Amino acid dipepetide frequency for Arthrobacter nitrophenolicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.873AlaAla: 21.873 ± 0.261	0.869AlaCys: 0.869 ± 0.031	7.056AlaAsp: 7.056 ± 0.083	8.034AlaGlu: 8.034 ± 0.097	3.649AlaPhe: 3.649 ± 0.064	14.104AlaGly: 14.104 ± 0.153	2.233AlaHis: 2.233 ± 0.045	4.869AlaIle: 4.869 ± 0.086	3.596AlaLys: 3.596 ± 0.069	12.989AlaLeu: 12.989 ± 0.128	2.884AlaMet: 2.884 ± 0.052	2.581AlaAsn: 2.581 ± 0.049	6.282AlaPro: 6.282 ± 0.099	3.664AlaGln: 3.664 ± 0.069	8.052AlaArg: 8.052 ± 0.106	7.063AlaSer: 7.063 ± 0.087	6.74AlaThr: 6.74 ± 0.082	11.576AlaVal: 11.576 ± 0.113	1.752AlaTrp: 1.752 ± 0.047	2.327AlaTyr: 2.327 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.739CysAla: 0.739 ± 0.026	0.094CysCys: 0.094 ± 0.01	0.314CysAsp: 0.314 ± 0.018	0.322CysGlu: 0.322 ± 0.017	0.23CysPhe: 0.23 ± 0.014	0.72CysGly: 0.72 ± 0.029	0.149CysHis: 0.149 ± 0.011	0.267CysIle: 0.267 ± 0.016	0.119CysLys: 0.119 ± 0.009	0.619CysLeu: 0.619 ± 0.025	0.105CysMet: 0.105 ± 0.009	0.155CysAsn: 0.155 ± 0.013	0.401CysPro: 0.401 ± 0.022	0.156CysGln: 0.156 ± 0.012	0.512CysArg: 0.512 ± 0.025	0.51CysSer: 0.51 ± 0.023	0.416CysThr: 0.416 ± 0.021	0.433CysVal: 0.433 ± 0.018	0.121CysTrp: 0.121 ± 0.014	0.142CysTyr: 0.142 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.173AspAla: 7.173 ± 0.084	0.327AspCys: 0.327 ± 0.018	3.03AspAsp: 3.03 ± 0.054	3.405AspGlu: 3.405 ± 0.068	1.869AspPhe: 1.869 ± 0.046	5.956AspGly: 5.956 ± 0.083	1.252AspHis: 1.252 ± 0.033	2.428AspIle: 2.428 ± 0.05	1.377AspLys: 1.377 ± 0.043	5.551AspLeu: 5.551 ± 0.073	0.909AspMet: 0.909 ± 0.03	1.221AspAsn: 1.221 ± 0.034	3.665AspPro: 3.665 ± 0.067	1.677AspGln: 1.677 ± 0.039	3.499AspArg: 3.499 ± 0.06	2.762AspSer: 2.762 ± 0.05	2.712AspThr: 2.712 ± 0.051	4.868AspVal: 4.868 ± 0.067	0.907AspTrp: 0.907 ± 0.028	1.279AspTyr: 1.279 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.462GluAla: 7.462 ± 0.101	0.318GluCys: 0.318 ± 0.018	3.118GluAsp: 3.118 ± 0.058	3.405GluGlu: 3.405 ± 0.067	1.79GluPhe: 1.79 ± 0.044	4.105GluGly: 4.105 ± 0.062	1.479GluHis: 1.479 ± 0.036	2.405GluIle: 2.405 ± 0.05	1.731GluLys: 1.731 ± 0.04	6.709GluLeu: 6.709 ± 0.096	0.943GluMet: 0.943 ± 0.029	1.404GluAsn: 1.404 ± 0.035	3.05GluPro: 3.05 ± 0.063	2.382GluGln: 2.382 ± 0.049	4.035GluArg: 4.035 ± 0.076	2.91GluSer: 2.91 ± 0.056	3.008GluThr: 3.008 ± 0.055	4.241GluVal: 4.241 ± 0.07	0.861GluTrp: 0.861 ± 0.03	1.149GluTyr: 1.149 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.886PheAla: 3.886 ± 0.072	0.262PheCys: 0.262 ± 0.015	2.162PheAsp: 2.162 ± 0.043	1.74PheGlu: 1.74 ± 0.044	1.17PhePhe: 1.17 ± 0.04	3.279PheGly: 3.279 ± 0.067	0.647PheHis: 0.647 ± 0.027	1.321PheIle: 1.321 ± 0.043	0.764PheLys: 0.764 ± 0.031	3.141PheLeu: 3.141 ± 0.067	0.552PheMet: 0.552 ± 0.022	0.876PheAsn: 0.876 ± 0.027	1.583PhePro: 1.583 ± 0.039	0.877PheGln: 0.877 ± 0.029	1.951PheArg: 1.951 ± 0.046	1.946PheSer: 1.946 ± 0.045	2.115PheThr: 2.115 ± 0.051	2.492PheVal: 2.492 ± 0.055	0.495PheTrp: 0.495 ± 0.024	0.735PheTyr: 0.735 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.121GlyAla: 10.121 ± 0.101	0.67GlyCys: 0.67 ± 0.026	4.284GlyAsp: 4.284 ± 0.068	4.485GlyGlu: 4.485 ± 0.064	3.207GlyPhe: 3.207 ± 0.064	7.81GlyGly: 7.81 ± 0.115	2.161GlyHis: 2.161 ± 0.051	4.663GlyIle: 4.663 ± 0.068	3.16GlyLys: 3.16 ± 0.055	9.378GlyLeu: 9.378 ± 0.115	2.143GlyMet: 2.143 ± 0.045	2.368GlyAsn: 2.368 ± 0.051	4.465GlyPro: 4.465 ± 0.069	3.205GlyGln: 3.205 ± 0.056	6.1GlyArg: 6.1 ± 0.085	5.973GlySer: 5.973 ± 0.077	6.324GlyThr: 6.324 ± 0.08	7.131GlyVal: 7.131 ± 0.085	1.633GlyTrp: 1.633 ± 0.042	2.347GlyTyr: 2.347 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.366HisAla: 2.366 ± 0.049	0.157HisCys: 0.157 ± 0.013	1.171HisAsp: 1.171 ± 0.037	1.128HisGlu: 1.128 ± 0.033	0.669HisPhe: 0.669 ± 0.022	2.122HisGly: 2.122 ± 0.042	0.727HisHis: 0.727 ± 0.03	0.802HisIle: 0.802 ± 0.03	0.459HisLys: 0.459 ± 0.02	2.142HisLeu: 2.142 ± 0.046	0.38HisMet: 0.38 ± 0.02	0.481HisAsn: 0.481 ± 0.02	1.541HisPro: 1.541 ± 0.041	0.719HisGln: 0.719 ± 0.029	1.582HisArg: 1.582 ± 0.04	1.153HisSer: 1.153 ± 0.034	1.067HisThr: 1.067 ± 0.031	1.668HisVal: 1.668 ± 0.041	0.317HisTrp: 0.317 ± 0.019	0.493HisTyr: 0.493 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.387IleAla: 5.387 ± 0.086	0.299IleCys: 0.299 ± 0.017	2.566IleAsp: 2.566 ± 0.051	2.343IleGlu: 2.343 ± 0.05	1.379IlePhe: 1.379 ± 0.042	3.919IleGly: 3.919 ± 0.062	0.83IleHis: 0.83 ± 0.031	1.878IleIle: 1.878 ± 0.049	1.118IleLys: 1.118 ± 0.033	3.827IleLeu: 3.827 ± 0.072	0.713IleMet: 0.713 ± 0.028	1.274IleAsn: 1.274 ± 0.03	2.454IlePro: 2.454 ± 0.045	1.165IleGln: 1.165 ± 0.029	2.783IleArg: 2.783 ± 0.052	2.68IleSer: 2.68 ± 0.05	2.726IleThr: 2.726 ± 0.053	3.321IleVal: 3.321 ± 0.071	0.48IleTrp: 0.48 ± 0.024	0.825IleTyr: 0.825 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.707LysAla: 3.707 ± 0.072	0.111LysCys: 0.111 ± 0.01	1.752LysAsp: 1.752 ± 0.045	1.532LysGlu: 1.532 ± 0.041	0.751LysPhe: 0.751 ± 0.028	2.064LysGly: 2.064 ± 0.051	0.627LysHis: 0.627 ± 0.025	1.191LysIle: 1.191 ± 0.036	1.006LysLys: 1.006 ± 0.033	2.622LysLeu: 2.622 ± 0.054	0.584LysMet: 0.584 ± 0.026	0.704LysAsn: 0.704 ± 0.026	1.68LysPro: 1.68 ± 0.047	0.905LysGln: 0.905 ± 0.031	1.669LysArg: 1.669 ± 0.048	1.482LysSer: 1.482 ± 0.038	1.539LysThr: 1.539 ± 0.042	2.281LysVal: 2.281 ± 0.051	0.322LysTrp: 0.322 ± 0.017	0.658LysTyr: 0.658 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.871LeuAla: 14.871 ± 0.158	0.663LeuCys: 0.663 ± 0.027	6.31LeuAsp: 6.31 ± 0.088	5.718LeuGlu: 5.718 ± 0.088	2.904LeuPhe: 2.904 ± 0.07	9.034LeuGly: 9.034 ± 0.111	2.062LeuHis: 2.062 ± 0.04	3.947LeuIle: 3.947 ± 0.07	2.677LeuLys: 2.677 ± 0.049	10.7LeuLeu: 10.7 ± 0.139	1.945LeuMet: 1.945 ± 0.05	2.443LeuAsn: 2.443 ± 0.048	5.887LeuPro: 5.887 ± 0.072	3.129LeuGln: 3.129 ± 0.068	6.898LeuArg: 6.898 ± 0.102	5.656LeuSer: 5.656 ± 0.059	5.879LeuThr: 5.879 ± 0.082	8.661LeuVal: 8.661 ± 0.1	1.298LeuTrp: 1.298 ± 0.041	1.734LeuTyr: 1.734 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.724MetAla: 2.724 ± 0.052	0.107MetCys: 0.107 ± 0.011	1.096MetAsp: 1.096 ± 0.033	0.969MetGlu: 0.969 ± 0.028	0.598MetPhe: 0.598 ± 0.025	1.587MetGly: 1.587 ± 0.037	0.361MetHis: 0.361 ± 0.018	0.823MetIle: 0.823 ± 0.029	0.612MetLys: 0.612 ± 0.025	2.025MetLeu: 2.025 ± 0.047	0.385MetMet: 0.385 ± 0.022	0.589MetAsn: 0.589 ± 0.024	1.244MetPro: 1.244 ± 0.031	0.599MetGln: 0.599 ± 0.024	1.186MetArg: 1.186 ± 0.033	1.406MetSer: 1.406 ± 0.033	1.547MetThr: 1.547 ± 0.042	1.581MetVal: 1.581 ± 0.037	0.228MetTrp: 0.228 ± 0.015	0.308MetTyr: 0.308 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.797AsnAla: 2.797 ± 0.053	0.163AsnCys: 0.163 ± 0.011	1.22AsnAsp: 1.22 ± 0.037	1.177AsnGlu: 1.177 ± 0.034	0.817AsnPhe: 0.817 ± 0.028	2.28AsnGly: 2.28 ± 0.052	0.543AsnHis: 0.543 ± 0.026	1.08AsnIle: 1.08 ± 0.032	0.609AsnLys: 0.609 ± 0.026	2.411AsnLeu: 2.411 ± 0.046	0.453AsnMet: 0.453 ± 0.02	0.721AsnAsn: 0.721 ± 0.029	1.844AsnPro: 1.844 ± 0.045	0.851AsnGln: 0.851 ± 0.027	1.608AsnArg: 1.608 ± 0.042	1.441AsnSer: 1.441 ± 0.037	1.387AsnThr: 1.387 ± 0.043	1.854AsnVal: 1.854 ± 0.042	0.407AsnTrp: 0.407 ± 0.02	0.603AsnTyr: 0.603 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	8.662ProAla: 8.662 ± 0.129	0.269ProCys: 0.269 ± 0.016	3.726ProAsp: 3.726 ± 0.057	4.137ProGlu: 4.137 ± 0.064	1.715ProPhe: 1.715 ± 0.04	6.089ProGly: 6.089 ± 0.087	1.122ProHis: 1.122 ± 0.037	1.602ProIle: 1.602 ± 0.041	1.29ProLys: 1.29 ± 0.041	5.029ProLeu: 5.029 ± 0.076	1.051ProMet: 1.051 ± 0.033	1.172ProAsn: 1.172 ± 0.038	2.609ProPro: 2.609 ± 0.066	1.745ProGln: 1.745 ± 0.036	3.098ProArg: 3.098 ± 0.055	3.249ProSer: 3.249 ± 0.058	2.711ProThr: 2.711 ± 0.057	5.095ProVal: 5.095 ± 0.077	0.877ProTrp: 0.877 ± 0.028	1.071ProTyr: 1.071 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.159GlnAla: 4.159 ± 0.063	0.161GlnCys: 0.161 ± 0.013	1.828GlnAsp: 1.828 ± 0.04	1.884GlnGlu: 1.884 ± 0.046	0.911GlnPhe: 0.911 ± 0.029	2.512GlnGly: 2.512 ± 0.048	0.767GlnHis: 0.767 ± 0.03	1.363GlnIle: 1.363 ± 0.036	0.862GlnLys: 0.862 ± 0.029	3.643GlnLeu: 3.643 ± 0.06	0.62GlnMet: 0.62 ± 0.024	0.689GlnAsn: 0.689 ± 0.025	1.99GlnPro: 1.99 ± 0.048	1.465GlnGln: 1.465 ± 0.042	2.339GlnArg: 2.339 ± 0.049	1.559GlnSer: 1.559 ± 0.04	1.436GlnThr: 1.436 ± 0.036	2.587GlnVal: 2.587 ± 0.049	0.469GlnTrp: 0.469 ± 0.021	0.694GlnTyr: 0.694 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.033ArgAla: 7.033 ± 0.084	0.424ArgCys: 0.424 ± 0.023	3.474ArgAsp: 3.474 ± 0.068	3.917ArgGlu: 3.917 ± 0.069	2.241ArgPhe: 2.241 ± 0.049	4.81ArgGly: 4.81 ± 0.078	1.67ArgHis: 1.67 ± 0.034	3.291ArgIle: 3.291 ± 0.051	1.995ArgLys: 1.995 ± 0.046	7.003ArgLeu: 7.003 ± 0.105	1.553ArgMet: 1.553 ± 0.04	1.843ArgAsn: 1.843 ± 0.042	3.625ArgPro: 3.625 ± 0.061	2.507ArgGln: 2.507 ± 0.049	5.762ArgArg: 5.762 ± 0.097	3.938ArgSer: 3.938 ± 0.068	4.046ArgThr: 4.046 ± 0.059	4.449ArgVal: 4.449 ± 0.066	1.086ArgTrp: 1.086 ± 0.035	1.527ArgTyr: 1.527 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.186SerAla: 7.186 ± 0.091	0.388SerCys: 0.388 ± 0.02	2.768SerAsp: 2.768 ± 0.048	2.79SerGlu: 2.79 ± 0.053	2.066SerPhe: 2.066 ± 0.047	5.992SerGly: 5.992 ± 0.083	1.11SerHis: 1.11 ± 0.031	2.437SerIle: 2.437 ± 0.046	1.416SerLys: 1.416 ± 0.035	5.617SerLeu: 5.617 ± 0.076	1.404SerMet: 1.404 ± 0.033	1.398SerAsn: 1.398 ± 0.038	3.402SerPro: 3.402 ± 0.066	1.714SerGln: 1.714 ± 0.044	3.946SerArg: 3.946 ± 0.064	3.66SerSer: 3.66 ± 0.074	3.652SerThr: 3.652 ± 0.064	4.608SerVal: 4.608 ± 0.067	0.946SerTrp: 0.946 ± 0.031	1.333SerTyr: 1.333 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.96ThrAla: 7.96 ± 0.1	0.354ThrCys: 0.354 ± 0.022	3.0ThrAsp: 3.0 ± 0.049	2.939ThrGlu: 2.939 ± 0.064	1.91ThrPhe: 1.91 ± 0.044	6.003ThrGly: 6.003 ± 0.078	1.006ThrHis: 1.006 ± 0.032	2.47ThrIle: 2.47 ± 0.052	1.421ThrLys: 1.421 ± 0.037	5.587ThrLeu: 5.587 ± 0.081	1.094ThrMet: 1.094 ± 0.037	1.3ThrAsn: 1.3 ± 0.038	3.819ThrPro: 3.819 ± 0.068	1.444ThrGln: 1.444 ± 0.041	3.186ThrArg: 3.186 ± 0.047	3.524ThrSer: 3.524 ± 0.061	3.444ThrThr: 3.444 ± 0.066	5.438ThrVal: 5.438 ± 0.074	0.831ThrTrp: 0.831 ± 0.032	1.223ThrTyr: 1.223 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.225ValAla: 10.225 ± 0.104	0.591ValCys: 0.591 ± 0.024	4.959ValAsp: 4.959 ± 0.08	4.805ValGlu: 4.805 ± 0.076	2.715ValPhe: 2.715 ± 0.059	6.231ValGly: 6.231 ± 0.091	1.683ValHis: 1.683 ± 0.038	3.68ValIle: 3.68 ± 0.072	2.035ValLys: 2.035 ± 0.048	9.435ValLeu: 9.435 ± 0.117	1.607ValMet: 1.607 ± 0.042	1.996ValAsn: 1.996 ± 0.047	4.931ValPro: 4.931 ± 0.076	2.401ValGln: 2.401 ± 0.049	5.324ValArg: 5.324 ± 0.082	4.752ValSer: 4.752 ± 0.071	5.107ValThr: 5.107 ± 0.073	7.733ValVal: 7.733 ± 0.101	1.008ValTrp: 1.008 ± 0.032	1.462ValTyr: 1.462 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.548TrpAla: 1.548 ± 0.038	0.129TrpCys: 0.129 ± 0.012	0.809TrpAsp: 0.809 ± 0.026	0.666TrpGlu: 0.666 ± 0.022	0.553TrpPhe: 0.553 ± 0.024	1.014TrpGly: 1.014 ± 0.03	0.359TrpHis: 0.359 ± 0.019	0.684TrpIle: 0.684 ± 0.024	0.437TrpLys: 0.437 ± 0.021	1.801TrpLeu: 1.801 ± 0.044	0.332TrpMet: 0.332 ± 0.019	0.489TrpAsn: 0.489 ± 0.022	0.737TrpPro: 0.737 ± 0.027	0.67TrpGln: 0.67 ± 0.029	1.038TrpArg: 1.038 ± 0.034	0.887TrpSer: 0.887 ± 0.032	0.928TrpThr: 0.928 ± 0.031	1.024TrpVal: 1.024 ± 0.033	0.32TrpTrp: 0.32 ± 0.019	0.278TrpTyr: 0.278 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.313TyrAla: 2.313 ± 0.053	0.167TyrCys: 0.167 ± 0.012	1.225TyrAsp: 1.225 ± 0.033	1.109TyrGlu: 1.109 ± 0.036	0.853TyrPhe: 0.853 ± 0.029	1.997TyrGly: 1.997 ± 0.048	0.357TyrHis: 0.357 ± 0.02	0.765TyrIle: 0.765 ± 0.027	0.5TyrLys: 0.5 ± 0.021	2.185TyrLeu: 2.185 ± 0.042	0.315TyrMet: 0.315 ± 0.018	0.565TyrAsn: 0.565 ± 0.025	1.107TyrPro: 1.107 ± 0.035	0.664TyrGln: 0.664 ± 0.025	1.626TyrArg: 1.626 ± 0.043	1.283TyrSer: 1.283 ± 0.031	1.172TyrThr: 1.172 ± 0.037	1.639TyrVal: 1.639 ± 0.04	0.345TyrTrp: 0.345 ± 0.018	0.524TyrTyr: 0.524 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3633 proteins (1041394 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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