Amino acid dipepetide frequency for Xanthomonas phage XAJ2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.473AlaAla: 13.473 ± 2.564
0.774AlaCys: 0.774 ± 0.2
5.737AlaAsp: 5.737 ± 0.423
6.898AlaGlu: 6.898 ± 0.615
4.255AlaPhe: 4.255 ± 0.533
7.865AlaGly: 7.865 ± 0.688
1.483AlaHis: 1.483 ± 0.277
5.609AlaIle: 5.609 ± 0.556
6.318AlaLys: 6.318 ± 0.832
8.123AlaLeu: 8.123 ± 0.888
2.127AlaMet: 2.127 ± 0.372
4.384AlaAsn: 4.384 ± 0.569
3.675AlaPro: 3.675 ± 0.396
4.513AlaGln: 4.513 ± 1.238
4.899AlaArg: 4.899 ± 0.789
6.447AlaSer: 6.447 ± 1.184
6.511AlaThr: 6.511 ± 0.78
6.253AlaVal: 6.253 ± 0.625
1.676AlaTrp: 1.676 ± 0.313
3.094AlaTyr: 3.094 ± 0.569
0.0AlaXaa: 0.0 ± 0.0
Cys
0.838CysAla: 0.838 ± 0.28
0.193CysCys: 0.193 ± 0.122
0.838CysAsp: 0.838 ± 0.198
0.709CysGlu: 0.709 ± 0.273
0.645CysPhe: 0.645 ± 0.21
0.58CysGly: 0.58 ± 0.225
0.387CysHis: 0.387 ± 0.163
0.516CysIle: 0.516 ± 0.217
0.709CysLys: 0.709 ± 0.274
0.774CysLeu: 0.774 ± 0.213
0.193CysMet: 0.193 ± 0.147
0.451CysAsn: 0.451 ± 0.173
0.387CysPro: 0.387 ± 0.131
0.258CysGln: 0.258 ± 0.146
0.774CysArg: 0.774 ± 0.243
0.193CysSer: 0.193 ± 0.107
0.516CysThr: 0.516 ± 0.177
0.58CysVal: 0.58 ± 0.199
0.129CysTrp: 0.129 ± 0.079
0.258CysTyr: 0.258 ± 0.113
0.0CysXaa: 0.0 ± 0.0
Asp
5.931AspAla: 5.931 ± 0.568
0.451AspCys: 0.451 ± 0.161
3.094AspAsp: 3.094 ± 0.49
4.642AspGlu: 4.642 ± 0.523
2.579AspPhe: 2.579 ± 0.375
4.319AspGly: 4.319 ± 0.471
0.451AspHis: 0.451 ± 0.17
2.708AspIle: 2.708 ± 0.318
2.901AspLys: 2.901 ± 0.42
4.642AspLeu: 4.642 ± 0.709
0.967AspMet: 0.967 ± 0.261
2.127AspAsn: 2.127 ± 0.315
2.385AspPro: 2.385 ± 0.377
1.031AspGln: 1.031 ± 0.231
2.127AspArg: 2.127 ± 0.341
3.223AspSer: 3.223 ± 0.448
1.87AspThr: 1.87 ± 0.353
3.675AspVal: 3.675 ± 0.48
1.096AspTrp: 1.096 ± 0.343
1.87AspTyr: 1.87 ± 0.381
0.0AspXaa: 0.0 ± 0.0
Glu
6.511GluAla: 6.511 ± 0.73
0.516GluCys: 0.516 ± 0.236
3.739GluAsp: 3.739 ± 0.472
3.997GluGlu: 3.997 ± 0.585
3.288GluPhe: 3.288 ± 0.444
3.159GluGly: 3.159 ± 0.339
1.289GluHis: 1.289 ± 0.366
3.739GluIle: 3.739 ± 0.462
3.739GluLys: 3.739 ± 0.677
4.835GluLeu: 4.835 ± 0.515
2.063GluMet: 2.063 ± 0.373
2.127GluAsn: 2.127 ± 0.362
2.385GluPro: 2.385 ± 0.432
3.417GluGln: 3.417 ± 0.557
3.481GluArg: 3.481 ± 0.423
3.159GluSer: 3.159 ± 0.402
3.739GluThr: 3.739 ± 0.444
4.255GluVal: 4.255 ± 0.69
1.483GluTrp: 1.483 ± 0.308
2.192GluTyr: 2.192 ± 0.399
0.0GluXaa: 0.0 ± 0.0
Phe
3.739PheAla: 3.739 ± 0.588
0.322PheCys: 0.322 ± 0.148
3.61PheAsp: 3.61 ± 0.577
2.45PheGlu: 2.45 ± 0.385
1.934PhePhe: 1.934 ± 0.392
2.708PheGly: 2.708 ± 0.4
0.322PheHis: 0.322 ± 0.137
2.127PheIle: 2.127 ± 0.349
2.192PheLys: 2.192 ± 0.462
1.741PheLeu: 1.741 ± 0.309
1.031PheMet: 1.031 ± 0.281
2.385PheAsn: 2.385 ± 0.283
1.354PhePro: 1.354 ± 0.402
1.418PheGln: 1.418 ± 0.277
1.934PheArg: 1.934 ± 0.373
2.643PheSer: 2.643 ± 0.45
3.288PheThr: 3.288 ± 0.424
2.127PheVal: 2.127 ± 0.309
0.387PheTrp: 0.387 ± 0.143
1.418PheTyr: 1.418 ± 0.309
0.0PheXaa: 0.0 ± 0.0
Gly
5.737GlyAla: 5.737 ± 0.885
0.516GlyCys: 0.516 ± 0.19
3.159GlyAsp: 3.159 ± 0.451
4.448GlyGlu: 4.448 ± 0.52
3.546GlyPhe: 3.546 ± 0.518
6.447GlyGly: 6.447 ± 0.9
1.354GlyHis: 1.354 ± 0.362
3.546GlyIle: 3.546 ± 0.365
4.706GlyLys: 4.706 ± 0.555
5.866GlyLeu: 5.866 ± 0.721
1.225GlyMet: 1.225 ± 0.286
3.61GlyAsn: 3.61 ± 0.433
2.708GlyPro: 2.708 ± 0.416
2.837GlyGln: 2.837 ± 0.485
3.223GlyArg: 3.223 ± 0.38
5.737GlySer: 5.737 ± 0.579
4.771GlyThr: 4.771 ± 0.562
5.351GlyVal: 5.351 ± 0.616
1.289GlyTrp: 1.289 ± 0.301
2.45GlyTyr: 2.45 ± 0.375
0.0GlyXaa: 0.0 ± 0.0
His
1.418HisAla: 1.418 ± 0.309
0.258HisCys: 0.258 ± 0.153
0.709HisAsp: 0.709 ± 0.289
0.903HisGlu: 0.903 ± 0.265
0.451HisPhe: 0.451 ± 0.209
1.225HisGly: 1.225 ± 0.334
0.193HisHis: 0.193 ± 0.112
0.774HisIle: 0.774 ± 0.192
1.096HisLys: 1.096 ± 0.36
0.967HisLeu: 0.967 ± 0.237
0.387HisMet: 0.387 ± 0.176
0.838HisAsn: 0.838 ± 0.222
0.838HisPro: 0.838 ± 0.237
0.322HisGln: 0.322 ± 0.137
0.709HisArg: 0.709 ± 0.246
1.483HisSer: 1.483 ± 0.335
0.516HisThr: 0.516 ± 0.159
0.903HisVal: 0.903 ± 0.277
0.516HisTrp: 0.516 ± 0.211
0.58HisTyr: 0.58 ± 0.148
0.0HisXaa: 0.0 ± 0.0
Ile
7.349IleAla: 7.349 ± 0.602
1.031IleCys: 1.031 ± 0.313
3.675IleAsp: 3.675 ± 0.413
4.706IleGlu: 4.706 ± 0.507
1.418IlePhe: 1.418 ± 0.339
4.642IleGly: 4.642 ± 0.394
0.774IleHis: 0.774 ± 0.233
2.643IleIle: 2.643 ± 0.43
3.675IleLys: 3.675 ± 0.441
3.868IleLeu: 3.868 ± 0.547
1.289IleMet: 1.289 ± 0.295
3.546IleAsn: 3.546 ± 0.544
2.772IlePro: 2.772 ± 0.449
1.096IleGln: 1.096 ± 0.263
2.45IleArg: 2.45 ± 0.395
2.965IleSer: 2.965 ± 0.264
2.45IleThr: 2.45 ± 0.433
3.868IleVal: 3.868 ± 0.507
0.387IleTrp: 0.387 ± 0.138
1.676IleTyr: 1.676 ± 0.339
0.0IleXaa: 0.0 ± 0.0
Lys
5.866LysAla: 5.866 ± 0.735
0.58LysCys: 0.58 ± 0.17
2.063LysAsp: 2.063 ± 0.471
3.868LysGlu: 3.868 ± 0.553
2.772LysPhe: 2.772 ± 0.417
3.159LysGly: 3.159 ± 0.474
1.096LysHis: 1.096 ± 0.3
2.965LysIle: 2.965 ± 0.415
3.739LysLys: 3.739 ± 0.515
7.027LysLeu: 7.027 ± 0.831
1.805LysMet: 1.805 ± 0.371
2.385LysAsn: 2.385 ± 0.385
3.159LysPro: 3.159 ± 0.443
2.965LysGln: 2.965 ± 0.511
4.448LysArg: 4.448 ± 0.577
3.61LysSer: 3.61 ± 0.561
4.771LysThr: 4.771 ± 0.615
3.675LysVal: 3.675 ± 0.424
0.967LysTrp: 0.967 ± 0.272
1.418LysTyr: 1.418 ± 0.315
0.0LysXaa: 0.0 ± 0.0
Leu
7.478LeuAla: 7.478 ± 1.02
0.516LeuCys: 0.516 ± 0.181
4.513LeuAsp: 4.513 ± 0.422
4.19LeuGlu: 4.19 ± 0.516
2.45LeuPhe: 2.45 ± 0.371
5.028LeuGly: 5.028 ± 0.604
1.418LeuHis: 1.418 ± 0.341
4.964LeuIle: 4.964 ± 0.573
6.318LeuLys: 6.318 ± 0.666
5.866LeuLeu: 5.866 ± 0.676
2.643LeuMet: 2.643 ± 0.387
4.126LeuAsn: 4.126 ± 0.482
3.481LeuPro: 3.481 ± 0.534
4.061LeuGln: 4.061 ± 0.477
4.319LeuArg: 4.319 ± 0.58
5.737LeuSer: 5.737 ± 0.519
4.513LeuThr: 4.513 ± 0.491
3.804LeuVal: 3.804 ± 0.501
1.225LeuTrp: 1.225 ± 0.257
2.45LeuTyr: 2.45 ± 0.47
0.0LeuXaa: 0.0 ± 0.0
Met
2.192MetAla: 2.192 ± 0.393
0.129MetCys: 0.129 ± 0.087
1.031MetAsp: 1.031 ± 0.287
0.774MetGlu: 0.774 ± 0.221
0.838MetPhe: 0.838 ± 0.221
1.418MetGly: 1.418 ± 0.243
0.645MetHis: 0.645 ± 0.246
0.967MetIle: 0.967 ± 0.335
1.934MetLys: 1.934 ± 0.372
2.643MetLeu: 2.643 ± 0.485
0.387MetMet: 0.387 ± 0.149
1.289MetAsn: 1.289 ± 0.354
1.418MetPro: 1.418 ± 0.276
1.16MetGln: 1.16 ± 0.281
1.16MetArg: 1.16 ± 0.248
2.385MetSer: 2.385 ± 0.359
1.031MetThr: 1.031 ± 0.257
1.354MetVal: 1.354 ± 0.4
0.322MetTrp: 0.322 ± 0.161
0.645MetTyr: 0.645 ± 0.198
0.0MetXaa: 0.0 ± 0.0
Asn
5.544AsnAla: 5.544 ± 0.769
0.645AsnCys: 0.645 ± 0.204
1.998AsnAsp: 1.998 ± 0.386
2.643AsnGlu: 2.643 ± 0.52
1.16AsnPhe: 1.16 ± 0.244
3.932AsnGly: 3.932 ± 0.467
0.645AsnHis: 0.645 ± 0.169
2.901AsnIle: 2.901 ± 0.374
4.19AsnLys: 4.19 ± 0.524
2.45AsnLeu: 2.45 ± 0.311
1.16AsnMet: 1.16 ± 0.223
2.837AsnAsn: 2.837 ± 0.405
2.256AsnPro: 2.256 ± 0.333
1.998AsnGln: 1.998 ± 0.354
2.321AsnArg: 2.321 ± 0.35
2.772AsnSer: 2.772 ± 0.419
2.708AsnThr: 2.708 ± 0.42
4.061AsnVal: 4.061 ± 0.535
0.451AsnTrp: 0.451 ± 0.149
1.418AsnTyr: 1.418 ± 0.402
0.0AsnXaa: 0.0 ± 0.0
Pro
4.513ProAla: 4.513 ± 0.637
0.064ProCys: 0.064 ± 0.066
1.998ProAsp: 1.998 ± 0.367
2.708ProGlu: 2.708 ± 0.445
1.998ProPhe: 1.998 ± 0.367
2.772ProGly: 2.772 ± 0.512
0.709ProHis: 0.709 ± 0.216
2.514ProIle: 2.514 ± 0.333
2.772ProLys: 2.772 ± 0.449
2.45ProLeu: 2.45 ± 0.356
0.838ProMet: 0.838 ± 0.281
2.772ProAsn: 2.772 ± 0.484
2.256ProPro: 2.256 ± 0.425
1.934ProGln: 1.934 ± 0.308
1.998ProArg: 1.998 ± 0.321
3.03ProSer: 3.03 ± 0.438
3.094ProThr: 3.094 ± 0.422
3.546ProVal: 3.546 ± 0.433
0.58ProTrp: 0.58 ± 0.191
1.354ProTyr: 1.354 ± 0.419
0.0ProXaa: 0.0 ± 0.0
Gln
4.255GlnAla: 4.255 ± 0.746
0.129GlnCys: 0.129 ± 0.094
1.16GlnAsp: 1.16 ± 0.261
2.127GlnGlu: 2.127 ± 0.415
1.096GlnPhe: 1.096 ± 0.222
2.192GlnGly: 2.192 ± 0.554
0.58GlnHis: 0.58 ± 0.204
2.192GlnIle: 2.192 ± 0.45
2.192GlnLys: 2.192 ± 0.347
5.286GlnLeu: 5.286 ± 0.719
1.676GlnMet: 1.676 ± 0.397
2.127GlnAsn: 2.127 ± 0.618
2.192GlnPro: 2.192 ± 0.492
3.159GlnGln: 3.159 ± 1.533
2.063GlnArg: 2.063 ± 0.321
2.192GlnSer: 2.192 ± 0.393
2.579GlnThr: 2.579 ± 0.497
2.321GlnVal: 2.321 ± 0.305
0.58GlnTrp: 0.58 ± 0.206
1.676GlnTyr: 1.676 ± 0.306
0.0GlnXaa: 0.0 ± 0.0
Arg
5.351ArgAla: 5.351 ± 0.673
0.58ArgCys: 0.58 ± 0.188
2.772ArgAsp: 2.772 ± 0.425
2.127ArgGlu: 2.127 ± 0.32
1.934ArgPhe: 1.934 ± 0.319
3.932ArgGly: 3.932 ± 0.495
0.645ArgHis: 0.645 ± 0.191
3.932ArgIle: 3.932 ± 0.503
3.094ArgLys: 3.094 ± 0.445
4.126ArgLeu: 4.126 ± 0.488
1.547ArgMet: 1.547 ± 0.225
2.514ArgAsn: 2.514 ± 0.288
1.998ArgPro: 1.998 ± 0.308
1.805ArgGln: 1.805 ± 0.273
3.223ArgArg: 3.223 ± 0.452
3.159ArgSer: 3.159 ± 0.43
3.094ArgThr: 3.094 ± 0.479
3.094ArgVal: 3.094 ± 0.484
0.516ArgTrp: 0.516 ± 0.203
1.289ArgTyr: 1.289 ± 0.255
0.0ArgXaa: 0.0 ± 0.0
Ser
7.671SerAla: 7.671 ± 0.961
0.258SerCys: 0.258 ± 0.116
3.546SerAsp: 3.546 ± 0.463
4.513SerGlu: 4.513 ± 0.478
2.708SerPhe: 2.708 ± 0.432
5.286SerGly: 5.286 ± 0.569
0.774SerHis: 0.774 ± 0.246
4.642SerIle: 4.642 ± 0.559
3.417SerLys: 3.417 ± 0.452
4.577SerLeu: 4.577 ± 0.476
1.225SerMet: 1.225 ± 0.255
2.837SerAsn: 2.837 ± 0.358
2.256SerPro: 2.256 ± 0.436
3.094SerGln: 3.094 ± 0.454
2.192SerArg: 2.192 ± 0.322
4.255SerSer: 4.255 ± 0.791
4.255SerThr: 4.255 ± 0.697
3.546SerVal: 3.546 ± 0.506
1.354SerTrp: 1.354 ± 0.346
2.256SerTyr: 2.256 ± 0.515
0.0SerXaa: 0.0 ± 0.0
Thr
6.898ThrAla: 6.898 ± 1.002
1.16ThrCys: 1.16 ± 0.307
2.708ThrAsp: 2.708 ± 0.41
3.997ThrGlu: 3.997 ± 0.399
1.741ThrPhe: 1.741 ± 0.293
4.964ThrGly: 4.964 ± 0.576
0.903ThrHis: 0.903 ± 0.298
3.868ThrIle: 3.868 ± 0.523
3.546ThrLys: 3.546 ± 0.493
5.544ThrLeu: 5.544 ± 0.682
0.838ThrMet: 0.838 ± 0.217
2.385ThrAsn: 2.385 ± 0.429
2.901ThrPro: 2.901 ± 0.378
1.998ThrGln: 1.998 ± 0.376
2.901ThrArg: 2.901 ± 0.421
3.546ThrSer: 3.546 ± 0.453
3.223ThrThr: 3.223 ± 0.689
4.384ThrVal: 4.384 ± 0.621
0.903ThrTrp: 0.903 ± 0.247
1.547ThrTyr: 1.547 ± 0.305
0.0ThrXaa: 0.0 ± 0.0
Val
5.609ValAla: 5.609 ± 0.574
0.967ValCys: 0.967 ± 0.266
3.481ValAsp: 3.481 ± 0.503
4.255ValGlu: 4.255 ± 0.49
2.192ValPhe: 2.192 ± 0.445
5.351ValGly: 5.351 ± 0.563
0.903ValHis: 0.903 ± 0.222
3.352ValIle: 3.352 ± 0.429
3.481ValLys: 3.481 ± 0.534
4.899ValLeu: 4.899 ± 0.589
1.096ValMet: 1.096 ± 0.303
2.965ValAsn: 2.965 ± 0.282
3.094ValPro: 3.094 ± 0.591
2.643ValGln: 2.643 ± 0.408
3.094ValArg: 3.094 ± 0.517
5.093ValSer: 5.093 ± 0.585
3.932ValThr: 3.932 ± 0.578
5.157ValVal: 5.157 ± 0.67
1.289ValTrp: 1.289 ± 0.327
2.45ValTyr: 2.45 ± 0.391
0.0ValXaa: 0.0 ± 0.0
Trp
0.967TrpAla: 0.967 ± 0.199
0.322TrpCys: 0.322 ± 0.145
0.516TrpAsp: 0.516 ± 0.203
0.58TrpGlu: 0.58 ± 0.229
0.709TrpPhe: 0.709 ± 0.217
1.16TrpGly: 1.16 ± 0.316
0.193TrpHis: 0.193 ± 0.104
0.967TrpIle: 0.967 ± 0.238
0.645TrpLys: 0.645 ± 0.168
1.483TrpLeu: 1.483 ± 0.301
0.193TrpMet: 0.193 ± 0.096
1.225TrpAsn: 1.225 ± 0.238
1.031TrpPro: 1.031 ± 0.226
0.774TrpGln: 0.774 ± 0.209
1.16TrpArg: 1.16 ± 0.316
0.709TrpSer: 0.709 ± 0.188
0.903TrpThr: 0.903 ± 0.259
1.612TrpVal: 1.612 ± 0.26
0.129TrpTrp: 0.129 ± 0.076
0.838TrpTyr: 0.838 ± 0.226
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.772TyrAla: 2.772 ± 0.535
0.516TyrCys: 0.516 ± 0.203
1.741TyrAsp: 1.741 ± 0.453
2.579TyrGlu: 2.579 ± 0.378
1.418TyrPhe: 1.418 ± 0.339
2.385TyrGly: 2.385 ± 0.392
0.322TyrHis: 0.322 ± 0.131
1.354TyrIle: 1.354 ± 0.31
1.676TyrLys: 1.676 ± 0.263
1.934TyrLeu: 1.934 ± 0.336
0.967TyrMet: 0.967 ± 0.3
1.16TyrAsn: 1.16 ± 0.253
1.354TyrPro: 1.354 ± 0.321
1.354TyrGln: 1.354 ± 0.254
2.256TyrArg: 2.256 ± 0.386
2.321TyrSer: 2.321 ± 0.524
2.192TyrThr: 2.192 ± 0.414
1.741TyrVal: 1.741 ± 0.338
0.838TyrTrp: 0.838 ± 0.204
1.16TyrTyr: 1.16 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (15513 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski