Amino acid dipepetide frequency for Kundal virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.118AlaAla: 2.118 ± 0.326
0.953AlaCys: 0.953 ± 0.224
2.223AlaAsp: 2.223 ± 0.324
1.906AlaGlu: 1.906 ± 0.334
2.223AlaPhe: 2.223 ± 0.407
3.07AlaGly: 3.07 ± 0.628
0.953AlaHis: 0.953 ± 0.262
4.023AlaIle: 4.023 ± 0.62
2.435AlaLys: 2.435 ± 0.498
5.506AlaLeu: 5.506 ± 0.933
1.694AlaMet: 1.694 ± 0.268
2.435AlaAsn: 2.435 ± 0.469
2.223AlaPro: 2.223 ± 0.356
1.376AlaGln: 1.376 ± 0.293
4.129AlaArg: 4.129 ± 0.576
3.388AlaSer: 3.388 ± 0.651
2.012AlaThr: 2.012 ± 0.511
3.6AlaVal: 3.6 ± 0.499
0.529AlaTrp: 0.529 ± 0.245
2.859AlaTyr: 2.859 ± 0.571
0.0AlaXaa: 0.0 ± 0.0
Cys
1.165CysAla: 1.165 ± 0.414
0.424CysCys: 0.424 ± 0.156
1.271CysAsp: 1.271 ± 0.309
1.482CysGlu: 1.482 ± 0.33
0.635CysPhe: 0.635 ± 0.296
0.529CysGly: 0.529 ± 0.297
0.529CysHis: 0.529 ± 0.135
0.847CysIle: 0.847 ± 0.265
0.847CysLys: 0.847 ± 0.291
1.059CysLeu: 1.059 ± 0.412
0.318CysMet: 0.318 ± 0.148
0.635CysAsn: 0.635 ± 0.226
0.424CysPro: 0.424 ± 0.153
0.529CysGln: 0.529 ± 0.211
1.271CysArg: 1.271 ± 0.358
1.376CysSer: 1.376 ± 0.305
1.376CysThr: 1.376 ± 0.217
1.059CysVal: 1.059 ± 0.199
0.318CysTrp: 0.318 ± 0.152
0.529CysTyr: 0.529 ± 0.286
0.106CysXaa: 0.106 ± 0.103
Asp
2.329AspAla: 2.329 ± 0.598
1.165AspCys: 1.165 ± 0.292
4.447AspAsp: 4.447 ± 0.709
3.917AspGlu: 3.917 ± 1.146
3.07AspPhe: 3.07 ± 0.661
4.341AspGly: 4.341 ± 0.375
0.847AspHis: 0.847 ± 0.167
4.341AspIle: 4.341 ± 0.427
1.8AspLys: 1.8 ± 0.5
5.717AspLeu: 5.717 ± 0.871
1.059AspMet: 1.059 ± 0.552
2.012AspAsn: 2.012 ± 0.598
3.07AspPro: 3.07 ± 0.516
2.223AspGln: 2.223 ± 0.359
2.647AspArg: 2.647 ± 0.537
4.659AspSer: 4.659 ± 0.742
2.753AspThr: 2.753 ± 0.449
4.976AspVal: 4.976 ± 0.574
1.482AspTrp: 1.482 ± 0.497
2.118AspTyr: 2.118 ± 0.5
0.0AspXaa: 0.0 ± 0.0
Glu
4.341GluAla: 4.341 ± 0.474
1.059GluCys: 1.059 ± 0.252
3.07GluAsp: 3.07 ± 0.814
4.129GluGlu: 4.129 ± 0.837
2.118GluPhe: 2.118 ± 0.443
4.764GluGly: 4.764 ± 0.699
0.741GluHis: 0.741 ± 0.22
5.294GluIle: 5.294 ± 0.922
4.659GluLys: 4.659 ± 0.776
5.717GluLeu: 5.717 ± 0.751
2.118GluMet: 2.118 ± 0.646
3.388GluAsn: 3.388 ± 0.435
1.376GluPro: 1.376 ± 0.319
1.165GluGln: 1.165 ± 0.34
4.129GluArg: 4.129 ± 0.608
3.494GluSer: 3.494 ± 0.796
2.965GluThr: 2.965 ± 0.528
3.494GluVal: 3.494 ± 0.486
1.165GluTrp: 1.165 ± 0.352
2.223GluTyr: 2.223 ± 0.361
0.0GluXaa: 0.0 ± 0.0
Phe
1.8PheAla: 1.8 ± 0.365
0.741PheCys: 0.741 ± 0.19
2.965PheAsp: 2.965 ± 0.723
2.223PheGlu: 2.223 ± 0.389
2.118PhePhe: 2.118 ± 0.38
3.917PheGly: 3.917 ± 0.664
1.059PheHis: 1.059 ± 0.307
3.494PheIle: 3.494 ± 0.681
2.541PheLys: 2.541 ± 0.378
4.023PheLeu: 4.023 ± 0.632
1.271PheMet: 1.271 ± 0.263
2.435PheAsn: 2.435 ± 0.444
2.435PhePro: 2.435 ± 0.466
2.329PheGln: 2.329 ± 0.467
2.753PheArg: 2.753 ± 0.536
4.023PheSer: 4.023 ± 0.517
1.694PheThr: 1.694 ± 0.503
2.647PheVal: 2.647 ± 0.599
0.106PheTrp: 0.106 ± 0.114
0.953PheTyr: 0.953 ± 0.201
0.0PheXaa: 0.0 ± 0.0
Gly
3.176GlyAla: 3.176 ± 0.572
1.482GlyCys: 1.482 ± 0.412
3.07GlyAsp: 3.07 ± 0.59
4.341GlyGlu: 4.341 ± 1.043
3.388GlyPhe: 3.388 ± 0.53
3.07GlyGly: 3.07 ± 0.704
1.165GlyHis: 1.165 ± 0.279
4.87GlyIle: 4.87 ± 0.847
2.647GlyLys: 2.647 ± 0.332
7.623GlyLeu: 7.623 ± 0.859
2.012GlyMet: 2.012 ± 0.344
3.176GlyAsn: 3.176 ± 0.681
1.8GlyPro: 1.8 ± 0.573
1.376GlyGln: 1.376 ± 0.288
4.023GlyArg: 4.023 ± 0.539
4.764GlySer: 4.764 ± 0.956
3.706GlyThr: 3.706 ± 0.654
5.082GlyVal: 5.082 ± 0.783
1.906GlyTrp: 1.906 ± 0.325
2.965GlyTyr: 2.965 ± 0.491
0.0GlyXaa: 0.0 ± 0.0
His
1.694HisAla: 1.694 ± 0.433
0.318HisCys: 0.318 ± 0.13
1.165HisAsp: 1.165 ± 0.257
1.165HisGlu: 1.165 ± 0.287
1.059HisPhe: 1.059 ± 0.427
2.118HisGly: 2.118 ± 0.4
0.847HisHis: 0.847 ± 0.294
1.271HisIle: 1.271 ± 0.37
0.741HisLys: 0.741 ± 0.323
1.588HisLeu: 1.588 ± 0.278
0.847HisMet: 0.847 ± 0.31
0.953HisAsn: 0.953 ± 0.242
1.059HisPro: 1.059 ± 0.22
0.635HisGln: 0.635 ± 0.339
0.635HisArg: 0.635 ± 0.208
1.588HisSer: 1.588 ± 0.329
1.271HisThr: 1.271 ± 0.467
1.482HisVal: 1.482 ± 0.412
0.106HisTrp: 0.106 ± 0.099
0.953HisTyr: 0.953 ± 0.263
0.0HisXaa: 0.0 ± 0.0
Ile
2.647IleAla: 2.647 ± 0.534
1.588IleCys: 1.588 ± 0.381
4.447IleAsp: 4.447 ± 0.664
5.506IleGlu: 5.506 ± 0.926
3.176IlePhe: 3.176 ± 0.675
4.659IleGly: 4.659 ± 0.572
1.694IleHis: 1.694 ± 0.54
4.235IleIle: 4.235 ± 0.865
4.553IleLys: 4.553 ± 0.497
6.564IleLeu: 6.564 ± 0.752
1.906IleMet: 1.906 ± 0.366
4.235IleAsn: 4.235 ± 0.66
4.235IlePro: 4.235 ± 0.486
3.176IleGln: 3.176 ± 0.568
4.764IleArg: 4.764 ± 0.809
5.506IleSer: 5.506 ± 0.475
3.07IleThr: 3.07 ± 0.643
4.023IleVal: 4.023 ± 0.762
1.271IleTrp: 1.271 ± 0.335
2.223IleTyr: 2.223 ± 0.439
0.0IleXaa: 0.0 ± 0.0
Lys
2.965LysAla: 2.965 ± 0.577
0.741LysCys: 0.741 ± 0.297
3.176LysAsp: 3.176 ± 0.313
3.6LysGlu: 3.6 ± 0.528
2.012LysPhe: 2.012 ± 0.477
3.07LysGly: 3.07 ± 0.338
0.635LysHis: 0.635 ± 0.224
5.717LysIle: 5.717 ± 0.727
3.6LysLys: 3.6 ± 0.749
4.87LysLeu: 4.87 ± 0.732
1.588LysMet: 1.588 ± 0.377
2.859LysAsn: 2.859 ± 0.449
2.435LysPro: 2.435 ± 0.396
1.906LysGln: 1.906 ± 0.24
3.6LysArg: 3.6 ± 0.819
4.659LysSer: 4.659 ± 0.737
2.965LysThr: 2.965 ± 0.4
3.176LysVal: 3.176 ± 0.424
0.635LysTrp: 0.635 ± 0.207
2.647LysTyr: 2.647 ± 0.598
0.0LysXaa: 0.0 ± 0.0
Leu
4.447LeuAla: 4.447 ± 0.407
1.271LeuCys: 1.271 ± 0.373
5.717LeuAsp: 5.717 ± 0.794
5.506LeuGlu: 5.506 ± 0.442
4.341LeuPhe: 4.341 ± 0.723
7.411LeuGly: 7.411 ± 1.418
2.753LeuHis: 2.753 ± 0.721
5.717LeuIle: 5.717 ± 0.811
4.764LeuLys: 4.764 ± 0.644
8.47LeuLeu: 8.47 ± 1.041
2.223LeuMet: 2.223 ± 0.407
4.87LeuAsn: 4.87 ± 0.533
5.082LeuPro: 5.082 ± 0.619
3.07LeuGln: 3.07 ± 0.799
4.553LeuArg: 4.553 ± 0.581
8.894LeuSer: 8.894 ± 0.759
4.976LeuThr: 4.976 ± 0.569
4.764LeuVal: 4.764 ± 0.781
1.271LeuTrp: 1.271 ± 0.371
3.282LeuTyr: 3.282 ± 0.389
0.0LeuXaa: 0.0 ± 0.0
Met
2.012MetAla: 2.012 ± 0.384
0.424MetCys: 0.424 ± 0.162
1.271MetAsp: 1.271 ± 0.262
1.376MetGlu: 1.376 ± 0.275
1.482MetPhe: 1.482 ± 0.444
1.059MetGly: 1.059 ± 0.331
0.424MetHis: 0.424 ± 0.266
2.647MetIle: 2.647 ± 0.443
1.165MetLys: 1.165 ± 0.315
2.541MetLeu: 2.541 ± 0.594
0.953MetMet: 0.953 ± 0.234
1.376MetAsn: 1.376 ± 0.315
1.059MetPro: 1.059 ± 0.232
1.165MetGln: 1.165 ± 0.386
1.271MetArg: 1.271 ± 0.32
2.223MetSer: 2.223 ± 0.536
1.376MetThr: 1.376 ± 0.334
2.012MetVal: 2.012 ± 0.528
0.106MetTrp: 0.106 ± 0.099
1.271MetTyr: 1.271 ± 0.357
0.0MetXaa: 0.0 ± 0.0
Asn
2.435AsnAla: 2.435 ± 0.508
0.953AsnCys: 0.953 ± 0.292
3.494AsnAsp: 3.494 ± 0.533
2.753AsnGlu: 2.753 ± 0.544
2.435AsnPhe: 2.435 ± 0.599
3.917AsnGly: 3.917 ± 0.587
0.847AsnHis: 0.847 ± 0.244
4.447AsnIle: 4.447 ± 0.686
1.8AsnLys: 1.8 ± 0.489
4.764AsnLeu: 4.764 ± 0.818
1.059AsnMet: 1.059 ± 0.331
2.012AsnAsn: 2.012 ± 0.496
1.694AsnPro: 1.694 ± 0.35
1.694AsnGln: 1.694 ± 0.74
2.223AsnArg: 2.223 ± 0.468
2.753AsnSer: 2.753 ± 0.568
1.588AsnThr: 1.588 ± 0.527
5.294AsnVal: 5.294 ± 0.71
0.953AsnTrp: 0.953 ± 0.286
2.329AsnTyr: 2.329 ± 0.408
0.0AsnXaa: 0.0 ± 0.0
Pro
2.329ProAla: 2.329 ± 0.368
0.529ProCys: 0.529 ± 0.217
1.8ProAsp: 1.8 ± 0.341
2.965ProGlu: 2.965 ± 0.517
2.435ProPhe: 2.435 ± 0.388
2.647ProGly: 2.647 ± 0.496
0.741ProHis: 0.741 ± 0.327
2.965ProIle: 2.965 ± 0.606
2.118ProLys: 2.118 ± 0.61
3.494ProLeu: 3.494 ± 0.507
1.059ProMet: 1.059 ± 0.358
2.223ProAsn: 2.223 ± 0.347
2.753ProPro: 2.753 ± 0.718
1.588ProGln: 1.588 ± 0.368
1.906ProArg: 1.906 ± 0.245
4.235ProSer: 4.235 ± 0.738
2.329ProThr: 2.329 ± 0.342
2.012ProVal: 2.012 ± 0.519
0.529ProTrp: 0.529 ± 0.247
2.012ProTyr: 2.012 ± 0.486
0.0ProXaa: 0.0 ± 0.0
Gln
2.223GlnAla: 2.223 ± 0.493
0.318GlnCys: 0.318 ± 0.153
1.694GlnAsp: 1.694 ± 0.465
1.8GlnGlu: 1.8 ± 0.558
1.8GlnPhe: 1.8 ± 0.271
1.376GlnGly: 1.376 ± 0.296
0.953GlnHis: 0.953 ± 0.257
2.647GlnIle: 2.647 ± 0.578
2.118GlnLys: 2.118 ± 0.589
4.023GlnLeu: 4.023 ± 0.638
1.376GlnMet: 1.376 ± 0.353
1.482GlnAsn: 1.482 ± 0.553
0.953GlnPro: 0.953 ± 0.342
0.953GlnGln: 0.953 ± 0.33
1.8GlnArg: 1.8 ± 0.463
2.647GlnSer: 2.647 ± 0.359
1.694GlnThr: 1.694 ± 0.358
2.118GlnVal: 2.118 ± 0.397
0.318GlnTrp: 0.318 ± 0.178
0.847GlnTyr: 0.847 ± 0.334
0.0GlnXaa: 0.0 ± 0.0
Arg
2.435ArgAla: 2.435 ± 0.55
0.424ArgCys: 0.424 ± 0.244
4.235ArgAsp: 4.235 ± 0.684
3.917ArgGlu: 3.917 ± 0.754
1.906ArgPhe: 1.906 ± 0.399
3.812ArgGly: 3.812 ± 0.67
1.8ArgHis: 1.8 ± 0.451
3.706ArgIle: 3.706 ± 0.688
2.435ArgLys: 2.435 ± 0.409
5.823ArgLeu: 5.823 ± 1.02
2.541ArgMet: 2.541 ± 0.417
3.07ArgAsn: 3.07 ± 0.689
2.012ArgPro: 2.012 ± 0.392
1.906ArgGln: 1.906 ± 0.453
4.764ArgArg: 4.764 ± 1.138
4.023ArgSer: 4.023 ± 0.533
2.541ArgThr: 2.541 ± 0.544
3.6ArgVal: 3.6 ± 0.734
1.059ArgTrp: 1.059 ± 0.34
1.694ArgTyr: 1.694 ± 0.405
0.0ArgXaa: 0.0 ± 0.0
Ser
3.706SerAla: 3.706 ± 0.804
1.059SerCys: 1.059 ± 0.299
5.294SerAsp: 5.294 ± 0.99
4.87SerGlu: 4.87 ± 0.823
2.965SerPhe: 2.965 ± 0.58
4.764SerGly: 4.764 ± 0.795
2.329SerHis: 2.329 ± 0.331
4.659SerIle: 4.659 ± 0.562
5.506SerLys: 5.506 ± 0.906
8.258SerLeu: 8.258 ± 1.131
1.906SerMet: 1.906 ± 0.349
3.282SerAsn: 3.282 ± 0.361
2.753SerPro: 2.753 ± 0.673
2.329SerGln: 2.329 ± 0.641
3.706SerArg: 3.706 ± 0.422
4.553SerSer: 4.553 ± 0.665
5.082SerThr: 5.082 ± 0.439
4.659SerVal: 4.659 ± 0.865
1.165SerTrp: 1.165 ± 0.261
2.859SerTyr: 2.859 ± 0.389
0.0SerXaa: 0.0 ± 0.0
Thr
2.859ThrAla: 2.859 ± 0.414
0.953ThrCys: 0.953 ± 0.26
2.329ThrAsp: 2.329 ± 0.586
2.223ThrGlu: 2.223 ± 0.377
3.388ThrPhe: 3.388 ± 0.748
3.07ThrGly: 3.07 ± 0.652
0.953ThrHis: 0.953 ± 0.32
3.176ThrIle: 3.176 ± 0.566
3.706ThrLys: 3.706 ± 0.749
4.023ThrLeu: 4.023 ± 0.52
0.953ThrMet: 0.953 ± 0.342
2.753ThrAsn: 2.753 ± 0.402
2.435ThrPro: 2.435 ± 0.416
1.588ThrGln: 1.588 ± 0.345
3.07ThrArg: 3.07 ± 0.453
4.129ThrSer: 4.129 ± 0.707
2.859ThrThr: 2.859 ± 0.552
4.235ThrVal: 4.235 ± 0.611
0.741ThrTrp: 0.741 ± 0.272
2.223ThrTyr: 2.223 ± 0.374
0.0ThrXaa: 0.0 ± 0.0
Val
2.223ValAla: 2.223 ± 0.468
1.271ValCys: 1.271 ± 0.466
3.706ValAsp: 3.706 ± 0.559
4.553ValGlu: 4.553 ± 0.531
2.859ValPhe: 2.859 ± 0.514
4.235ValGly: 4.235 ± 0.647
1.059ValHis: 1.059 ± 0.408
4.764ValIle: 4.764 ± 0.614
5.717ValLys: 5.717 ± 0.773
4.341ValLeu: 4.341 ± 0.671
0.953ValMet: 0.953 ± 0.244
3.6ValAsn: 3.6 ± 0.702
3.388ValPro: 3.388 ± 0.542
2.223ValGln: 2.223 ± 0.483
4.023ValArg: 4.023 ± 1.044
5.294ValSer: 5.294 ± 1.083
4.235ValThr: 4.235 ± 0.616
3.388ValVal: 3.388 ± 0.559
0.424ValTrp: 0.424 ± 0.245
3.176ValTyr: 3.176 ± 0.526
0.0ValXaa: 0.0 ± 0.0
Trp
0.635TrpAla: 0.635 ± 0.246
0.212TrpCys: 0.212 ± 0.154
0.212TrpAsp: 0.212 ± 0.126
0.847TrpGlu: 0.847 ± 0.384
0.529TrpPhe: 0.529 ± 0.212
0.424TrpGly: 0.424 ± 0.206
0.318TrpHis: 0.318 ± 0.206
1.906TrpIle: 1.906 ± 0.328
0.847TrpLys: 0.847 ± 0.322
1.376TrpLeu: 1.376 ± 0.285
0.424TrpMet: 0.424 ± 0.17
0.953TrpAsn: 0.953 ± 0.423
0.212TrpPro: 0.212 ± 0.135
0.635TrpGln: 0.635 ± 0.314
1.376TrpArg: 1.376 ± 0.314
0.529TrpSer: 0.529 ± 0.182
1.165TrpThr: 1.165 ± 0.339
1.165TrpVal: 1.165 ± 0.375
0.318TrpTrp: 0.318 ± 0.21
0.529TrpTyr: 0.529 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.118TyrAla: 2.118 ± 0.49
0.847TyrCys: 0.847 ± 0.358
3.388TyrAsp: 3.388 ± 0.771
2.329TyrGlu: 2.329 ± 0.373
1.588TyrPhe: 1.588 ± 0.312
3.388TyrGly: 3.388 ± 0.551
0.847TyrHis: 0.847 ± 0.294
2.753TyrIle: 2.753 ± 0.6
2.859TyrLys: 2.859 ± 0.578
3.6TyrLeu: 3.6 ± 0.714
0.847TyrMet: 0.847 ± 0.301
1.694TyrAsn: 1.694 ± 0.498
1.271TyrPro: 1.271 ± 0.247
1.376TyrGln: 1.376 ± 0.351
0.953TyrArg: 0.953 ± 0.377
2.965TyrSer: 2.965 ± 0.37
2.012TyrThr: 2.012 ± 0.342
2.647TyrVal: 2.647 ± 0.489
0.212TyrTrp: 0.212 ± 0.154
1.482TyrTyr: 1.482 ± 0.309
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.106XaaArg: 0.106 ± 0.103
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (9446 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski