Amino acid dipepetide frequency for Yellowstone Lake virophage 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.569AlaAla: 2.569 ± 0.462
0.447AlaCys: 0.447 ± 0.199
4.356AlaAsp: 4.356 ± 0.651
7.037AlaGlu: 7.037 ± 1.29
3.463AlaPhe: 3.463 ± 0.54
6.813AlaGly: 6.813 ± 0.944
2.122AlaHis: 2.122 ± 0.418
4.468AlaIle: 4.468 ± 0.632
7.26AlaLys: 7.26 ± 1.605
8.154AlaLeu: 8.154 ± 0.991
2.346AlaMet: 2.346 ± 0.344
3.574AlaAsn: 3.574 ± 0.824
6.367AlaPro: 6.367 ± 1.455
3.351AlaGln: 3.351 ± 0.498
4.133AlaArg: 4.133 ± 0.933
5.92AlaSer: 5.92 ± 0.793
6.143AlaThr: 6.143 ± 1.118
5.25AlaVal: 5.25 ± 0.81
0.558AlaTrp: 0.558 ± 0.226
3.127AlaTyr: 3.127 ± 0.532
0.0AlaXaa: 0.0 ± 0.0
Cys
0.894CysAla: 0.894 ± 0.278
0.67CysCys: 0.67 ± 0.431
1.117CysAsp: 1.117 ± 0.707
1.452CysGlu: 1.452 ± 0.391
0.447CysPhe: 0.447 ± 0.206
1.564CysGly: 1.564 ± 0.496
0.335CysHis: 0.335 ± 0.178
0.67CysIle: 0.67 ± 0.251
0.223CysLys: 0.223 ± 0.248
1.117CysLeu: 1.117 ± 0.384
0.223CysMet: 0.223 ± 0.175
0.447CysAsn: 0.447 ± 0.26
0.558CysPro: 0.558 ± 0.263
1.005CysGln: 1.005 ± 0.355
0.558CysArg: 0.558 ± 0.277
0.335CysSer: 0.335 ± 0.178
0.0CysThr: 0.0 ± 0.0
0.782CysVal: 0.782 ± 0.303
0.0CysTrp: 0.0 ± 0.0
0.447CysTyr: 0.447 ± 0.243
0.0CysXaa: 0.0 ± 0.0
Asp
5.361AspAla: 5.361 ± 0.641
0.67AspCys: 0.67 ± 0.328
3.574AspAsp: 3.574 ± 0.854
3.909AspGlu: 3.909 ± 0.645
2.904AspPhe: 2.904 ± 0.625
4.691AspGly: 4.691 ± 0.714
0.335AspHis: 0.335 ± 0.259
4.021AspIle: 4.021 ± 0.626
2.904AspLys: 2.904 ± 0.672
3.463AspLeu: 3.463 ± 0.76
1.117AspMet: 1.117 ± 0.303
2.792AspAsn: 2.792 ± 0.528
2.234AspPro: 2.234 ± 0.527
0.67AspGln: 0.67 ± 0.344
2.122AspArg: 2.122 ± 0.475
3.127AspSer: 3.127 ± 0.487
4.915AspThr: 4.915 ± 0.857
3.239AspVal: 3.239 ± 0.654
1.229AspTrp: 1.229 ± 0.344
3.686AspTyr: 3.686 ± 0.693
0.0AspXaa: 0.0 ± 0.0
Glu
6.813GluAla: 6.813 ± 0.893
1.34GluCys: 1.34 ± 0.443
3.798GluAsp: 3.798 ± 0.64
4.244GluGlu: 4.244 ± 0.96
2.346GluPhe: 2.346 ± 0.471
4.803GluGly: 4.803 ± 0.782
1.117GluHis: 1.117 ± 0.297
2.792GluIle: 2.792 ± 0.458
5.026GluLys: 5.026 ± 1.322
3.016GluLeu: 3.016 ± 0.517
2.122GluMet: 2.122 ± 0.535
2.234GluAsn: 2.234 ± 0.426
2.457GluPro: 2.457 ± 0.955
2.122GluGln: 2.122 ± 0.385
4.244GluArg: 4.244 ± 0.846
3.686GluSer: 3.686 ± 0.938
2.569GluThr: 2.569 ± 0.669
3.798GluVal: 3.798 ± 0.599
1.005GluTrp: 1.005 ± 0.388
2.792GluTyr: 2.792 ± 0.51
0.0GluXaa: 0.0 ± 0.0
Phe
3.351PheAla: 3.351 ± 0.52
0.67PheCys: 0.67 ± 0.357
2.234PheAsp: 2.234 ± 0.516
1.452PheGlu: 1.452 ± 0.396
1.899PhePhe: 1.899 ± 0.425
4.021PheGly: 4.021 ± 0.911
0.67PheHis: 0.67 ± 0.283
1.564PheIle: 1.564 ± 0.406
2.569PheLys: 2.569 ± 0.953
2.792PheLeu: 2.792 ± 0.641
0.894PheMet: 0.894 ± 0.325
2.01PheAsn: 2.01 ± 0.557
1.787PhePro: 1.787 ± 0.555
1.675PheGln: 1.675 ± 0.343
1.452PheArg: 1.452 ± 0.503
2.01PheSer: 2.01 ± 0.391
2.457PheThr: 2.457 ± 0.565
3.016PheVal: 3.016 ± 0.438
0.335PheTrp: 0.335 ± 0.242
1.787PheTyr: 1.787 ± 0.481
0.0PheXaa: 0.0 ± 0.0
Gly
8.154GlyAla: 8.154 ± 1.502
0.447GlyCys: 0.447 ± 0.27
4.803GlyAsp: 4.803 ± 0.712
4.021GlyGlu: 4.021 ± 0.763
2.904GlyPhe: 2.904 ± 0.544
9.829GlyGly: 9.829 ± 2.002
1.117GlyHis: 1.117 ± 0.508
3.351GlyIle: 3.351 ± 0.641
5.25GlyLys: 5.25 ± 0.866
5.696GlyLeu: 5.696 ± 0.841
2.122GlyMet: 2.122 ± 0.636
3.016GlyAsn: 3.016 ± 0.669
1.34GlyPro: 1.34 ± 0.392
2.234GlyGln: 2.234 ± 0.632
3.798GlyArg: 3.798 ± 0.671
6.143GlySer: 6.143 ± 1.194
4.691GlyThr: 4.691 ± 0.857
5.361GlyVal: 5.361 ± 0.752
0.782GlyTrp: 0.782 ± 0.288
3.016GlyTyr: 3.016 ± 0.448
0.0GlyXaa: 0.0 ± 0.0
His
0.67HisAla: 0.67 ± 0.247
0.223HisCys: 0.223 ± 0.146
0.447HisAsp: 0.447 ± 0.249
0.67HisGlu: 0.67 ± 0.22
0.782HisPhe: 0.782 ± 0.381
0.782HisGly: 0.782 ± 0.47
0.447HisHis: 0.447 ± 0.214
0.894HisIle: 0.894 ± 0.31
1.564HisLys: 1.564 ± 0.441
1.005HisLeu: 1.005 ± 0.397
0.335HisMet: 0.335 ± 0.168
0.894HisAsn: 0.894 ± 0.353
1.229HisPro: 1.229 ± 0.446
0.223HisGln: 0.223 ± 0.14
1.564HisArg: 1.564 ± 0.405
1.787HisSer: 1.787 ± 0.532
1.229HisThr: 1.229 ± 0.448
0.223HisVal: 0.223 ± 0.16
0.558HisTrp: 0.558 ± 0.233
0.67HisTyr: 0.67 ± 0.273
0.0HisXaa: 0.0 ± 0.0
Ile
5.138IleAla: 5.138 ± 0.843
0.782IleCys: 0.782 ± 0.31
4.244IleAsp: 4.244 ± 0.842
2.792IleGlu: 2.792 ± 0.503
1.34IlePhe: 1.34 ± 0.401
2.457IleGly: 2.457 ± 0.606
0.782IleHis: 0.782 ± 0.338
3.127IleIle: 3.127 ± 0.423
3.574IleLys: 3.574 ± 0.749
3.798IleLeu: 3.798 ± 0.74
1.34IleMet: 1.34 ± 0.354
3.127IleAsn: 3.127 ± 0.437
3.686IlePro: 3.686 ± 1.006
1.34IleGln: 1.34 ± 0.48
3.239IleArg: 3.239 ± 0.511
2.122IleSer: 2.122 ± 0.512
3.127IleThr: 3.127 ± 0.769
3.239IleVal: 3.239 ± 0.588
0.67IleTrp: 0.67 ± 0.271
1.564IleTyr: 1.564 ± 0.395
0.0IleXaa: 0.0 ± 0.0
Lys
7.93LysAla: 7.93 ± 1.577
1.117LysCys: 1.117 ± 0.445
3.686LysAsp: 3.686 ± 0.959
5.473LysGlu: 5.473 ± 1.406
2.569LysPhe: 2.569 ± 0.724
6.255LysGly: 6.255 ± 1.114
1.117LysHis: 1.117 ± 0.427
2.681LysIle: 2.681 ± 0.596
5.808LysLys: 5.808 ± 1.124
4.468LysLeu: 4.468 ± 1.126
2.569LysMet: 2.569 ± 0.493
3.463LysAsn: 3.463 ± 0.64
3.686LysPro: 3.686 ± 0.748
2.122LysGln: 2.122 ± 0.426
4.244LysArg: 4.244 ± 1.114
4.579LysSer: 4.579 ± 0.735
3.016LysThr: 3.016 ± 0.765
2.904LysVal: 2.904 ± 0.733
0.67LysTrp: 0.67 ± 0.271
2.234LysTyr: 2.234 ± 0.408
0.0LysXaa: 0.0 ± 0.0
Leu
6.59LeuAla: 6.59 ± 0.688
1.229LeuCys: 1.229 ± 0.276
4.133LeuAsp: 4.133 ± 0.839
5.026LeuGlu: 5.026 ± 0.891
2.346LeuPhe: 2.346 ± 0.686
4.133LeuGly: 4.133 ± 0.777
0.782LeuHis: 0.782 ± 0.376
2.346LeuIle: 2.346 ± 0.527
4.915LeuLys: 4.915 ± 1.333
5.361LeuLeu: 5.361 ± 0.883
1.229LeuMet: 1.229 ± 0.373
3.239LeuAsn: 3.239 ± 0.568
4.915LeuPro: 4.915 ± 0.829
2.457LeuGln: 2.457 ± 0.508
4.803LeuArg: 4.803 ± 0.961
7.819LeuSer: 7.819 ± 0.765
5.473LeuThr: 5.473 ± 1.154
4.915LeuVal: 4.915 ± 1.137
1.005LeuTrp: 1.005 ± 0.404
3.574LeuTyr: 3.574 ± 0.503
0.0LeuXaa: 0.0 ± 0.0
Met
2.569MetAla: 2.569 ± 0.576
0.223MetCys: 0.223 ± 0.166
1.899MetAsp: 1.899 ± 0.396
1.787MetGlu: 1.787 ± 0.443
0.67MetPhe: 0.67 ± 0.275
2.122MetGly: 2.122 ± 0.358
0.0MetHis: 0.0 ± 0.0
1.899MetIle: 1.899 ± 0.501
1.899MetLys: 1.899 ± 0.449
1.34MetLeu: 1.34 ± 0.412
0.782MetMet: 0.782 ± 0.226
1.229MetAsn: 1.229 ± 0.333
1.117MetPro: 1.117 ± 0.328
0.0MetGln: 0.0 ± 0.0
1.34MetArg: 1.34 ± 0.509
2.234MetSer: 2.234 ± 0.534
2.681MetThr: 2.681 ± 0.563
1.005MetVal: 1.005 ± 0.481
0.223MetTrp: 0.223 ± 0.14
1.005MetTyr: 1.005 ± 0.388
0.0MetXaa: 0.0 ± 0.0
Asn
3.016AsnAla: 3.016 ± 0.53
0.67AsnCys: 0.67 ± 0.349
2.234AsnAsp: 2.234 ± 0.508
1.899AsnGlu: 1.899 ± 0.59
1.229AsnPhe: 1.229 ± 0.359
3.574AsnGly: 3.574 ± 0.743
0.558AsnHis: 0.558 ± 0.235
2.234AsnIle: 2.234 ± 0.493
2.457AsnLys: 2.457 ± 0.455
3.127AsnLeu: 3.127 ± 0.661
1.452AsnMet: 1.452 ± 0.344
2.234AsnAsn: 2.234 ± 0.483
3.574AsnPro: 3.574 ± 0.565
1.117AsnGln: 1.117 ± 0.337
2.346AsnArg: 2.346 ± 0.44
1.899AsnSer: 1.899 ± 0.533
2.569AsnThr: 2.569 ± 0.765
3.909AsnVal: 3.909 ± 0.661
0.335AsnTrp: 0.335 ± 0.161
1.34AsnTyr: 1.34 ± 0.458
0.0AsnXaa: 0.0 ± 0.0
Pro
4.691ProAla: 4.691 ± 0.965
0.335ProCys: 0.335 ± 0.176
2.234ProAsp: 2.234 ± 0.357
3.909ProGlu: 3.909 ± 0.542
2.792ProPhe: 2.792 ± 0.441
2.346ProGly: 2.346 ± 0.513
0.894ProHis: 0.894 ± 0.318
3.127ProIle: 3.127 ± 0.827
4.356ProLys: 4.356 ± 1.25
3.909ProLeu: 3.909 ± 0.732
1.005ProMet: 1.005 ± 0.361
1.564ProAsn: 1.564 ± 0.403
5.138ProPro: 5.138 ± 1.52
1.452ProGln: 1.452 ± 0.448
2.569ProArg: 2.569 ± 0.495
4.244ProSer: 4.244 ± 0.922
5.361ProThr: 5.361 ± 1.067
3.239ProVal: 3.239 ± 0.465
0.335ProTrp: 0.335 ± 0.157
1.34ProTyr: 1.34 ± 0.332
0.0ProXaa: 0.0 ± 0.0
Gln
1.452GlnAla: 1.452 ± 0.376
0.558GlnCys: 0.558 ± 0.358
1.117GlnAsp: 1.117 ± 0.323
1.899GlnGlu: 1.899 ± 0.382
2.122GlnPhe: 2.122 ± 0.482
1.564GlnGly: 1.564 ± 0.438
0.67GlnHis: 0.67 ± 0.212
1.564GlnIle: 1.564 ± 0.276
2.234GlnLys: 2.234 ± 0.573
3.574GlnLeu: 3.574 ± 0.814
0.447GlnMet: 0.447 ± 0.243
1.005GlnAsn: 1.005 ± 0.335
1.452GlnPro: 1.452 ± 0.551
1.005GlnGln: 1.005 ± 0.264
2.122GlnArg: 2.122 ± 0.538
2.234GlnSer: 2.234 ± 0.551
1.452GlnThr: 1.452 ± 0.292
1.34GlnVal: 1.34 ± 0.423
0.782GlnTrp: 0.782 ± 0.182
0.782GlnTyr: 0.782 ± 0.309
0.0GlnXaa: 0.0 ± 0.0
Arg
3.686ArgAla: 3.686 ± 0.825
0.894ArgCys: 0.894 ± 0.319
2.681ArgAsp: 2.681 ± 0.475
4.021ArgGlu: 4.021 ± 1.121
2.346ArgPhe: 2.346 ± 0.596
3.016ArgGly: 3.016 ± 0.566
1.005ArgHis: 1.005 ± 0.448
3.016ArgIle: 3.016 ± 0.589
4.691ArgLys: 4.691 ± 0.814
5.696ArgLeu: 5.696 ± 0.839
1.452ArgMet: 1.452 ± 0.529
1.787ArgAsn: 1.787 ± 0.371
2.681ArgPro: 2.681 ± 0.5
1.34ArgGln: 1.34 ± 0.38
4.468ArgArg: 4.468 ± 0.947
2.569ArgSer: 2.569 ± 0.544
2.569ArgThr: 2.569 ± 0.529
3.463ArgVal: 3.463 ± 0.661
1.229ArgTrp: 1.229 ± 0.308
2.01ArgTyr: 2.01 ± 0.358
0.0ArgXaa: 0.0 ± 0.0
Ser
6.813SerAla: 6.813 ± 0.966
0.782SerCys: 0.782 ± 0.287
2.904SerAsp: 2.904 ± 0.63
3.463SerGlu: 3.463 ± 0.565
2.234SerPhe: 2.234 ± 0.467
5.696SerGly: 5.696 ± 1.429
1.675SerHis: 1.675 ± 0.405
5.026SerIle: 5.026 ± 0.628
3.798SerLys: 3.798 ± 0.648
5.25SerLeu: 5.25 ± 0.632
1.34SerMet: 1.34 ± 0.408
1.117SerAsn: 1.117 ± 0.384
3.574SerPro: 3.574 ± 0.827
2.457SerGln: 2.457 ± 0.375
2.904SerArg: 2.904 ± 0.449
5.138SerSer: 5.138 ± 0.813
4.579SerThr: 4.579 ± 0.778
5.92SerVal: 5.92 ± 1.072
0.447SerTrp: 0.447 ± 0.23
2.569SerTyr: 2.569 ± 0.43
0.0SerXaa: 0.0 ± 0.0
Thr
7.148ThrAla: 7.148 ± 0.961
0.335ThrCys: 0.335 ± 0.208
4.803ThrAsp: 4.803 ± 1.129
2.346ThrGlu: 2.346 ± 0.533
1.787ThrPhe: 1.787 ± 0.403
3.909ThrGly: 3.909 ± 0.72
0.782ThrHis: 0.782 ± 0.356
3.463ThrIle: 3.463 ± 0.746
2.904ThrLys: 2.904 ± 0.626
5.696ThrLeu: 5.696 ± 0.763
1.899ThrMet: 1.899 ± 0.378
3.351ThrAsn: 3.351 ± 0.783
3.463ThrPro: 3.463 ± 0.668
1.899ThrGln: 1.899 ± 0.551
2.681ThrArg: 2.681 ± 0.707
4.244ThrSer: 4.244 ± 1.095
4.133ThrThr: 4.133 ± 0.774
2.681ThrVal: 2.681 ± 0.8
0.558ThrTrp: 0.558 ± 0.291
1.899ThrTyr: 1.899 ± 0.482
0.0ThrXaa: 0.0 ± 0.0
Val
5.808ValAla: 5.808 ± 0.776
0.894ValCys: 0.894 ± 0.336
2.681ValAsp: 2.681 ± 0.6
3.463ValGlu: 3.463 ± 0.803
2.681ValPhe: 2.681 ± 0.615
7.037ValGly: 7.037 ± 1.119
0.67ValHis: 0.67 ± 0.308
3.127ValIle: 3.127 ± 0.502
5.138ValLys: 5.138 ± 1.116
4.915ValLeu: 4.915 ± 0.885
2.234ValMet: 2.234 ± 0.424
1.787ValAsn: 1.787 ± 0.578
3.686ValPro: 3.686 ± 0.916
1.452ValGln: 1.452 ± 0.401
3.239ValArg: 3.239 ± 0.711
4.579ValSer: 4.579 ± 0.906
1.005ValThr: 1.005 ± 0.499
4.915ValVal: 4.915 ± 0.744
0.67ValTrp: 0.67 ± 0.244
3.016ValTyr: 3.016 ± 0.5
0.0ValXaa: 0.0 ± 0.0
Trp
0.67TrpAla: 0.67 ± 0.269
0.223TrpCys: 0.223 ± 0.16
0.782TrpAsp: 0.782 ± 0.23
1.229TrpGlu: 1.229 ± 0.427
0.558TrpPhe: 0.558 ± 0.274
0.782TrpGly: 0.782 ± 0.281
0.335TrpHis: 0.335 ± 0.185
0.335TrpIle: 0.335 ± 0.184
1.005TrpLys: 1.005 ± 0.321
0.894TrpLeu: 0.894 ± 0.256
0.558TrpMet: 0.558 ± 0.214
0.447TrpAsn: 0.447 ± 0.164
0.223TrpPro: 0.223 ± 0.141
0.335TrpGln: 0.335 ± 0.167
1.117TrpArg: 1.117 ± 0.28
1.117TrpSer: 1.117 ± 0.444
0.67TrpThr: 0.67 ± 0.292
0.67TrpVal: 0.67 ± 0.184
0.447TrpTrp: 0.447 ± 0.213
0.335TrpTyr: 0.335 ± 0.191
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.133TyrAla: 4.133 ± 0.561
0.335TyrCys: 0.335 ± 0.228
3.239TyrAsp: 3.239 ± 0.527
2.346TyrGlu: 2.346 ± 0.472
1.229TyrPhe: 1.229 ± 0.353
2.681TyrGly: 2.681 ± 0.71
0.782TyrHis: 0.782 ± 0.265
1.787TyrIle: 1.787 ± 0.569
3.016TyrLys: 3.016 ± 0.58
3.016TyrLeu: 3.016 ± 0.615
0.447TyrMet: 0.447 ± 0.242
2.457TyrAsn: 2.457 ± 0.59
1.675TyrPro: 1.675 ± 0.505
1.117TyrGln: 1.117 ± 0.403
1.675TyrArg: 1.675 ± 0.501
1.899TyrSer: 1.899 ± 0.57
1.34TyrThr: 1.34 ± 0.367
3.127TyrVal: 3.127 ± 0.457
0.894TyrTrp: 0.894 ± 0.386
1.899TyrTyr: 1.899 ± 0.676
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 32 proteins (8954 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski