Amino acid dipepetide frequency for Pectinatus cerevisiiphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.356AlaAla: 9.356 ± 0.158
1.004AlaCys: 1.004 ± 0.038
5.272AlaAsp: 5.272 ± 0.087
5.143AlaGlu: 5.143 ± 0.097
3.199AlaPhe: 3.199 ± 0.071
6.534AlaGly: 6.534 ± 0.106
1.553AlaHis: 1.553 ± 0.049
6.454AlaIle: 6.454 ± 0.095
5.646AlaLys: 5.646 ± 0.097
7.6AlaLeu: 7.6 ± 0.122
2.488AlaMet: 2.488 ± 0.059
3.35AlaAsn: 3.35 ± 0.08
2.467AlaPro: 2.467 ± 0.056
3.067AlaGln: 3.067 ± 0.063
2.892AlaArg: 2.892 ± 0.07
4.339AlaSer: 4.339 ± 0.084
3.557AlaThr: 3.557 ± 0.071
6.969AlaVal: 6.969 ± 0.109
0.574AlaTrp: 0.574 ± 0.027
2.732AlaTyr: 2.732 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.957CysAla: 0.957 ± 0.033
0.211CysCys: 0.211 ± 0.017
0.671CysAsp: 0.671 ± 0.027
0.598CysGlu: 0.598 ± 0.031
0.512CysPhe: 0.512 ± 0.026
1.322CysGly: 1.322 ± 0.041
0.29CysHis: 0.29 ± 0.019
1.044CysIle: 1.044 ± 0.038
0.748CysLys: 0.748 ± 0.032
1.077CysLeu: 1.077 ± 0.035
0.364CysMet: 0.364 ± 0.023
0.555CysAsn: 0.555 ± 0.03
0.629CysPro: 0.629 ± 0.029
0.412CysGln: 0.412 ± 0.022
0.605CysArg: 0.605 ± 0.031
0.798CysSer: 0.798 ± 0.034
0.661CysThr: 0.661 ± 0.033
0.75CysVal: 0.75 ± 0.03
0.093CysTrp: 0.093 ± 0.011
0.459CysTyr: 0.459 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.241AspAla: 4.241 ± 0.069
0.615AspCys: 0.615 ± 0.032
3.031AspAsp: 3.031 ± 0.073
3.536AspGlu: 3.536 ± 0.078
2.664AspPhe: 2.664 ± 0.057
3.729AspGly: 3.729 ± 0.077
0.827AspHis: 0.827 ± 0.033
5.284AspIle: 5.284 ± 0.089
4.541AspLys: 4.541 ± 0.079
4.437AspLeu: 4.437 ± 0.084
1.71AspMet: 1.71 ± 0.048
2.76AspAsn: 2.76 ± 0.068
1.77AspPro: 1.77 ± 0.042
1.242AspGln: 1.242 ± 0.042
2.01AspArg: 2.01 ± 0.05
2.794AspSer: 2.794 ± 0.06
2.989AspThr: 2.989 ± 0.072
3.767AspVal: 3.767 ± 0.072
0.535AspTrp: 0.535 ± 0.03
2.191AspTyr: 2.191 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
4.431GluAla: 4.431 ± 0.084
0.615GluCys: 0.615 ± 0.032
2.743GluAsp: 2.743 ± 0.061
3.869GluGlu: 3.869 ± 0.081
2.09GluPhe: 2.09 ± 0.058
3.07GluGly: 3.07 ± 0.076
1.292GluHis: 1.292 ± 0.045
4.857GluIle: 4.857 ± 0.092
6.303GluLys: 6.303 ± 0.111
5.712GluLeu: 5.712 ± 0.091
1.747GluMet: 1.747 ± 0.049
3.774GluAsn: 3.774 ± 0.079
1.535GluPro: 1.535 ± 0.048
2.299GluGln: 2.299 ± 0.067
2.495GluArg: 2.495 ± 0.057
2.467GluSer: 2.467 ± 0.057
3.004GluThr: 3.004 ± 0.072
3.339GluVal: 3.339 ± 0.078
0.48GluTrp: 0.48 ± 0.026
2.247GluTyr: 2.247 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.578PheAla: 3.578 ± 0.071
0.686PheCys: 0.686 ± 0.029
2.295PheAsp: 2.295 ± 0.054
1.803PheGlu: 1.803 ± 0.048
2.219PhePhe: 2.219 ± 0.072
2.901PheGly: 2.901 ± 0.071
0.763PheHis: 0.763 ± 0.031
3.787PheIle: 3.787 ± 0.092
2.223PheLys: 2.223 ± 0.049
4.016PheLeu: 4.016 ± 0.084
1.222PheMet: 1.222 ± 0.044
1.941PheAsn: 1.941 ± 0.056
1.421PhePro: 1.421 ± 0.047
1.004PheGln: 1.004 ± 0.037
1.352PheArg: 1.352 ± 0.043
3.227PheSer: 3.227 ± 0.068
2.548PheThr: 2.548 ± 0.059
2.604PheVal: 2.604 ± 0.062
0.414PheTrp: 0.414 ± 0.026
1.587PheTyr: 1.587 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.31GlyAla: 5.31 ± 0.099
1.1GlyCys: 1.1 ± 0.04
3.195GlyAsp: 3.195 ± 0.073
3.516GlyGlu: 3.516 ± 0.068
2.976GlyPhe: 2.976 ± 0.064
4.763GlyGly: 4.763 ± 0.08
1.438GlyHis: 1.438 ± 0.044
6.541GlyIle: 6.541 ± 0.091
5.317GlyLys: 5.317 ± 0.078
5.802GlyLeu: 5.802 ± 0.095
2.175GlyMet: 2.175 ± 0.056
2.989GlyAsn: 2.989 ± 0.067
1.604GlyPro: 1.604 ± 0.049
2.3GlyGln: 2.3 ± 0.061
2.957GlyArg: 2.957 ± 0.075
4.084GlySer: 4.084 ± 0.084
4.144GlyThr: 4.144 ± 0.083
4.469GlyVal: 4.469 ± 0.078
0.629GlyTrp: 0.629 ± 0.03
2.74GlyTyr: 2.74 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.373HisAla: 1.373 ± 0.043
0.31HisCys: 0.31 ± 0.018
1.077HisAsp: 1.077 ± 0.044
1.051HisGlu: 1.051 ± 0.034
0.924HisPhe: 0.924 ± 0.032
1.443HisGly: 1.443 ± 0.043
0.483HisHis: 0.483 ± 0.032
1.761HisIle: 1.761 ± 0.046
1.208HisLys: 1.208 ± 0.038
1.747HisLeu: 1.747 ± 0.044
0.597HisMet: 0.597 ± 0.029
0.988HisAsn: 0.988 ± 0.036
1.013HisPro: 1.013 ± 0.037
0.513HisGln: 0.513 ± 0.029
0.79HisArg: 0.79 ± 0.033
1.069HisSer: 1.069 ± 0.035
1.128HisThr: 1.128 ± 0.043
1.179HisVal: 1.179 ± 0.043
0.179HisTrp: 0.179 ± 0.014
0.779HisTyr: 0.779 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
7.18IleAla: 7.18 ± 0.099
1.199IleCys: 1.199 ± 0.04
5.156IleAsp: 5.156 ± 0.088
4.656IleGlu: 4.656 ± 0.086
3.582IlePhe: 3.582 ± 0.082
6.032IleGly: 6.032 ± 0.107
1.492IleHis: 1.492 ± 0.042
7.185IleIle: 7.185 ± 0.124
6.073IleLys: 6.073 ± 0.09
7.676IleLeu: 7.676 ± 0.122
2.209IleMet: 2.209 ± 0.06
4.482IleAsn: 4.482 ± 0.091
3.295IlePro: 3.295 ± 0.068
2.039IleGln: 2.039 ± 0.051
3.004IleArg: 3.004 ± 0.063
5.267IleSer: 5.267 ± 0.08
4.77IleThr: 4.77 ± 0.077
5.474IleVal: 5.474 ± 0.102
0.603IleTrp: 0.603 ± 0.029
2.72IleTyr: 2.72 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.676LysAla: 5.676 ± 0.097
0.754LysCys: 0.754 ± 0.036
3.886LysAsp: 3.886 ± 0.074
5.169LysGlu: 5.169 ± 0.097
2.389LysPhe: 2.389 ± 0.055
3.871LysGly: 3.871 ± 0.074
1.25LysHis: 1.25 ± 0.046
6.713LysIle: 6.713 ± 0.099
6.862LysLys: 6.862 ± 0.106
6.256LysLeu: 6.256 ± 0.093
2.556LysMet: 2.556 ± 0.066
4.706LysAsn: 4.706 ± 0.085
2.214LysPro: 2.214 ± 0.051
2.584LysGln: 2.584 ± 0.067
3.055LysArg: 3.055 ± 0.066
3.418LysSer: 3.418 ± 0.072
4.347LysThr: 4.347 ± 0.066
4.284LysVal: 4.284 ± 0.077
0.645LysTrp: 0.645 ± 0.032
3.016LysTyr: 3.016 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
8.39LeuAla: 8.39 ± 0.124
1.263LeuCys: 1.263 ± 0.048
4.788LeuAsp: 4.788 ± 0.093
4.914LeuGlu: 4.914 ± 0.1
3.927LeuPhe: 3.927 ± 0.079
5.98LeuGly: 5.98 ± 0.113
1.913LeuHis: 1.913 ± 0.054
6.6LeuIle: 6.6 ± 0.101
6.616LeuLys: 6.616 ± 0.101
9.643LeuLeu: 9.643 ± 0.143
2.387LeuMet: 2.387 ± 0.054
4.028LeuAsn: 4.028 ± 0.074
4.253LeuPro: 4.253 ± 0.083
3.712LeuGln: 3.712 ± 0.08
3.919LeuArg: 3.919 ± 0.075
6.324LeuSer: 6.324 ± 0.098
5.188LeuThr: 5.188 ± 0.081
5.365LeuVal: 5.365 ± 0.089
0.721LeuTrp: 0.721 ± 0.036
3.001LeuTyr: 3.001 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.73MetAla: 2.73 ± 0.069
0.249MetCys: 0.249 ± 0.019
1.676MetAsp: 1.676 ± 0.044
1.719MetGlu: 1.719 ± 0.05
0.917MetPhe: 0.917 ± 0.041
2.001MetGly: 2.001 ± 0.057
0.632MetHis: 0.632 ± 0.03
2.01MetIle: 2.01 ± 0.054
2.126MetLys: 2.126 ± 0.053
2.891MetLeu: 2.891 ± 0.065
0.826MetMet: 0.826 ± 0.037
1.341MetAsn: 1.341 ± 0.045
1.327MetPro: 1.327 ± 0.046
1.318MetGln: 1.318 ± 0.046
1.268MetArg: 1.268 ± 0.043
1.725MetSer: 1.725 ± 0.047
1.633MetThr: 1.633 ± 0.046
1.854MetVal: 1.854 ± 0.053
0.153MetTrp: 0.153 ± 0.015
0.752MetTyr: 0.752 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.766AsnAla: 3.766 ± 0.086
0.618AsnCys: 0.618 ± 0.03
2.747AsnAsp: 2.747 ± 0.064
2.824AsnGlu: 2.824 ± 0.061
1.977AsnPhe: 1.977 ± 0.049
3.339AsnGly: 3.339 ± 0.07
0.792AsnHis: 0.792 ± 0.031
5.037AsnIle: 5.037 ± 0.1
3.733AsnLys: 3.733 ± 0.081
4.145AsnLeu: 4.145 ± 0.069
1.53AsnMet: 1.53 ± 0.046
2.846AsnAsn: 2.846 ± 0.072
1.994AsnPro: 1.994 ± 0.052
1.191AsnGln: 1.191 ± 0.041
1.71AsnArg: 1.71 ± 0.062
2.613AsnSer: 2.613 ± 0.066
2.777AsnThr: 2.777 ± 0.064
3.303AsnVal: 3.303 ± 0.07
0.446AsnTrp: 0.446 ± 0.024
1.904AsnTyr: 1.904 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
3.151ProAla: 3.151 ± 0.077
0.421ProCys: 0.421 ± 0.022
2.2ProAsp: 2.2 ± 0.061
2.604ProGlu: 2.604 ± 0.07
1.64ProPhe: 1.64 ± 0.049
2.308ProGly: 2.308 ± 0.052
0.848ProHis: 0.848 ± 0.031
2.709ProIle: 2.709 ± 0.064
1.986ProLys: 1.986 ± 0.057
3.478ProLeu: 3.478 ± 0.069
0.9ProMet: 0.9 ± 0.035
1.452ProAsn: 1.452 ± 0.045
1.069ProPro: 1.069 ± 0.047
1.46ProGln: 1.46 ± 0.042
1.197ProArg: 1.197 ± 0.037
1.951ProSer: 1.951 ± 0.052
1.818ProThr: 1.818 ± 0.054
2.872ProVal: 2.872 ± 0.067
0.321ProTrp: 0.321 ± 0.021
1.375ProTyr: 1.375 ± 0.044
0.001ProXaa: 0.001 ± 0.001
Gln
2.817GlnAla: 2.817 ± 0.067
0.325GlnCys: 0.325 ± 0.022
1.566GlnAsp: 1.566 ± 0.04
2.201GlnGlu: 2.201 ± 0.055
1.222GlnPhe: 1.222 ± 0.044
1.784GlnGly: 1.784 ± 0.046
0.648GlnHis: 0.648 ± 0.031
2.743GlnIle: 2.743 ± 0.061
3.154GlnLys: 3.154 ± 0.067
3.192GlnLeu: 3.192 ± 0.067
1.076GlnMet: 1.076 ± 0.038
1.893GlnAsn: 1.893 ± 0.051
1.123GlnPro: 1.123 ± 0.049
1.645GlnGln: 1.645 ± 0.062
1.403GlnArg: 1.403 ± 0.039
1.708GlnSer: 1.708 ± 0.057
1.917GlnThr: 1.917 ± 0.059
1.836GlnVal: 1.836 ± 0.055
0.254GlnTrp: 0.254 ± 0.017
1.256GlnTyr: 1.256 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.684ArgAla: 2.684 ± 0.066
0.501ArgCys: 0.501 ± 0.027
1.873ArgAsp: 1.873 ± 0.05
2.609ArgGlu: 2.609 ± 0.065
1.621ArgPhe: 1.621 ± 0.045
2.328ArgGly: 2.328 ± 0.063
0.868ArgHis: 0.868 ± 0.035
3.278ArgIle: 3.278 ± 0.072
2.942ArgLys: 2.942 ± 0.068
3.754ArgLeu: 3.754 ± 0.073
1.271ArgMet: 1.271 ± 0.044
1.963ArgAsn: 1.963 ± 0.055
1.449ArgPro: 1.449 ± 0.058
1.672ArgGln: 1.672 ± 0.048
1.971ArgArg: 1.971 ± 0.055
2.065ArgSer: 2.065 ± 0.05
2.1ArgThr: 2.1 ± 0.058
2.378ArgVal: 2.378 ± 0.053
0.37ArgTrp: 0.37 ± 0.02
1.549ArgTyr: 1.549 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.778SerAla: 4.778 ± 0.099
0.66SerCys: 0.66 ± 0.03
2.867SerAsp: 2.867 ± 0.059
2.833SerGlu: 2.833 ± 0.063
2.764SerPhe: 2.764 ± 0.065
4.397SerGly: 4.397 ± 0.087
1.112SerHis: 1.112 ± 0.035
4.89SerIle: 4.89 ± 0.08
3.254SerLys: 3.254 ± 0.073
5.728SerLeu: 5.728 ± 0.099
1.679SerMet: 1.679 ± 0.051
2.3SerAsn: 2.3 ± 0.054
1.913SerPro: 1.913 ± 0.055
1.79SerGln: 1.79 ± 0.052
2.331SerArg: 2.331 ± 0.057
3.638SerSer: 3.638 ± 0.088
3.176SerThr: 3.176 ± 0.073
4.088SerVal: 4.088 ± 0.075
0.531SerTrp: 0.531 ± 0.025
2.253SerTyr: 2.253 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.466ThrAla: 5.466 ± 0.091
0.61ThrCys: 0.61 ± 0.027
3.271ThrAsp: 3.271 ± 0.07
3.13ThrGlu: 3.13 ± 0.066
2.068ThrPhe: 2.068 ± 0.051
4.689ThrGly: 4.689 ± 0.086
1.035ThrHis: 1.035 ± 0.037
4.321ThrIle: 4.321 ± 0.079
3.244ThrLys: 3.244 ± 0.061
4.942ThrLeu: 4.942 ± 0.083
1.386ThrMet: 1.386 ± 0.044
2.395ThrAsn: 2.395 ± 0.063
2.374ThrPro: 2.374 ± 0.061
1.645ThrGln: 1.645 ± 0.057
1.832ThrArg: 1.832 ± 0.043
2.898ThrSer: 2.898 ± 0.07
3.012ThrThr: 3.012 ± 0.075
4.354ThrVal: 4.354 ± 0.076
0.457ThrTrp: 0.457 ± 0.03
1.772ThrTyr: 1.772 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
4.962ValAla: 4.962 ± 0.098
0.994ValCys: 0.994 ± 0.034
3.698ValAsp: 3.698 ± 0.079
3.695ValGlu: 3.695 ± 0.071
2.858ValPhe: 2.858 ± 0.07
4.414ValGly: 4.414 ± 0.087
1.29ValHis: 1.29 ± 0.042
5.428ValIle: 5.428 ± 0.086
4.592ValLys: 4.592 ± 0.077
6.56ValLeu: 6.56 ± 0.117
1.867ValMet: 1.867 ± 0.052
3.146ValAsn: 3.146 ± 0.073
2.713ValPro: 2.713 ± 0.058
2.06ValGln: 2.06 ± 0.05
2.586ValArg: 2.586 ± 0.064
4.025ValSer: 4.025 ± 0.07
3.601ValThr: 3.601 ± 0.075
4.694ValVal: 4.694 ± 0.089
0.533ValTrp: 0.533 ± 0.029
2.358ValTyr: 2.358 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.572TrpAla: 0.572 ± 0.033
0.135TrpCys: 0.135 ± 0.016
0.41TrpAsp: 0.41 ± 0.024
0.491TrpGlu: 0.491 ± 0.026
0.362TrpPhe: 0.362 ± 0.025
0.585TrpGly: 0.585 ± 0.028
0.294TrpHis: 0.294 ± 0.021
0.522TrpIle: 0.522 ± 0.026
0.483TrpLys: 0.483 ± 0.029
0.928TrpLeu: 0.928 ± 0.038
0.224TrpMet: 0.224 ± 0.019
0.429TrpAsn: 0.429 ± 0.025
0.263TrpPro: 0.263 ± 0.02
0.628TrpGln: 0.628 ± 0.035
0.396TrpArg: 0.396 ± 0.021
0.453TrpSer: 0.453 ± 0.026
0.347TrpThr: 0.347 ± 0.022
0.427TrpVal: 0.427 ± 0.027
0.12TrpTrp: 0.12 ± 0.014
0.31TrpTyr: 0.31 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.781TyrAla: 2.781 ± 0.07
0.488TyrCys: 0.488 ± 0.031
2.251TyrAsp: 2.251 ± 0.062
2.009TyrGlu: 2.009 ± 0.05
1.679TyrPhe: 1.679 ± 0.051
2.562TyrGly: 2.562 ± 0.06
0.792TyrHis: 0.792 ± 0.032
2.929TyrIle: 2.929 ± 0.061
2.6TyrLys: 2.6 ± 0.065
3.349TyrLeu: 3.349 ± 0.066
0.936TyrMet: 0.936 ± 0.036
1.955TyrAsn: 1.955 ± 0.059
1.336TyrPro: 1.336 ± 0.042
1.179TyrGln: 1.179 ± 0.04
1.471TyrArg: 1.471 ± 0.048
2.119TyrSer: 2.119 ± 0.055
2.183TyrThr: 2.183 ± 0.06
2.068TyrVal: 2.068 ± 0.06
0.319TyrTrp: 0.319 ± 0.02
1.534TyrTyr: 1.534 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 2417 proteins (764205 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski