Amino acid dipepetide frequency for Streptococcus satellite phage Javan319

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
2.572AlaAsp: 2.572 ± 1.094
5.572AlaGlu: 5.572 ± 1.622
4.286AlaPhe: 4.286 ± 1.202
2.143AlaGly: 2.143 ± 0.913
1.286AlaHis: 1.286 ± 0.536
2.572AlaIle: 2.572 ± 0.906
7.287AlaLys: 7.287 ± 0.995
5.144AlaLeu: 5.144 ± 0.846
3.0AlaMet: 3.0 ± 1.417
2.572AlaAsn: 2.572 ± 1.138
1.286AlaPro: 1.286 ± 0.536
3.429AlaGln: 3.429 ± 0.954
3.429AlaArg: 3.429 ± 1.168
3.858AlaSer: 3.858 ± 1.007
3.429AlaThr: 3.429 ± 1.064
2.572AlaVal: 2.572 ± 0.836
0.429AlaTrp: 0.429 ± 0.362
1.286AlaTyr: 1.286 ± 0.735
0.0AlaXaa: 0.0 ± 0.0
Cys
0.429CysAla: 0.429 ± 0.444
0.0CysCys: 0.0 ± 0.0
0.857CysAsp: 0.857 ± 0.5
0.0CysGlu: 0.0 ± 0.0
0.429CysPhe: 0.429 ± 0.362
0.0CysGly: 0.0 ± 0.0
0.429CysHis: 0.429 ± 0.353
0.0CysIle: 0.0 ± 0.0
0.429CysLys: 0.429 ± 0.416
0.429CysLeu: 0.429 ± 0.353
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.429CysPro: 0.429 ± 0.353
0.429CysGln: 0.429 ± 0.478
0.429CysArg: 0.429 ± 0.416
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.286AspAla: 1.286 ± 0.721
0.429AspCys: 0.429 ± 0.362
2.143AspAsp: 2.143 ± 1.064
4.715AspGlu: 4.715 ± 1.705
2.572AspPhe: 2.572 ± 0.977
2.572AspGly: 2.572 ± 0.977
0.429AspHis: 0.429 ± 0.478
3.0AspIle: 3.0 ± 1.37
6.001AspLys: 6.001 ± 1.385
6.858AspLeu: 6.858 ± 1.406
1.286AspMet: 1.286 ± 0.725
3.858AspAsn: 3.858 ± 1.053
1.286AspPro: 1.286 ± 0.902
1.715AspGln: 1.715 ± 0.77
2.143AspArg: 2.143 ± 0.693
4.286AspSer: 4.286 ± 1.18
2.143AspThr: 2.143 ± 0.864
1.286AspVal: 1.286 ± 0.782
0.0AspTrp: 0.0 ± 0.0
6.001AspTyr: 6.001 ± 1.247
0.0AspXaa: 0.0 ± 0.0
Glu
3.0GluAla: 3.0 ± 1.141
0.857GluCys: 0.857 ± 0.511
4.286GluAsp: 4.286 ± 1.146
7.715GluGlu: 7.715 ± 1.906
3.0GluPhe: 3.0 ± 0.762
1.286GluGly: 1.286 ± 0.711
0.857GluHis: 0.857 ± 0.396
4.286GluIle: 4.286 ± 0.736
7.715GluLys: 7.715 ± 1.394
7.715GluLeu: 7.715 ± 1.518
2.572GluMet: 2.572 ± 0.894
6.001GluAsn: 6.001 ± 1.47
3.0GluPro: 3.0 ± 1.2
6.429GluGln: 6.429 ± 1.744
6.001GluArg: 6.001 ± 0.865
5.144GluSer: 5.144 ± 1.748
3.429GluThr: 3.429 ± 0.805
3.858GluVal: 3.858 ± 1.154
1.715GluTrp: 1.715 ± 0.678
3.0GluTyr: 3.0 ± 1.179
0.0GluXaa: 0.0 ± 0.0
Phe
1.286PheAla: 1.286 ± 0.668
0.0PheCys: 0.0 ± 0.0
2.143PheAsp: 2.143 ± 0.927
6.001PheGlu: 6.001 ± 2.287
1.715PhePhe: 1.715 ± 0.489
3.0PheGly: 3.0 ± 0.643
0.429PheHis: 0.429 ± 0.353
0.857PheIle: 0.857 ± 0.636
3.429PheLys: 3.429 ± 1.217
2.572PheLeu: 2.572 ± 0.708
0.857PheMet: 0.857 ± 0.518
0.857PheAsn: 0.857 ± 0.449
0.857PhePro: 0.857 ± 0.625
2.572PheGln: 2.572 ± 0.824
3.429PheArg: 3.429 ± 1.313
1.286PheSer: 1.286 ± 0.512
1.286PheThr: 1.286 ± 1.035
2.572PheVal: 2.572 ± 1.338
0.429PheTrp: 0.429 ± 0.425
1.286PheTyr: 1.286 ± 0.676
0.0PheXaa: 0.0 ± 0.0
Gly
2.572GlyAla: 2.572 ± 2.689
0.429GlyCys: 0.429 ± 0.353
2.143GlyAsp: 2.143 ± 0.707
1.715GlyGlu: 1.715 ± 0.766
2.143GlyPhe: 2.143 ± 0.953
3.858GlyGly: 3.858 ± 1.061
1.286GlyHis: 1.286 ± 0.614
3.858GlyIle: 3.858 ± 1.276
3.0GlyLys: 3.0 ± 1.27
5.572GlyLeu: 5.572 ± 1.031
0.429GlyMet: 0.429 ± 0.571
1.286GlyAsn: 1.286 ± 0.795
0.429GlyPro: 0.429 ± 0.362
2.143GlyGln: 2.143 ± 0.81
0.857GlyArg: 0.857 ± 0.51
2.143GlySer: 2.143 ± 0.855
3.0GlyThr: 3.0 ± 1.515
3.858GlyVal: 3.858 ± 1.693
0.429GlyTrp: 0.429 ± 0.425
4.286GlyTyr: 4.286 ± 1.878
0.0GlyXaa: 0.0 ± 0.0
His
2.572HisAla: 2.572 ± 1.041
0.429HisCys: 0.429 ± 0.362
1.286HisAsp: 1.286 ± 0.657
0.429HisGlu: 0.429 ± 0.362
0.429HisPhe: 0.429 ± 0.362
0.857HisGly: 0.857 ± 0.65
0.0HisHis: 0.0 ± 0.0
0.857HisIle: 0.857 ± 0.449
0.857HisLys: 0.857 ± 0.5
2.143HisLeu: 2.143 ± 0.663
0.0HisMet: 0.0 ± 0.0
0.429HisAsn: 0.429 ± 0.362
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
2.143HisArg: 2.143 ± 0.901
1.286HisSer: 1.286 ± 0.554
1.286HisThr: 1.286 ± 0.714
1.286HisVal: 1.286 ± 0.561
0.0HisTrp: 0.0 ± 0.0
0.857HisTyr: 0.857 ± 0.527
0.0HisXaa: 0.0 ± 0.0
Ile
3.858IleAla: 3.858 ± 1.473
0.857IleCys: 0.857 ± 0.643
5.144IleAsp: 5.144 ± 1.521
6.429IleGlu: 6.429 ± 2.179
0.857IlePhe: 0.857 ± 0.716
2.143IleGly: 2.143 ± 0.641
0.0IleHis: 0.0 ± 0.0
4.715IleIle: 4.715 ± 1.223
5.572IleLys: 5.572 ± 1.369
6.001IleLeu: 6.001 ± 1.514
0.429IleMet: 0.429 ± 0.411
3.429IleAsn: 3.429 ± 1.107
1.715IlePro: 1.715 ± 0.823
3.0IleGln: 3.0 ± 0.772
2.143IleArg: 2.143 ± 0.738
6.429IleSer: 6.429 ± 1.636
4.286IleThr: 4.286 ± 1.558
2.572IleVal: 2.572 ± 0.704
0.0IleTrp: 0.0 ± 0.0
1.286IleTyr: 1.286 ± 0.41
0.0IleXaa: 0.0 ± 0.0
Lys
6.429LysAla: 6.429 ± 1.628
0.429LysCys: 0.429 ± 0.416
4.715LysAsp: 4.715 ± 0.987
10.287LysGlu: 10.287 ± 2.475
4.286LysPhe: 4.286 ± 1.299
3.858LysGly: 3.858 ± 0.864
3.0LysHis: 3.0 ± 1.33
5.572LysIle: 5.572 ± 0.993
10.287LysLys: 10.287 ± 2.535
8.144LysLeu: 8.144 ± 1.811
3.0LysMet: 3.0 ± 0.896
4.715LysAsn: 4.715 ± 1.169
1.286LysPro: 1.286 ± 0.742
5.144LysGln: 5.144 ± 1.59
6.429LysArg: 6.429 ± 1.537
6.429LysSer: 6.429 ± 1.295
6.001LysThr: 6.001 ± 1.71
6.001LysVal: 6.001 ± 1.059
0.0LysTrp: 0.0 ± 0.0
3.429LysTyr: 3.429 ± 1.417
0.0LysXaa: 0.0 ± 0.0
Leu
9.001LeuAla: 9.001 ± 1.654
0.0LeuCys: 0.0 ± 0.0
8.144LeuAsp: 8.144 ± 1.953
9.859LeuGlu: 9.859 ± 2.004
1.286LeuPhe: 1.286 ± 0.53
6.429LeuGly: 6.429 ± 1.365
1.715LeuHis: 1.715 ± 0.78
4.286LeuIle: 4.286 ± 1.893
12.859LeuLys: 12.859 ± 1.354
16.288LeuLeu: 16.288 ± 2.128
1.286LeuMet: 1.286 ± 0.696
8.573LeuAsn: 8.573 ± 1.507
4.286LeuPro: 4.286 ± 1.511
4.286LeuGln: 4.286 ± 1.384
3.429LeuArg: 3.429 ± 1.141
6.858LeuSer: 6.858 ± 1.326
9.001LeuThr: 9.001 ± 2.542
4.286LeuVal: 4.286 ± 1.467
0.0LeuTrp: 0.0 ± 0.0
3.429LeuTyr: 3.429 ± 0.759
0.0LeuXaa: 0.0 ± 0.0
Met
2.143MetAla: 2.143 ± 1.068
0.0MetCys: 0.0 ± 0.0
1.715MetAsp: 1.715 ± 0.719
2.572MetGlu: 2.572 ± 0.942
0.429MetPhe: 0.429 ± 0.425
0.857MetGly: 0.857 ± 0.706
0.0MetHis: 0.0 ± 0.0
1.715MetIle: 1.715 ± 0.855
2.143MetLys: 2.143 ± 0.932
2.572MetLeu: 2.572 ± 0.933
0.0MetMet: 0.0 ± 0.0
2.143MetAsn: 2.143 ± 0.892
0.0MetPro: 0.0 ± 0.0
0.857MetGln: 0.857 ± 0.535
1.286MetArg: 1.286 ± 0.956
0.429MetSer: 0.429 ± 0.444
3.429MetThr: 3.429 ± 1.345
1.286MetVal: 1.286 ± 0.956
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.572AsnAla: 2.572 ± 0.748
0.0AsnCys: 0.0 ± 0.0
1.715AsnAsp: 1.715 ± 1.23
1.715AsnGlu: 1.715 ± 0.664
2.572AsnPhe: 2.572 ± 0.949
3.0AsnGly: 3.0 ± 0.869
2.572AsnHis: 2.572 ± 0.826
1.715AsnIle: 1.715 ± 0.791
6.429AsnLys: 6.429 ± 1.277
5.572AsnLeu: 5.572 ± 1.223
1.286AsnMet: 1.286 ± 0.734
3.0AsnAsn: 3.0 ± 0.999
1.286AsnPro: 1.286 ± 0.601
6.429AsnGln: 6.429 ± 1.264
2.143AsnArg: 2.143 ± 0.99
1.715AsnSer: 1.715 ± 0.867
3.858AsnThr: 3.858 ± 0.943
6.001AsnVal: 6.001 ± 1.727
1.286AsnTrp: 1.286 ± 0.501
1.286AsnTyr: 1.286 ± 0.699
0.0AsnXaa: 0.0 ± 0.0
Pro
2.143ProAla: 2.143 ± 1.01
0.0ProCys: 0.0 ± 0.0
1.715ProAsp: 1.715 ± 1.043
1.286ProGlu: 1.286 ± 0.709
0.429ProPhe: 0.429 ± 0.353
1.286ProGly: 1.286 ± 0.694
0.0ProHis: 0.0 ± 0.0
1.286ProIle: 1.286 ± 0.643
3.429ProLys: 3.429 ± 1.218
2.143ProLeu: 2.143 ± 0.687
0.429ProMet: 0.429 ± 0.478
2.143ProAsn: 2.143 ± 0.973
0.857ProPro: 0.857 ± 0.605
0.857ProGln: 0.857 ± 0.6
0.857ProArg: 0.857 ± 0.449
1.286ProSer: 1.286 ± 0.601
0.857ProThr: 0.857 ± 0.724
1.715ProVal: 1.715 ± 1.069
0.429ProTrp: 0.429 ± 0.435
1.286ProTyr: 1.286 ± 0.583
0.0ProXaa: 0.0 ± 0.0
Gln
5.144GlnAla: 5.144 ± 1.38
0.0GlnCys: 0.0 ± 0.0
1.286GlnAsp: 1.286 ± 0.781
3.858GlnGlu: 3.858 ± 0.947
1.286GlnPhe: 1.286 ± 0.644
0.857GlnGly: 0.857 ± 0.6
0.429GlnHis: 0.429 ± 0.362
5.572GlnIle: 5.572 ± 1.271
6.001GlnLys: 6.001 ± 1.467
9.43GlnLeu: 9.43 ± 2.135
0.857GlnMet: 0.857 ± 0.638
1.715GlnAsn: 1.715 ± 0.579
0.857GlnPro: 0.857 ± 0.956
3.0GlnGln: 3.0 ± 1.169
1.715GlnArg: 1.715 ± 1.047
2.143GlnSer: 2.143 ± 0.77
2.572GlnThr: 2.572 ± 0.652
3.0GlnVal: 3.0 ± 1.275
0.857GlnTrp: 0.857 ± 0.449
1.286GlnTyr: 1.286 ± 0.657
0.0GlnXaa: 0.0 ± 0.0
Arg
2.572ArgAla: 2.572 ± 1.111
0.0ArgCys: 0.0 ± 0.0
3.858ArgAsp: 3.858 ± 1.206
3.858ArgGlu: 3.858 ± 1.439
1.286ArgPhe: 1.286 ± 0.694
2.143ArgGly: 2.143 ± 0.728
1.286ArgHis: 1.286 ± 0.653
3.0ArgIle: 3.0 ± 1.196
5.144ArgLys: 5.144 ± 1.371
6.429ArgLeu: 6.429 ± 1.21
0.857ArgMet: 0.857 ± 0.511
3.429ArgAsn: 3.429 ± 1.361
1.715ArgPro: 1.715 ± 0.774
1.715ArgGln: 1.715 ± 0.626
1.286ArgArg: 1.286 ± 0.735
1.286ArgSer: 1.286 ± 0.601
3.429ArgThr: 3.429 ± 1.263
3.0ArgVal: 3.0 ± 0.925
0.0ArgTrp: 0.0 ± 0.0
2.143ArgTyr: 2.143 ± 0.878
0.0ArgXaa: 0.0 ± 0.0
Ser
3.0SerAla: 3.0 ± 0.933
0.0SerCys: 0.0 ± 0.0
5.144SerAsp: 5.144 ± 1.309
6.001SerGlu: 6.001 ± 1.824
3.858SerPhe: 3.858 ± 0.717
0.857SerGly: 0.857 ± 0.511
1.286SerHis: 1.286 ± 0.527
5.144SerIle: 5.144 ± 1.092
4.715SerLys: 4.715 ± 1.064
6.429SerLeu: 6.429 ± 1.585
1.715SerMet: 1.715 ± 0.712
3.0SerAsn: 3.0 ± 0.76
1.715SerPro: 1.715 ± 0.667
3.0SerGln: 3.0 ± 1.162
1.715SerArg: 1.715 ± 0.873
3.0SerSer: 3.0 ± 1.016
3.0SerThr: 3.0 ± 1.0
2.143SerVal: 2.143 ± 0.554
0.429SerTrp: 0.429 ± 0.444
3.0SerTyr: 3.0 ± 1.634
0.0SerXaa: 0.0 ± 0.0
Thr
2.572ThrAla: 2.572 ± 1.298
0.0ThrCys: 0.0 ± 0.0
2.572ThrAsp: 2.572 ± 0.812
3.858ThrGlu: 3.858 ± 1.056
3.0ThrPhe: 3.0 ± 2.084
5.144ThrGly: 5.144 ± 1.362
1.715ThrHis: 1.715 ± 0.636
2.143ThrIle: 2.143 ± 0.534
2.572ThrLys: 2.572 ± 0.867
9.43ThrLeu: 9.43 ± 2.05
1.286ThrMet: 1.286 ± 0.62
3.429ThrAsn: 3.429 ± 1.196
0.857ThrPro: 0.857 ± 0.51
2.143ThrGln: 2.143 ± 0.805
3.858ThrArg: 3.858 ± 1.041
4.715ThrSer: 4.715 ± 0.873
4.286ThrThr: 4.286 ± 1.337
3.0ThrVal: 3.0 ± 1.942
0.429ThrTrp: 0.429 ± 0.484
3.858ThrTyr: 3.858 ± 1.644
0.0ThrXaa: 0.0 ± 0.0
Val
3.0ValAla: 3.0 ± 1.38
0.0ValCys: 0.0 ± 0.0
1.715ValAsp: 1.715 ± 0.96
2.572ValGlu: 2.572 ± 0.947
1.286ValPhe: 1.286 ± 0.58
3.858ValGly: 3.858 ± 1.258
0.0ValHis: 0.0 ± 0.0
6.001ValIle: 6.001 ± 1.195
4.715ValLys: 4.715 ± 1.504
6.429ValLeu: 6.429 ± 1.501
1.286ValMet: 1.286 ± 0.706
3.429ValAsn: 3.429 ± 1.544
1.715ValPro: 1.715 ± 1.23
2.143ValGln: 2.143 ± 1.186
1.715ValArg: 1.715 ± 0.827
3.0ValSer: 3.0 ± 1.38
3.0ValThr: 3.0 ± 0.695
3.0ValVal: 3.0 ± 1.925
0.857ValTrp: 0.857 ± 0.515
3.0ValTyr: 3.0 ± 1.145
0.0ValXaa: 0.0 ± 0.0
Trp
0.857TrpAla: 0.857 ± 0.449
0.0TrpCys: 0.0 ± 0.0
0.429TrpAsp: 0.429 ± 0.362
1.286TrpGlu: 1.286 ± 0.845
0.0TrpPhe: 0.0 ± 0.0
0.429TrpGly: 0.429 ± 0.39
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.857TrpLys: 0.857 ± 0.587
1.715TrpLeu: 1.715 ± 0.728
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.857TrpArg: 0.857 ± 0.532
1.286TrpSer: 1.286 ± 0.61
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.715TyrAla: 1.715 ± 0.797
0.857TyrCys: 0.857 ± 0.543
0.429TyrAsp: 0.429 ± 0.362
2.143TyrGlu: 2.143 ± 1.246
1.715TyrPhe: 1.715 ± 0.898
1.286TyrGly: 1.286 ± 0.825
0.429TyrHis: 0.429 ± 0.362
4.286TyrIle: 4.286 ± 1.337
6.001TyrLys: 6.001 ± 2.446
4.286TyrLeu: 4.286 ± 1.162
2.572TyrMet: 2.572 ± 1.066
2.143TyrAsn: 2.143 ± 0.693
0.857TyrPro: 0.857 ± 0.449
2.572TyrGln: 2.572 ± 1.365
2.572TyrArg: 2.572 ± 0.98
2.572TyrSer: 2.572 ± 1.27
2.572TyrThr: 2.572 ± 0.779
1.286TyrVal: 1.286 ± 0.735
0.429TyrTrp: 0.429 ± 0.362
3.0TyrTyr: 3.0 ± 1.152
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski