Amino acid dipepetide frequency for Streptococcus phage Javan1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.554AlaAla: 2.554 ± 0.654
0.567AlaCys: 0.567 ± 0.211
4.445AlaAsp: 4.445 ± 0.699
5.58AlaGlu: 5.58 ± 0.819
3.027AlaPhe: 3.027 ± 0.608
4.351AlaGly: 4.351 ± 0.698
0.757AlaHis: 0.757 ± 0.244
6.337AlaIle: 6.337 ± 0.741
6.148AlaLys: 6.148 ± 0.771
6.904AlaLeu: 6.904 ± 1.533
2.365AlaMet: 2.365 ± 0.547
2.932AlaAsn: 2.932 ± 0.403
1.419AlaPro: 1.419 ± 0.365
2.175AlaGln: 2.175 ± 0.488
2.175AlaArg: 2.175 ± 0.352
3.31AlaSer: 3.31 ± 0.506
4.256AlaThr: 4.256 ± 0.422
4.445AlaVal: 4.445 ± 0.743
0.378AlaTrp: 0.378 ± 0.171
2.743AlaTyr: 2.743 ± 0.55
0.0AlaXaa: 0.0 ± 0.0
Cys
0.284CysAla: 0.284 ± 0.161
0.0CysCys: 0.0 ± 0.0
0.189CysAsp: 0.189 ± 0.109
0.284CysGlu: 0.284 ± 0.199
0.189CysPhe: 0.189 ± 0.123
0.473CysGly: 0.473 ± 0.221
0.284CysHis: 0.284 ± 0.181
0.284CysIle: 0.284 ± 0.189
0.284CysLys: 0.284 ± 0.154
0.378CysLeu: 0.378 ± 0.221
0.189CysMet: 0.189 ± 0.127
0.284CysAsn: 0.284 ± 0.128
0.189CysPro: 0.189 ± 0.12
0.0CysGln: 0.0 ± 0.0
0.473CysArg: 0.473 ± 0.233
0.473CysSer: 0.473 ± 0.243
0.284CysThr: 0.284 ± 0.174
0.284CysVal: 0.284 ± 0.167
0.095CysTrp: 0.095 ± 0.087
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.689AspAla: 3.689 ± 0.596
0.567AspCys: 0.567 ± 0.288
3.689AspAsp: 3.689 ± 0.648
5.959AspGlu: 5.959 ± 0.693
2.365AspPhe: 2.365 ± 0.675
4.54AspGly: 4.54 ± 0.51
0.851AspHis: 0.851 ± 0.316
4.918AspIle: 4.918 ± 0.616
3.594AspLys: 3.594 ± 0.76
5.202AspLeu: 5.202 ± 0.728
1.513AspMet: 1.513 ± 0.379
3.499AspAsn: 3.499 ± 0.525
1.986AspPro: 1.986 ± 0.431
1.324AspGln: 1.324 ± 0.347
2.365AspArg: 2.365 ± 0.4
3.972AspSer: 3.972 ± 0.631
3.594AspThr: 3.594 ± 0.531
4.256AspVal: 4.256 ± 0.554
0.851AspTrp: 0.851 ± 0.216
2.459AspTyr: 2.459 ± 0.502
0.0AspXaa: 0.0 ± 0.0
Glu
6.431GluAla: 6.431 ± 0.87
0.378GluCys: 0.378 ± 0.219
3.027GluAsp: 3.027 ± 0.634
7.188GluGlu: 7.188 ± 1.044
3.783GluPhe: 3.783 ± 0.703
3.405GluGly: 3.405 ± 0.552
1.513GluHis: 1.513 ± 0.361
6.526GluIle: 6.526 ± 0.703
5.107GluLys: 5.107 ± 0.83
9.269GluLeu: 9.269 ± 0.974
2.648GluMet: 2.648 ± 0.575
4.256GluAsn: 4.256 ± 0.679
1.892GluPro: 1.892 ± 0.56
4.54GluGln: 4.54 ± 0.709
4.824GluArg: 4.824 ± 0.768
4.256GluSer: 4.256 ± 0.571
3.878GluThr: 3.878 ± 0.579
5.959GluVal: 5.959 ± 0.719
0.946GluTrp: 0.946 ± 0.283
4.634GluTyr: 4.634 ± 0.771
0.0GluXaa: 0.0 ± 0.0
Phe
2.648PheAla: 2.648 ± 0.494
0.189PheCys: 0.189 ± 0.121
2.743PheAsp: 2.743 ± 0.468
3.216PheGlu: 3.216 ± 0.491
1.608PhePhe: 1.608 ± 0.367
2.459PheGly: 2.459 ± 0.475
0.567PheHis: 0.567 ± 0.252
2.175PheIle: 2.175 ± 0.584
3.31PheLys: 3.31 ± 0.605
3.499PheLeu: 3.499 ± 0.528
1.04PheMet: 1.04 ± 0.317
2.27PheAsn: 2.27 ± 0.396
1.23PhePro: 1.23 ± 0.381
0.757PheGln: 0.757 ± 0.286
2.27PheArg: 2.27 ± 0.446
3.216PheSer: 3.216 ± 0.535
2.459PheThr: 2.459 ± 0.393
2.175PheVal: 2.175 ± 0.426
0.284PheTrp: 0.284 ± 0.137
2.175PheTyr: 2.175 ± 0.413
0.0PheXaa: 0.0 ± 0.0
Gly
3.689GlyAla: 3.689 ± 0.766
0.189GlyCys: 0.189 ± 0.122
3.405GlyAsp: 3.405 ± 0.635
4.634GlyGlu: 4.634 ± 0.629
2.932GlyPhe: 2.932 ± 0.588
3.594GlyGly: 3.594 ± 0.95
0.946GlyHis: 0.946 ± 0.283
4.351GlyIle: 4.351 ± 0.921
6.715GlyLys: 6.715 ± 1.054
4.445GlyLeu: 4.445 ± 0.601
1.135GlyMet: 1.135 ± 0.342
3.027GlyAsn: 3.027 ± 0.577
0.473GlyPro: 0.473 ± 0.274
2.459GlyGln: 2.459 ± 0.379
3.405GlyArg: 3.405 ± 0.541
4.162GlySer: 4.162 ± 0.587
3.027GlyThr: 3.027 ± 0.664
4.824GlyVal: 4.824 ± 0.532
0.567GlyTrp: 0.567 ± 0.213
2.743GlyTyr: 2.743 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
1.04HisAla: 1.04 ± 0.35
0.0HisCys: 0.0 ± 0.0
0.851HisAsp: 0.851 ± 0.322
1.135HisGlu: 1.135 ± 0.373
0.757HisPhe: 0.757 ± 0.248
1.702HisGly: 1.702 ± 0.501
0.851HisHis: 0.851 ± 0.276
1.324HisIle: 1.324 ± 0.294
1.04HisLys: 1.04 ± 0.395
1.04HisLeu: 1.04 ± 0.305
0.189HisMet: 0.189 ± 0.142
0.567HisAsn: 0.567 ± 0.24
1.04HisPro: 1.04 ± 0.384
0.284HisGln: 0.284 ± 0.159
0.473HisArg: 0.473 ± 0.237
1.04HisSer: 1.04 ± 0.287
0.851HisThr: 0.851 ± 0.252
1.04HisVal: 1.04 ± 0.278
0.095HisTrp: 0.095 ± 0.094
1.324HisTyr: 1.324 ± 0.443
0.0HisXaa: 0.0 ± 0.0
Ile
5.297IleAla: 5.297 ± 1.078
0.378IleCys: 0.378 ± 0.16
7.377IleAsp: 7.377 ± 0.762
7.188IleGlu: 7.188 ± 0.735
2.459IlePhe: 2.459 ± 0.484
4.54IleGly: 4.54 ± 1.545
0.662IleHis: 0.662 ± 0.214
5.675IleIle: 5.675 ± 0.83
5.675IleLys: 5.675 ± 0.753
4.918IleLeu: 4.918 ± 0.609
1.135IleMet: 1.135 ± 0.298
4.256IleAsn: 4.256 ± 0.712
1.892IlePro: 1.892 ± 0.567
2.554IleGln: 2.554 ± 0.609
3.121IleArg: 3.121 ± 0.484
4.54IleSer: 4.54 ± 0.519
5.202IleThr: 5.202 ± 0.944
2.648IleVal: 2.648 ± 0.537
0.189IleTrp: 0.189 ± 0.122
2.27IleTyr: 2.27 ± 0.639
0.0IleXaa: 0.0 ± 0.0
Lys
5.675LysAla: 5.675 ± 0.606
0.284LysCys: 0.284 ± 0.174
3.972LysAsp: 3.972 ± 0.536
6.621LysGlu: 6.621 ± 0.954
2.837LysPhe: 2.837 ± 0.423
4.445LysGly: 4.445 ± 0.614
1.419LysHis: 1.419 ± 0.298
5.391LysIle: 5.391 ± 0.681
6.148LysLys: 6.148 ± 0.97
7.85LysLeu: 7.85 ± 0.919
2.459LysMet: 2.459 ± 0.505
4.729LysAsn: 4.729 ± 0.572
1.797LysPro: 1.797 ± 0.418
3.027LysGln: 3.027 ± 0.475
4.634LysArg: 4.634 ± 0.666
4.634LysSer: 4.634 ± 0.684
3.689LysThr: 3.689 ± 0.512
5.391LysVal: 5.391 ± 0.808
0.567LysTrp: 0.567 ± 0.249
3.216LysTyr: 3.216 ± 0.428
0.0LysXaa: 0.0 ± 0.0
Leu
5.864LeuAla: 5.864 ± 0.837
0.473LeuCys: 0.473 ± 0.258
4.918LeuAsp: 4.918 ± 0.682
8.607LeuGlu: 8.607 ± 1.039
3.31LeuPhe: 3.31 ± 0.667
5.297LeuGly: 5.297 ± 0.952
1.135LeuHis: 1.135 ± 0.355
5.486LeuIle: 5.486 ± 0.631
6.337LeuLys: 6.337 ± 0.749
6.904LeuLeu: 6.904 ± 0.955
1.986LeuMet: 1.986 ± 0.361
5.013LeuAsn: 5.013 ± 0.676
3.121LeuPro: 3.121 ± 0.588
3.689LeuGln: 3.689 ± 0.7
4.634LeuArg: 4.634 ± 0.616
6.148LeuSer: 6.148 ± 0.763
5.107LeuThr: 5.107 ± 0.817
5.013LeuVal: 5.013 ± 0.723
0.757LeuTrp: 0.757 ± 0.288
3.027LeuTyr: 3.027 ± 0.614
0.0LeuXaa: 0.0 ± 0.0
Met
1.324MetAla: 1.324 ± 0.401
0.0MetCys: 0.0 ± 0.0
0.662MetAsp: 0.662 ± 0.26
1.513MetGlu: 1.513 ± 0.364
0.662MetPhe: 0.662 ± 0.243
1.23MetGly: 1.23 ± 0.377
0.473MetHis: 0.473 ± 0.226
1.797MetIle: 1.797 ± 0.485
1.986MetLys: 1.986 ± 0.419
1.892MetLeu: 1.892 ± 0.413
0.284MetMet: 0.284 ± 0.163
1.419MetAsn: 1.419 ± 0.331
1.135MetPro: 1.135 ± 0.367
0.851MetGln: 0.851 ± 0.295
1.513MetArg: 1.513 ± 0.371
1.797MetSer: 1.797 ± 0.484
1.892MetThr: 1.892 ± 0.309
1.23MetVal: 1.23 ± 0.416
0.189MetTrp: 0.189 ± 0.12
0.567MetTyr: 0.567 ± 0.273
0.0MetXaa: 0.0 ± 0.0
Asn
4.54AsnAla: 4.54 ± 0.672
0.095AsnCys: 0.095 ± 0.087
2.837AsnAsp: 2.837 ± 0.559
3.027AsnGlu: 3.027 ± 0.64
2.175AsnPhe: 2.175 ± 0.445
3.499AsnGly: 3.499 ± 0.578
1.135AsnHis: 1.135 ± 0.313
3.31AsnIle: 3.31 ± 0.571
4.445AsnLys: 4.445 ± 0.712
4.729AsnLeu: 4.729 ± 0.729
1.23AsnMet: 1.23 ± 0.28
2.554AsnAsn: 2.554 ± 0.626
1.419AsnPro: 1.419 ± 0.429
1.702AsnGln: 1.702 ± 0.396
2.932AsnArg: 2.932 ± 0.468
4.256AsnSer: 4.256 ± 0.635
3.31AsnThr: 3.31 ± 0.616
3.027AsnVal: 3.027 ± 0.568
0.662AsnTrp: 0.662 ± 0.248
1.608AsnTyr: 1.608 ± 0.317
0.0AsnXaa: 0.0 ± 0.0
Pro
1.702ProAla: 1.702 ± 0.353
0.095ProCys: 0.095 ± 0.095
1.135ProAsp: 1.135 ± 0.319
2.932ProGlu: 2.932 ± 0.479
1.04ProPhe: 1.04 ± 0.259
1.135ProGly: 1.135 ± 0.288
0.662ProHis: 0.662 ± 0.203
1.608ProIle: 1.608 ± 0.43
3.31ProLys: 3.31 ± 0.742
2.365ProLeu: 2.365 ± 0.434
0.189ProMet: 0.189 ± 0.159
0.946ProAsn: 0.946 ± 0.32
1.23ProPro: 1.23 ± 0.341
0.662ProGln: 0.662 ± 0.243
1.23ProArg: 1.23 ± 0.468
1.23ProSer: 1.23 ± 0.262
1.986ProThr: 1.986 ± 0.547
2.365ProVal: 2.365 ± 0.501
0.662ProTrp: 0.662 ± 0.302
1.324ProTyr: 1.324 ± 0.331
0.0ProXaa: 0.0 ± 0.0
Gln
3.689GlnAla: 3.689 ± 0.581
0.189GlnCys: 0.189 ± 0.145
1.324GlnAsp: 1.324 ± 0.353
3.027GlnGlu: 3.027 ± 0.622
0.946GlnPhe: 0.946 ± 0.253
1.797GlnGly: 1.797 ± 0.418
0.473GlnHis: 0.473 ± 0.184
3.405GlnIle: 3.405 ± 0.53
2.648GlnLys: 2.648 ± 0.69
3.689GlnLeu: 3.689 ± 0.724
0.946GlnMet: 0.946 ± 0.256
1.892GlnAsn: 1.892 ± 0.394
0.946GlnPro: 0.946 ± 0.284
2.459GlnGln: 2.459 ± 0.578
1.797GlnArg: 1.797 ± 0.476
2.932GlnSer: 2.932 ± 0.522
1.702GlnThr: 1.702 ± 0.467
2.27GlnVal: 2.27 ± 0.531
0.378GlnTrp: 0.378 ± 0.145
1.513GlnTyr: 1.513 ± 0.392
0.0GlnXaa: 0.0 ± 0.0
Arg
2.932ArgAla: 2.932 ± 0.544
0.0ArgCys: 0.0 ± 0.0
2.743ArgAsp: 2.743 ± 0.499
4.162ArgGlu: 4.162 ± 0.713
2.081ArgPhe: 2.081 ± 0.368
2.459ArgGly: 2.459 ± 0.451
0.946ArgHis: 0.946 ± 0.277
3.972ArgIle: 3.972 ± 0.668
3.783ArgLys: 3.783 ± 0.829
3.689ArgLeu: 3.689 ± 0.585
1.135ArgMet: 1.135 ± 0.296
3.405ArgAsn: 3.405 ± 0.63
0.851ArgPro: 0.851 ± 0.335
1.702ArgGln: 1.702 ± 0.334
1.892ArgArg: 1.892 ± 0.415
3.216ArgSer: 3.216 ± 0.469
3.405ArgThr: 3.405 ± 0.595
3.027ArgVal: 3.027 ± 0.512
0.851ArgTrp: 0.851 ± 0.257
2.743ArgTyr: 2.743 ± 0.62
0.0ArgXaa: 0.0 ± 0.0
Ser
3.972SerAla: 3.972 ± 0.602
0.095SerCys: 0.095 ± 0.115
5.202SerAsp: 5.202 ± 0.533
6.053SerGlu: 6.053 ± 0.816
2.837SerPhe: 2.837 ± 0.505
4.351SerGly: 4.351 ± 0.754
1.135SerHis: 1.135 ± 0.355
4.256SerIle: 4.256 ± 0.655
5.297SerLys: 5.297 ± 0.747
6.148SerLeu: 6.148 ± 0.85
0.946SerMet: 0.946 ± 0.239
3.499SerAsn: 3.499 ± 0.666
1.702SerPro: 1.702 ± 0.406
2.175SerGln: 2.175 ± 0.472
2.837SerArg: 2.837 ± 0.568
4.351SerSer: 4.351 ± 0.596
3.31SerThr: 3.31 ± 0.566
3.689SerVal: 3.689 ± 0.643
0.757SerTrp: 0.757 ± 0.189
2.648SerTyr: 2.648 ± 0.52
0.0SerXaa: 0.0 ± 0.0
Thr
4.445ThrAla: 4.445 ± 0.698
0.378ThrCys: 0.378 ± 0.201
4.445ThrAsp: 4.445 ± 0.668
3.405ThrGlu: 3.405 ± 0.546
2.27ThrPhe: 2.27 ± 0.455
4.445ThrGly: 4.445 ± 0.728
0.757ThrHis: 0.757 ± 0.288
3.972ThrIle: 3.972 ± 0.546
3.878ThrLys: 3.878 ± 0.626
5.58ThrLeu: 5.58 ± 0.829
0.851ThrMet: 0.851 ± 0.277
2.743ThrAsn: 2.743 ± 0.455
1.513ThrPro: 1.513 ± 0.46
2.837ThrGln: 2.837 ± 0.447
1.986ThrArg: 1.986 ± 0.439
3.689ThrSer: 3.689 ± 0.794
3.216ThrThr: 3.216 ± 0.637
4.445ThrVal: 4.445 ± 0.563
0.473ThrTrp: 0.473 ± 0.21
1.986ThrTyr: 1.986 ± 0.358
0.0ThrXaa: 0.0 ± 0.0
Val
3.878ValAla: 3.878 ± 0.486
0.662ValCys: 0.662 ± 0.226
4.824ValAsp: 4.824 ± 0.666
5.58ValGlu: 5.58 ± 0.937
2.648ValPhe: 2.648 ± 0.503
3.783ValGly: 3.783 ± 0.511
1.324ValHis: 1.324 ± 0.456
4.162ValIle: 4.162 ± 0.55
4.824ValLys: 4.824 ± 0.715
4.918ValLeu: 4.918 ± 0.663
1.419ValMet: 1.419 ± 0.326
3.027ValAsn: 3.027 ± 0.577
1.892ValPro: 1.892 ± 0.346
2.365ValGln: 2.365 ± 0.444
3.31ValArg: 3.31 ± 0.52
4.351ValSer: 4.351 ± 0.647
3.878ValThr: 3.878 ± 0.774
3.972ValVal: 3.972 ± 0.541
0.473ValTrp: 0.473 ± 0.169
2.175ValTyr: 2.175 ± 0.357
0.0ValXaa: 0.0 ± 0.0
Trp
0.378TrpAla: 0.378 ± 0.245
0.095TrpCys: 0.095 ± 0.091
0.473TrpAsp: 0.473 ± 0.23
1.135TrpGlu: 1.135 ± 0.283
0.567TrpPhe: 0.567 ± 0.263
0.662TrpGly: 0.662 ± 0.318
0.189TrpHis: 0.189 ± 0.12
0.757TrpIle: 0.757 ± 0.265
1.04TrpLys: 1.04 ± 0.256
0.662TrpLeu: 0.662 ± 0.257
0.0TrpMet: 0.0 ± 0.0
0.378TrpAsn: 0.378 ± 0.153
0.189TrpPro: 0.189 ± 0.114
0.473TrpGln: 0.473 ± 0.207
0.567TrpArg: 0.567 ± 0.214
0.662TrpSer: 0.662 ± 0.211
0.378TrpThr: 0.378 ± 0.178
0.473TrpVal: 0.473 ± 0.201
0.095TrpTrp: 0.095 ± 0.089
0.378TrpTyr: 0.378 ± 0.194
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.837TyrAla: 2.837 ± 0.588
0.284TyrCys: 0.284 ± 0.146
2.932TyrAsp: 2.932 ± 0.537
3.216TyrGlu: 3.216 ± 0.678
1.797TyrPhe: 1.797 ± 0.421
2.648TyrGly: 2.648 ± 0.492
0.567TyrHis: 0.567 ± 0.204
2.27TyrIle: 2.27 ± 0.441
3.216TyrLys: 3.216 ± 0.607
2.743TyrLeu: 2.743 ± 0.634
0.662TyrMet: 0.662 ± 0.243
1.797TyrAsn: 1.797 ± 0.492
1.892TyrPro: 1.892 ± 0.385
1.986TyrGln: 1.986 ± 0.455
2.554TyrArg: 2.554 ± 0.478
3.027TyrSer: 3.027 ± 0.472
1.892TyrThr: 1.892 ± 0.42
2.932TyrVal: 2.932 ± 0.48
0.284TyrTrp: 0.284 ± 0.167
2.459TyrTyr: 2.459 ± 0.573
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (10574 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski