Amino acid dipepetide frequency for Lachnospiraceae bacterium 3-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.836AlaAla: 6.836 ± 0.093	0.981AlaCys: 0.981 ± 0.025	4.13AlaAsp: 4.13 ± 0.054	5.599AlaGlu: 5.599 ± 0.077	2.89AlaPhe: 2.89 ± 0.044	5.7AlaGly: 5.7 ± 0.071	1.056AlaHis: 1.056 ± 0.029	4.568AlaIle: 4.568 ± 0.062	4.981AlaLys: 4.981 ± 0.066	6.296AlaLeu: 6.296 ± 0.075	2.231AlaMet: 2.231 ± 0.037	2.585AlaAsn: 2.585 ± 0.041	1.856AlaPro: 1.856 ± 0.042	2.415AlaGln: 2.415 ± 0.044	2.736AlaArg: 2.736 ± 0.045	3.769AlaSer: 3.769 ± 0.056	2.959AlaThr: 2.959 ± 0.049	5.843AlaVal: 5.843 ± 0.075	0.65AlaTrp: 0.65 ± 0.02	2.723AlaTyr: 2.723 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.972CysAla: 0.972 ± 0.027	0.308CysCys: 0.308 ± 0.017	0.759CysAsp: 0.759 ± 0.025	0.978CysGlu: 0.978 ± 0.027	0.67CysPhe: 0.67 ± 0.024	1.419CysGly: 1.419 ± 0.03	0.331CysHis: 0.331 ± 0.015	1.103CysIle: 1.103 ± 0.028	0.907CysLys: 0.907 ± 0.025	1.182CysLeu: 1.182 ± 0.026	0.5CysMet: 0.5 ± 0.02	0.625CysAsn: 0.625 ± 0.023	0.618CysPro: 0.618 ± 0.02	0.515CysGln: 0.515 ± 0.019	0.782CysArg: 0.782 ± 0.025	0.962CysSer: 0.962 ± 0.025	0.725CysThr: 0.725 ± 0.022	0.941CysVal: 0.941 ± 0.026	0.139CysTrp: 0.139 ± 0.011	0.629CysTyr: 0.629 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.552AspAla: 3.552 ± 0.055	0.878AspCys: 0.878 ± 0.025	2.503AspAsp: 2.503 ± 0.042	4.164AspGlu: 4.164 ± 0.059	2.714AspPhe: 2.714 ± 0.045	4.269AspGly: 4.269 ± 0.061	0.797AspHis: 0.797 ± 0.027	4.424AspIle: 4.424 ± 0.061	3.483AspLys: 3.483 ± 0.056	4.286AspLeu: 4.286 ± 0.05	1.902AspMet: 1.902 ± 0.031	2.164AspAsn: 2.164 ± 0.045	1.349AspPro: 1.349 ± 0.034	1.204AspGln: 1.204 ± 0.025	2.337AspArg: 2.337 ± 0.042	2.986AspSer: 2.986 ± 0.046	3.055AspThr: 3.055 ± 0.051	3.404AspVal: 3.404 ± 0.055	0.579AspTrp: 0.579 ± 0.02	2.749AspTyr: 2.749 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.371GluAla: 5.371 ± 0.07	0.945GluCys: 0.945 ± 0.024	4.417GluAsp: 4.417 ± 0.068	8.283GluGlu: 8.283 ± 0.121	2.845GluPhe: 2.845 ± 0.047	4.73GluGly: 4.73 ± 0.055	1.521GluHis: 1.521 ± 0.037	6.288GluIle: 6.288 ± 0.068	7.773GluLys: 7.773 ± 0.092	7.2GluLeu: 7.2 ± 0.077	2.619GluMet: 2.619 ± 0.04	4.616GluAsn: 4.616 ± 0.05	2.067GluPro: 2.067 ± 0.048	3.701GluGln: 3.701 ± 0.061	3.919GluArg: 3.919 ± 0.057	3.574GluSer: 3.574 ± 0.048	3.985GluThr: 3.985 ± 0.061	4.423GluVal: 4.423 ± 0.067	0.802GluTrp: 0.802 ± 0.023	3.482GluTyr: 3.482 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.84PheAla: 2.84 ± 0.045	0.837PheCys: 0.837 ± 0.023	2.405PheAsp: 2.405 ± 0.038	2.857PheGlu: 2.857 ± 0.043	1.957PhePhe: 1.957 ± 0.046	2.853PheGly: 2.853 ± 0.048	0.981PheHis: 0.981 ± 0.025	2.627PheIle: 2.627 ± 0.047	1.856PheLys: 1.856 ± 0.039	4.327PheLeu: 4.327 ± 0.063	1.145PheMet: 1.145 ± 0.029	1.347PheAsn: 1.347 ± 0.033	1.39PhePro: 1.39 ± 0.034	1.733PheGln: 1.733 ± 0.035	1.767PheArg: 1.767 ± 0.037	3.052PheSer: 3.052 ± 0.051	2.252PheThr: 2.252 ± 0.043	2.68PheVal: 2.68 ± 0.049	0.468PheTrp: 0.468 ± 0.021	1.877PheTyr: 1.877 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.621GlyAla: 4.621 ± 0.072	1.168GlyCys: 1.168 ± 0.031	3.212GlyAsp: 3.212 ± 0.048	5.047GlyGlu: 5.047 ± 0.06	3.086GlyPhe: 3.086 ± 0.047	4.503GlyGly: 4.503 ± 0.073	1.161GlyHis: 1.161 ± 0.029	6.172GlyIle: 6.172 ± 0.082	6.093GlyLys: 6.093 ± 0.074	5.381GlyLeu: 5.381 ± 0.062	2.545GlyMet: 2.545 ± 0.046	3.537GlyAsn: 3.537 ± 0.048	1.025GlyPro: 1.025 ± 0.028	2.244GlyGln: 2.244 ± 0.042	3.183GlyArg: 3.183 ± 0.046	3.867GlySer: 3.867 ± 0.056	4.043GlyThr: 4.043 ± 0.065	4.393GlyVal: 4.393 ± 0.06	0.721GlyTrp: 0.721 ± 0.023	3.234GlyTyr: 3.234 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.099HisAla: 1.099 ± 0.029	0.305HisCys: 0.305 ± 0.016	0.871HisAsp: 0.871 ± 0.024	1.139HisGlu: 1.139 ± 0.032	0.815HisPhe: 0.815 ± 0.023	1.338HisGly: 1.338 ± 0.032	0.432HisHis: 0.432 ± 0.024	1.462HisIle: 1.462 ± 0.037	1.044HisLys: 1.044 ± 0.029	1.572HisLeu: 1.572 ± 0.031	0.595HisMet: 0.595 ± 0.018	0.757HisAsn: 0.757 ± 0.021	0.882HisPro: 0.882 ± 0.026	0.627HisGln: 0.627 ± 0.021	0.853HisArg: 0.853 ± 0.024	1.04HisSer: 1.04 ± 0.024	1.015HisThr: 1.015 ± 0.027	1.052HisVal: 1.052 ± 0.025	0.184HisTrp: 0.184 ± 0.011	0.762HisTyr: 0.762 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.341IleAla: 5.341 ± 0.072	1.375IleCys: 1.375 ± 0.034	3.762IleAsp: 3.762 ± 0.047	4.991IleGlu: 4.991 ± 0.064	3.138IlePhe: 3.138 ± 0.053	4.877IleGly: 4.877 ± 0.069	1.403IleHis: 1.403 ± 0.032	4.739IleIle: 4.739 ± 0.067	4.163IleLys: 4.163 ± 0.059	7.164IleLeu: 7.164 ± 0.093	1.993IleMet: 1.993 ± 0.04	2.94IleAsn: 2.94 ± 0.05	2.969IlePro: 2.969 ± 0.049	2.709IleGln: 2.709 ± 0.047	3.656IleArg: 3.656 ± 0.058	5.17IleSer: 5.17 ± 0.07	4.059IleThr: 4.059 ± 0.061	4.478IleVal: 4.478 ± 0.06	0.673IleTrp: 0.673 ± 0.025	2.89IleTyr: 2.89 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.993LysAla: 4.993 ± 0.062	0.84LysCys: 0.84 ± 0.026	3.922LysAsp: 3.922 ± 0.052	7.658LysGlu: 7.658 ± 0.093	2.086LysPhe: 2.086 ± 0.043	4.57LysGly: 4.57 ± 0.056	1.164LysHis: 1.164 ± 0.027	5.376LysIle: 5.376 ± 0.063	6.81LysLys: 6.81 ± 0.088	5.482LysLeu: 5.482 ± 0.071	2.231LysMet: 2.231 ± 0.046	3.892LysAsn: 3.892 ± 0.057	2.132LysPro: 2.132 ± 0.043	2.805LysGln: 2.805 ± 0.052	3.436LysArg: 3.436 ± 0.056	3.83LysSer: 3.83 ± 0.053	3.794LysThr: 3.794 ± 0.055	4.332LysVal: 4.332 ± 0.062	0.647LysTrp: 0.647 ± 0.026	3.028LysTyr: 3.028 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	6.404LeuAla: 6.404 ± 0.066	1.477LeuCys: 1.477 ± 0.031	4.743LeuAsp: 4.743 ± 0.054	7.263LeuGlu: 7.263 ± 0.087	3.697LeuPhe: 3.697 ± 0.066	5.469LeuGly: 5.469 ± 0.065	1.577LeuHis: 1.577 ± 0.03	5.495LeuIle: 5.495 ± 0.077	6.428LeuLys: 6.428 ± 0.072	8.457LeuLeu: 8.457 ± 0.102	2.573LeuMet: 2.573 ± 0.046	3.717LeuAsn: 3.717 ± 0.052	3.407LeuPro: 3.407 ± 0.054	3.258LeuGln: 3.258 ± 0.05	3.742LeuArg: 3.742 ± 0.05	6.373LeuSer: 6.373 ± 0.074	4.696LeuThr: 4.696 ± 0.056	5.104LeuVal: 5.104 ± 0.066	0.84LeuTrp: 0.84 ± 0.022	3.429LeuTyr: 3.429 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.445MetAla: 2.445 ± 0.048	0.343MetCys: 0.343 ± 0.016	1.924MetAsp: 1.924 ± 0.034	3.208MetGlu: 3.208 ± 0.057	0.985MetPhe: 0.985 ± 0.025	2.152MetGly: 2.152 ± 0.047	0.446MetHis: 0.446 ± 0.018	2.042MetIle: 2.042 ± 0.042	2.63MetLys: 2.63 ± 0.045	2.706MetLeu: 2.706 ± 0.046	0.927MetMet: 0.927 ± 0.028	1.53MetAsn: 1.53 ± 0.033	1.185MetPro: 1.185 ± 0.029	1.177MetGln: 1.177 ± 0.028	1.274MetArg: 1.274 ± 0.028	1.732MetSer: 1.732 ± 0.035	1.526MetThr: 1.526 ± 0.033	1.944MetVal: 1.944 ± 0.038	0.222MetTrp: 0.222 ± 0.012	0.929MetTyr: 0.929 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.05AsnAla: 3.05 ± 0.051	0.661AsnCys: 0.661 ± 0.022	2.021AsnAsp: 2.021 ± 0.037	2.903AsnGlu: 2.903 ± 0.05	1.718AsnPhe: 1.718 ± 0.037	3.652AsnGly: 3.652 ± 0.055	0.952AsnHis: 0.952 ± 0.025	3.621AsnIle: 3.621 ± 0.053	2.632AsnLys: 2.632 ± 0.049	3.924AsnLeu: 3.924 ± 0.055	1.454AsnMet: 1.454 ± 0.038	1.946AsnAsn: 1.946 ± 0.056	1.976AsnPro: 1.976 ± 0.037	1.804AsnGln: 1.804 ± 0.036	2.27AsnArg: 2.27 ± 0.044	2.539AsnSer: 2.539 ± 0.05	2.382AsnThr: 2.382 ± 0.047	2.865AsnVal: 2.865 ± 0.042	0.435AsnTrp: 0.435 ± 0.017	1.944AsnTyr: 1.944 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.154ProAla: 2.154 ± 0.047	0.435ProCys: 0.435 ± 0.017	2.071ProAsp: 2.071 ± 0.042	3.463ProGlu: 3.463 ± 0.064	1.441ProPhe: 1.441 ± 0.034	2.125ProGly: 2.125 ± 0.04	0.54ProHis: 0.54 ± 0.018	2.0ProIle: 2.0 ± 0.037	2.13ProLys: 2.13 ± 0.041	2.618ProLeu: 2.618 ± 0.044	0.894ProMet: 0.894 ± 0.027	1.217ProAsn: 1.217 ± 0.031	0.819ProPro: 0.819 ± 0.024	1.166ProGln: 1.166 ± 0.031	0.979ProArg: 0.979 ± 0.028	1.705ProSer: 1.705 ± 0.038	1.471ProThr: 1.471 ± 0.032	2.634ProVal: 2.634 ± 0.041	0.303ProTrp: 0.303 ± 0.013	1.419ProTyr: 1.419 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.785GlnAla: 2.785 ± 0.051	0.386GlnCys: 0.386 ± 0.015	1.636GlnAsp: 1.636 ± 0.037	3.815GlnGlu: 3.815 ± 0.058	1.275GlnPhe: 1.275 ± 0.031	2.367GlnGly: 2.367 ± 0.039	0.489GlnHis: 0.489 ± 0.019	2.833GlnIle: 2.833 ± 0.045	3.355GlnLys: 3.355 ± 0.055	2.983GlnLeu: 2.983 ± 0.046	1.348GlnMet: 1.348 ± 0.03	1.834GlnAsn: 1.834 ± 0.036	1.012GlnPro: 1.012 ± 0.026	1.642GlnGln: 1.642 ± 0.046	1.665GlnArg: 1.665 ± 0.033	1.81GlnSer: 1.81 ± 0.037	1.906GlnThr: 1.906 ± 0.037	2.261GlnVal: 2.261 ± 0.037	0.369GlnTrp: 0.369 ± 0.016	1.483GlnTyr: 1.483 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.606ArgAla: 2.606 ± 0.041	0.607ArgCys: 0.607 ± 0.02	2.172ArgAsp: 2.172 ± 0.038	4.265ArgGlu: 4.265 ± 0.063	1.909ArgPhe: 1.909 ± 0.035	2.403ArgGly: 2.403 ± 0.045	0.795ArgHis: 0.795 ± 0.029	3.58ArgIle: 3.58 ± 0.049	4.155ArgLys: 4.155 ± 0.058	4.0ArgLeu: 4.0 ± 0.049	1.711ArgMet: 1.711 ± 0.037	2.347ArgAsn: 2.347 ± 0.04	1.237ArgPro: 1.237 ± 0.037	1.976ArgGln: 1.976 ± 0.041	2.439ArgArg: 2.439 ± 0.051	2.11ArgSer: 2.11 ± 0.046	2.151ArgThr: 2.151 ± 0.041	2.481ArgVal: 2.481 ± 0.043	0.405ArgTrp: 0.405 ± 0.016	1.937ArgTyr: 1.937 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.964SerAla: 3.964 ± 0.057	0.826SerCys: 0.826 ± 0.023	3.048SerAsp: 3.048 ± 0.051	4.026SerGlu: 4.026 ± 0.056	2.828SerPhe: 2.828 ± 0.048	4.89SerGly: 4.89 ± 0.058	1.164SerHis: 1.164 ± 0.031	4.218SerIle: 4.218 ± 0.06	3.646SerLys: 3.646 ± 0.056	5.22SerLeu: 5.22 ± 0.071	1.923SerMet: 1.923 ± 0.039	2.424SerAsn: 2.424 ± 0.045	1.746SerPro: 1.746 ± 0.036	2.118SerGln: 2.118 ± 0.042	2.8SerArg: 2.8 ± 0.042	3.659SerSer: 3.659 ± 0.058	2.589SerThr: 2.589 ± 0.049	4.219SerVal: 4.219 ± 0.061	0.582SerTrp: 0.582 ± 0.02	2.596SerTyr: 2.596 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.229ThrAla: 4.229 ± 0.077	0.616ThrCys: 0.616 ± 0.021	2.955ThrAsp: 2.955 ± 0.053	4.034ThrGlu: 4.034 ± 0.056	2.053ThrPhe: 2.053 ± 0.038	4.317ThrGly: 4.317 ± 0.065	0.852ThrHis: 0.852 ± 0.023	3.738ThrIle: 3.738 ± 0.056	3.209ThrLys: 3.209 ± 0.053	4.605ThrLeu: 4.605 ± 0.063	1.412ThrMet: 1.412 ± 0.033	2.038ThrAsn: 2.038 ± 0.039	2.011ThrPro: 2.011 ± 0.042	1.573ThrGln: 1.573 ± 0.031	1.96ThrArg: 1.96 ± 0.037	2.771ThrSer: 2.771 ± 0.046	2.538ThrThr: 2.538 ± 0.05	4.267ThrVal: 4.267 ± 0.066	0.495ThrTrp: 0.495 ± 0.021	1.98ThrTyr: 1.98 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.3ValAla: 4.3 ± 0.069	1.213ValCys: 1.213 ± 0.031	3.348ValAsp: 3.348 ± 0.045	4.739ValGlu: 4.739 ± 0.065	2.825ValPhe: 2.825 ± 0.045	3.938ValGly: 3.938 ± 0.057	1.015ValHis: 1.015 ± 0.028	4.705ValIle: 4.705 ± 0.072	4.497ValLys: 4.497 ± 0.058	6.005ValLeu: 6.005 ± 0.073	1.884ValMet: 1.884 ± 0.033	2.854ValAsn: 2.854 ± 0.042	2.276ValPro: 2.276 ± 0.044	2.125ValGln: 2.125 ± 0.036	2.903ValArg: 2.903 ± 0.047	4.66ValSer: 4.66 ± 0.067	3.905ValThr: 3.905 ± 0.071	4.308ValVal: 4.308 ± 0.069	0.648ValTrp: 0.648 ± 0.023	2.559ValTyr: 2.559 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.54TrpAla: 0.54 ± 0.021	0.146TrpCys: 0.146 ± 0.012	0.544TrpAsp: 0.544 ± 0.02	0.873TrpGlu: 0.873 ± 0.027	0.39TrpPhe: 0.39 ± 0.019	0.658TrpGly: 0.658 ± 0.022	0.183TrpHis: 0.183 ± 0.01	0.654TrpIle: 0.654 ± 0.02	0.869TrpLys: 0.869 ± 0.026	0.844TrpLeu: 0.844 ± 0.023	0.341TrpMet: 0.341 ± 0.015	0.605TrpAsn: 0.605 ± 0.021	0.17TrpPro: 0.17 ± 0.01	0.457TrpGln: 0.457 ± 0.018	0.389TrpArg: 0.389 ± 0.016	0.493TrpSer: 0.493 ± 0.018	0.421TrpThr: 0.421 ± 0.019	0.569TrpVal: 0.569 ± 0.018	0.104TrpTrp: 0.104 ± 0.009	0.406TrpTyr: 0.406 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.702TyrAla: 2.702 ± 0.043	0.717TyrCys: 0.717 ± 0.022	2.359TyrAsp: 2.359 ± 0.043	3.257TyrGlu: 3.257 ± 0.053	1.93TyrPhe: 1.93 ± 0.036	3.004TyrGly: 3.004 ± 0.046	0.985TyrHis: 0.985 ± 0.03	2.845TyrIle: 2.845 ± 0.054	2.367TyrLys: 2.367 ± 0.047	3.897TyrLeu: 3.897 ± 0.061	1.099TyrMet: 1.099 ± 0.027	1.772TyrAsn: 1.772 ± 0.042	1.454TyrPro: 1.454 ± 0.034	2.003TyrGln: 2.003 ± 0.042	2.197TyrArg: 2.197 ± 0.042	2.386TyrSer: 2.386 ± 0.044	2.18TyrThr: 2.18 ± 0.05	2.511TyrVal: 2.511 ± 0.044	0.391TyrTrp: 0.391 ± 0.019	2.013TyrTyr: 2.013 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4984 proteins (1447276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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