Amino acid dipepetide frequency for Helcococcus kunzii ATCC 51366

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.098AlaAla: 3.098 ± 0.1
0.41AlaCys: 0.41 ± 0.022
2.719AlaAsp: 2.719 ± 0.076
3.308AlaGlu: 3.308 ± 0.089
2.468AlaPhe: 2.468 ± 0.075
3.554AlaGly: 3.554 ± 0.09
0.749AlaHis: 0.749 ± 0.036
5.521AlaIle: 5.521 ± 0.123
4.805AlaLys: 4.805 ± 0.093
4.989AlaLeu: 4.989 ± 0.094
1.532AlaMet: 1.532 ± 0.057
2.823AlaAsn: 2.823 ± 0.072
1.25AlaPro: 1.25 ± 0.045
1.453AlaGln: 1.453 ± 0.059
1.79AlaArg: 1.79 ± 0.056
3.09AlaSer: 3.09 ± 0.071
2.716AlaThr: 2.716 ± 0.085
3.154AlaVal: 3.154 ± 0.081
0.395AlaTrp: 0.395 ± 0.029
2.061AlaTyr: 2.061 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.309CysAla: 0.309 ± 0.021
0.045CysCys: 0.045 ± 0.009
0.405CysAsp: 0.405 ± 0.028
0.398CysGlu: 0.398 ± 0.026
0.217CysPhe: 0.217 ± 0.017
0.532CysGly: 0.532 ± 0.032
0.124CysHis: 0.124 ± 0.014
0.468CysIle: 0.468 ± 0.029
0.388CysLys: 0.388 ± 0.031
0.486CysLeu: 0.486 ± 0.031
0.126CysMet: 0.126 ± 0.016
0.307CysAsn: 0.307 ± 0.024
0.207CysPro: 0.207 ± 0.02
0.127CysGln: 0.127 ± 0.014
0.18CysArg: 0.18 ± 0.018
0.298CysSer: 0.298 ± 0.022
0.256CysThr: 0.256 ± 0.023
0.337CysVal: 0.337 ± 0.025
0.026CysTrp: 0.026 ± 0.006
0.165CysTyr: 0.165 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.954AspAla: 2.954 ± 0.08
0.269AspCys: 0.269 ± 0.022
3.471AspAsp: 3.471 ± 0.08
5.447AspGlu: 5.447 ± 0.114
3.316AspPhe: 3.316 ± 0.078
3.698AspGly: 3.698 ± 0.106
0.724AspHis: 0.724 ± 0.038
6.326AspIle: 6.326 ± 0.098
6.64AspLys: 6.64 ± 0.116
5.579AspLeu: 5.579 ± 0.097
1.384AspMet: 1.384 ± 0.051
3.871AspAsn: 3.871 ± 0.091
1.443AspPro: 1.443 ± 0.057
1.263AspGln: 1.263 ± 0.045
2.066AspArg: 2.066 ± 0.066
3.319AspSer: 3.319 ± 0.083
2.868AspThr: 2.868 ± 0.067
3.612AspVal: 3.612 ± 0.083
0.45AspTrp: 0.45 ± 0.025
3.061AspTyr: 3.061 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
3.699GluAla: 3.699 ± 0.086
0.326GluCys: 0.326 ± 0.024
4.847GluAsp: 4.847 ± 0.093
7.126GluGlu: 7.126 ± 0.141
3.455GluPhe: 3.455 ± 0.076
3.718GluGly: 3.718 ± 0.102
0.921GluHis: 0.921 ± 0.04
8.168GluIle: 8.168 ± 0.123
8.417GluLys: 8.417 ± 0.138
6.567GluLeu: 6.567 ± 0.119
2.104GluMet: 2.104 ± 0.063
6.511GluAsn: 6.511 ± 0.113
1.346GluPro: 1.346 ± 0.053
1.994GluGln: 1.994 ± 0.062
2.602GluArg: 2.602 ± 0.071
3.994GluSer: 3.994 ± 0.089
3.822GluThr: 3.822 ± 0.127
4.6GluVal: 4.6 ± 0.098
0.63GluTrp: 0.63 ± 0.029
3.389GluTyr: 3.389 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
2.475PheAla: 2.475 ± 0.077
0.299PheCys: 0.299 ± 0.022
3.427PheAsp: 3.427 ± 0.084
3.67PheGlu: 3.67 ± 0.084
2.184PhePhe: 2.184 ± 0.069
3.012PheGly: 3.012 ± 0.079
0.486PheHis: 0.486 ± 0.028
4.885PheIle: 4.885 ± 0.128
3.395PheLys: 3.395 ± 0.075
3.959PheLeu: 3.959 ± 0.113
1.225PheMet: 1.225 ± 0.05
3.215PheAsn: 3.215 ± 0.069
1.139PhePro: 1.139 ± 0.045
0.932PheGln: 0.932 ± 0.041
1.65PheArg: 1.65 ± 0.06
3.542PheSer: 3.542 ± 0.076
2.766PheThr: 2.766 ± 0.074
3.053PheVal: 3.053 ± 0.081
0.331PheTrp: 0.331 ± 0.027
2.07PheTyr: 2.07 ± 0.066
0.0PheXaa: 0.0 ± 0.0
Gly
3.443GlyAla: 3.443 ± 0.093
0.359GlyCys: 0.359 ± 0.03
3.124GlyAsp: 3.124 ± 0.08
4.222GlyGlu: 4.222 ± 0.108
2.99GlyPhe: 2.99 ± 0.084
3.648GlyGly: 3.648 ± 0.104
0.965GlyHis: 0.965 ± 0.04
5.637GlyIle: 5.637 ± 0.129
5.786GlyLys: 5.786 ± 0.112
5.267GlyLeu: 5.267 ± 0.108
1.739GlyMet: 1.739 ± 0.059
3.179GlyAsn: 3.179 ± 0.079
1.17GlyPro: 1.17 ± 0.046
1.615GlyGln: 1.615 ± 0.054
2.098GlyArg: 2.098 ± 0.061
3.331GlySer: 3.331 ± 0.074
3.151GlyThr: 3.151 ± 0.091
4.075GlyVal: 4.075 ± 0.077
0.612GlyTrp: 0.612 ± 0.055
2.88GlyTyr: 2.88 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
0.669HisAla: 0.669 ± 0.035
0.088HisCys: 0.088 ± 0.013
0.825HisAsp: 0.825 ± 0.042
0.937HisGlu: 0.937 ± 0.039
0.696HisPhe: 0.696 ± 0.037
1.015HisGly: 1.015 ± 0.04
0.334HisHis: 0.334 ± 0.03
1.184HisIle: 1.184 ± 0.047
1.051HisLys: 1.051 ± 0.042
1.238HisLeu: 1.238 ± 0.044
0.314HisMet: 0.314 ± 0.023
0.807HisAsn: 0.807 ± 0.04
0.491HisPro: 0.491 ± 0.032
0.37HisGln: 0.37 ± 0.023
0.524HisArg: 0.524 ± 0.03
0.914HisSer: 0.914 ± 0.046
0.707HisThr: 0.707 ± 0.033
0.711HisVal: 0.711 ± 0.033
0.114HisTrp: 0.114 ± 0.015
0.61HisTyr: 0.61 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.515IleAla: 5.515 ± 0.122
0.689IleCys: 0.689 ± 0.035
6.824IleAsp: 6.824 ± 0.117
7.68IleGlu: 7.68 ± 0.138
5.007IlePhe: 5.007 ± 0.123
5.554IleGly: 5.554 ± 0.12
1.202IleHis: 1.202 ± 0.045
9.356IleIle: 9.356 ± 0.203
8.678IleLys: 8.678 ± 0.129
8.964IleLeu: 8.964 ± 0.185
2.048IleMet: 2.048 ± 0.065
6.501IleAsn: 6.501 ± 0.131
2.979IlePro: 2.979 ± 0.078
2.129IleGln: 2.129 ± 0.061
2.974IleArg: 2.974 ± 0.072
7.325IleSer: 7.325 ± 0.143
4.437IleThr: 4.437 ± 0.085
6.303IleVal: 6.303 ± 0.134
0.484IleTrp: 0.484 ± 0.028
4.055IleTyr: 4.055 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
4.179LysAla: 4.179 ± 0.079
0.316LysCys: 0.316 ± 0.026
6.379LysAsp: 6.379 ± 0.14
8.708LysGlu: 8.708 ± 0.154
3.663LysPhe: 3.663 ± 0.08
4.521LysGly: 4.521 ± 0.097
1.246LysHis: 1.246 ± 0.045
8.743LysIle: 8.743 ± 0.138
8.285LysLys: 8.285 ± 0.134
8.204LysLeu: 8.204 ± 0.127
2.423LysMet: 2.423 ± 0.06
6.908LysAsn: 6.908 ± 0.125
2.033LysPro: 2.033 ± 0.066
2.397LysGln: 2.397 ± 0.065
2.866LysArg: 2.866 ± 0.084
5.597LysSer: 5.597 ± 0.104
4.556LysThr: 4.556 ± 0.088
5.318LysVal: 5.318 ± 0.107
0.719LysTrp: 0.719 ± 0.043
4.804LysTyr: 4.804 ± 0.099
0.0LysXaa: 0.0 ± 0.0
Leu
5.009LeuAla: 5.009 ± 0.106
0.503LeuCys: 0.503 ± 0.031
5.944LeuAsp: 5.944 ± 0.114
6.893LeuGlu: 6.893 ± 0.105
4.134LeuPhe: 4.134 ± 0.101
5.44LeuGly: 5.44 ± 0.124
1.142LeuHis: 1.142 ± 0.048
8.396LeuIle: 8.396 ± 0.158
7.437LeuLys: 7.437 ± 0.111
8.093LeuLeu: 8.093 ± 0.155
2.134LeuMet: 2.134 ± 0.07
5.878LeuAsn: 5.878 ± 0.11
2.689LeuPro: 2.689 ± 0.079
2.152LeuGln: 2.152 ± 0.057
2.944LeuArg: 2.944 ± 0.074
6.921LeuSer: 6.921 ± 0.128
4.478LeuThr: 4.478 ± 0.093
5.589LeuVal: 5.589 ± 0.106
0.512LeuTrp: 0.512 ± 0.031
3.438LeuTyr: 3.438 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
1.496MetAla: 1.496 ± 0.048
0.121MetCys: 0.121 ± 0.014
1.479MetAsp: 1.479 ± 0.057
1.559MetGlu: 1.559 ± 0.052
0.99MetPhe: 0.99 ± 0.045
1.537MetGly: 1.537 ± 0.059
0.312MetHis: 0.312 ± 0.024
2.349MetIle: 2.349 ± 0.072
2.478MetLys: 2.478 ± 0.067
2.169MetLeu: 2.169 ± 0.068
0.665MetMet: 0.665 ± 0.034
1.628MetAsn: 1.628 ± 0.049
0.782MetPro: 0.782 ± 0.035
0.603MetGln: 0.603 ± 0.03
0.846MetArg: 0.846 ± 0.037
1.643MetSer: 1.643 ± 0.053
1.207MetThr: 1.207 ± 0.046
1.509MetVal: 1.509 ± 0.052
0.117MetTrp: 0.117 ± 0.014
0.845MetTyr: 0.845 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.091AsnAla: 3.091 ± 0.074
0.331AsnCys: 0.331 ± 0.024
3.607AsnAsp: 3.607 ± 0.087
4.824AsnGlu: 4.824 ± 0.115
2.817AsnPhe: 2.817 ± 0.065
4.027AsnGly: 4.027 ± 0.105
0.869AsnHis: 0.869 ± 0.035
7.339AsnIle: 7.339 ± 0.123
6.48AsnLys: 6.48 ± 0.13
6.034AsnLeu: 6.034 ± 0.1
1.379AsnMet: 1.379 ± 0.042
4.812AsnAsn: 4.812 ± 0.102
2.318AsnPro: 2.318 ± 0.07
1.727AsnGln: 1.727 ± 0.058
2.261AsnArg: 2.261 ± 0.065
4.095AsnSer: 4.095 ± 0.099
3.247AsnThr: 3.247 ± 0.072
3.638AsnVal: 3.638 ± 0.087
0.544AsnTrp: 0.544 ± 0.036
3.081AsnTyr: 3.081 ± 0.079
0.0AsnXaa: 0.0 ± 0.0
Pro
1.337ProAla: 1.337 ± 0.047
0.132ProCys: 0.132 ± 0.017
1.552ProAsp: 1.552 ± 0.052
2.377ProGlu: 2.377 ± 0.071
1.427ProPhe: 1.427 ± 0.052
1.565ProGly: 1.565 ± 0.047
0.443ProHis: 0.443 ± 0.027
2.481ProIle: 2.481 ± 0.062
2.2ProLys: 2.2 ± 0.068
2.17ProLeu: 2.17 ± 0.064
0.618ProMet: 0.618 ± 0.036
1.708ProAsn: 1.708 ± 0.052
0.382ProPro: 0.382 ± 0.026
0.77ProGln: 0.77 ± 0.034
0.671ProArg: 0.671 ± 0.034
1.704ProSer: 1.704 ± 0.054
1.534ProThr: 1.534 ± 0.05
1.797ProVal: 1.797 ± 0.055
0.187ProTrp: 0.187 ± 0.02
1.164ProTyr: 1.164 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
1.494GlnAla: 1.494 ± 0.059
0.098GlnCys: 0.098 ± 0.013
1.367GlnAsp: 1.367 ± 0.046
1.913GlnGlu: 1.913 ± 0.064
1.225GlnPhe: 1.225 ± 0.046
1.309GlnGly: 1.309 ± 0.05
0.303GlnHis: 0.303 ± 0.02
2.595GlnIle: 2.595 ± 0.077
2.408GlnLys: 2.408 ± 0.059
2.192GlnLeu: 2.192 ± 0.061
0.666GlnMet: 0.666 ± 0.033
1.845GlnAsn: 1.845 ± 0.057
0.603GlnPro: 0.603 ± 0.032
0.686GlnGln: 0.686 ± 0.032
0.922GlnArg: 0.922 ± 0.039
1.471GlnSer: 1.471 ± 0.049
1.251GlnThr: 1.251 ± 0.045
1.491GlnVal: 1.491 ± 0.051
0.228GlnTrp: 0.228 ± 0.023
1.227GlnTyr: 1.227 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
1.734ArgAla: 1.734 ± 0.061
0.167ArgCys: 0.167 ± 0.018
1.908ArgAsp: 1.908 ± 0.055
2.825ArgGlu: 2.825 ± 0.072
1.688ArgPhe: 1.688 ± 0.057
1.785ArgGly: 1.785 ± 0.056
0.471ArgHis: 0.471 ± 0.031
3.033ArgIle: 3.033 ± 0.072
3.2ArgLys: 3.2 ± 0.076
3.037ArgLeu: 3.037 ± 0.08
0.903ArgMet: 0.903 ± 0.034
2.207ArgAsn: 2.207 ± 0.056
0.984ArgPro: 0.984 ± 0.042
1.046ArgGln: 1.046 ± 0.045
1.408ArgArg: 1.408 ± 0.051
1.673ArgSer: 1.673 ± 0.054
1.476ArgThr: 1.476 ± 0.046
2.113ArgVal: 2.113 ± 0.059
0.266ArgTrp: 0.266 ± 0.024
1.646ArgTyr: 1.646 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
2.999SerAla: 2.999 ± 0.063
0.293SerCys: 0.293 ± 0.022
3.699SerAsp: 3.699 ± 0.075
4.481SerGlu: 4.481 ± 0.091
3.268SerPhe: 3.268 ± 0.076
4.189SerGly: 4.189 ± 0.083
0.898SerHis: 0.898 ± 0.04
6.581SerIle: 6.581 ± 0.129
6.035SerLys: 6.035 ± 0.098
5.86SerLeu: 5.86 ± 0.112
1.521SerMet: 1.521 ± 0.048
3.99SerAsn: 3.99 ± 0.095
1.527SerPro: 1.527 ± 0.045
1.756SerGln: 1.756 ± 0.052
2.243SerArg: 2.243 ± 0.067
4.291SerSer: 4.291 ± 0.083
3.26SerThr: 3.26 ± 0.07
3.637SerVal: 3.637 ± 0.081
0.455SerTrp: 0.455 ± 0.034
2.734SerTyr: 2.734 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
2.57ThrAla: 2.57 ± 0.064
0.233ThrCys: 0.233 ± 0.021
2.795ThrAsp: 2.795 ± 0.081
3.362ThrGlu: 3.362 ± 0.084
2.437ThrPhe: 2.437 ± 0.054
3.405ThrGly: 3.405 ± 0.085
0.793ThrHis: 0.793 ± 0.039
5.113ThrIle: 5.113 ± 0.086
4.219ThrLys: 4.219 ± 0.099
4.59ThrLeu: 4.59 ± 0.097
1.038ThrMet: 1.038 ± 0.041
3.099ThrAsn: 3.099 ± 0.076
1.693ThrPro: 1.693 ± 0.054
1.394ThrGln: 1.394 ± 0.061
1.731ThrArg: 1.731 ± 0.057
3.187ThrSer: 3.187 ± 0.076
2.678ThrThr: 2.678 ± 0.08
3.136ThrVal: 3.136 ± 0.08
0.453ThrTrp: 0.453 ± 0.032
1.947ThrTyr: 1.947 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
3.306ValAla: 3.306 ± 0.079
0.39ValCys: 0.39 ± 0.023
4.009ValAsp: 4.009 ± 0.099
4.936ValGlu: 4.936 ± 0.095
3.005ValPhe: 3.005 ± 0.08
3.774ValGly: 3.774 ± 0.083
0.792ValHis: 0.792 ± 0.034
5.475ValIle: 5.475 ± 0.101
5.313ValLys: 5.313 ± 0.107
5.672ValLeu: 5.672 ± 0.102
1.309ValMet: 1.309 ± 0.046
3.79ValAsn: 3.79 ± 0.087
1.805ValPro: 1.805 ± 0.05
1.319ValGln: 1.319 ± 0.053
1.797ValArg: 1.797 ± 0.06
4.085ValSer: 4.085 ± 0.069
2.959ValThr: 2.959 ± 0.085
3.992ValVal: 3.992 ± 0.081
0.407ValTrp: 0.407 ± 0.026
2.575ValTyr: 2.575 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.392TrpAla: 0.392 ± 0.031
0.053TrpCys: 0.053 ± 0.01
0.488TrpAsp: 0.488 ± 0.032
0.496TrpGlu: 0.496 ± 0.029
0.276TrpPhe: 0.276 ± 0.023
0.478TrpGly: 0.478 ± 0.03
0.154TrpHis: 0.154 ± 0.017
0.726TrpIle: 0.726 ± 0.036
0.66TrpLys: 0.66 ± 0.041
0.62TrpLeu: 0.62 ± 0.034
0.195TrpMet: 0.195 ± 0.019
0.458TrpAsn: 0.458 ± 0.03
0.162TrpPro: 0.162 ± 0.017
0.283TrpGln: 0.283 ± 0.031
0.326TrpArg: 0.326 ± 0.03
0.367TrpSer: 0.367 ± 0.03
0.41TrpThr: 0.41 ± 0.033
0.324TrpVal: 0.324 ± 0.023
0.116TrpTrp: 0.116 ± 0.016
0.352TrpTyr: 0.352 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.116TyrAla: 2.116 ± 0.061
0.283TyrCys: 0.283 ± 0.02
2.893TyrAsp: 2.893 ± 0.08
3.073TyrGlu: 3.073 ± 0.074
2.451TyrPhe: 2.451 ± 0.067
2.527TyrGly: 2.527 ± 0.068
0.671TyrHis: 0.671 ± 0.033
4.329TyrIle: 4.329 ± 0.092
3.989TyrLys: 3.989 ± 0.078
4.038TyrLeu: 4.038 ± 0.092
1.012TyrMet: 1.012 ± 0.036
2.98TyrAsn: 2.98 ± 0.09
1.218TyrPro: 1.218 ± 0.046
1.278TyrGln: 1.278 ± 0.05
1.67TyrArg: 1.67 ± 0.055
2.87TyrSer: 2.87 ± 0.058
2.096TyrThr: 2.096 ± 0.063
2.323TyrVal: 2.323 ± 0.063
0.288TyrTrp: 0.288 ± 0.023
2.139TyrTyr: 2.139 ± 0.068
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1876 proteins (604950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski