Amino acid dipepetide frequency for Proteus phage vB_PmiP_RS51pmB

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.401AlaAla: 7.401 ± 1.014
0.61AlaCys: 0.61 ± 0.201
5.57AlaAsp: 5.57 ± 0.698
4.197AlaGlu: 4.197 ± 0.601
2.442AlaPhe: 2.442 ± 0.524
6.486AlaGly: 6.486 ± 0.682
1.679AlaHis: 1.679 ± 0.279
6.562AlaIle: 6.562 ± 0.794
5.341AlaLys: 5.341 ± 0.553
6.028AlaLeu: 6.028 ± 0.816
2.823AlaMet: 2.823 ± 0.452
3.281AlaAsn: 3.281 ± 0.538
2.594AlaPro: 2.594 ± 0.42
3.434AlaGln: 3.434 ± 0.495
3.128AlaArg: 3.128 ± 0.585
4.502AlaSer: 4.502 ± 0.589
3.739AlaThr: 3.739 ± 0.604
4.807AlaVal: 4.807 ± 0.634
0.992AlaTrp: 0.992 ± 0.33
3.128AlaTyr: 3.128 ± 0.427
0.0AlaXaa: 0.0 ± 0.0
Cys
0.534CysAla: 0.534 ± 0.223
0.076CysCys: 0.076 ± 0.089
0.763CysAsp: 0.763 ± 0.235
1.45CysGlu: 1.45 ± 0.373
0.61CysPhe: 0.61 ± 0.285
1.755CysGly: 1.755 ± 0.449
0.153CysHis: 0.153 ± 0.118
1.297CysIle: 1.297 ± 0.317
0.763CysLys: 0.763 ± 0.224
0.763CysLeu: 0.763 ± 0.218
0.382CysMet: 0.382 ± 0.159
0.839CysAsn: 0.839 ± 0.253
0.687CysPro: 0.687 ± 0.261
0.305CysGln: 0.305 ± 0.15
0.687CysArg: 0.687 ± 0.246
0.687CysSer: 0.687 ± 0.209
0.839CysThr: 0.839 ± 0.25
1.297CysVal: 1.297 ± 0.318
0.076CysTrp: 0.076 ± 0.072
0.305CysTyr: 0.305 ± 0.13
0.0CysXaa: 0.0 ± 0.0
Asp
6.257AspAla: 6.257 ± 0.61
0.61AspCys: 0.61 ± 0.255
4.654AspAsp: 4.654 ± 0.529
4.807AspGlu: 4.807 ± 0.697
2.365AspPhe: 2.365 ± 0.365
6.714AspGly: 6.714 ± 0.656
0.992AspHis: 0.992 ± 0.23
4.883AspIle: 4.883 ± 0.569
5.036AspLys: 5.036 ± 0.54
4.731AspLeu: 4.731 ± 0.562
3.357AspMet: 3.357 ± 0.539
2.823AspAsn: 2.823 ± 0.42
1.984AspPro: 1.984 ± 0.375
1.602AspGln: 1.602 ± 0.356
2.976AspArg: 2.976 ± 0.445
3.357AspSer: 3.357 ± 0.532
2.823AspThr: 2.823 ± 0.449
4.578AspVal: 4.578 ± 0.637
1.45AspTrp: 1.45 ± 0.379
3.739AspTyr: 3.739 ± 0.535
0.0AspXaa: 0.0 ± 0.0
Glu
4.807GluAla: 4.807 ± 0.559
0.992GluCys: 0.992 ± 0.27
4.807GluAsp: 4.807 ± 0.78
5.417GluGlu: 5.417 ± 0.695
2.899GluPhe: 2.899 ± 0.394
3.281GluGly: 3.281 ± 0.474
1.297GluHis: 1.297 ± 0.316
4.654GluIle: 4.654 ± 0.529
4.197GluLys: 4.197 ± 0.568
5.265GluLeu: 5.265 ± 0.641
3.434GluMet: 3.434 ± 0.601
2.899GluAsn: 2.899 ± 0.457
0.839GluPro: 0.839 ± 0.292
2.365GluGln: 2.365 ± 0.378
2.289GluArg: 2.289 ± 0.367
4.12GluSer: 4.12 ± 0.449
2.823GluThr: 2.823 ± 0.619
4.731GluVal: 4.731 ± 0.438
1.526GluTrp: 1.526 ± 0.391
3.052GluTyr: 3.052 ± 0.384
0.0GluXaa: 0.0 ± 0.0
Phe
2.518PheAla: 2.518 ± 0.497
0.305PheCys: 0.305 ± 0.147
2.976PheAsp: 2.976 ± 0.545
2.442PheGlu: 2.442 ± 0.391
1.297PhePhe: 1.297 ± 0.297
3.662PheGly: 3.662 ± 0.476
0.61PheHis: 0.61 ± 0.269
2.899PheIle: 2.899 ± 0.332
3.357PheLys: 3.357 ± 0.519
2.365PheLeu: 2.365 ± 0.466
1.679PheMet: 1.679 ± 0.31
2.06PheAsn: 2.06 ± 0.415
1.602PhePro: 1.602 ± 0.45
0.839PheGln: 0.839 ± 0.246
1.373PheArg: 1.373 ± 0.258
2.365PheSer: 2.365 ± 0.337
1.984PheThr: 1.984 ± 0.421
2.899PheVal: 2.899 ± 0.439
0.534PheTrp: 0.534 ± 0.187
1.068PheTyr: 1.068 ± 0.329
0.0PheXaa: 0.0 ± 0.0
Gly
5.799GlyAla: 5.799 ± 0.784
1.45GlyCys: 1.45 ± 0.351
5.646GlyAsp: 5.646 ± 0.742
4.807GlyGlu: 4.807 ± 0.542
3.815GlyPhe: 3.815 ± 0.551
6.867GlyGly: 6.867 ± 0.878
0.992GlyHis: 0.992 ± 0.239
5.57GlyIle: 5.57 ± 0.698
7.096GlyLys: 7.096 ± 0.695
4.273GlyLeu: 4.273 ± 0.544
2.518GlyMet: 2.518 ± 0.38
3.739GlyAsn: 3.739 ± 0.632
0.382GlyPro: 0.382 ± 0.173
2.289GlyGln: 2.289 ± 0.38
4.044GlyArg: 4.044 ± 0.506
4.12GlySer: 4.12 ± 0.465
3.205GlyThr: 3.205 ± 0.475
6.409GlyVal: 6.409 ± 0.697
0.916GlyTrp: 0.916 ± 0.253
2.976GlyTyr: 2.976 ± 0.43
0.0GlyXaa: 0.0 ± 0.0
His
0.992HisAla: 0.992 ± 0.252
0.229HisCys: 0.229 ± 0.123
1.373HisAsp: 1.373 ± 0.295
1.602HisGlu: 1.602 ± 0.284
0.687HisPhe: 0.687 ± 0.216
1.908HisGly: 1.908 ± 0.337
0.229HisHis: 0.229 ± 0.124
1.221HisIle: 1.221 ± 0.273
0.992HisLys: 0.992 ± 0.274
1.068HisLeu: 1.068 ± 0.276
0.229HisMet: 0.229 ± 0.125
0.763HisAsn: 0.763 ± 0.215
0.763HisPro: 0.763 ± 0.323
0.61HisGln: 0.61 ± 0.215
0.534HisArg: 0.534 ± 0.2
1.297HisSer: 1.297 ± 0.352
0.992HisThr: 0.992 ± 0.27
0.687HisVal: 0.687 ± 0.232
0.076HisTrp: 0.076 ± 0.079
0.763HisTyr: 0.763 ± 0.262
0.0HisXaa: 0.0 ± 0.0
Ile
5.57IleAla: 5.57 ± 0.592
0.916IleCys: 0.916 ± 0.287
7.096IleAsp: 7.096 ± 0.69
3.281IleGlu: 3.281 ± 0.619
1.755IlePhe: 1.755 ± 0.358
5.57IleGly: 5.57 ± 0.792
1.679IleHis: 1.679 ± 0.505
4.425IleIle: 4.425 ± 0.663
4.807IleLys: 4.807 ± 0.487
3.662IleLeu: 3.662 ± 0.49
2.289IleMet: 2.289 ± 0.478
4.12IleAsn: 4.12 ± 0.593
1.984IlePro: 1.984 ± 0.368
1.679IleGln: 1.679 ± 0.328
2.899IleArg: 2.899 ± 0.474
5.188IleSer: 5.188 ± 0.682
5.188IleThr: 5.188 ± 0.578
4.807IleVal: 4.807 ± 0.446
0.458IleTrp: 0.458 ± 0.202
2.365IleTyr: 2.365 ± 0.346
0.0IleXaa: 0.0 ± 0.0
Lys
6.257LysAla: 6.257 ± 0.636
1.221LysCys: 1.221 ± 0.337
4.654LysAsp: 4.654 ± 0.604
4.578LysGlu: 4.578 ± 0.569
3.357LysPhe: 3.357 ± 0.465
3.891LysGly: 3.891 ± 0.51
1.221LysHis: 1.221 ± 0.287
3.739LysIle: 3.739 ± 0.585
4.96LysLys: 4.96 ± 0.631
5.341LysLeu: 5.341 ± 0.59
2.747LysMet: 2.747 ± 0.399
3.739LysAsn: 3.739 ± 0.533
2.747LysPro: 2.747 ± 0.475
2.442LysGln: 2.442 ± 0.437
3.128LysArg: 3.128 ± 0.535
3.815LysSer: 3.815 ± 0.506
4.731LysThr: 4.731 ± 0.616
4.807LysVal: 4.807 ± 0.594
1.679LysTrp: 1.679 ± 0.338
2.747LysTyr: 2.747 ± 0.438
0.0LysXaa: 0.0 ± 0.0
Leu
5.951LeuAla: 5.951 ± 0.566
1.145LeuCys: 1.145 ± 0.365
3.662LeuAsp: 3.662 ± 0.479
4.425LeuGlu: 4.425 ± 0.546
2.518LeuPhe: 2.518 ± 0.45
4.349LeuGly: 4.349 ± 0.478
1.068LeuHis: 1.068 ± 0.283
4.731LeuIle: 4.731 ± 0.54
4.273LeuLys: 4.273 ± 0.464
4.502LeuLeu: 4.502 ± 0.584
2.365LeuMet: 2.365 ± 0.411
3.662LeuAsn: 3.662 ± 0.525
1.831LeuPro: 1.831 ± 0.443
2.289LeuGln: 2.289 ± 0.425
3.205LeuArg: 3.205 ± 0.414
4.654LeuSer: 4.654 ± 0.658
4.807LeuThr: 4.807 ± 0.541
5.188LeuVal: 5.188 ± 0.63
0.61LeuTrp: 0.61 ± 0.242
1.679LeuTyr: 1.679 ± 0.363
0.0LeuXaa: 0.0 ± 0.0
Met
3.357MetAla: 3.357 ± 0.436
0.458MetCys: 0.458 ± 0.17
1.679MetAsp: 1.679 ± 0.425
1.221MetGlu: 1.221 ± 0.274
1.297MetPhe: 1.297 ± 0.316
1.755MetGly: 1.755 ± 0.364
0.534MetHis: 0.534 ± 0.204
2.136MetIle: 2.136 ± 0.411
3.434MetLys: 3.434 ± 0.499
2.823MetLeu: 2.823 ± 0.491
1.221MetMet: 1.221 ± 0.313
2.06MetAsn: 2.06 ± 0.302
0.992MetPro: 0.992 ± 0.274
1.373MetGln: 1.373 ± 0.278
1.755MetArg: 1.755 ± 0.327
2.823MetSer: 2.823 ± 0.403
3.128MetThr: 3.128 ± 0.519
1.602MetVal: 1.602 ± 0.347
0.382MetTrp: 0.382 ± 0.165
1.45MetTyr: 1.45 ± 0.349
0.0MetXaa: 0.0 ± 0.0
Asn
3.739AsnAla: 3.739 ± 0.626
0.839AsnCys: 0.839 ± 0.25
3.281AsnAsp: 3.281 ± 0.446
2.518AsnGlu: 2.518 ± 0.387
1.221AsnPhe: 1.221 ± 0.254
4.425AsnGly: 4.425 ± 0.679
0.992AsnHis: 0.992 ± 0.251
2.899AsnIle: 2.899 ± 0.461
4.044AsnLys: 4.044 ± 0.614
2.594AsnLeu: 2.594 ± 0.446
0.992AsnMet: 0.992 ± 0.273
2.365AsnAsn: 2.365 ± 0.468
2.823AsnPro: 2.823 ± 0.484
1.526AsnGln: 1.526 ± 0.417
1.984AsnArg: 1.984 ± 0.348
3.51AsnSer: 3.51 ± 0.511
2.213AsnThr: 2.213 ± 0.385
2.976AsnVal: 2.976 ± 0.503
0.839AsnTrp: 0.839 ± 0.198
1.679AsnTyr: 1.679 ± 0.351
0.0AsnXaa: 0.0 ± 0.0
Pro
2.442ProAla: 2.442 ± 0.422
0.458ProCys: 0.458 ± 0.178
2.976ProAsp: 2.976 ± 0.506
3.052ProGlu: 3.052 ± 0.465
1.373ProPhe: 1.373 ± 0.343
1.831ProGly: 1.831 ± 0.377
0.534ProHis: 0.534 ± 0.212
2.06ProIle: 2.06 ± 0.455
1.755ProLys: 1.755 ± 0.421
2.06ProLeu: 2.06 ± 0.32
1.602ProMet: 1.602 ± 0.34
0.839ProAsn: 0.839 ± 0.291
1.45ProPro: 1.45 ± 0.363
0.305ProGln: 0.305 ± 0.149
1.145ProArg: 1.145 ± 0.236
1.602ProSer: 1.602 ± 0.292
1.221ProThr: 1.221 ± 0.308
3.815ProVal: 3.815 ± 0.602
0.305ProTrp: 0.305 ± 0.159
1.297ProTyr: 1.297 ± 0.383
0.0ProXaa: 0.0 ± 0.0
Gln
2.289GlnAla: 2.289 ± 0.377
0.534GlnCys: 0.534 ± 0.18
1.755GlnAsp: 1.755 ± 0.364
2.06GlnGlu: 2.06 ± 0.465
0.763GlnPhe: 0.763 ± 0.209
1.755GlnGly: 1.755 ± 0.317
0.763GlnHis: 0.763 ± 0.235
1.526GlnIle: 1.526 ± 0.345
1.297GlnLys: 1.297 ± 0.348
2.747GlnLeu: 2.747 ± 0.423
0.839GlnMet: 0.839 ± 0.247
1.679GlnAsn: 1.679 ± 0.341
1.373GlnPro: 1.373 ± 0.269
1.45GlnGln: 1.45 ± 0.376
1.373GlnArg: 1.373 ± 0.335
2.442GlnSer: 2.442 ± 0.408
2.365GlnThr: 2.365 ± 0.369
2.747GlnVal: 2.747 ± 0.382
0.382GlnTrp: 0.382 ± 0.189
1.221GlnTyr: 1.221 ± 0.302
0.0GlnXaa: 0.0 ± 0.0
Arg
2.518ArgAla: 2.518 ± 0.522
0.916ArgCys: 0.916 ± 0.257
2.594ArgAsp: 2.594 ± 0.508
3.128ArgGlu: 3.128 ± 0.514
1.373ArgPhe: 1.373 ± 0.381
3.434ArgGly: 3.434 ± 0.463
0.992ArgHis: 0.992 ± 0.25
2.365ArgIle: 2.365 ± 0.421
3.815ArgLys: 3.815 ± 0.592
2.823ArgLeu: 2.823 ± 0.372
2.289ArgMet: 2.289 ± 0.349
1.908ArgAsn: 1.908 ± 0.305
1.45ArgPro: 1.45 ± 0.415
0.839ArgGln: 0.839 ± 0.231
1.679ArgArg: 1.679 ± 0.316
2.213ArgSer: 2.213 ± 0.453
1.908ArgThr: 1.908 ± 0.429
3.052ArgVal: 3.052 ± 0.476
0.763ArgTrp: 0.763 ± 0.242
2.289ArgTyr: 2.289 ± 0.412
0.0ArgXaa: 0.0 ± 0.0
Ser
4.883SerAla: 4.883 ± 0.578
0.992SerCys: 0.992 ± 0.307
4.578SerAsp: 4.578 ± 0.491
4.654SerGlu: 4.654 ± 0.527
2.823SerPhe: 2.823 ± 0.393
5.188SerGly: 5.188 ± 0.667
1.297SerHis: 1.297 ± 0.336
5.646SerIle: 5.646 ± 0.788
4.12SerLys: 4.12 ± 0.431
3.815SerLeu: 3.815 ± 0.385
1.679SerMet: 1.679 ± 0.28
2.442SerAsn: 2.442 ± 0.379
2.289SerPro: 2.289 ± 0.342
1.984SerGln: 1.984 ± 0.34
2.365SerArg: 2.365 ± 0.38
3.128SerSer: 3.128 ± 0.471
2.899SerThr: 2.899 ± 0.469
4.349SerVal: 4.349 ± 0.589
0.916SerTrp: 0.916 ± 0.27
2.213SerTyr: 2.213 ± 0.4
0.0SerXaa: 0.0 ± 0.0
Thr
4.349ThrAla: 4.349 ± 0.626
0.916ThrCys: 0.916 ± 0.311
4.197ThrAsp: 4.197 ± 0.533
3.51ThrGlu: 3.51 ± 0.507
2.213ThrPhe: 2.213 ± 0.436
5.417ThrGly: 5.417 ± 0.502
0.839ThrHis: 0.839 ± 0.31
3.815ThrIle: 3.815 ± 0.539
3.815ThrLys: 3.815 ± 0.428
3.739ThrLeu: 3.739 ± 0.647
1.373ThrMet: 1.373 ± 0.361
2.899ThrAsn: 2.899 ± 0.474
2.518ThrPro: 2.518 ± 0.486
1.831ThrGln: 1.831 ± 0.263
1.602ThrArg: 1.602 ± 0.336
2.747ThrSer: 2.747 ± 0.401
2.213ThrThr: 2.213 ± 0.416
4.197ThrVal: 4.197 ± 0.524
0.458ThrTrp: 0.458 ± 0.177
1.679ThrTyr: 1.679 ± 0.377
0.0ThrXaa: 0.0 ± 0.0
Val
6.257ValAla: 6.257 ± 0.698
0.687ValCys: 0.687 ± 0.227
4.197ValAsp: 4.197 ± 0.458
4.578ValGlu: 4.578 ± 0.522
2.747ValPhe: 2.747 ± 0.512
4.807ValGly: 4.807 ± 0.773
0.458ValHis: 0.458 ± 0.184
5.417ValIle: 5.417 ± 0.591
4.807ValLys: 4.807 ± 0.703
3.662ValLeu: 3.662 ± 0.6
2.823ValMet: 2.823 ± 0.472
3.357ValAsn: 3.357 ± 0.573
2.518ValPro: 2.518 ± 0.41
2.136ValGln: 2.136 ± 0.388
3.281ValArg: 3.281 ± 0.432
6.257ValSer: 6.257 ± 0.729
4.883ValThr: 4.883 ± 0.665
5.417ValVal: 5.417 ± 0.698
1.221ValTrp: 1.221 ± 0.301
2.823ValTyr: 2.823 ± 0.504
0.0ValXaa: 0.0 ± 0.0
Trp
0.534TrpAla: 0.534 ± 0.207
0.382TrpCys: 0.382 ± 0.165
0.916TrpAsp: 0.916 ± 0.196
1.145TrpGlu: 1.145 ± 0.229
0.916TrpPhe: 0.916 ± 0.275
0.916TrpGly: 0.916 ± 0.316
0.076TrpHis: 0.076 ± 0.074
1.068TrpIle: 1.068 ± 0.309
0.839TrpLys: 0.839 ± 0.269
1.755TrpLeu: 1.755 ± 0.349
0.153TrpMet: 0.153 ± 0.106
0.382TrpAsn: 0.382 ± 0.181
0.153TrpPro: 0.153 ± 0.108
0.534TrpGln: 0.534 ± 0.183
0.305TrpArg: 0.305 ± 0.153
1.526TrpSer: 1.526 ± 0.294
0.687TrpThr: 0.687 ± 0.296
1.145TrpVal: 1.145 ± 0.297
0.382TrpTrp: 0.382 ± 0.226
0.458TrpTyr: 0.458 ± 0.164
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.289TyrAla: 2.289 ± 0.391
0.534TyrCys: 0.534 ± 0.205
2.365TyrAsp: 2.365 ± 0.475
2.823TyrGlu: 2.823 ± 0.46
2.365TyrPhe: 2.365 ± 0.337
2.899TyrGly: 2.899 ± 0.434
0.61TyrHis: 0.61 ± 0.216
2.823TyrIle: 2.823 ± 0.425
3.128TyrLys: 3.128 ± 0.525
2.899TyrLeu: 2.899 ± 0.5
0.61TyrMet: 0.61 ± 0.221
1.602TyrAsn: 1.602 ± 0.415
1.145TyrPro: 1.145 ± 0.289
1.526TyrGln: 1.526 ± 0.347
2.594TyrArg: 2.594 ± 0.508
1.908TyrSer: 1.908 ± 0.462
1.679TyrThr: 1.679 ± 0.342
2.823TyrVal: 2.823 ± 0.434
0.305TyrTrp: 0.305 ± 0.144
1.45TyrTyr: 1.45 ± 0.406
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (13107 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski