048	4.035ThrGly: 4.035 ± 0.081	1.116ThrHis: 1.116 ± 0.038	3.154ThrIle: 3.154 ± 0.065	1.835ThrLys: 1.835 ± 0.054	5.851ThrLeu: 5.851 ± 0.087	1.07ThrMet: 1.07 ± 0.035	1.945ThrAsn: 1.945 ± 0.054	2.803ThrPro: 2.803 ± 0.058	2.183ThrGln: 2.183 ± 0.053	2.485ThrArg: 2.485 ± 0.054	3.398ThrSer: 3.398 ± 0.074	3.121ThrThr: 3.121 ± 0.07	3.781ThrVal: 3.781 ± 0.079	0.642ThrTrp: 0.642 ± 0.032	1.275ThrTyr: 1.275 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	7.825ValAla: 7.825 ± 0.104	0.741ValCys: 0.741 ± 0.031	4.811ValAsp: 4.811 ± 0.078	5.068ValGlu: 5.068 ± 0.101	2.775ValPhe: 2.775 ± 0.064	5.259ValGly: 5.259 ± 0.093	1.299ValHis: 1.299 ± 0.042	4.765ValIle: 4.765 ± 0.077	2.719ValLys: 2.719 ± 0.063	6.858ValLeu: 6.858 ± 0.1	1.867ValMet: 1.867 ± 0.053	2.99ValAsn: 2.99 ± 0.056	2.766ValPro: 2.766 ± 0.06	2.134ValGln: 2.134 ± 0.059	3.382ValArg: 3.382 ± 0.072	5.302ValSer: 5.302 ± 0.091	4.005ValThr: 4.005 ± 0.082	6.122ValVal: 6.122 ± 0.095	0.825ValTrp: 0.825 ± 0.031	1.799ValTyr: 1.799 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.973TrpAla: 0.973 ± 0.039	0.167TrpCys: 0.167 ± 0.014	0.69TrpAsp: 0.69 ± 0.03	0.669TrpGlu: 0.669 ± 0.035	0.612TrpPhe: 0.612 ± 0.03	0.881TrpGly: 0.881 ± 0.038	0.338TrpHis: 0.338 ± 0.018	0.704TrpIle: 0.704 ± 0.035	0.345TrpLys: 0.345 ± 0.02	1.919TrpLeu: 1.919 ± 0.055	0.328TrpMet: 0.328 ± 0.021	0.463TrpAsn: 0.463 ± 0.025	0.524TrpPro: 0.524 ± 0.026	0.842TrpGln: 0.842 ± 0.036	0.91TrpArg: 0.91 ± 0.036	0.866TrpSer: 0.866 ± 0.031	0.577TrpThr: 0.577 ± 0.029	0.937TrpVal: 0.937 ± 0.036	0.235TrpTrp: 0.235 ± 0.018	0.394TrpTyr: 0.394 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.281TyrAla: 2.281 ± 0.06	0.31TyrCys: 0.31 ± 0.017	1.736TyrAsp: 1.736 ± 0.06	1.746TyrGlu: 1.746 ± 0.048	1.306TyrPhe: 1.306 ± 0.039	2.224TyrGly: 2.224 ± 0.056	0.723TyrHis: 0.723 ± 0.036	1.234TyrIle: 1.234 ± 0.042	0.847TyrLys: 0.847 ± 0.033	3.076TyrLeu: 3.076 ± 0.063	0.491TyrMet: 0.491 ± 0.028	0.995TyrAsn: 0.995 ± 0.035	1.25TyrPro: 1.25 ± 0.045	1.657TyrGln: 1.657 ± 0.046	2.062TyrArg: 2.062 ± 0.056	2.05TyrSer: 2.05 ± 0.057	1.473TyrThr: 1.473 ± 0.04	1.812TyrVal: 1.812 ± 0.048	0.464TyrTrp: 0.464 ± 0.028	0.953TyrTyr: 0.953 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2413 proteins (804001 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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