Amino acid dipepetide frequency for Acidianus rod-shaped virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.114AlaCys: 0.114 ± 0.107
3.194AlaAsp: 3.194 ± 0.581
4.107AlaGlu: 4.107 ± 0.916
2.396AlaPhe: 2.396 ± 0.753
2.282AlaGly: 2.282 ± 0.594
0.228AlaHis: 0.228 ± 0.176
6.845AlaIle: 6.845 ± 1.192
5.704AlaLys: 5.704 ± 0.736
7.415AlaLeu: 7.415 ± 0.929
0.684AlaMet: 0.684 ± 0.314
3.194AlaAsn: 3.194 ± 0.6
1.255AlaPro: 1.255 ± 0.351
2.624AlaGln: 2.624 ± 0.615
2.396AlaArg: 2.396 ± 0.406
2.966AlaSer: 2.966 ± 0.579
3.765AlaThr: 3.765 ± 0.584
3.308AlaVal: 3.308 ± 0.543
0.913AlaTrp: 0.913 ± 0.267
3.536AlaTyr: 3.536 ± 1.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.114CysAla: 0.114 ± 0.121
0.0CysCys: 0.0 ± 0.0
0.114CysAsp: 0.114 ± 0.138
1.027CysGlu: 1.027 ± 0.482
0.342CysPhe: 0.342 ± 0.204
0.684CysGly: 0.684 ± 0.295
0.0CysHis: 0.0 ± 0.0
0.456CysIle: 0.456 ± 0.228
0.913CysLys: 0.913 ± 0.343
0.57CysLeu: 0.57 ± 0.254
0.114CysMet: 0.114 ± 0.101
0.456CysAsn: 0.456 ± 0.24
0.228CysPro: 0.228 ± 0.172
0.456CysGln: 0.456 ± 0.232
0.228CysArg: 0.228 ± 0.164
0.456CysSer: 0.456 ± 0.182
0.342CysThr: 0.342 ± 0.19
0.114CysVal: 0.114 ± 0.138
0.0CysTrp: 0.0 ± 0.0
0.684CysTyr: 0.684 ± 0.257
0.0CysXaa: 0.0 ± 0.0
Asp
3.308AspAla: 3.308 ± 0.544
0.57AspCys: 0.57 ± 0.32
2.624AspAsp: 2.624 ± 0.576
3.993AspGlu: 3.993 ± 0.742
2.396AspPhe: 2.396 ± 0.433
1.597AspGly: 1.597 ± 0.406
0.456AspHis: 0.456 ± 0.176
4.107AspIle: 4.107 ± 0.701
4.677AspLys: 4.677 ± 1.072
6.274AspLeu: 6.274 ± 0.9
0.342AspMet: 0.342 ± 0.18
3.765AspAsn: 3.765 ± 0.716
1.597AspPro: 1.597 ± 0.39
2.282AspGln: 2.282 ± 0.583
1.711AspArg: 1.711 ± 0.443
2.396AspSer: 2.396 ± 0.527
1.711AspThr: 1.711 ± 0.447
4.221AspVal: 4.221 ± 0.712
0.913AspTrp: 0.913 ± 0.371
2.167AspTyr: 2.167 ± 0.572
0.0AspXaa: 0.0 ± 0.0
Glu
3.194GluAla: 3.194 ± 0.655
0.456GluCys: 0.456 ± 0.224
3.194GluAsp: 3.194 ± 0.699
4.449GluGlu: 4.449 ± 0.767
2.966GluPhe: 2.966 ± 0.53
2.282GluGly: 2.282 ± 0.503
0.342GluHis: 0.342 ± 0.172
10.153GluIle: 10.153 ± 1.725
7.415GluLys: 7.415 ± 0.976
6.046GluLeu: 6.046 ± 1.258
2.167GluMet: 2.167 ± 0.74
4.335GluAsn: 4.335 ± 0.65
1.939GluPro: 1.939 ± 0.418
3.08GluGln: 3.08 ± 0.753
1.939GluArg: 1.939 ± 0.43
1.483GluSer: 1.483 ± 0.325
2.966GluThr: 2.966 ± 0.538
3.65GluVal: 3.65 ± 0.708
0.456GluTrp: 0.456 ± 0.245
3.422GluTyr: 3.422 ± 0.65
0.0GluXaa: 0.0 ± 0.0
Phe
3.65PheAla: 3.65 ± 0.893
1.027PheCys: 1.027 ± 0.404
3.308PheAsp: 3.308 ± 0.713
3.194PheGlu: 3.194 ± 0.615
2.282PhePhe: 2.282 ± 0.651
2.966PheGly: 2.966 ± 0.541
0.684PheHis: 0.684 ± 0.321
4.221PheIle: 4.221 ± 0.893
3.879PheLys: 3.879 ± 0.717
4.905PheLeu: 4.905 ± 0.915
0.799PheMet: 0.799 ± 0.286
3.422PheAsn: 3.422 ± 0.613
1.369PhePro: 1.369 ± 0.472
1.711PheGln: 1.711 ± 0.434
1.711PheArg: 1.711 ± 0.405
3.422PheSer: 3.422 ± 0.379
3.08PheThr: 3.08 ± 0.723
4.221PheVal: 4.221 ± 0.767
0.228PheTrp: 0.228 ± 0.249
2.053PheTyr: 2.053 ± 0.472
0.0PheXaa: 0.0 ± 0.0
Gly
2.624GlyAla: 2.624 ± 0.51
0.57GlyCys: 0.57 ± 0.321
2.396GlyAsp: 2.396 ± 0.514
3.08GlyGlu: 3.08 ± 0.501
2.738GlyPhe: 2.738 ± 0.605
2.624GlyGly: 2.624 ± 0.786
0.684GlyHis: 0.684 ± 0.308
4.335GlyIle: 4.335 ± 0.772
3.765GlyLys: 3.765 ± 0.617
4.107GlyLeu: 4.107 ± 0.686
1.369GlyMet: 1.369 ± 0.385
2.852GlyAsn: 2.852 ± 1.012
1.939GlyPro: 1.939 ± 0.559
1.255GlyGln: 1.255 ± 0.428
0.799GlyArg: 0.799 ± 0.3
2.624GlySer: 2.624 ± 0.741
1.597GlyThr: 1.597 ± 0.499
4.107GlyVal: 4.107 ± 0.66
0.456GlyTrp: 0.456 ± 0.236
2.966GlyTyr: 2.966 ± 0.603
0.0GlyXaa: 0.0 ± 0.0
His
0.57HisAla: 0.57 ± 0.228
0.228HisCys: 0.228 ± 0.173
0.799HisAsp: 0.799 ± 0.412
0.228HisGlu: 0.228 ± 0.138
1.141HisPhe: 1.141 ± 0.322
0.799HisGly: 0.799 ± 0.353
0.342HisHis: 0.342 ± 0.194
1.027HisIle: 1.027 ± 0.332
0.456HisLys: 0.456 ± 0.223
1.027HisLeu: 1.027 ± 0.291
0.342HisMet: 0.342 ± 0.19
0.456HisAsn: 0.456 ± 0.205
0.456HisPro: 0.456 ± 0.285
0.114HisGln: 0.114 ± 0.122
0.456HisArg: 0.456 ± 0.222
0.799HisSer: 0.799 ± 0.289
0.684HisThr: 0.684 ± 0.342
0.799HisVal: 0.799 ± 0.305
0.114HisTrp: 0.114 ± 0.121
0.684HisTyr: 0.684 ± 0.267
0.0HisXaa: 0.0 ± 0.0
Ile
6.16IleAla: 6.16 ± 0.903
0.57IleCys: 0.57 ± 0.261
3.536IleAsp: 3.536 ± 0.581
7.415IleGlu: 7.415 ± 0.987
5.59IlePhe: 5.59 ± 0.952
3.536IleGly: 3.536 ± 0.742
1.369IleHis: 1.369 ± 0.45
6.959IleIle: 6.959 ± 1.229
6.046IleLys: 6.046 ± 0.744
7.757IleLeu: 7.757 ± 1.227
1.255IleMet: 1.255 ± 0.331
4.791IleAsn: 4.791 ± 0.792
5.59IlePro: 5.59 ± 0.774
4.905IleGln: 4.905 ± 0.996
3.308IleArg: 3.308 ± 0.861
6.388IleSer: 6.388 ± 1.18
4.221IleThr: 4.221 ± 1.122
7.643IleVal: 7.643 ± 1.509
0.799IleTrp: 0.799 ± 0.228
4.563IleTyr: 4.563 ± 0.914
0.0IleXaa: 0.0 ± 0.0
Lys
3.765LysAla: 3.765 ± 0.596
0.342LysCys: 0.342 ± 0.212
4.335LysAsp: 4.335 ± 0.834
5.248LysGlu: 5.248 ± 0.913
3.65LysPhe: 3.65 ± 0.727
2.966LysGly: 2.966 ± 0.429
0.456LysHis: 0.456 ± 0.24
9.468LysIle: 9.468 ± 1.185
6.731LysLys: 6.731 ± 1.054
8.214LysLeu: 8.214 ± 1.02
2.624LysMet: 2.624 ± 0.552
3.993LysAsn: 3.993 ± 0.816
1.369LysPro: 1.369 ± 0.404
3.536LysGln: 3.536 ± 0.61
2.167LysArg: 2.167 ± 0.504
3.422LysSer: 3.422 ± 0.576
3.422LysThr: 3.422 ± 0.635
4.563LysVal: 4.563 ± 0.903
0.57LysTrp: 0.57 ± 0.258
6.502LysTyr: 6.502 ± 0.816
0.0LysXaa: 0.0 ± 0.0
Leu
5.019LeuAla: 5.019 ± 0.971
0.57LeuCys: 0.57 ± 0.256
6.16LeuAsp: 6.16 ± 1.241
6.046LeuGlu: 6.046 ± 0.791
3.536LeuPhe: 3.536 ± 0.525
4.449LeuGly: 4.449 ± 0.934
1.027LeuHis: 1.027 ± 0.423
7.643LeuIle: 7.643 ± 1.322
7.871LeuLys: 7.871 ± 0.857
8.898LeuLeu: 8.898 ± 1.364
2.282LeuMet: 2.282 ± 0.412
5.476LeuAsn: 5.476 ± 0.61
3.879LeuPro: 3.879 ± 0.562
5.704LeuGln: 5.704 ± 1.272
4.221LeuArg: 4.221 ± 0.819
5.932LeuSer: 5.932 ± 0.862
5.362LeuThr: 5.362 ± 0.885
3.65LeuVal: 3.65 ± 0.567
1.027LeuTrp: 1.027 ± 0.362
7.073LeuTyr: 7.073 ± 0.974
0.0LeuXaa: 0.0 ± 0.0
Met
1.597MetAla: 1.597 ± 0.574
0.0MetCys: 0.0 ± 0.0
0.684MetAsp: 0.684 ± 0.299
1.597MetGlu: 1.597 ± 0.566
1.255MetPhe: 1.255 ± 0.315
1.027MetGly: 1.027 ± 0.343
0.228MetHis: 0.228 ± 0.158
1.825MetIle: 1.825 ± 0.41
0.913MetLys: 0.913 ± 0.346
1.255MetLeu: 1.255 ± 0.376
0.342MetMet: 0.342 ± 0.162
0.913MetAsn: 0.913 ± 0.292
1.711MetPro: 1.711 ± 0.343
1.027MetGln: 1.027 ± 0.314
0.799MetArg: 0.799 ± 0.305
2.51MetSer: 2.51 ± 0.364
1.141MetThr: 1.141 ± 0.39
0.684MetVal: 0.684 ± 0.275
0.228MetTrp: 0.228 ± 0.164
1.255MetTyr: 1.255 ± 0.395
0.0MetXaa: 0.0 ± 0.0
Asn
4.107AsnAla: 4.107 ± 0.915
1.141AsnCys: 1.141 ± 0.332
1.939AsnAsp: 1.939 ± 0.397
3.879AsnGlu: 3.879 ± 0.698
4.563AsnPhe: 4.563 ± 0.664
2.624AsnGly: 2.624 ± 0.452
0.684AsnHis: 0.684 ± 0.255
5.59AsnIle: 5.59 ± 1.149
3.422AsnLys: 3.422 ± 0.865
5.818AsnLeu: 5.818 ± 0.795
1.369AsnMet: 1.369 ± 0.506
3.879AsnAsn: 3.879 ± 0.925
2.738AsnPro: 2.738 ± 0.606
2.053AsnGln: 2.053 ± 0.446
1.369AsnArg: 1.369 ± 0.379
4.107AsnSer: 4.107 ± 1.127
2.624AsnThr: 2.624 ± 0.634
5.818AsnVal: 5.818 ± 0.98
0.228AsnTrp: 0.228 ± 0.121
3.993AsnTyr: 3.993 ± 0.69
0.0AsnXaa: 0.0 ± 0.0
Pro
2.282ProAla: 2.282 ± 0.399
0.228ProCys: 0.228 ± 0.185
2.624ProAsp: 2.624 ± 0.47
3.08ProGlu: 3.08 ± 0.525
1.255ProPhe: 1.255 ± 0.376
2.053ProGly: 2.053 ± 0.539
1.027ProHis: 1.027 ± 0.331
3.194ProIle: 3.194 ± 0.541
2.053ProLys: 2.053 ± 0.565
2.167ProLeu: 2.167 ± 0.352
0.342ProMet: 0.342 ± 0.228
1.939ProAsn: 1.939 ± 0.501
2.624ProPro: 2.624 ± 0.541
0.799ProGln: 0.799 ± 0.308
1.483ProArg: 1.483 ± 0.403
3.308ProSer: 3.308 ± 0.587
3.308ProThr: 3.308 ± 0.706
2.738ProVal: 2.738 ± 0.652
0.228ProTrp: 0.228 ± 0.15
2.282ProTyr: 2.282 ± 0.482
0.0ProXaa: 0.0 ± 0.0
Gln
1.141GlnAla: 1.141 ± 0.424
0.114GlnCys: 0.114 ± 0.096
1.597GlnAsp: 1.597 ± 0.363
2.738GlnGlu: 2.738 ± 0.626
2.053GlnPhe: 2.053 ± 0.367
1.825GlnGly: 1.825 ± 0.451
0.57GlnHis: 0.57 ± 0.203
5.019GlnIle: 5.019 ± 0.772
4.335GlnLys: 4.335 ± 0.704
5.932GlnLeu: 5.932 ± 1.05
0.913GlnMet: 0.913 ± 0.346
4.905GlnAsn: 4.905 ± 1.15
1.027GlnPro: 1.027 ± 0.324
2.396GlnGln: 2.396 ± 0.603
1.027GlnArg: 1.027 ± 0.276
1.825GlnSer: 1.825 ± 0.388
1.141GlnThr: 1.141 ± 0.317
2.51GlnVal: 2.51 ± 0.545
0.228GlnTrp: 0.228 ± 0.152
2.966GlnTyr: 2.966 ± 0.665
0.0GlnXaa: 0.0 ± 0.0
Arg
1.825ArgAla: 1.825 ± 0.517
0.114ArgCys: 0.114 ± 0.114
0.799ArgAsp: 0.799 ± 0.262
1.939ArgGlu: 1.939 ± 0.552
2.167ArgPhe: 2.167 ± 0.631
1.369ArgGly: 1.369 ± 0.355
0.342ArgHis: 0.342 ± 0.203
3.308ArgIle: 3.308 ± 0.625
2.852ArgLys: 2.852 ± 0.702
2.51ArgLeu: 2.51 ± 0.334
0.684ArgMet: 0.684 ± 0.249
1.597ArgAsn: 1.597 ± 0.325
0.456ArgPro: 0.456 ± 0.217
2.282ArgGln: 2.282 ± 0.532
1.711ArgArg: 1.711 ± 0.488
2.282ArgSer: 2.282 ± 0.575
0.913ArgThr: 0.913 ± 0.253
1.939ArgVal: 1.939 ± 0.479
0.0ArgTrp: 0.0 ± 0.0
2.053ArgTyr: 2.053 ± 0.564
0.0ArgXaa: 0.0 ± 0.0
Ser
4.677SerAla: 4.677 ± 0.781
0.342SerCys: 0.342 ± 0.189
4.221SerAsp: 4.221 ± 0.855
3.08SerGlu: 3.08 ± 0.578
2.966SerPhe: 2.966 ± 0.639
4.107SerGly: 4.107 ± 1.094
0.799SerHis: 0.799 ± 0.266
3.765SerIle: 3.765 ± 0.774
3.65SerLys: 3.65 ± 0.646
4.905SerLeu: 4.905 ± 1.038
1.483SerMet: 1.483 ± 0.541
3.879SerAsn: 3.879 ± 0.796
2.624SerPro: 2.624 ± 0.711
2.51SerGln: 2.51 ± 0.557
1.711SerArg: 1.711 ± 0.409
3.536SerSer: 3.536 ± 1.318
3.65SerThr: 3.65 ± 0.459
2.966SerVal: 2.966 ± 0.568
1.027SerTrp: 1.027 ± 0.283
2.053SerTyr: 2.053 ± 0.41
0.0SerXaa: 0.0 ± 0.0
Thr
3.765ThrAla: 3.765 ± 0.688
0.114ThrCys: 0.114 ± 0.109
1.711ThrAsp: 1.711 ± 0.417
3.308ThrGlu: 3.308 ± 0.593
2.738ThrPhe: 2.738 ± 0.546
2.396ThrGly: 2.396 ± 0.599
0.57ThrHis: 0.57 ± 0.249
5.476ThrIle: 5.476 ± 1.204
2.738ThrLys: 2.738 ± 0.549
4.335ThrLeu: 4.335 ± 0.745
0.799ThrMet: 0.799 ± 0.344
3.308ThrAsn: 3.308 ± 0.738
2.852ThrPro: 2.852 ± 0.596
2.396ThrGln: 2.396 ± 0.541
0.913ThrArg: 0.913 ± 0.279
2.053ThrSer: 2.053 ± 0.365
3.993ThrThr: 3.993 ± 0.643
4.221ThrVal: 4.221 ± 0.661
0.57ThrTrp: 0.57 ± 0.302
2.51ThrTyr: 2.51 ± 0.567
0.0ThrXaa: 0.0 ± 0.0
Val
5.019ValAla: 5.019 ± 0.733
0.57ValCys: 0.57 ± 0.327
4.449ValAsp: 4.449 ± 0.69
4.677ValGlu: 4.677 ± 0.64
3.422ValPhe: 3.422 ± 0.611
3.765ValGly: 3.765 ± 0.586
0.799ValHis: 0.799 ± 0.33
3.765ValIle: 3.765 ± 0.548
4.677ValLys: 4.677 ± 0.845
6.502ValLeu: 6.502 ± 0.998
0.913ValMet: 0.913 ± 0.3
3.08ValAsn: 3.08 ± 0.46
2.282ValPro: 2.282 ± 0.562
1.711ValGln: 1.711 ± 0.449
1.255ValArg: 1.255 ± 0.368
5.476ValSer: 5.476 ± 0.75
3.65ValThr: 3.65 ± 0.723
4.335ValVal: 4.335 ± 0.75
0.456ValTrp: 0.456 ± 0.194
5.362ValTyr: 5.362 ± 0.746
0.0ValXaa: 0.0 ± 0.0
Trp
0.57TrpAla: 0.57 ± 0.28
0.0TrpCys: 0.0 ± 0.0
0.228TrpAsp: 0.228 ± 0.161
0.684TrpGlu: 0.684 ± 0.221
0.57TrpPhe: 0.57 ± 0.232
0.0TrpGly: 0.0 ± 0.0
0.342TrpHis: 0.342 ± 0.164
0.57TrpIle: 0.57 ± 0.242
1.483TrpLys: 1.483 ± 0.403
0.114TrpLeu: 0.114 ± 0.107
0.228TrpMet: 0.228 ± 0.18
1.369TrpAsn: 1.369 ± 0.401
0.0TrpPro: 0.0 ± 0.0
0.342TrpGln: 0.342 ± 0.17
0.228TrpArg: 0.228 ± 0.146
0.228TrpSer: 0.228 ± 0.172
0.799TrpThr: 0.799 ± 0.355
0.456TrpVal: 0.456 ± 0.214
0.0TrpTrp: 0.0 ± 0.0
0.913TrpTyr: 0.913 ± 0.283
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.536TyrAla: 3.536 ± 0.61
0.228TyrCys: 0.228 ± 0.157
3.194TyrAsp: 3.194 ± 0.687
2.167TyrGlu: 2.167 ± 0.453
4.107TyrPhe: 4.107 ± 0.763
3.536TyrGly: 3.536 ± 0.5
0.57TyrHis: 0.57 ± 0.234
4.677TyrIle: 4.677 ± 0.644
3.765TyrLys: 3.765 ± 0.642
7.073TyrLeu: 7.073 ± 0.673
1.825TyrMet: 1.825 ± 0.34
4.335TyrAsn: 4.335 ± 0.87
3.08TyrPro: 3.08 ± 0.691
3.08TyrGln: 3.08 ± 0.644
1.711TyrArg: 1.711 ± 0.481
2.738TyrSer: 2.738 ± 0.645
2.396TyrThr: 2.396 ± 0.525
4.335TyrVal: 4.335 ± 0.623
0.684TyrTrp: 0.684 ± 0.265
4.221TyrTyr: 4.221 ± 0.64
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (8767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski