Amino acid dipepetide frequency for Roseovarius marisflavi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.626AlaAla: 15.626 ± 0.158	1.121AlaCys: 1.121 ± 0.037	6.725AlaAsp: 6.725 ± 0.082	7.672AlaGlu: 7.672 ± 0.097	4.184AlaPhe: 4.184 ± 0.064	10.369AlaGly: 10.369 ± 0.153	2.467AlaHis: 2.467 ± 0.048	5.98AlaIle: 5.98 ± 0.084	3.861AlaLys: 3.861 ± 0.072	13.561AlaLeu: 13.561 ± 0.136	3.971AlaMet: 3.971 ± 0.068	2.776AlaAsn: 2.776 ± 0.058	5.795AlaPro: 5.795 ± 0.092	4.497AlaGln: 4.497 ± 0.075	8.936AlaArg: 8.936 ± 0.108	5.677AlaSer: 5.677 ± 0.084	5.91AlaThr: 5.91 ± 0.082	8.104AlaVal: 8.104 ± 0.099	1.336AlaTrp: 1.336 ± 0.032	2.589AlaTyr: 2.589 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.17CysAla: 1.17 ± 0.035	0.115CysCys: 0.115 ± 0.009	0.658CysAsp: 0.658 ± 0.025	0.474CysGlu: 0.474 ± 0.021	0.364CysPhe: 0.364 ± 0.018	1.01CysGly: 1.01 ± 0.034	0.312CysHis: 0.312 ± 0.017	0.448CysIle: 0.448 ± 0.02	0.259CysLys: 0.259 ± 0.015	0.927CysLeu: 0.927 ± 0.03	0.196CysMet: 0.196 ± 0.012	0.245CysAsn: 0.245 ± 0.015	0.535CysPro: 0.535 ± 0.017	0.263CysGln: 0.263 ± 0.015	0.564CysArg: 0.564 ± 0.024	0.453CysSer: 0.453 ± 0.019	0.471CysThr: 0.471 ± 0.02	0.633CysVal: 0.633 ± 0.024	0.123CysTrp: 0.123 ± 0.009	0.246CysTyr: 0.246 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.939AspAla: 6.939 ± 0.098	0.555AspCys: 0.555 ± 0.023	3.516AspAsp: 3.516 ± 0.103	3.509AspGlu: 3.509 ± 0.057	2.275AspPhe: 2.275 ± 0.042	5.294AspGly: 5.294 ± 0.114	1.483AspHis: 1.483 ± 0.036	3.498AspIle: 3.498 ± 0.073	1.825AspLys: 1.825 ± 0.04	6.551AspLeu: 6.551 ± 0.079	1.825AspMet: 1.825 ± 0.042	1.376AspAsn: 1.376 ± 0.043	3.491AspPro: 3.491 ± 0.059	1.981AspGln: 1.981 ± 0.042	3.933AspArg: 3.933 ± 0.058	2.259AspSer: 2.259 ± 0.06	3.159AspThr: 3.159 ± 0.082	4.299AspVal: 4.299 ± 0.084	1.175AspTrp: 1.175 ± 0.036	1.533AspTyr: 1.533 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.965GluAla: 7.965 ± 0.112	0.398GluCys: 0.398 ± 0.02	3.178GluAsp: 3.178 ± 0.063	3.135GluGlu: 3.135 ± 0.063	1.861GluPhe: 1.861 ± 0.036	4.803GluGly: 4.803 ± 0.067	1.215GluHis: 1.215 ± 0.034	3.686GluIle: 3.686 ± 0.058	2.185GluLys: 2.185 ± 0.051	4.763GluLeu: 4.763 ± 0.062	1.868GluMet: 1.868 ± 0.038	1.777GluAsn: 1.777 ± 0.041	2.367GluPro: 2.367 ± 0.058	1.85GluGln: 1.85 ± 0.04	4.197GluArg: 4.197 ± 0.076	2.162GluSer: 2.162 ± 0.039	3.827GluThr: 3.827 ± 0.065	4.42GluVal: 4.42 ± 0.067	0.721GluTrp: 0.721 ± 0.025	1.124GluTyr: 1.124 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.351PheAla: 4.351 ± 0.069	0.451PheCys: 0.451 ± 0.021	2.835PheAsp: 2.835 ± 0.048	2.273PheGlu: 2.273 ± 0.049	1.434PhePhe: 1.434 ± 0.042	3.735PheGly: 3.735 ± 0.061	0.764PheHis: 0.764 ± 0.027	1.719PheIle: 1.719 ± 0.045	1.024PheLys: 1.024 ± 0.03	3.428PheLeu: 3.428 ± 0.071	0.926PheMet: 0.926 ± 0.029	1.072PheAsn: 1.072 ± 0.028	1.476PhePro: 1.476 ± 0.035	1.064PheGln: 1.064 ± 0.025	2.116PheArg: 2.116 ± 0.042	2.19PheSer: 2.19 ± 0.051	2.052PheThr: 2.052 ± 0.045	2.645PheVal: 2.645 ± 0.055	0.576PheTrp: 0.576 ± 0.023	0.981PheTyr: 0.981 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.247GlyAla: 10.247 ± 0.157	0.874GlyCys: 0.874 ± 0.029	5.1GlyAsp: 5.1 ± 0.128	4.68GlyGlu: 4.68 ± 0.065	3.795GlyPhe: 3.795 ± 0.063	7.609GlyGly: 7.609 ± 0.182	2.058GlyHis: 2.058 ± 0.049	4.467GlyIle: 4.467 ± 0.065	3.214GlyLys: 3.214 ± 0.067	9.442GlyLeu: 9.442 ± 0.105	2.626GlyMet: 2.626 ± 0.058	2.259GlyAsn: 2.259 ± 0.084	3.655GlyPro: 3.655 ± 0.063	3.219GlyGln: 3.219 ± 0.057	5.651GlyArg: 5.651 ± 0.084	4.159GlySer: 4.159 ± 0.099	4.584GlyThr: 4.584 ± 0.103	6.627GlyVal: 6.627 ± 0.078	1.446GlyTrp: 1.446 ± 0.039	2.318GlyTyr: 2.318 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.439HisAla: 2.439 ± 0.054	0.246HisCys: 0.246 ± 0.015	1.398HisAsp: 1.398 ± 0.039	1.056HisGlu: 1.056 ± 0.027	0.907HisPhe: 0.907 ± 0.03	1.961HisGly: 1.961 ± 0.038	0.576HisHis: 0.576 ± 0.031	1.022HisIle: 1.022 ± 0.031	0.6HisLys: 0.6 ± 0.023	2.229HisLeu: 2.229 ± 0.053	0.587HisMet: 0.587 ± 0.026	0.502HisAsn: 0.502 ± 0.02	1.365HisPro: 1.365 ± 0.037	0.638HisGln: 0.638 ± 0.022	1.333HisArg: 1.333 ± 0.034	1.014HisSer: 1.014 ± 0.031	0.849HisThr: 0.849 ± 0.032	1.493HisVal: 1.493 ± 0.038	0.365HisTrp: 0.365 ± 0.019	0.568HisTyr: 0.568 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.957IleAla: 6.957 ± 0.08	0.69IleCys: 0.69 ± 0.025	3.498IleAsp: 3.498 ± 0.074	3.679IleGlu: 3.679 ± 0.059	1.843IlePhe: 1.843 ± 0.044	4.969IleGly: 4.969 ± 0.08	0.91IleHis: 0.91 ± 0.027	2.437IleIle: 2.437 ± 0.046	1.715IleLys: 1.715 ± 0.045	5.013IleLeu: 5.013 ± 0.078	1.207IleMet: 1.207 ± 0.041	1.566IleAsn: 1.566 ± 0.053	2.307IlePro: 2.307 ± 0.05	1.186IleGln: 1.186 ± 0.036	3.14IleArg: 3.14 ± 0.056	3.294IleSer: 3.294 ± 0.056	3.253IleThr: 3.253 ± 0.058	3.651IleVal: 3.651 ± 0.059	0.754IleTrp: 0.754 ± 0.027	1.233IleTyr: 1.233 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.886LysAla: 3.886 ± 0.077	0.219LysCys: 0.219 ± 0.012	1.733LysAsp: 1.733 ± 0.046	1.614LysGlu: 1.614 ± 0.045	0.982LysPhe: 0.982 ± 0.033	2.88LysGly: 2.88 ± 0.055	0.656LysHis: 0.656 ± 0.023	1.833LysIle: 1.833 ± 0.039	1.218LysLys: 1.218 ± 0.04	2.994LysLeu: 2.994 ± 0.059	0.96LysMet: 0.96 ± 0.029	0.806LysAsn: 0.806 ± 0.029	1.97LysPro: 1.97 ± 0.052	0.924LysGln: 0.924 ± 0.03	2.356LysArg: 2.356 ± 0.055	1.985LysSer: 1.985 ± 0.045	2.204LysThr: 2.204 ± 0.048	2.296LysVal: 2.296 ± 0.053	0.451LysTrp: 0.451 ± 0.021	0.721LysTyr: 0.721 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.008LeuAla: 13.008 ± 0.145	1.072LeuCys: 1.072 ± 0.035	6.013LeuAsp: 6.013 ± 0.079	5.4LeuGlu: 5.4 ± 0.072	3.466LeuPhe: 3.466 ± 0.066	8.74LeuGly: 8.74 ± 0.112	1.933LeuHis: 1.933 ± 0.047	5.429LeuIle: 5.429 ± 0.076	3.29LeuLys: 3.29 ± 0.062	8.738LeuLeu: 8.738 ± 0.137	2.762LeuMet: 2.762 ± 0.054	2.82LeuAsn: 2.82 ± 0.052	5.321LeuPro: 5.321 ± 0.077	2.608LeuGln: 2.608 ± 0.047	7.191LeuArg: 7.191 ± 0.105	6.804LeuSer: 6.804 ± 0.097	5.578LeuThr: 5.578 ± 0.078	6.879LeuVal: 6.879 ± 0.081	1.335LeuTrp: 1.335 ± 0.04	1.996LeuTyr: 1.996 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.635MetAla: 3.635 ± 0.064	0.212MetCys: 0.212 ± 0.013	1.369MetAsp: 1.369 ± 0.036	1.263MetGlu: 1.263 ± 0.039	0.861MetPhe: 0.861 ± 0.029	2.337MetGly: 2.337 ± 0.051	0.481MetHis: 0.481 ± 0.02	1.74MetIle: 1.74 ± 0.038	1.058MetLys: 1.058 ± 0.03	2.753MetLeu: 2.753 ± 0.053	0.846MetMet: 0.846 ± 0.032	0.854MetAsn: 0.854 ± 0.028	1.62MetPro: 1.62 ± 0.04	1.063MetGln: 1.063 ± 0.03	2.051MetArg: 2.051 ± 0.047	1.828MetSer: 1.828 ± 0.041	2.19MetThr: 2.19 ± 0.04	1.935MetVal: 1.935 ± 0.038	0.23MetTrp: 0.23 ± 0.014	0.36MetTyr: 0.36 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.239AsnAla: 3.239 ± 0.063	0.279AsnCys: 0.279 ± 0.015	1.561AsnAsp: 1.561 ± 0.058	1.305AsnGlu: 1.305 ± 0.036	0.954AsnPhe: 0.954 ± 0.029	2.49AsnGly: 2.49 ± 0.057	0.539AsnHis: 0.539 ± 0.018	1.446AsnIle: 1.446 ± 0.039	0.716AsnLys: 0.716 ± 0.025	2.628AsnLeu: 2.628 ± 0.052	0.668AsnMet: 0.668 ± 0.022	0.703AsnAsn: 0.703 ± 0.031	1.906AsnPro: 1.906 ± 0.045	0.728AsnGln: 0.728 ± 0.025	1.765AsnArg: 1.765 ± 0.042	1.258AsnSer: 1.258 ± 0.039	1.448AsnThr: 1.448 ± 0.046	1.896AsnVal: 1.896 ± 0.06	0.44AsnTrp: 0.44 ± 0.02	0.626AsnTyr: 0.626 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.2ProAla: 5.2 ± 0.09	0.38ProCys: 0.38 ± 0.02	3.896ProAsp: 3.896 ± 0.058	4.151ProGlu: 4.151 ± 0.071	1.926ProPhe: 1.926 ± 0.043	4.623ProGly: 4.623 ± 0.067	1.035ProHis: 1.035 ± 0.033	2.304ProIle: 2.304 ± 0.04	1.783ProLys: 1.783 ± 0.044	4.704ProLeu: 4.704 ± 0.074	1.354ProMet: 1.354 ± 0.038	1.341ProAsn: 1.341 ± 0.036	2.165ProPro: 2.165 ± 0.05	1.657ProGln: 1.657 ± 0.036	2.717ProArg: 2.717 ± 0.051	2.437ProSer: 2.437 ± 0.05	2.324ProThr: 2.324 ± 0.045	4.181ProVal: 4.181 ± 0.076	0.642ProTrp: 0.642 ± 0.025	1.122ProTyr: 1.122 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.867GlnAla: 3.867 ± 0.068	0.23GlnCys: 0.23 ± 0.016	1.76GlnAsp: 1.76 ± 0.039	1.618GlnGlu: 1.618 ± 0.042	1.089GlnPhe: 1.089 ± 0.029	2.749GlnGly: 2.749 ± 0.056	0.587GlnHis: 0.587 ± 0.021	1.99GlnIle: 1.99 ± 0.04	1.143GlnLys: 1.143 ± 0.035	2.707GlnLeu: 2.707 ± 0.052	1.119GlnMet: 1.119 ± 0.028	0.943GlnAsn: 0.943 ± 0.026	1.5GlnPro: 1.5 ± 0.038	0.979GlnGln: 0.979 ± 0.027	1.987GlnArg: 1.987 ± 0.049	1.981GlnSer: 1.981 ± 0.035	1.832GlnThr: 1.832 ± 0.039	2.389GlnVal: 2.389 ± 0.045	0.395GlnTrp: 0.395 ± 0.02	0.61GlnTyr: 0.61 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.318ArgAla: 8.318 ± 0.106	0.515ArgCys: 0.515 ± 0.025	4.44ArgAsp: 4.44 ± 0.067	3.653ArgGlu: 3.653 ± 0.064	2.603ArgPhe: 2.603 ± 0.044	4.53ArgGly: 4.53 ± 0.069	1.597ArgHis: 1.597 ± 0.041	3.653ArgIle: 3.653 ± 0.056	2.357ArgLys: 2.357 ± 0.052	7.34ArgLeu: 7.34 ± 0.097	1.927ArgMet: 1.927 ± 0.045	1.805ArgAsn: 1.805 ± 0.037	3.215ArgPro: 3.215 ± 0.06	2.245ArgGln: 2.245 ± 0.046	4.862ArgArg: 4.862 ± 0.088	3.196ArgSer: 3.196 ± 0.046	2.834ArgThr: 2.834 ± 0.049	4.81ArgVal: 4.81 ± 0.069	0.892ArgTrp: 0.892 ± 0.027	1.5ArgTyr: 1.5 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.908SerAla: 5.908 ± 0.089	0.492SerCys: 0.492 ± 0.023	3.482SerAsp: 3.482 ± 0.071	3.027SerGlu: 3.027 ± 0.052	2.179SerPhe: 2.179 ± 0.052	5.681SerGly: 5.681 ± 0.103	1.163SerHis: 1.163 ± 0.037	2.524SerIle: 2.524 ± 0.051	1.624SerLys: 1.624 ± 0.041	5.069SerLeu: 5.069 ± 0.067	1.341SerMet: 1.341 ± 0.04	1.36SerAsn: 1.36 ± 0.039	2.505SerPro: 2.505 ± 0.047	1.548SerGln: 1.548 ± 0.038	3.137SerArg: 3.137 ± 0.058	2.599SerSer: 2.599 ± 0.067	2.559SerThr: 2.559 ± 0.06	4.001SerVal: 4.001 ± 0.08	0.676SerTrp: 0.676 ± 0.023	1.305SerTyr: 1.305 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.112ThrAla: 6.112 ± 0.102	0.538ThrCys: 0.538 ± 0.022	3.039ThrAsp: 3.039 ± 0.071	2.805ThrGlu: 2.805 ± 0.054	2.008ThrPhe: 2.008 ± 0.045	5.623ThrGly: 5.623 ± 0.089	1.144ThrHis: 1.144 ± 0.031	2.744ThrIle: 2.744 ± 0.064	1.542ThrLys: 1.542 ± 0.04	6.032ThrLeu: 6.032 ± 0.083	1.298ThrMet: 1.298 ± 0.03	1.345ThrAsn: 1.345 ± 0.04	3.502ThrPro: 3.502 ± 0.061	1.629ThrGln: 1.629 ± 0.035	3.619ThrArg: 3.619 ± 0.061	2.762ThrSer: 2.762 ± 0.059	2.984ThrThr: 2.984 ± 0.099	4.106ThrVal: 4.106 ± 0.096	0.69ThrTrp: 0.69 ± 0.024	1.332ThrTyr: 1.332 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.463ValAla: 8.463 ± 0.088	0.672ValCys: 0.672 ± 0.023	3.963ValAsp: 3.963 ± 0.077	4.294ValGlu: 4.294 ± 0.059	2.909ValPhe: 2.909 ± 0.05	5.401ValGly: 5.401 ± 0.08	1.32ValHis: 1.32 ± 0.029	4.654ValIle: 4.654 ± 0.072	2.216ValLys: 2.216 ± 0.052	7.534ValLeu: 7.534 ± 0.099	2.295ValMet: 2.295 ± 0.048	2.048ValAsn: 2.048 ± 0.056	3.451ValPro: 3.451 ± 0.065	2.019ValGln: 2.019 ± 0.044	4.087ValArg: 4.087 ± 0.058	4.166ValSer: 4.166 ± 0.066	4.954ValThr: 4.954 ± 0.103	5.557ValVal: 5.557 ± 0.092	0.923ValTrp: 0.923 ± 0.026	1.49ValTyr: 1.49 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.387TrpAla: 1.387 ± 0.035	0.14TrpCys: 0.14 ± 0.009	0.695TrpAsp: 0.695 ± 0.026	0.621TrpGlu: 0.621 ± 0.025	0.556TrpPhe: 0.556 ± 0.022	1.028TrpGly: 1.028 ± 0.031	0.349TrpHis: 0.349 ± 0.016	0.718TrpIle: 0.718 ± 0.025	0.444TrpLys: 0.444 ± 0.022	1.617TrpLeu: 1.617 ± 0.046	0.403TrpMet: 0.403 ± 0.021	0.406TrpAsn: 0.406 ± 0.017	0.728TrpPro: 0.728 ± 0.028	0.652TrpGln: 0.652 ± 0.02	1.1TrpArg: 1.1 ± 0.036	0.789TrpSer: 0.789 ± 0.026	0.708TrpThr: 0.708 ± 0.025	0.916TrpVal: 0.916 ± 0.032	0.215TrpTrp: 0.215 ± 0.011	0.276TrpTyr: 0.276 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.438TyrAla: 2.438 ± 0.047	0.265TyrCys: 0.265 ± 0.014	1.618TyrAsp: 1.618 ± 0.041	1.274TyrGlu: 1.274 ± 0.038	0.916TyrPhe: 0.916 ± 0.029	2.199TyrGly: 2.199 ± 0.046	0.558TyrHis: 0.558 ± 0.021	1.009TyrIle: 1.009 ± 0.023	0.615TyrLys: 0.615 ± 0.025	2.351TyrLeu: 2.351 ± 0.051	0.507TyrMet: 0.507 ± 0.022	0.591TyrAsn: 0.591 ± 0.025	1.066TyrPro: 1.066 ± 0.031	0.724TyrGln: 0.724 ± 0.025	1.55TyrArg: 1.55 ± 0.036	1.169TyrSer: 1.169 ± 0.033	1.138TyrThr: 1.138 ± 0.029	1.577TyrVal: 1.577 ± 0.038	0.363TyrTrp: 0.363 ± 0.02	0.625TyrTyr: 0.625 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3958 proteins (1212272 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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