Amino acid dipepetide frequency for Paenibacillus selenitireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.868AlaAla: 6.868 ± 0.079	0.713AlaCys: 0.713 ± 0.021	3.91AlaAsp: 3.91 ± 0.052	4.835AlaGlu: 4.835 ± 0.053	3.194AlaPhe: 3.194 ± 0.048	5.513AlaGly: 5.513 ± 0.059	1.453AlaHis: 1.453 ± 0.029	5.45AlaIle: 5.45 ± 0.055	4.335AlaLys: 4.335 ± 0.054	7.58AlaLeu: 7.58 ± 0.068	2.315AlaMet: 2.315 ± 0.032	2.774AlaAsn: 2.774 ± 0.042	2.394AlaPro: 2.394 ± 0.046	2.769AlaGln: 2.769 ± 0.04	3.074AlaArg: 3.074 ± 0.04	4.805AlaSer: 4.805 ± 0.053	3.763AlaThr: 3.763 ± 0.086	5.662AlaVal: 5.662 ± 0.059	0.947AlaTrp: 0.947 ± 0.023	2.557AlaTyr: 2.557 ± 0.037	0.002AlaXaa: 0.002 ± 0.001
Cys	0.511CysAla: 0.511 ± 0.02	0.112CysCys: 0.112 ± 0.008	0.399CysAsp: 0.399 ± 0.015	0.457CysGlu: 0.457 ± 0.018	0.336CysPhe: 0.336 ± 0.013	0.717CysGly: 0.717 ± 0.02	0.219CysHis: 0.219 ± 0.01	0.604CysIle: 0.604 ± 0.019	0.383CysLys: 0.383 ± 0.014	0.734CysLeu: 0.734 ± 0.019	0.265CysMet: 0.265 ± 0.013	0.308CysAsn: 0.308 ± 0.014	0.345CysPro: 0.345 ± 0.015	0.23CysGln: 0.23 ± 0.011	0.4CysArg: 0.4 ± 0.015	0.587CysSer: 0.587 ± 0.019	0.449CysThr: 0.449 ± 0.015	0.507CysVal: 0.507 ± 0.017	0.094CysTrp: 0.094 ± 0.007	0.304CysTyr: 0.304 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.858AspAla: 3.858 ± 0.055	0.36AspCys: 0.36 ± 0.012	2.385AspAsp: 2.385 ± 0.036	3.731AspGlu: 3.731 ± 0.052	2.192AspPhe: 2.192 ± 0.036	3.756AspGly: 3.756 ± 0.054	1.366AspHis: 1.366 ± 0.03	3.871AspIle: 3.871 ± 0.053	2.756AspLys: 2.756 ± 0.044	4.964AspLeu: 4.964 ± 0.057	1.569AspMet: 1.569 ± 0.029	1.838AspAsn: 1.838 ± 0.037	2.331AspPro: 2.331 ± 0.037	2.384AspGln: 2.384 ± 0.035	2.648AspArg: 2.648 ± 0.038	2.668AspSer: 2.668 ± 0.042	2.761AspThr: 2.761 ± 0.038	3.855AspVal: 3.855 ± 0.047	0.805AspTrp: 0.805 ± 0.023	2.126AspTyr: 2.126 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.387GluAla: 5.387 ± 0.063	0.403GluCys: 0.403 ± 0.014	3.269GluAsp: 3.269 ± 0.045	5.06GluGlu: 5.06 ± 0.07	2.239GluPhe: 2.239 ± 0.034	4.062GluGly: 4.062 ± 0.049	1.672GluHis: 1.672 ± 0.034	4.631GluIle: 4.631 ± 0.056	4.013GluLys: 4.013 ± 0.056	6.552GluLeu: 6.552 ± 0.071	2.13GluMet: 2.13 ± 0.035	2.498GluAsn: 2.498 ± 0.039	2.144GluPro: 2.144 ± 0.037	3.874GluGln: 3.874 ± 0.054	3.659GluArg: 3.659 ± 0.053	3.465GluSer: 3.465 ± 0.039	3.128GluThr: 3.128 ± 0.04	4.417GluVal: 4.417 ± 0.045	0.888GluTrp: 0.888 ± 0.022	2.104GluTyr: 2.104 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.144PheAla: 3.144 ± 0.046	0.361PheCys: 0.361 ± 0.015	2.354PheAsp: 2.354 ± 0.035	2.487PheGlu: 2.487 ± 0.038	1.905PhePhe: 1.905 ± 0.041	3.14PheGly: 3.14 ± 0.048	1.05PheHis: 1.05 ± 0.027	3.401PheIle: 3.401 ± 0.051	2.066PheLys: 2.066 ± 0.034	3.89PheLeu: 3.89 ± 0.056	1.317PheMet: 1.317 ± 0.028	1.714PheAsn: 1.714 ± 0.031	1.542PhePro: 1.542 ± 0.029	1.633PheGln: 1.633 ± 0.028	1.891PheArg: 1.891 ± 0.03	2.821PheSer: 2.821 ± 0.042	2.596PheThr: 2.596 ± 0.036	3.056PheVal: 3.056 ± 0.042	0.542PheTrp: 0.542 ± 0.017	1.639PheTyr: 1.639 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	4.813GlyAla: 4.813 ± 0.081	0.711GlyCys: 0.711 ± 0.02	3.343GlyAsp: 3.343 ± 0.047	4.079GlyGlu: 4.079 ± 0.049	3.239GlyPhe: 3.239 ± 0.039	4.755GlyGly: 4.755 ± 0.064	1.442GlyHis: 1.442 ± 0.032	5.839GlyIle: 5.839 ± 0.063	4.339GlyLys: 4.339 ± 0.047	6.713GlyLeu: 6.713 ± 0.073	2.342GlyMet: 2.342 ± 0.042	2.681GlyAsn: 2.681 ± 0.048	1.758GlyPro: 1.758 ± 0.036	2.631GlyGln: 2.631 ± 0.037	2.893GlyArg: 2.893 ± 0.044	4.358GlySer: 4.358 ± 0.059	4.321GlyThr: 4.321 ± 0.061	5.051GlyVal: 5.051 ± 0.054	1.02GlyTrp: 1.02 ± 0.026	3.018GlyTyr: 3.018 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.728HisAla: 1.728 ± 0.034	0.205HisCys: 0.205 ± 0.01	1.133HisAsp: 1.133 ± 0.025	1.448HisGlu: 1.448 ± 0.032	1.089HisPhe: 1.089 ± 0.025	1.616HisGly: 1.616 ± 0.034	0.786HisHis: 0.786 ± 0.024	1.7HisIle: 1.7 ± 0.036	0.995HisLys: 0.995 ± 0.023	2.241HisLeu: 2.241 ± 0.035	0.66HisMet: 0.66 ± 0.017	0.734HisAsn: 0.734 ± 0.018	1.243HisPro: 1.243 ± 0.026	1.032HisGln: 1.032 ± 0.027	1.192HisArg: 1.192 ± 0.026	1.213HisSer: 1.213 ± 0.028	1.234HisThr: 1.234 ± 0.028	1.696HisVal: 1.696 ± 0.032	0.371HisTrp: 0.371 ± 0.015	0.948HisTyr: 0.948 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.03IleAla: 6.03 ± 0.062	0.706IleCys: 0.706 ± 0.02	3.963IleAsp: 3.963 ± 0.052	4.89IleGlu: 4.89 ± 0.06	2.826IlePhe: 2.826 ± 0.044	5.5IleGly: 5.5 ± 0.07	1.874IleHis: 1.874 ± 0.039	4.984IleIle: 4.984 ± 0.071	3.22IleLys: 3.22 ± 0.048	6.66IleLeu: 6.66 ± 0.086	1.907IleMet: 1.907 ± 0.033	2.58IleAsn: 2.58 ± 0.043	3.416IlePro: 3.416 ± 0.039	3.288IleGln: 3.288 ± 0.046	3.85IleArg: 3.85 ± 0.049	4.919IleSer: 4.919 ± 0.062	4.257IleThr: 4.257 ± 0.054	5.508IleVal: 5.508 ± 0.065	0.771IleTrp: 0.771 ± 0.024	2.377IleTyr: 2.377 ± 0.037	0.002IleXaa: 0.002 ± 0.001
Lys	4.017LysAla: 4.017 ± 0.053	0.284LysCys: 0.284 ± 0.013	3.194LysAsp: 3.194 ± 0.054	4.286LysGlu: 4.286 ± 0.059	1.815LysPhe: 1.815 ± 0.032	3.629LysGly: 3.629 ± 0.049	1.225LysHis: 1.225 ± 0.027	3.568LysIle: 3.568 ± 0.044	3.663LysLys: 3.663 ± 0.054	5.36LysLeu: 5.36 ± 0.058	1.815LysMet: 1.815 ± 0.029	2.42LysAsn: 2.42 ± 0.036	2.169LysPro: 2.169 ± 0.031	2.688LysGln: 2.688 ± 0.041	2.633LysArg: 2.633 ± 0.043	3.348LysSer: 3.348 ± 0.048	3.003LysThr: 3.003 ± 0.042	3.85LysVal: 3.85 ± 0.047	0.767LysTrp: 0.767 ± 0.021	2.078LysTyr: 2.078 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	7.359LeuAla: 7.359 ± 0.076	0.843LeuCys: 0.843 ± 0.024	5.094LeuAsp: 5.094 ± 0.052	6.003LeuGlu: 6.003 ± 0.068	4.556LeuPhe: 4.556 ± 0.061	6.492LeuGly: 6.492 ± 0.064	2.274LeuHis: 2.274 ± 0.036	6.809LeuIle: 6.809 ± 0.081	5.312LeuLys: 5.312 ± 0.055	10.016LeuLeu: 10.016 ± 0.105	2.72LeuMet: 2.72 ± 0.037	4.053LeuAsn: 4.053 ± 0.053	4.116LeuPro: 4.116 ± 0.051	4.383LeuGln: 4.383 ± 0.052	4.584LeuArg: 4.584 ± 0.058	6.773LeuSer: 6.773 ± 0.061	5.674LeuThr: 5.674 ± 0.056	6.118LeuVal: 6.118 ± 0.059	1.047LeuTrp: 1.047 ± 0.027	3.151LeuTyr: 3.151 ± 0.045	0.004LeuXaa: 0.004 ± 0.002
Met	2.142MetAla: 2.142 ± 0.03	0.169MetCys: 0.169 ± 0.01	1.675MetAsp: 1.675 ± 0.028	1.926MetGlu: 1.926 ± 0.032	1.157MetPhe: 1.157 ± 0.026	1.835MetGly: 1.835 ± 0.033	0.596MetHis: 0.596 ± 0.019	2.383MetIle: 2.383 ± 0.033	2.332MetLys: 2.332 ± 0.034	3.065MetLeu: 3.065 ± 0.039	1.086MetMet: 1.086 ± 0.025	1.759MetAsn: 1.759 ± 0.03	1.168MetPro: 1.168 ± 0.029	1.248MetGln: 1.248 ± 0.027	1.37MetArg: 1.37 ± 0.025	1.884MetSer: 1.884 ± 0.033	1.784MetThr: 1.784 ± 0.033	1.897MetVal: 1.897 ± 0.032	0.261MetTrp: 0.261 ± 0.011	0.9MetTyr: 0.9 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.869AsnAla: 2.869 ± 0.047	0.277AsnCys: 0.277 ± 0.013	2.04AsnAsp: 2.04 ± 0.039	2.71AsnGlu: 2.71 ± 0.038	1.489AsnPhe: 1.489 ± 0.028	3.203AsnGly: 3.203 ± 0.048	0.993AsnHis: 0.993 ± 0.025	2.798AsnIle: 2.798 ± 0.047	2.326AsnLys: 2.326 ± 0.04	3.477AsnLeu: 3.477 ± 0.039	1.214AsnMet: 1.214 ± 0.025	1.745AsnAsn: 1.745 ± 0.039	2.084AsnPro: 2.084 ± 0.033	1.835AsnGln: 1.835 ± 0.035	2.065AsnArg: 2.065 ± 0.037	2.207AsnSer: 2.207 ± 0.04	2.267AsnThr: 2.267 ± 0.042	2.795AsnVal: 2.795 ± 0.048	0.564AsnTrp: 0.564 ± 0.019	1.572AsnTyr: 1.572 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.797ProAla: 2.797 ± 0.044	0.254ProCys: 0.254 ± 0.012	2.358ProAsp: 2.358 ± 0.034	2.981ProGlu: 2.981 ± 0.047	1.807ProPhe: 1.807 ± 0.03	2.445ProGly: 2.445 ± 0.04	0.941ProHis: 0.941 ± 0.022	2.768ProIle: 2.768 ± 0.038	1.934ProLys: 1.934 ± 0.03	3.685ProLeu: 3.685 ± 0.052	1.056ProMet: 1.056 ± 0.024	1.755ProAsn: 1.755 ± 0.031	1.101ProPro: 1.101 ± 0.025	1.423ProGln: 1.423 ± 0.028	1.314ProArg: 1.314 ± 0.028	2.625ProSer: 2.625 ± 0.038	2.208ProThr: 2.208 ± 0.038	2.921ProVal: 2.921 ± 0.038	0.536ProTrp: 0.536 ± 0.018	1.556ProTyr: 1.556 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.481GlnAla: 3.481 ± 0.048	0.259GlnCys: 0.259 ± 0.012	2.08GlnAsp: 2.08 ± 0.029	2.928GlnGlu: 2.928 ± 0.047	1.76GlnPhe: 1.76 ± 0.032	2.842GlnGly: 2.842 ± 0.036	1.123GlnHis: 1.123 ± 0.029	3.01GlnIle: 3.01 ± 0.037	2.188GlnLys: 2.188 ± 0.039	4.434GlnLeu: 4.434 ± 0.049	1.401GlnMet: 1.401 ± 0.027	1.433GlnAsn: 1.433 ± 0.028	1.646GlnPro: 1.646 ± 0.031	2.301GlnGln: 2.301 ± 0.043	1.987GlnArg: 1.987 ± 0.036	2.485GlnSer: 2.485 ± 0.038	2.044GlnThr: 2.044 ± 0.029	3.006GlnVal: 3.006 ± 0.038	0.588GlnTrp: 0.588 ± 0.019	1.589GlnTyr: 1.589 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.969ArgAla: 2.969 ± 0.036	0.368ArgCys: 0.368 ± 0.013	2.405ArgAsp: 2.405 ± 0.037	3.365ArgGlu: 3.365 ± 0.057	2.071ArgPhe: 2.071 ± 0.034	2.639ArgGly: 2.639 ± 0.042	1.038ArgHis: 1.038 ± 0.025	3.696ArgIle: 3.696 ± 0.05	2.965ArgLys: 2.965 ± 0.041	4.548ArgLeu: 4.548 ± 0.051	1.654ArgMet: 1.654 ± 0.033	2.092ArgAsn: 2.092 ± 0.033	1.448ArgPro: 1.448 ± 0.027	1.966ArgGln: 1.966 ± 0.038	2.373ArgArg: 2.373 ± 0.039	2.779ArgSer: 2.779 ± 0.035	2.592ArgThr: 2.592 ± 0.037	3.152ArgVal: 3.152 ± 0.043	0.628ArgTrp: 0.628 ± 0.021	1.847ArgTyr: 1.847 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.18SerAla: 4.18 ± 0.055	0.455SerCys: 0.455 ± 0.017	3.146SerAsp: 3.146 ± 0.042	3.691SerGlu: 3.691 ± 0.042	3.014SerPhe: 3.014 ± 0.048	4.663SerGly: 4.663 ± 0.051	1.331SerHis: 1.331 ± 0.025	4.929SerIle: 4.929 ± 0.052	3.544SerLys: 3.544 ± 0.051	6.099SerLeu: 6.099 ± 0.064	2.008SerMet: 2.008 ± 0.029	2.684SerAsn: 2.684 ± 0.046	2.272SerPro: 2.272 ± 0.035	2.22SerGln: 2.22 ± 0.035	2.655SerArg: 2.655 ± 0.037	4.368SerSer: 4.368 ± 0.061	3.47SerThr: 3.47 ± 0.05	4.43SerVal: 4.43 ± 0.05	0.817SerTrp: 0.817 ± 0.023	2.427SerTyr: 2.427 ± 0.04	0.001SerXaa: 0.001 ± 0.001
Thr	4.306ThrAla: 4.306 ± 0.063	0.412ThrCys: 0.412 ± 0.015	2.993ThrAsp: 2.993 ± 0.04	3.303ThrGlu: 3.303 ± 0.049	2.542ThrPhe: 2.542 ± 0.047	4.387ThrGly: 4.387 ± 0.112	1.14ThrHis: 1.14 ± 0.024	4.18ThrIle: 4.18 ± 0.047	2.92ThrLys: 2.92 ± 0.043	5.642ThrLeu: 5.642 ± 0.061	1.531ThrMet: 1.531 ± 0.028	2.286ThrAsn: 2.286 ± 0.041	2.527ThrPro: 2.527 ± 0.038	1.841ThrGln: 1.841 ± 0.032	2.159ThrArg: 2.159 ± 0.031	3.51ThrSer: 3.51 ± 0.046	3.21ThrThr: 3.21 ± 0.05	4.284ThrVal: 4.284 ± 0.056	0.756ThrTrp: 0.756 ± 0.022	2.085ThrTyr: 2.085 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	4.976ValAla: 4.976 ± 0.06	0.619ValCys: 0.619 ± 0.021	3.742ValAsp: 3.742 ± 0.049	4.316ValGlu: 4.316 ± 0.041	2.958ValPhe: 2.958 ± 0.038	4.616ValGly: 4.616 ± 0.055	1.569ValHis: 1.569 ± 0.03	5.452ValIle: 5.452 ± 0.061	3.986ValLys: 3.986 ± 0.045	6.949ValLeu: 6.949 ± 0.072	2.142ValMet: 2.142 ± 0.032	2.94ValAsn: 2.94 ± 0.048	2.824ValPro: 2.824 ± 0.037	2.864ValGln: 2.864 ± 0.04	3.233ValArg: 3.233 ± 0.047	4.676ValSer: 4.676 ± 0.055	4.475ValThr: 4.475 ± 0.062	5.023ValVal: 5.023 ± 0.063	0.845ValTrp: 0.845 ± 0.02	2.432ValTyr: 2.432 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.79TrpAla: 0.79 ± 0.023	0.12TrpCys: 0.12 ± 0.007	0.718TrpAsp: 0.718 ± 0.02	0.743TrpGlu: 0.743 ± 0.023	0.604TrpPhe: 0.604 ± 0.016	0.865TrpGly: 0.865 ± 0.023	0.294TrpHis: 0.294 ± 0.013	1.027TrpIle: 1.027 ± 0.025	0.751TrpLys: 0.751 ± 0.019	1.345TrpLeu: 1.345 ± 0.03	0.472TrpMet: 0.472 ± 0.017	0.749TrpAsn: 0.749 ± 0.02	0.328TrpPro: 0.328 ± 0.014	0.452TrpGln: 0.452 ± 0.017	0.585TrpArg: 0.585 ± 0.021	0.799TrpSer: 0.799 ± 0.021	0.736TrpThr: 0.736 ± 0.021	0.888TrpVal: 0.888 ± 0.023	0.191TrpTrp: 0.191 ± 0.011	0.449TrpTyr: 0.449 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.687TyrAla: 2.687 ± 0.035	0.33TyrCys: 0.33 ± 0.014	2.023TyrAsp: 2.023 ± 0.039	2.358TyrGlu: 2.358 ± 0.042	1.758TyrPhe: 1.758 ± 0.035	2.669TyrGly: 2.669 ± 0.037	0.878TyrHis: 0.878 ± 0.023	2.425TyrIle: 2.425 ± 0.042	1.782TyrLys: 1.782 ± 0.029	3.423TyrLeu: 3.423 ± 0.045	1.028TyrMet: 1.028 ± 0.021	1.487TyrAsn: 1.487 ± 0.032	1.611TyrPro: 1.611 ± 0.031	1.523TyrGln: 1.523 ± 0.029	2.03TyrArg: 2.03 ± 0.032	2.111TyrSer: 2.111 ± 0.034	2.044TyrThr: 2.044 ± 0.042	2.522TyrVal: 2.522 ± 0.036	0.47TyrTrp: 0.47 ± 0.016	1.476TyrTyr: 1.476 ± 0.031	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.01XaaXaa: 0.01 ± 0.004

Statistics based on 6187 proteins (1956302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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