Amino acid dipepetide frequency for Streptococcus sp. WM07

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.341AlaAla: 7.341 ± 0.429
0.475AlaCys: 0.475 ± 0.034
4.332AlaAsp: 4.332 ± 0.097
5.223AlaGlu: 5.223 ± 0.125
3.295AlaPhe: 3.295 ± 0.087
6.296AlaGly: 6.296 ± 0.156
1.264AlaHis: 1.264 ± 0.058
5.318AlaIle: 5.318 ± 0.127
5.227AlaLys: 5.227 ± 0.332
8.267AlaLeu: 8.267 ± 0.165
1.854AlaMet: 1.854 ± 0.071
3.009AlaAsn: 3.009 ± 0.095
2.242AlaPro: 2.242 ± 0.082
3.943AlaGln: 3.943 ± 0.118
3.452AlaArg: 3.452 ± 0.084
4.953AlaSer: 4.953 ± 0.12
4.054AlaThr: 4.054 ± 0.13
5.517AlaVal: 5.517 ± 0.167
0.737AlaTrp: 0.737 ± 0.043
2.999AlaTyr: 2.999 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.223CysAla: 0.223 ± 0.021
0.038CysCys: 0.038 ± 0.009
0.264CysAsp: 0.264 ± 0.023
0.173CysGlu: 0.173 ± 0.017
0.242CysPhe: 0.242 ± 0.022
0.429CysGly: 0.429 ± 0.029
0.153CysHis: 0.153 ± 0.018
0.27CysIle: 0.27 ± 0.024
0.163CysLys: 0.163 ± 0.02
0.556CysLeu: 0.556 ± 0.039
0.107CysMet: 0.107 ± 0.013
0.161CysAsn: 0.161 ± 0.017
0.252CysPro: 0.252 ± 0.025
0.358CysGln: 0.358 ± 0.029
0.266CysArg: 0.266 ± 0.023
0.312CysSer: 0.312 ± 0.026
0.179CysThr: 0.179 ± 0.021
0.296CysVal: 0.296 ± 0.028
0.056CysTrp: 0.056 ± 0.011
0.151CysTyr: 0.151 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.152AspAla: 4.152 ± 0.218
0.258AspCys: 0.258 ± 0.023
2.285AspAsp: 2.285 ± 0.086
3.683AspGlu: 3.683 ± 0.1
3.047AspPhe: 3.047 ± 0.078
3.929AspGly: 3.929 ± 0.116
0.984AspHis: 0.984 ± 0.05
3.512AspIle: 3.512 ± 0.093
3.369AspLys: 3.369 ± 0.099
6.63AspLeu: 6.63 ± 0.143
1.385AspMet: 1.385 ± 0.052
1.695AspAsn: 1.695 ± 0.062
2.283AspPro: 2.283 ± 0.114
2.876AspGln: 2.876 ± 0.068
2.442AspArg: 2.442 ± 0.086
3.214AspSer: 3.214 ± 0.083
2.701AspThr: 2.701 ± 0.081
3.597AspVal: 3.597 ± 0.111
0.817AspTrp: 0.817 ± 0.039
2.619AspTyr: 2.619 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
6.604GluAla: 6.604 ± 0.169
0.233GluCys: 0.233 ± 0.022
4.024GluAsp: 4.024 ± 0.083
7.214GluGlu: 7.214 ± 0.162
2.611GluPhe: 2.611 ± 0.079
4.424GluGly: 4.424 ± 0.118
1.188GluHis: 1.188 ± 0.054
4.964GluIle: 4.964 ± 0.1
5.239GluLys: 5.239 ± 0.131
7.228GluLeu: 7.228 ± 0.147
1.96GluMet: 1.96 ± 0.068
3.315GluAsn: 3.315 ± 0.081
2.069GluPro: 2.069 ± 0.122
3.329GluGln: 3.329 ± 0.1
3.422GluArg: 3.422 ± 0.086
4.581GluSer: 4.581 ± 0.53
4.044GluThr: 4.044 ± 0.142
5.529GluVal: 5.529 ± 0.134
0.644GluTrp: 0.644 ± 0.033
1.952GluTyr: 1.952 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
2.975PheAla: 2.975 ± 0.082
0.221PheCys: 0.221 ± 0.024
2.653PheAsp: 2.653 ± 0.087
3.021PheGlu: 3.021 ± 0.085
2.023PhePhe: 2.023 ± 0.081
3.013PheGly: 3.013 ± 0.088
0.807PheHis: 0.807 ± 0.043
2.514PheIle: 2.514 ± 0.085
2.154PheLys: 2.154 ± 0.076
4.859PheLeu: 4.859 ± 0.143
0.946PheMet: 0.946 ± 0.049
1.498PheAsn: 1.498 ± 0.062
1.648PhePro: 1.648 ± 0.062
2.061PheGln: 2.061 ± 0.071
1.759PheArg: 1.759 ± 0.056
2.923PheSer: 2.923 ± 0.075
2.214PheThr: 2.214 ± 0.073
3.001PheVal: 3.001 ± 0.093
0.493PheTrp: 0.493 ± 0.033
1.63PheTyr: 1.63 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.666GlyAla: 4.666 ± 0.112
0.368GlyCys: 0.368 ± 0.028
3.645GlyAsp: 3.645 ± 0.106
3.887GlyGlu: 3.887 ± 0.098
3.295GlyPhe: 3.295 ± 0.093
4.183GlyGly: 4.183 ± 0.132
1.399GlyHis: 1.399 ± 0.066
5.058GlyIle: 5.058 ± 0.131
4.116GlyLys: 4.116 ± 0.088
7.317GlyLeu: 7.317 ± 0.17
1.822GlyMet: 1.822 ± 0.062
2.446GlyAsn: 2.446 ± 0.077
1.681GlyPro: 1.681 ± 0.067
4.068GlyGln: 4.068 ± 0.135
3.355GlyArg: 3.355 ± 0.1
4.191GlySer: 4.191 ± 0.093
3.975GlyThr: 3.975 ± 0.118
5.139GlyVal: 5.139 ± 0.118
0.666GlyTrp: 0.666 ± 0.036
2.605GlyTyr: 2.605 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.057HisAla: 1.057 ± 0.052
0.117HisCys: 0.117 ± 0.015
0.819HisAsp: 0.819 ± 0.046
1.037HisGlu: 1.037 ± 0.047
1.057HisPhe: 1.057 ± 0.045
1.169HisGly: 1.169 ± 0.06
0.519HisHis: 0.519 ± 0.032
1.129HisIle: 1.129 ± 0.052
0.934HisLys: 0.934 ± 0.059
2.186HisLeu: 2.186 ± 0.085
0.413HisMet: 0.413 ± 0.029
0.56HisAsn: 0.56 ± 0.036
1.023HisPro: 1.023 ± 0.051
1.153HisGln: 1.153 ± 0.054
1.006HisArg: 1.006 ± 0.047
1.045HisSer: 1.045 ± 0.052
0.829HisThr: 0.829 ± 0.039
1.204HisVal: 1.204 ± 0.051
0.181HisTrp: 0.181 ± 0.016
0.906HisTyr: 0.906 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.245IleAla: 5.245 ± 0.102
0.413IleCys: 0.413 ± 0.029
3.76IleAsp: 3.76 ± 0.102
4.4IleGlu: 4.4 ± 0.095
2.844IlePhe: 2.844 ± 0.094
4.346IleGly: 4.346 ± 0.116
1.286IleHis: 1.286 ± 0.046
3.665IleIle: 3.665 ± 0.11
3.082IleLys: 3.082 ± 0.08
7.204IleLeu: 7.204 ± 0.154
1.28IleMet: 1.28 ± 0.062
2.329IleAsn: 2.329 ± 0.073
2.979IlePro: 2.979 ± 0.09
3.321IleGln: 3.321 ± 0.077
3.108IleArg: 3.108 ± 0.076
4.209IleSer: 4.209 ± 0.198
3.072IleThr: 3.072 ± 0.088
4.195IleVal: 4.195 ± 0.101
0.614IleTrp: 0.614 ± 0.033
2.305IleTyr: 2.305 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
4.923LysAla: 4.923 ± 0.257
0.133LysCys: 0.133 ± 0.015
3.476LysAsp: 3.476 ± 0.097
5.704LysGlu: 5.704 ± 0.155
1.59LysPhe: 1.59 ± 0.058
3.726LysGly: 3.726 ± 0.096
0.908LysHis: 0.908 ± 0.052
3.726LysIle: 3.726 ± 0.093
4.394LysLys: 4.394 ± 0.146
4.821LysLeu: 4.821 ± 0.14
1.729LysMet: 1.729 ± 0.059
2.655LysAsn: 2.655 ± 0.075
2.28LysPro: 2.28 ± 0.112
2.502LysGln: 2.502 ± 0.073
2.995LysArg: 2.995 ± 0.085
3.285LysSer: 3.285 ± 0.095
3.482LysThr: 3.482 ± 0.107
4.265LysVal: 4.265 ± 0.117
0.479LysTrp: 0.479 ± 0.032
1.608LysTyr: 1.608 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
9.736LeuAla: 9.736 ± 0.189
0.447LeuCys: 0.447 ± 0.033
6.183LeuAsp: 6.183 ± 0.118
8.794LeuGlu: 8.794 ± 0.202
4.295LeuPhe: 4.295 ± 0.128
7.298LeuGly: 7.298 ± 0.146
1.699LeuHis: 1.699 ± 0.077
6.014LeuIle: 6.014 ± 0.146
5.734LeuLys: 5.734 ± 0.149
11.332LeuLeu: 11.332 ± 0.246
2.45LeuMet: 2.45 ± 0.074
3.782LeuAsn: 3.782 ± 0.093
4.549LeuPro: 4.549 ± 0.113
4.243LeuGln: 4.243 ± 0.118
4.452LeuArg: 4.452 ± 0.118
7.129LeuSer: 7.129 ± 0.144
5.94LeuThr: 5.94 ± 0.123
7.455LeuVal: 7.455 ± 0.133
0.791LeuTrp: 0.791 ± 0.038
3.295LeuTyr: 3.295 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
2.069MetAla: 2.069 ± 0.074
0.097MetCys: 0.097 ± 0.012
1.493MetAsp: 1.493 ± 0.056
1.747MetGlu: 1.747 ± 0.064
0.696MetPhe: 0.696 ± 0.039
1.703MetGly: 1.703 ± 0.071
0.324MetHis: 0.324 ± 0.023
1.59MetIle: 1.59 ± 0.062
1.844MetLys: 1.844 ± 0.056
1.946MetLeu: 1.946 ± 0.07
0.713MetMet: 0.713 ± 0.04
1.214MetAsn: 1.214 ± 0.054
0.725MetPro: 0.725 ± 0.039
0.904MetGln: 0.904 ± 0.044
1.089MetArg: 1.089 ± 0.046
1.53MetSer: 1.53 ± 0.061
1.63MetThr: 1.63 ± 0.051
1.751MetVal: 1.751 ± 0.064
0.169MetTrp: 0.169 ± 0.02
0.509MetTyr: 0.509 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.605AsnAla: 2.605 ± 0.102
0.191AsnCys: 0.191 ± 0.022
1.663AsnAsp: 1.663 ± 0.068
2.043AsnGlu: 2.043 ± 0.071
1.669AsnPhe: 1.669 ± 0.067
2.739AsnGly: 2.739 ± 0.093
0.896AsnHis: 0.896 ± 0.04
2.419AsnIle: 2.419 ± 0.079
2.027AsnLys: 2.027 ± 0.077
4.444AsnLeu: 4.444 ± 0.117
0.934AsnMet: 0.934 ± 0.045
1.459AsnAsn: 1.459 ± 0.055
2.462AsnPro: 2.462 ± 0.086
2.369AsnGln: 2.369 ± 0.067
2.224AsnArg: 2.224 ± 0.073
2.075AsnSer: 2.075 ± 0.08
1.956AsnThr: 1.956 ± 0.076
2.297AsnVal: 2.297 ± 0.07
0.493AsnTrp: 0.493 ± 0.036
1.644AsnTyr: 1.644 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
3.118ProAla: 3.118 ± 0.109
0.163ProCys: 0.163 ± 0.02
2.315ProAsp: 2.315 ± 0.08
3.359ProGlu: 3.359 ± 0.129
1.761ProPhe: 1.761 ± 0.069
2.341ProGly: 2.341 ± 0.07
0.747ProHis: 0.747 ± 0.038
2.433ProIle: 2.433 ± 0.087
2.027ProLys: 2.027 ± 0.068
3.45ProLeu: 3.45 ± 0.092
0.755ProMet: 0.755 ± 0.039
1.691ProAsn: 1.691 ± 0.083
0.829ProPro: 0.829 ± 0.058
1.61ProGln: 1.61 ± 0.064
1.278ProArg: 1.278 ± 0.052
2.488ProSer: 2.488 ± 0.078
2.166ProThr: 2.166 ± 0.112
3.486ProVal: 3.486 ± 0.174
0.34ProTrp: 0.34 ± 0.03
1.469ProTyr: 1.469 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
5.026GlnAla: 5.026 ± 0.115
0.103GlnCys: 0.103 ± 0.012
2.617GlnAsp: 2.617 ± 0.08
4.815GlnGlu: 4.815 ± 0.138
1.65GlnPhe: 1.65 ± 0.058
3.186GlnGly: 3.186 ± 0.091
0.715GlnHis: 0.715 ± 0.041
3.027GlnIle: 3.027 ± 0.076
2.784GlnLys: 2.784 ± 0.068
4.966GlnLeu: 4.966 ± 0.125
1.119GlnMet: 1.119 ± 0.051
1.799GlnAsn: 1.799 ± 0.069
1.673GlnPro: 1.673 ± 0.075
1.912GlnGln: 1.912 ± 0.08
1.92GlnArg: 1.92 ± 0.064
2.599GlnSer: 2.599 ± 0.075
2.566GlnThr: 2.566 ± 0.086
4.394GlnVal: 4.394 ± 0.117
0.417GlnTrp: 0.417 ± 0.03
1.246GlnTyr: 1.246 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
2.904ArgAla: 2.904 ± 0.075
0.185ArgCys: 0.185 ± 0.021
2.313ArgAsp: 2.313 ± 0.067
3.516ArgGlu: 3.516 ± 0.095
2.192ArgPhe: 2.192 ± 0.081
2.615ArgGly: 2.615 ± 0.077
0.914ArgHis: 0.914 ± 0.049
3.194ArgIle: 3.194 ± 0.085
3.027ArgLys: 3.027 ± 0.077
4.913ArgLeu: 4.913 ± 0.115
1.218ArgMet: 1.218 ± 0.049
1.836ArgAsn: 1.836 ± 0.062
1.655ArgPro: 1.655 ± 0.079
2.506ArgGln: 2.506 ± 0.075
2.456ArgArg: 2.456 ± 0.071
2.419ArgSer: 2.419 ± 0.075
2.23ArgThr: 2.23 ± 0.079
3.138ArgVal: 3.138 ± 0.095
0.415ArgTrp: 0.415 ± 0.028
1.801ArgTyr: 1.801 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
3.852SerAla: 3.852 ± 0.089
0.312SerCys: 0.312 ± 0.031
3.096SerAsp: 3.096 ± 0.095
4.241SerGlu: 4.241 ± 0.532
2.904SerPhe: 2.904 ± 0.085
4.372SerGly: 4.372 ± 0.093
1.326SerHis: 1.326 ± 0.057
4.171SerIle: 4.171 ± 0.199
3.388SerLys: 3.388 ± 0.088
7.371SerLeu: 7.371 ± 0.134
1.449SerMet: 1.449 ± 0.057
2.564SerAsn: 2.564 ± 0.096
2.383SerPro: 2.383 ± 0.083
3.547SerGln: 3.547 ± 0.095
2.715SerArg: 2.715 ± 0.084
4.299SerSer: 4.299 ± 0.154
3.063SerThr: 3.063 ± 0.079
4.38SerVal: 4.38 ± 0.357
0.711SerTrp: 0.711 ± 0.038
2.504SerTyr: 2.504 ± 0.088
0.0SerXaa: 0.0 ± 0.0
Thr
4.132ThrAla: 4.132 ± 0.17
0.264ThrCys: 0.264 ± 0.027
3.218ThrAsp: 3.218 ± 0.085
3.305ThrGlu: 3.305 ± 0.114
2.276ThrPhe: 2.276 ± 0.072
4.253ThrGly: 4.253 ± 0.116
0.89ThrHis: 0.89 ± 0.042
3.625ThrIle: 3.625 ± 0.086
2.973ThrLys: 2.973 ± 0.091
5.429ThrLeu: 5.429 ± 0.119
1.095ThrMet: 1.095 ± 0.05
2.202ThrAsn: 2.202 ± 0.081
2.592ThrPro: 2.592 ± 0.106
2.073ThrGln: 2.073 ± 0.087
2.037ThrArg: 2.037 ± 0.076
3.506ThrSer: 3.506 ± 0.097
3.22ThrThr: 3.22 ± 0.133
4.362ThrVal: 4.362 ± 0.139
0.576ThrTrp: 0.576 ± 0.035
2.355ThrTyr: 2.355 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
6.169ValAla: 6.169 ± 0.136
0.362ValCys: 0.362 ± 0.031
4.792ValAsp: 4.792 ± 0.141
5.628ValGlu: 5.628 ± 0.162
2.882ValPhe: 2.882 ± 0.092
4.799ValGly: 4.799 ± 0.126
1.272ValHis: 1.272 ± 0.063
4.338ValIle: 4.338 ± 0.103
3.913ValLys: 3.913 ± 0.124
7.246ValLeu: 7.246 ± 0.142
1.552ValMet: 1.552 ± 0.062
2.552ValAsn: 2.552 ± 0.076
2.687ValPro: 2.687 ± 0.1
2.786ValGln: 2.786 ± 0.082
3.07ValArg: 3.07 ± 0.089
5.004ValSer: 5.004 ± 0.362
4.7ValThr: 4.7 ± 0.148
5.366ValVal: 5.366 ± 0.18
0.672ValTrp: 0.672 ± 0.045
2.381ValTyr: 2.381 ± 0.077
0.0ValXaa: 0.0 ± 0.0
Trp
0.638TrpAla: 0.638 ± 0.04
0.046TrpCys: 0.046 ± 0.009
0.539TrpAsp: 0.539 ± 0.037
0.676TrpGlu: 0.676 ± 0.043
0.419TrpPhe: 0.419 ± 0.031
0.644TrpGly: 0.644 ± 0.04
0.211TrpHis: 0.211 ± 0.02
0.747TrpIle: 0.747 ± 0.039
0.523TrpLys: 0.523 ± 0.032
1.173TrpLeu: 1.173 ± 0.055
0.274TrpMet: 0.274 ± 0.027
0.495TrpAsn: 0.495 ± 0.029
0.229TrpPro: 0.229 ± 0.022
0.475TrpGln: 0.475 ± 0.033
0.417TrpArg: 0.417 ± 0.03
0.678TrpSer: 0.678 ± 0.039
0.572TrpThr: 0.572 ± 0.038
0.541TrpVal: 0.541 ± 0.033
0.113TrpTrp: 0.113 ± 0.016
0.316TrpTyr: 0.316 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.361TyrAla: 2.361 ± 0.067
0.221TyrCys: 0.221 ± 0.022
1.993TyrAsp: 1.993 ± 0.08
2.107TyrGlu: 2.107 ± 0.07
1.665TyrPhe: 1.665 ± 0.063
2.415TyrGly: 2.415 ± 0.073
0.841TyrHis: 0.841 ± 0.042
1.94TyrIle: 1.94 ± 0.077
1.765TyrLys: 1.765 ± 0.077
4.283TyrLeu: 4.283 ± 0.105
0.69TyrMet: 0.69 ± 0.037
1.349TyrAsn: 1.349 ± 0.064
1.586TyrPro: 1.586 ± 0.063
2.496TyrGln: 2.496 ± 0.082
1.985TyrArg: 1.985 ± 0.073
2.208TyrSer: 2.208 ± 0.078
1.789TyrThr: 1.789 ± 0.066
2.258TyrVal: 2.258 ± 0.086
0.344TyrTrp: 0.344 ± 0.026
1.524TyrTyr: 1.524 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1709 proteins (496822 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski