Amino acid dipepetide frequency for Wallemia hederae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.899AlaAla: 7.899 ± 0.083
0.794AlaCys: 0.794 ± 0.017
4.356AlaAsp: 4.356 ± 0.048
4.529AlaGlu: 4.529 ± 0.055
3.163AlaPhe: 3.163 ± 0.05
4.75AlaGly: 4.75 ± 0.057
2.105AlaHis: 2.105 ± 0.032
4.378AlaIle: 4.378 ± 0.052
4.329AlaLys: 4.329 ± 0.051
7.799AlaLeu: 7.799 ± 0.068
1.745AlaMet: 1.745 ± 0.026
3.278AlaAsn: 3.278 ± 0.041
4.06AlaPro: 4.06 ± 0.061
3.986AlaGln: 3.986 ± 0.047
4.202AlaArg: 4.202 ± 0.051
7.109AlaSer: 7.109 ± 0.066
4.711AlaThr: 4.711 ± 0.048
4.941AlaVal: 4.941 ± 0.049
0.796AlaTrp: 0.796 ± 0.019
2.272AlaTyr: 2.272 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.764CysAla: 0.764 ± 0.017
0.193CysCys: 0.193 ± 0.011
0.592CysAsp: 0.592 ± 0.018
0.511CysGlu: 0.511 ± 0.016
0.448CysPhe: 0.448 ± 0.015
0.708CysGly: 0.708 ± 0.02
0.252CysHis: 0.252 ± 0.012
0.636CysIle: 0.636 ± 0.015
0.508CysLys: 0.508 ± 0.017
1.096CysLeu: 1.096 ± 0.026
0.219CysMet: 0.219 ± 0.01
0.397CysAsn: 0.397 ± 0.013
0.463CysPro: 0.463 ± 0.018
0.352CysGln: 0.352 ± 0.014
0.535CysArg: 0.535 ± 0.015
0.782CysSer: 0.782 ± 0.021
0.623CysThr: 0.623 ± 0.019
0.726CysVal: 0.726 ± 0.018
0.155CysTrp: 0.155 ± 0.008
0.325CysTyr: 0.325 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
5.335AspAla: 5.335 ± 0.05
0.58AspCys: 0.58 ± 0.017
5.623AspAsp: 5.623 ± 0.077
5.213AspGlu: 5.213 ± 0.064
2.204AspPhe: 2.204 ± 0.034
3.963AspGly: 3.963 ± 0.045
1.202AspHis: 1.202 ± 0.022
3.417AspIle: 3.417 ± 0.043
3.951AspLys: 3.951 ± 0.06
5.276AspLeu: 5.276 ± 0.051
1.286AspMet: 1.286 ± 0.024
2.639AspAsn: 2.639 ± 0.034
2.4AspPro: 2.4 ± 0.031
1.986AspGln: 1.986 ± 0.03
2.857AspArg: 2.857 ± 0.044
4.859AspSer: 4.859 ± 0.054
3.376AspThr: 3.376 ± 0.043
4.285AspVal: 4.285 ± 0.044
0.753AspTrp: 0.753 ± 0.02
1.872AspTyr: 1.872 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
4.901GluAla: 4.901 ± 0.053
0.667GluCys: 0.667 ± 0.015
4.352GluAsp: 4.352 ± 0.057
5.651GluGlu: 5.651 ± 0.088
1.894GluPhe: 1.894 ± 0.031
3.345GluGly: 3.345 ± 0.045
1.64GluHis: 1.64 ± 0.039
3.1GluIle: 3.1 ± 0.041
4.104GluLys: 4.104 ± 0.051
5.56GluLeu: 5.56 ± 0.054
1.535GluMet: 1.535 ± 0.03
2.508GluAsn: 2.508 ± 0.034
2.176GluPro: 2.176 ± 0.037
3.041GluGln: 3.041 ± 0.048
3.922GluArg: 3.922 ± 0.055
4.632GluSer: 4.632 ± 0.048
2.887GluThr: 2.887 ± 0.035
3.244GluVal: 3.244 ± 0.037
0.75GluTrp: 0.75 ± 0.018
1.879GluTyr: 1.879 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
2.807PheAla: 2.807 ± 0.042
0.436PheCys: 0.436 ± 0.015
2.554PheAsp: 2.554 ± 0.037
2.26PheGlu: 2.26 ± 0.034
1.402PhePhe: 1.402 ± 0.028
2.64PheGly: 2.64 ± 0.059
0.762PheHis: 0.762 ± 0.019
2.016PheIle: 2.016 ± 0.034
2.124PheLys: 2.124 ± 0.033
2.915PheLeu: 2.915 ± 0.042
0.707PheMet: 0.707 ± 0.016
1.945PheAsn: 1.945 ± 0.031
1.475PhePro: 1.475 ± 0.027
1.145PheGln: 1.145 ± 0.023
1.553PheArg: 1.553 ± 0.033
2.982PheSer: 2.982 ± 0.037
2.085PheThr: 2.085 ± 0.032
2.399PheVal: 2.399 ± 0.033
0.445PheTrp: 0.445 ± 0.015
1.131PheTyr: 1.131 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
4.534GlyAla: 4.534 ± 0.058
0.743GlyCys: 0.743 ± 0.019
3.602GlyAsp: 3.602 ± 0.049
3.426GlyGlu: 3.426 ± 0.044
2.328GlyPhe: 2.328 ± 0.036
5.022GlyGly: 5.022 ± 0.077
1.429GlyHis: 1.429 ± 0.037
3.041GlyIle: 3.041 ± 0.039
3.423GlyLys: 3.423 ± 0.048
5.188GlyLeu: 5.188 ± 0.053
1.372GlyMet: 1.372 ± 0.03
2.233GlyAsn: 2.233 ± 0.033
1.943GlyPro: 1.943 ± 0.035
2.178GlyGln: 2.178 ± 0.036
3.069GlyArg: 3.069 ± 0.039
4.861GlySer: 4.861 ± 0.06
3.063GlyThr: 3.063 ± 0.042
4.419GlyVal: 4.419 ± 0.052
0.854GlyTrp: 0.854 ± 0.019
1.899GlyTyr: 1.899 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
2.053HisAla: 2.053 ± 0.034
0.29HisCys: 0.29 ± 0.01
1.512HisAsp: 1.512 ± 0.035
1.338HisGlu: 1.338 ± 0.03
0.938HisPhe: 0.938 ± 0.022
1.388HisGly: 1.388 ± 0.044
0.909HisHis: 0.909 ± 0.039
1.338HisIle: 1.338 ± 0.025
1.425HisLys: 1.425 ± 0.028
2.624HisLeu: 2.624 ± 0.035
0.458HisMet: 0.458 ± 0.012
1.103HisAsn: 1.103 ± 0.024
1.588HisPro: 1.588 ± 0.028
1.12HisGln: 1.12 ± 0.024
1.305HisArg: 1.305 ± 0.022
2.504HisSer: 2.504 ± 0.04
1.624HisThr: 1.624 ± 0.029
1.419HisVal: 1.419 ± 0.03
0.274HisTrp: 0.274 ± 0.011
0.757HisTyr: 0.757 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.272IleAla: 4.272 ± 0.049
0.621IleCys: 0.621 ± 0.016
3.641IleAsp: 3.641 ± 0.039
3.299IleGlu: 3.299 ± 0.04
1.783IlePhe: 1.783 ± 0.03
3.058IleGly: 3.058 ± 0.041
1.344IleHis: 1.344 ± 0.025
2.581IleIle: 2.581 ± 0.041
3.004IleLys: 3.004 ± 0.035
4.495IleLeu: 4.495 ± 0.06
0.95IleMet: 0.95 ± 0.021
2.463IleAsn: 2.463 ± 0.036
3.004IlePro: 3.004 ± 0.038
2.094IleGln: 2.094 ± 0.031
2.671IleArg: 2.671 ± 0.04
4.19IleSer: 4.19 ± 0.046
2.85IleThr: 2.85 ± 0.037
3.205IleVal: 3.205 ± 0.039
0.577IleTrp: 0.577 ± 0.017
1.462IleTyr: 1.462 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.729LysAla: 4.729 ± 0.053
0.539LysCys: 0.539 ± 0.017
3.626LysAsp: 3.626 ± 0.05
4.377LysGlu: 4.377 ± 0.051
1.742LysPhe: 1.742 ± 0.032
3.004LysGly: 3.004 ± 0.043
1.617LysHis: 1.617 ± 0.031
2.591LysIle: 2.591 ± 0.032
4.402LysLys: 4.402 ± 0.077
5.316LysLeu: 5.316 ± 0.058
1.275LysMet: 1.275 ± 0.021
2.251LysAsn: 2.251 ± 0.038
2.953LysPro: 2.953 ± 0.047
2.858LysGln: 2.858 ± 0.039
3.865LysArg: 3.865 ± 0.05
4.832LysSer: 4.832 ± 0.053
3.004LysThr: 3.004 ± 0.041
3.321LysVal: 3.321 ± 0.043
0.641LysTrp: 0.641 ± 0.018
1.68LysTyr: 1.68 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
7.393LeuAla: 7.393 ± 0.072
1.032LeuCys: 1.032 ± 0.026
5.802LeuAsp: 5.802 ± 0.049
5.42LeuGlu: 5.42 ± 0.065
3.359LeuPhe: 3.359 ± 0.048
5.097LeuGly: 5.097 ± 0.052
2.407LeuHis: 2.407 ± 0.039
4.664LeuIle: 4.664 ± 0.049
5.251LeuLys: 5.251 ± 0.054
8.68LeuLeu: 8.68 ± 0.092
1.711LeuMet: 1.711 ± 0.026
4.452LeuAsn: 4.452 ± 0.048
4.913LeuPro: 4.913 ± 0.056
3.931LeuGln: 3.931 ± 0.047
5.156LeuArg: 5.156 ± 0.056
8.529LeuSer: 8.529 ± 0.081
5.116LeuThr: 5.116 ± 0.056
5.334LeuVal: 5.334 ± 0.058
0.911LeuTrp: 0.911 ± 0.022
2.522LeuTyr: 2.522 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
1.688MetAla: 1.688 ± 0.026
0.195MetCys: 0.195 ± 0.009
1.256MetAsp: 1.256 ± 0.027
1.152MetGlu: 1.152 ± 0.022
0.686MetPhe: 0.686 ± 0.019
1.167MetGly: 1.167 ± 0.024
0.547MetHis: 0.547 ± 0.016
0.983MetIle: 0.983 ± 0.02
1.15MetLys: 1.15 ± 0.022
1.846MetLeu: 1.846 ± 0.03
0.539MetMet: 0.539 ± 0.015
0.912MetAsn: 0.912 ± 0.022
1.058MetPro: 1.058 ± 0.024
1.038MetGln: 1.038 ± 0.021
1.252MetArg: 1.252 ± 0.024
2.124MetSer: 2.124 ± 0.032
1.192MetThr: 1.192 ± 0.022
1.083MetVal: 1.083 ± 0.022
0.182MetTrp: 0.182 ± 0.01
0.51MetTyr: 0.51 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.782AsnAla: 3.782 ± 0.04
0.386AsnCys: 0.386 ± 0.012
2.98AsnAsp: 2.98 ± 0.04
2.759AsnGlu: 2.759 ± 0.036
1.425AsnPhe: 1.425 ± 0.025
2.713AsnGly: 2.713 ± 0.039
1.03AsnHis: 1.03 ± 0.022
2.256AsnIle: 2.256 ± 0.034
2.808AsnLys: 2.808 ± 0.038
3.861AsnLeu: 3.861 ± 0.04
0.856AsnMet: 0.856 ± 0.021
2.138AsnAsn: 2.138 ± 0.044
2.235AsnPro: 2.235 ± 0.035
1.73AsnGln: 1.73 ± 0.03
1.972AsnArg: 1.972 ± 0.031
3.497AsnSer: 3.497 ± 0.052
2.791AsnThr: 2.791 ± 0.039
2.803AsnVal: 2.803 ± 0.037
0.519AsnTrp: 0.519 ± 0.014
1.275AsnTyr: 1.275 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
4.289ProAla: 4.289 ± 0.072
0.338ProCys: 0.338 ± 0.014
2.504ProAsp: 2.504 ± 0.036
2.797ProGlu: 2.797 ± 0.039
1.875ProPhe: 1.875 ± 0.032
2.418ProGly: 2.418 ± 0.043
1.386ProHis: 1.386 ± 0.027
2.513ProIle: 2.513 ± 0.033
2.575ProLys: 2.575 ± 0.039
4.354ProLeu: 4.354 ± 0.049
0.863ProMet: 0.863 ± 0.022
2.058ProAsn: 2.058 ± 0.03
4.556ProPro: 4.556 ± 0.092
2.743ProGln: 2.743 ± 0.051
2.37ProArg: 2.37 ± 0.038
5.552ProSer: 5.552 ± 0.07
3.519ProThr: 3.519 ± 0.045
2.821ProVal: 2.821 ± 0.039
0.455ProTrp: 0.455 ± 0.013
1.445ProTyr: 1.445 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.524GlnAla: 3.524 ± 0.042
0.385GlnCys: 0.385 ± 0.014
2.38GlnAsp: 2.38 ± 0.033
2.396GlnGlu: 2.396 ± 0.036
1.456GlnPhe: 1.456 ± 0.025
2.164GlnGly: 2.164 ± 0.035
1.387GlnHis: 1.387 ± 0.026
2.157GlnIle: 2.157 ± 0.027
2.147GlnLys: 2.147 ± 0.035
4.467GlnLeu: 4.467 ± 0.049
0.988GlnMet: 0.988 ± 0.021
1.732GlnAsn: 1.732 ± 0.03
3.021GlnPro: 3.021 ± 0.05
3.756GlnGln: 3.756 ± 0.091
2.725GlnArg: 2.725 ± 0.036
4.249GlnSer: 4.249 ± 0.055
2.403GlnThr: 2.403 ± 0.036
2.507GlnVal: 2.507 ± 0.038
0.437GlnTrp: 0.437 ± 0.013
1.196GlnTyr: 1.196 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
3.89ArgAla: 3.89 ± 0.043
0.608ArgCys: 0.608 ± 0.018
3.221ArgAsp: 3.221 ± 0.044
3.386ArgGlu: 3.386 ± 0.051
1.904ArgPhe: 1.904 ± 0.029
3.005ArgGly: 3.005 ± 0.054
1.337ArgHis: 1.337 ± 0.023
2.751ArgIle: 2.751 ± 0.029
3.525ArgLys: 3.525 ± 0.043
5.042ArgLeu: 5.042 ± 0.058
1.237ArgMet: 1.237 ± 0.024
2.301ArgAsn: 2.301 ± 0.034
2.403ArgPro: 2.403 ± 0.038
2.54ArgGln: 2.54 ± 0.038
4.185ArgArg: 4.185 ± 0.058
4.624ArgSer: 4.624 ± 0.054
2.717ArgThr: 2.717 ± 0.036
3.305ArgVal: 3.305 ± 0.042
0.635ArgTrp: 0.635 ± 0.018
1.606ArgTyr: 1.606 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
6.857SerAla: 6.857 ± 0.064
0.706SerCys: 0.706 ± 0.021
5.024SerAsp: 5.024 ± 0.058
4.34SerGlu: 4.34 ± 0.051
3.183SerPhe: 3.183 ± 0.041
4.856SerGly: 4.856 ± 0.056
2.356SerHis: 2.356 ± 0.04
4.711SerIle: 4.711 ± 0.053
4.961SerLys: 4.961 ± 0.051
7.98SerLeu: 7.98 ± 0.066
1.631SerMet: 1.631 ± 0.028
4.223SerAsn: 4.223 ± 0.053
4.673SerPro: 4.673 ± 0.077
4.061SerGln: 4.061 ± 0.053
4.473SerArg: 4.473 ± 0.048
9.467SerSer: 9.467 ± 0.109
6.16SerThr: 6.16 ± 0.06
5.064SerVal: 5.064 ± 0.049
0.836SerTrp: 0.836 ± 0.021
2.284SerTyr: 2.284 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
4.634ThrAla: 4.634 ± 0.046
0.546ThrCys: 0.546 ± 0.017
2.865ThrAsp: 2.865 ± 0.039
2.716ThrGlu: 2.716 ± 0.034
2.13ThrPhe: 2.13 ± 0.032
3.193ThrGly: 3.193 ± 0.041
1.712ThrHis: 1.712 ± 0.03
3.033ThrIle: 3.033 ± 0.039
2.983ThrLys: 2.983 ± 0.038
5.814ThrLeu: 5.814 ± 0.061
0.983ThrMet: 0.983 ± 0.023
2.497ThrAsn: 2.497 ± 0.034
4.175ThrPro: 4.175 ± 0.058
2.804ThrGln: 2.804 ± 0.038
2.897ThrArg: 2.897 ± 0.038
5.228ThrSer: 5.228 ± 0.059
3.83ThrThr: 3.83 ± 0.048
3.304ThrVal: 3.304 ± 0.038
0.553ThrTrp: 0.553 ± 0.02
1.582ThrTyr: 1.582 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
4.839ValAla: 4.839 ± 0.051
0.731ValCys: 0.731 ± 0.021
4.513ValAsp: 4.513 ± 0.048
3.986ValGlu: 3.986 ± 0.047
2.296ValPhe: 2.296 ± 0.03
3.697ValGly: 3.697 ± 0.05
1.557ValHis: 1.557 ± 0.025
3.208ValIle: 3.208 ± 0.045
3.598ValLys: 3.598 ± 0.044
5.478ValLeu: 5.478 ± 0.062
1.312ValMet: 1.312 ± 0.023
2.697ValAsn: 2.697 ± 0.039
2.738ValPro: 2.738 ± 0.031
2.555ValGln: 2.555 ± 0.045
3.038ValArg: 3.038 ± 0.039
4.543ValSer: 4.543 ± 0.043
3.035ValThr: 3.035 ± 0.041
4.255ValVal: 4.255 ± 0.052
0.696ValTrp: 0.696 ± 0.02
1.92ValTyr: 1.92 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
0.683TrpAla: 0.683 ± 0.018
0.151TrpCys: 0.151 ± 0.009
0.719TrpAsp: 0.719 ± 0.02
0.588TrpGlu: 0.588 ± 0.017
0.446TrpPhe: 0.446 ± 0.015
0.619TrpGly: 0.619 ± 0.02
0.272TrpHis: 0.272 ± 0.012
0.631TrpIle: 0.631 ± 0.017
0.681TrpLys: 0.681 ± 0.017
1.096TrpLeu: 1.096 ± 0.022
0.299TrpMet: 0.299 ± 0.012
0.547TrpAsn: 0.547 ± 0.014
0.394TrpPro: 0.394 ± 0.013
0.453TrpGln: 0.453 ± 0.015
0.675TrpArg: 0.675 ± 0.019
0.975TrpSer: 0.975 ± 0.021
0.654TrpThr: 0.654 ± 0.016
0.601TrpVal: 0.601 ± 0.017
0.187TrpTrp: 0.187 ± 0.01
0.342TrpTyr: 0.342 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.326TyrAla: 2.326 ± 0.033
0.345TyrCys: 0.345 ± 0.014
1.955TyrAsp: 1.955 ± 0.028
1.644TyrGlu: 1.644 ± 0.03
1.12TyrPhe: 1.12 ± 0.025
1.82TyrGly: 1.82 ± 0.038
0.718TyrHis: 0.718 ± 0.016
1.561TyrIle: 1.561 ± 0.028
1.675TyrLys: 1.675 ± 0.027
2.793TyrLeu: 2.793 ± 0.039
0.594TyrMet: 0.594 ± 0.017
1.441TyrAsn: 1.441 ± 0.027
1.201TyrPro: 1.201 ± 0.026
1.106TyrGln: 1.106 ± 0.022
1.5TyrArg: 1.5 ± 0.025
2.305TyrSer: 2.305 ± 0.029
1.839TyrThr: 1.839 ± 0.03
1.659TyrVal: 1.659 ± 0.03
0.357TyrTrp: 0.357 ± 0.013
0.906TyrTyr: 0.906 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4107 proteins (2297997 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski