Amino acid dipepetide frequency for Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.835AlaAla: 3.835 ± 0.031	1.162AlaCys: 1.162 ± 0.015	3.071AlaAsp: 3.071 ± 0.025	3.266AlaGlu: 3.266 ± 0.025	2.143AlaPhe: 2.143 ± 0.02	3.448AlaGly: 3.448 ± 0.055	1.137AlaHis: 1.137 ± 0.013	3.099AlaIle: 3.099 ± 0.024	3.244AlaLys: 3.244 ± 0.025	4.777AlaLeu: 4.777 ± 0.047	1.632AlaMet: 1.632 ± 0.02	2.355AlaAsn: 2.355 ± 0.024	2.361AlaPro: 2.361 ± 0.03	1.933AlaGln: 1.933 ± 0.02	2.543AlaArg: 2.543 ± 0.02	4.408AlaSer: 4.408 ± 0.03	3.567AlaThr: 3.567 ± 0.04	4.082AlaVal: 4.082 ± 0.032	0.597AlaTrp: 0.597 ± 0.01	1.6AlaTyr: 1.6 ± 0.02	0.001AlaXaa: 0.001 ± 0.0
Cys	1.041CysAla: 1.041 ± 0.019	0.599CysCys: 0.599 ± 0.011	1.546CysAsp: 1.546 ± 0.048	1.16CysGlu: 1.16 ± 0.019	0.821CysPhe: 0.821 ± 0.013	1.528CysGly: 1.528 ± 0.03	0.637CysHis: 0.637 ± 0.014	1.164CysIle: 1.164 ± 0.022	1.245CysLys: 1.245 ± 0.02	2.014CysLeu: 2.014 ± 0.021	0.567CysMet: 0.567 ± 0.02	1.077CysAsn: 1.077 ± 0.023	1.223CysPro: 1.223 ± 0.034	0.966CysGln: 0.966 ± 0.024	1.213CysArg: 1.213 ± 0.025	1.818CysSer: 1.818 ± 0.029	1.439CysThr: 1.439 ± 0.029	1.613CysVal: 1.613 ± 0.022	0.225CysTrp: 0.225 ± 0.005	0.736CysTyr: 0.736 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	2.755AspAla: 2.755 ± 0.019	1.161AspCys: 1.161 ± 0.028	4.055AspAsp: 4.055 ± 0.04	3.814AspGlu: 3.814 ± 0.03	2.271AspPhe: 2.271 ± 0.018	3.574AspGly: 3.574 ± 0.036	1.43AspHis: 1.43 ± 0.025	4.05AspIle: 4.05 ± 0.051	3.492AspLys: 3.492 ± 0.036	4.944AspLeu: 4.944 ± 0.041	1.711AspMet: 1.711 ± 0.029	3.107AspAsn: 3.107 ± 0.045	2.51AspPro: 2.51 ± 0.027	2.147AspGln: 2.147 ± 0.025	2.865AspArg: 2.865 ± 0.03	4.656AspSer: 4.656 ± 0.04	3.836AspThr: 3.836 ± 0.054	4.165AspVal: 4.165 ± 0.04	0.642AspTrp: 0.642 ± 0.014	1.888AspTyr: 1.888 ± 0.043	0.001AspXaa: 0.001 ± 0.0
Glu	3.388GluAla: 3.388 ± 0.028	1.191GluCys: 1.191 ± 0.021	4.089GluAsp: 4.089 ± 0.036	5.589GluGlu: 5.589 ± 0.057	1.984GluPhe: 1.984 ± 0.018	3.228GluGly: 3.228 ± 0.028	1.347GluHis: 1.347 ± 0.017	3.232GluIle: 3.232 ± 0.029	4.529GluLys: 4.529 ± 0.04	4.729GluLeu: 4.729 ± 0.046	1.708GluMet: 1.708 ± 0.018	3.173GluAsn: 3.173 ± 0.029	2.058GluPro: 2.058 ± 0.024	2.422GluGln: 2.422 ± 0.026	3.182GluArg: 3.182 ± 0.034	4.215GluSer: 4.215 ± 0.041	3.677GluThr: 3.677 ± 0.03	3.794GluVal: 3.794 ± 0.037	0.6GluTrp: 0.6 ± 0.012	1.729GluTyr: 1.729 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	1.854PheAla: 1.854 ± 0.018	0.898PheCys: 0.898 ± 0.016	2.228PheAsp: 2.228 ± 0.025	1.94PheGlu: 1.94 ± 0.018	1.447PhePhe: 1.447 ± 0.018	2.416PheGly: 2.416 ± 0.026	1.003PheHis: 1.003 ± 0.014	2.146PheIle: 2.146 ± 0.03	2.009PheLys: 2.009 ± 0.023	3.527PheLeu: 3.527 ± 0.027	0.969PheMet: 0.969 ± 0.018	1.716PheAsn: 1.716 ± 0.02	1.732PhePro: 1.732 ± 0.018	1.468PheGln: 1.468 ± 0.016	1.818PheArg: 1.818 ± 0.02	2.993PheSer: 2.993 ± 0.026	2.439PheThr: 2.439 ± 0.026	2.617PheVal: 2.617 ± 0.041	0.452PheTrp: 0.452 ± 0.008	1.35PheTyr: 1.35 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	3.102GlyAla: 3.102 ± 0.029	1.271GlyCys: 1.271 ± 0.039	3.497GlyAsp: 3.497 ± 0.033	3.164GlyGlu: 3.164 ± 0.025	2.308GlyPhe: 2.308 ± 0.019	4.437GlyGly: 4.437 ± 0.091	1.737GlyHis: 1.737 ± 0.025	3.304GlyIle: 3.304 ± 0.028	3.691GlyLys: 3.691 ± 0.03	4.664GlyLeu: 4.664 ± 0.049	1.693GlyMet: 1.693 ± 0.039	3.081GlyAsn: 3.081 ± 0.028	2.358GlyPro: 2.358 ± 0.041	2.701GlyGln: 2.701 ± 0.053	3.088GlyArg: 3.088 ± 0.032	5.114GlySer: 5.114 ± 0.069	3.836GlyThr: 3.836 ± 0.042	3.82GlyVal: 3.82 ± 0.039	0.707GlyTrp: 0.707 ± 0.015	2.282GlyTyr: 2.282 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	1.182HisAla: 1.182 ± 0.014	0.729HisCys: 0.729 ± 0.024	1.318HisAsp: 1.318 ± 0.029	1.207HisGlu: 1.207 ± 0.02	1.021HisPhe: 1.021 ± 0.014	1.554HisGly: 1.554 ± 0.021	0.945HisHis: 0.945 ± 0.024	1.53HisIle: 1.53 ± 0.026	1.43HisLys: 1.43 ± 0.021	2.312HisLeu: 2.312 ± 0.023	0.764HisMet: 0.764 ± 0.014	1.273HisAsn: 1.273 ± 0.023	1.274HisPro: 1.274 ± 0.02	1.182HisGln: 1.182 ± 0.019	1.443HisArg: 1.443 ± 0.023	2.166HisSer: 2.166 ± 0.032	1.704HisThr: 1.704 ± 0.039	1.838HisVal: 1.838 ± 0.034	0.315HisTrp: 0.315 ± 0.009	0.926HisTyr: 0.926 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	3.064IleAla: 3.064 ± 0.032	1.271IleCys: 1.271 ± 0.027	3.209IleAsp: 3.209 ± 0.038	2.887IleGlu: 2.887 ± 0.025	1.982IlePhe: 1.982 ± 0.021	3.207IleGly: 3.207 ± 0.043	1.563IleHis: 1.563 ± 0.022	2.981IleIle: 2.981 ± 0.039	3.025IleLys: 3.025 ± 0.023	4.838IleLeu: 4.838 ± 0.044	1.304IleMet: 1.304 ± 0.019	2.602IleAsn: 2.602 ± 0.03	3.084IlePro: 3.084 ± 0.039	2.483IleGln: 2.483 ± 0.045	2.635IleArg: 2.635 ± 0.027	4.373IleSer: 4.373 ± 0.043	3.743IleThr: 3.743 ± 0.044	3.664IleVal: 3.664 ± 0.043	0.553IleTrp: 0.553 ± 0.01	1.766IleTyr: 1.766 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.346LysAla: 3.346 ± 0.031	1.292LysCys: 1.292 ± 0.02	3.701LysAsp: 3.701 ± 0.032	4.494LysGlu: 4.494 ± 0.04	1.982LysPhe: 1.982 ± 0.016	3.255LysGly: 3.255 ± 0.034	1.661LysHis: 1.661 ± 0.036	3.004LysIle: 3.004 ± 0.023	4.842LysLys: 4.842 ± 0.05	5.029LysLeu: 5.029 ± 0.044	1.657LysMet: 1.657 ± 0.018	2.667LysAsn: 2.667 ± 0.021	2.806LysPro: 2.806 ± 0.035	2.776LysGln: 2.776 ± 0.037	3.507LysArg: 3.507 ± 0.032	4.692LysSer: 4.692 ± 0.039	3.895LysThr: 3.895 ± 0.032	3.797LysVal: 3.797 ± 0.028	0.63LysTrp: 0.63 ± 0.009	2.013LysTyr: 2.013 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	4.764LeuAla: 4.764 ± 0.034	2.037LeuCys: 2.037 ± 0.03	4.772LeuAsp: 4.772 ± 0.05	5.068LeuGlu: 5.068 ± 0.043	3.275LeuPhe: 3.275 ± 0.041	4.449LeuGly: 4.449 ± 0.037	2.443LeuHis: 2.443 ± 0.029	4.013LeuIle: 4.013 ± 0.045	5.121LeuLys: 5.121 ± 0.038	7.844LeuLeu: 7.844 ± 0.067	2.249LeuMet: 2.249 ± 0.031	3.754LeuAsn: 3.754 ± 0.044	4.48LeuPro: 4.48 ± 0.044	4.269LeuGln: 4.269 ± 0.049	4.251LeuArg: 4.251 ± 0.028	7.204LeuSer: 7.204 ± 0.067	5.685LeuThr: 5.685 ± 0.072	5.397LeuVal: 5.397 ± 0.042	0.874LeuTrp: 0.874 ± 0.018	2.886LeuTyr: 2.886 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.016MetAla: 2.016 ± 0.019	0.642MetCys: 0.642 ± 0.019	1.654MetAsp: 1.654 ± 0.023	1.965MetGlu: 1.965 ± 0.031	1.12MetPhe: 1.12 ± 0.015	1.47MetGly: 1.47 ± 0.029	0.484MetHis: 0.484 ± 0.008	1.271MetIle: 1.271 ± 0.026	1.732MetLys: 1.732 ± 0.023	2.071MetLeu: 2.071 ± 0.022	0.891MetMet: 0.891 ± 0.024	1.156MetAsn: 1.156 ± 0.016	1.113MetPro: 1.113 ± 0.017	0.889MetGln: 0.889 ± 0.011	1.163MetArg: 1.163 ± 0.016	2.542MetSer: 2.542 ± 0.042	1.853MetThr: 1.853 ± 0.025	1.847MetVal: 1.847 ± 0.04	0.282MetTrp: 0.282 ± 0.01	1.01MetTyr: 1.01 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.423AsnAla: 2.423 ± 0.024	1.053AsnCys: 1.053 ± 0.019	2.617AsnAsp: 2.617 ± 0.038	2.477AsnGlu: 2.477 ± 0.023	1.756AsnPhe: 1.756 ± 0.023	3.223AsnGly: 3.223 ± 0.06	1.148AsnHis: 1.148 ± 0.021	3.235AsnIle: 3.235 ± 0.032	2.97AsnLys: 2.97 ± 0.028	3.879AsnLeu: 3.879 ± 0.034	1.423AsnMet: 1.423 ± 0.035	2.723AsnAsn: 2.723 ± 0.04	2.241AsnPro: 2.241 ± 0.025	1.928AsnGln: 1.928 ± 0.029	2.404AsnArg: 2.404 ± 0.027	3.858AsnSer: 3.858 ± 0.037	3.482AsnThr: 3.482 ± 0.047	3.423AsnVal: 3.423 ± 0.057	0.479AsnTrp: 0.479 ± 0.008	1.535AsnTyr: 1.535 ± 0.026	0.001AsnXaa: 0.001 ± 0.0
Pro	2.693ProAla: 2.693 ± 0.031	0.965ProCys: 0.965 ± 0.022	2.805ProAsp: 2.805 ± 0.035	2.867ProGlu: 2.867 ± 0.026	1.638ProPhe: 1.638 ± 0.023	3.059ProGly: 3.059 ± 0.047	1.243ProHis: 1.243 ± 0.025	2.296ProIle: 2.296 ± 0.035	2.685ProLys: 2.685 ± 0.032	3.793ProLeu: 3.793 ± 0.038	1.1ProMet: 1.1 ± 0.014	2.262ProAsn: 2.262 ± 0.03	3.661ProPro: 3.661 ± 0.051	2.023ProGln: 2.023 ± 0.025	2.332ProArg: 2.332 ± 0.029	4.529ProSer: 4.529 ± 0.054	3.53ProThr: 3.53 ± 0.058	3.589ProVal: 3.589 ± 0.037	0.466ProTrp: 0.466 ± 0.009	1.53ProTyr: 1.53 ± 0.025	0.001ProXaa: 0.001 ± 0.0
Gln	2.331GlnAla: 2.331 ± 0.025	0.951GlnCys: 0.951 ± 0.02	2.152GlnAsp: 2.152 ± 0.021	2.728GlnGlu: 2.728 ± 0.03	1.387GlnPhe: 1.387 ± 0.014	2.462GlnGly: 2.462 ± 0.032	1.228GlnHis: 1.228 ± 0.018	2.135GlnIle: 2.135 ± 0.034	2.622GlnLys: 2.622 ± 0.027	3.534GlnLeu: 3.534 ± 0.034	1.125GlnMet: 1.125 ± 0.013	2.161GlnAsn: 2.161 ± 0.039	2.028GlnPro: 2.028 ± 0.029	2.702GlnGln: 2.702 ± 0.051	2.417GlnArg: 2.417 ± 0.037	3.366GlnSer: 3.366 ± 0.042	2.983GlnThr: 2.983 ± 0.059	2.44GlnVal: 2.44 ± 0.048	0.454GlnTrp: 0.454 ± 0.008	1.454GlnTyr: 1.454 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.399ArgAla: 2.399 ± 0.028	1.121ArgCys: 1.121 ± 0.02	2.827ArgAsp: 2.827 ± 0.033	3.078ArgGlu: 3.078 ± 0.024	1.821ArgPhe: 1.821 ± 0.018	2.875ArgGly: 2.875 ± 0.035	1.595ArgHis: 1.595 ± 0.027	2.523ArgIle: 2.523 ± 0.024	3.78ArgLys: 3.78 ± 0.031	4.372ArgLeu: 4.372 ± 0.043	1.313ArgMet: 1.313 ± 0.019	2.525ArgAsn: 2.525 ± 0.028	2.359ArgPro: 2.359 ± 0.026	2.46ArgGln: 2.46 ± 0.036	3.605ArgArg: 3.605 ± 0.05	4.032ArgSer: 4.032 ± 0.036	3.017ArgThr: 3.017 ± 0.033	2.914ArgVal: 2.914 ± 0.035	0.557ArgTrp: 0.557 ± 0.012	1.78ArgTyr: 1.78 ± 0.025	0.001ArgXaa: 0.001 ± 0.0
Ser	4.373SerAla: 4.373 ± 0.031	1.739SerCys: 1.739 ± 0.027	5.157SerAsp: 5.157 ± 0.05	4.485SerGlu: 4.485 ± 0.04	2.925SerPhe: 2.925 ± 0.026	5.215SerGly: 5.215 ± 0.047	2.128SerHis: 2.128 ± 0.03	4.122SerIle: 4.122 ± 0.044	4.627SerLys: 4.627 ± 0.038	7.064SerLeu: 7.064 ± 0.052	2.173SerMet: 2.173 ± 0.032	3.912SerAsn: 3.912 ± 0.055	4.687SerPro: 4.687 ± 0.054	3.437SerGln: 3.437 ± 0.045	4.078SerArg: 4.078 ± 0.039	8.6SerSer: 8.6 ± 0.089	5.894SerThr: 5.894 ± 0.07	5.649SerVal: 5.649 ± 0.055	0.832SerTrp: 0.832 ± 0.016	2.544SerTyr: 2.544 ± 0.038	0.001SerXaa: 0.001 ± 0.0
Thr	3.938ThrAla: 3.938 ± 0.043	1.738ThrCys: 1.738 ± 0.041	4.111ThrAsp: 4.111 ± 0.049	3.898ThrGlu: 3.898 ± 0.041	2.543ThrPhe: 2.543 ± 0.034	4.244ThrGly: 4.244 ± 0.055	1.591ThrHis: 1.591 ± 0.038	3.496ThrIle: 3.496 ± 0.041	3.611ThrLys: 3.611 ± 0.036	5.612ThrLeu: 5.612 ± 0.065	1.74ThrMet: 1.74 ± 0.027	3.096ThrAsn: 3.096 ± 0.035	3.916ThrPro: 3.916 ± 0.054	2.477ThrGln: 2.477 ± 0.036	2.959ThrArg: 2.959 ± 0.037	6.166ThrSer: 6.166 ± 0.064	5.721ThrThr: 5.721 ± 0.131	4.751ThrVal: 4.751 ± 0.051	0.728ThrTrp: 0.728 ± 0.016	2.172ThrTyr: 2.172 ± 0.041	0.001ThrXaa: 0.001 ± 0.0
Val	3.701ValAla: 3.701 ± 0.054	1.719ValCys: 1.719 ± 0.03	3.772ValAsp: 3.772 ± 0.043	3.595ValGlu: 3.595 ± 0.029	2.786ValPhe: 2.786 ± 0.03	3.559ValGly: 3.559 ± 0.045	1.575ValHis: 1.575 ± 0.026	4.004ValIle: 4.004 ± 0.044	3.865ValLys: 3.865 ± 0.027	5.793ValLeu: 5.793 ± 0.047	1.882ValMet: 1.882 ± 0.034	3.21ValAsn: 3.21 ± 0.061	3.258ValPro: 3.258 ± 0.045	2.602ValGln: 2.602 ± 0.03	2.967ValArg: 2.967 ± 0.031	5.484ValSer: 5.484 ± 0.056	5.182ValThr: 5.182 ± 0.059	4.718ValVal: 4.718 ± 0.057	0.752ValTrp: 0.752 ± 0.012	2.401ValTyr: 2.401 ± 0.045	0.001ValXaa: 0.001 ± 0.0
Trp	0.535TrpAla: 0.535 ± 0.009	0.243TrpCys: 0.243 ± 0.007	0.609TrpAsp: 0.609 ± 0.013	0.582TrpGlu: 0.582 ± 0.011	0.455TrpPhe: 0.455 ± 0.012	0.583TrpGly: 0.583 ± 0.01	0.254TrpHis: 0.254 ± 0.007	0.614TrpIle: 0.614 ± 0.012	0.733TrpLys: 0.733 ± 0.009	0.962TrpLeu: 0.962 ± 0.023	0.327TrpMet: 0.327 ± 0.005	0.583TrpAsn: 0.583 ± 0.012	0.381TrpPro: 0.381 ± 0.008	0.42TrpGln: 0.42 ± 0.006	0.619TrpArg: 0.619 ± 0.008	0.851TrpSer: 0.851 ± 0.015	0.746TrpThr: 0.746 ± 0.013	0.607TrpVal: 0.607 ± 0.014	0.165TrpTrp: 0.165 ± 0.005	0.424TrpTyr: 0.424 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.519TyrAla: 1.519 ± 0.021	0.849TyrCys: 0.849 ± 0.027	1.884TyrAsp: 1.884 ± 0.027	1.6TyrGlu: 1.6 ± 0.022	1.358TyrPhe: 1.358 ± 0.037	2.071TyrGly: 2.071 ± 0.029	0.963TyrHis: 0.963 ± 0.024	2.015TyrIle: 2.015 ± 0.038	1.794TyrLys: 1.794 ± 0.022	3.076TyrLeu: 3.076 ± 0.048	0.942TyrMet: 0.942 ± 0.022	1.843TyrAsn: 1.843 ± 0.036	1.535TyrPro: 1.535 ± 0.026	1.371TyrGln: 1.371 ± 0.028	1.864TyrArg: 1.864 ± 0.034	2.576TyrSer: 2.576 ± 0.039	2.281TyrThr: 2.281 ± 0.043	2.1TyrVal: 2.1 ± 0.038	0.384TyrTrp: 0.384 ± 0.013	1.229TyrTyr: 1.229 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.006

Statistics based on 22409 proteins (11322112 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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