Amino acid dipepetide frequency for Klebsiella phage ST13-OXA48phi12.5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.853AlaAla: 11.853 ± 2.002
0.889AlaCys: 0.889 ± 0.216
6.149AlaAsp: 6.149 ± 0.639
6.667AlaGlu: 6.667 ± 0.95
3.334AlaPhe: 3.334 ± 0.445
7.112AlaGly: 7.112 ± 0.927
1.482AlaHis: 1.482 ± 0.28
5.704AlaIle: 5.704 ± 0.608
5.556AlaLys: 5.556 ± 0.68
8.075AlaLeu: 8.075 ± 1.101
3.334AlaMet: 3.334 ± 0.401
5.111AlaAsn: 5.111 ± 0.677
2.222AlaPro: 2.222 ± 0.51
4.445AlaGln: 4.445 ± 0.719
5.334AlaArg: 5.334 ± 0.827
6.297AlaSer: 6.297 ± 0.764
5.63AlaThr: 5.63 ± 0.796
5.26AlaVal: 5.26 ± 0.593
1.852AlaTrp: 1.852 ± 0.329
2.963AlaTyr: 2.963 ± 0.507
0.0AlaXaa: 0.0 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.262
0.37CysCys: 0.37 ± 0.151
1.408CysAsp: 1.408 ± 0.328
0.741CysGlu: 0.741 ± 0.255
0.296CysPhe: 0.296 ± 0.145
1.037CysGly: 1.037 ± 0.299
0.741CysHis: 0.741 ± 0.239
0.444CysIle: 0.444 ± 0.178
0.667CysLys: 0.667 ± 0.215
0.741CysLeu: 0.741 ± 0.199
0.444CysMet: 0.444 ± 0.173
0.667CysAsn: 0.667 ± 0.245
0.667CysPro: 0.667 ± 0.336
0.444CysGln: 0.444 ± 0.239
1.037CysArg: 1.037 ± 0.342
1.185CysSer: 1.185 ± 0.281
0.444CysThr: 0.444 ± 0.187
0.296CysVal: 0.296 ± 0.19
0.37CysTrp: 0.37 ± 0.142
0.222CysTyr: 0.222 ± 0.134
0.0CysXaa: 0.0 ± 0.0
Asp
5.26AspAla: 5.26 ± 0.576
0.741AspCys: 0.741 ± 0.288
3.185AspAsp: 3.185 ± 0.589
3.63AspGlu: 3.63 ± 0.754
2.889AspPhe: 2.889 ± 0.378
5.408AspGly: 5.408 ± 0.664
1.259AspHis: 1.259 ± 0.3
2.815AspIle: 2.815 ± 0.56
3.111AspLys: 3.111 ± 0.548
4.667AspLeu: 4.667 ± 0.511
1.408AspMet: 1.408 ± 0.307
2.593AspAsn: 2.593 ± 0.441
2.148AspPro: 2.148 ± 0.377
1.778AspGln: 1.778 ± 0.282
2.889AspArg: 2.889 ± 0.44
4.445AspSer: 4.445 ± 0.63
3.26AspThr: 3.26 ± 0.539
3.926AspVal: 3.926 ± 0.491
1.111AspTrp: 1.111 ± 0.294
2.667AspTyr: 2.667 ± 0.48
0.0AspXaa: 0.0 ± 0.0
Glu
4.963GluAla: 4.963 ± 0.615
1.111GluCys: 1.111 ± 0.361
3.037GluAsp: 3.037 ± 0.52
3.778GluGlu: 3.778 ± 0.596
2.593GluPhe: 2.593 ± 0.431
3.852GluGly: 3.852 ± 0.558
1.408GluHis: 1.408 ± 0.323
4.148GluIle: 4.148 ± 0.652
4.371GluLys: 4.371 ± 0.695
4.815GluLeu: 4.815 ± 0.71
1.556GluMet: 1.556 ± 0.333
2.593GluAsn: 2.593 ± 0.44
2.148GluPro: 2.148 ± 0.537
4.0GluGln: 4.0 ± 0.563
4.445GluArg: 4.445 ± 0.494
4.0GluSer: 4.0 ± 0.606
2.815GluThr: 2.815 ± 0.467
4.148GluVal: 4.148 ± 0.525
1.259GluTrp: 1.259 ± 0.351
2.445GluTyr: 2.445 ± 0.305
0.0GluXaa: 0.0 ± 0.0
Phe
3.26PheAla: 3.26 ± 0.496
0.667PheCys: 0.667 ± 0.207
2.889PheAsp: 2.889 ± 0.497
2.222PheGlu: 2.222 ± 0.288
1.111PhePhe: 1.111 ± 0.314
3.111PheGly: 3.111 ± 0.457
0.593PheHis: 0.593 ± 0.225
2.519PheIle: 2.519 ± 0.272
1.408PheLys: 1.408 ± 0.37
1.556PheLeu: 1.556 ± 0.3
0.889PheMet: 0.889 ± 0.271
1.333PheAsn: 1.333 ± 0.286
1.111PhePro: 1.111 ± 0.327
1.037PheGln: 1.037 ± 0.213
1.926PheArg: 1.926 ± 0.363
2.741PheSer: 2.741 ± 0.463
2.371PheThr: 2.371 ± 0.394
2.296PheVal: 2.296 ± 0.385
0.667PheTrp: 0.667 ± 0.243
0.815PheTyr: 0.815 ± 0.228
0.0PheXaa: 0.0 ± 0.0
Gly
6.445GlyAla: 6.445 ± 0.665
1.185GlyCys: 1.185 ± 0.302
4.593GlyAsp: 4.593 ± 0.57
5.556GlyGlu: 5.556 ± 0.723
2.741GlyPhe: 2.741 ± 0.525
5.408GlyGly: 5.408 ± 0.917
1.63GlyHis: 1.63 ± 0.386
4.074GlyIle: 4.074 ± 0.491
4.667GlyLys: 4.667 ± 0.638
5.852GlyLeu: 5.852 ± 0.648
1.926GlyMet: 1.926 ± 0.434
3.408GlyAsn: 3.408 ± 0.501
0.815GlyPro: 0.815 ± 0.217
2.445GlyGln: 2.445 ± 0.449
4.519GlyArg: 4.519 ± 0.519
3.852GlySer: 3.852 ± 0.532
4.889GlyThr: 4.889 ± 0.603
4.519GlyVal: 4.519 ± 0.492
0.963GlyTrp: 0.963 ± 0.252
2.741GlyTyr: 2.741 ± 0.409
0.0GlyXaa: 0.0 ± 0.0
His
1.482HisAla: 1.482 ± 0.329
0.444HisCys: 0.444 ± 0.155
1.111HisAsp: 1.111 ± 0.271
1.185HisGlu: 1.185 ± 0.306
1.111HisPhe: 1.111 ± 0.29
1.185HisGly: 1.185 ± 0.288
0.37HisHis: 0.37 ± 0.145
1.408HisIle: 1.408 ± 0.383
0.741HisLys: 0.741 ± 0.185
1.704HisLeu: 1.704 ± 0.391
0.296HisMet: 0.296 ± 0.152
0.519HisAsn: 0.519 ± 0.192
0.889HisPro: 0.889 ± 0.25
0.444HisGln: 0.444 ± 0.184
1.185HisArg: 1.185 ± 0.311
1.259HisSer: 1.259 ± 0.307
1.556HisThr: 1.556 ± 0.3
0.963HisVal: 0.963 ± 0.257
0.815HisTrp: 0.815 ± 0.209
0.741HisTyr: 0.741 ± 0.227
0.0HisXaa: 0.0 ± 0.0
Ile
5.26IleAla: 5.26 ± 0.581
0.815IleCys: 0.815 ± 0.244
2.741IleAsp: 2.741 ± 0.544
4.0IleGlu: 4.0 ± 0.489
1.333IlePhe: 1.333 ± 0.324
4.519IleGly: 4.519 ± 0.62
0.667IleHis: 0.667 ± 0.214
2.963IleIle: 2.963 ± 0.51
3.482IleLys: 3.482 ± 0.518
3.63IleLeu: 3.63 ± 0.491
0.963IleMet: 0.963 ± 0.285
2.815IleAsn: 2.815 ± 0.372
2.963IlePro: 2.963 ± 0.623
2.0IleGln: 2.0 ± 0.418
3.482IleArg: 3.482 ± 0.499
4.667IleSer: 4.667 ± 0.466
4.593IleThr: 4.593 ± 0.519
2.741IleVal: 2.741 ± 0.52
1.185IleTrp: 1.185 ± 0.382
1.556IleTyr: 1.556 ± 0.426
0.0IleXaa: 0.0 ± 0.0
Lys
5.63LysAla: 5.63 ± 0.659
0.741LysCys: 0.741 ± 0.31
2.519LysAsp: 2.519 ± 0.462
3.334LysGlu: 3.334 ± 0.489
1.778LysPhe: 1.778 ± 0.415
2.815LysGly: 2.815 ± 0.388
0.815LysHis: 0.815 ± 0.326
2.445LysIle: 2.445 ± 0.475
3.408LysLys: 3.408 ± 0.439
4.519LysLeu: 4.519 ± 0.641
1.556LysMet: 1.556 ± 0.312
1.778LysAsn: 1.778 ± 0.294
2.667LysPro: 2.667 ± 0.474
2.593LysGln: 2.593 ± 0.403
3.63LysArg: 3.63 ± 0.619
3.334LysSer: 3.334 ± 0.514
2.519LysThr: 2.519 ± 0.464
4.445LysVal: 4.445 ± 0.524
0.963LysTrp: 0.963 ± 0.29
1.704LysTyr: 1.704 ± 0.33
0.0LysXaa: 0.0 ± 0.0
Leu
8.593LeuAla: 8.593 ± 1.065
0.815LeuCys: 0.815 ± 0.265
4.223LeuAsp: 4.223 ± 0.617
4.963LeuGlu: 4.963 ± 0.727
1.704LeuPhe: 1.704 ± 0.363
4.815LeuGly: 4.815 ± 0.576
1.63LeuHis: 1.63 ± 0.311
5.704LeuIle: 5.704 ± 0.693
3.704LeuLys: 3.704 ± 0.514
4.371LeuLeu: 4.371 ± 0.723
1.482LeuMet: 1.482 ± 0.27
3.778LeuAsn: 3.778 ± 0.47
3.185LeuPro: 3.185 ± 0.478
2.296LeuGln: 2.296 ± 0.405
5.63LeuArg: 5.63 ± 0.629
6.445LeuSer: 6.445 ± 0.765
4.593LeuThr: 4.593 ± 0.622
4.667LeuVal: 4.667 ± 0.569
0.741LeuTrp: 0.741 ± 0.252
2.963LeuTyr: 2.963 ± 0.322
0.0LeuXaa: 0.0 ± 0.0
Met
3.704MetAla: 3.704 ± 0.575
0.148MetCys: 0.148 ± 0.1
1.259MetAsp: 1.259 ± 0.313
1.333MetGlu: 1.333 ± 0.348
0.667MetPhe: 0.667 ± 0.236
1.111MetGly: 1.111 ± 0.346
0.37MetHis: 0.37 ± 0.17
1.111MetIle: 1.111 ± 0.288
1.333MetLys: 1.333 ± 0.388
1.852MetLeu: 1.852 ± 0.34
0.593MetMet: 0.593 ± 0.268
1.704MetAsn: 1.704 ± 0.295
1.704MetPro: 1.704 ± 0.437
0.963MetGln: 0.963 ± 0.208
1.111MetArg: 1.111 ± 0.361
2.222MetSer: 2.222 ± 0.365
2.148MetThr: 2.148 ± 0.466
1.037MetVal: 1.037 ± 0.218
0.519MetTrp: 0.519 ± 0.208
0.667MetTyr: 0.667 ± 0.227
0.0MetXaa: 0.0 ± 0.0
Asn
5.334AsnAla: 5.334 ± 0.903
0.296AsnCys: 0.296 ± 0.159
3.556AsnAsp: 3.556 ± 0.584
2.074AsnGlu: 2.074 ± 0.372
1.63AsnPhe: 1.63 ± 0.334
4.223AsnGly: 4.223 ± 0.549
1.408AsnHis: 1.408 ± 0.325
2.445AsnIle: 2.445 ± 0.398
2.296AsnLys: 2.296 ± 0.308
3.852AsnLeu: 3.852 ± 0.592
1.111AsnMet: 1.111 ± 0.268
2.074AsnAsn: 2.074 ± 0.454
2.222AsnPro: 2.222 ± 0.373
1.852AsnGln: 1.852 ± 0.322
2.593AsnArg: 2.593 ± 0.374
2.741AsnSer: 2.741 ± 0.426
1.778AsnThr: 1.778 ± 0.362
3.111AsnVal: 3.111 ± 0.435
0.444AsnTrp: 0.444 ± 0.201
1.037AsnTyr: 1.037 ± 0.272
0.0AsnXaa: 0.0 ± 0.0
Pro
4.148ProAla: 4.148 ± 0.626
0.222ProCys: 0.222 ± 0.148
2.667ProAsp: 2.667 ± 0.436
3.26ProGlu: 3.26 ± 0.416
1.482ProPhe: 1.482 ± 0.399
3.111ProGly: 3.111 ± 0.623
0.963ProHis: 0.963 ± 0.222
1.852ProIle: 1.852 ± 0.407
1.111ProLys: 1.111 ± 0.287
3.408ProLeu: 3.408 ± 0.625
1.259ProMet: 1.259 ± 0.3
1.333ProAsn: 1.333 ± 0.262
1.482ProPro: 1.482 ± 0.337
0.815ProGln: 0.815 ± 0.262
1.111ProArg: 1.111 ± 0.278
2.741ProSer: 2.741 ± 0.441
2.074ProThr: 2.074 ± 0.435
4.445ProVal: 4.445 ± 0.574
0.667ProTrp: 0.667 ± 0.219
1.482ProTyr: 1.482 ± 0.361
0.0ProXaa: 0.0 ± 0.0
Gln
4.074GlnAla: 4.074 ± 0.917
0.889GlnCys: 0.889 ± 0.248
1.704GlnAsp: 1.704 ± 0.37
2.0GlnGlu: 2.0 ± 0.34
1.259GlnPhe: 1.259 ± 0.289
2.371GlnGly: 2.371 ± 0.514
0.889GlnHis: 0.889 ± 0.273
1.778GlnIle: 1.778 ± 0.31
2.148GlnLys: 2.148 ± 0.427
3.26GlnLeu: 3.26 ± 0.512
1.408GlnMet: 1.408 ± 0.347
1.259GlnAsn: 1.259 ± 0.326
1.185GlnPro: 1.185 ± 0.279
3.111GlnGln: 3.111 ± 1.042
2.519GlnArg: 2.519 ± 0.422
3.482GlnSer: 3.482 ± 0.588
2.815GlnThr: 2.815 ± 0.489
2.889GlnVal: 2.889 ± 0.393
0.963GlnTrp: 0.963 ± 0.35
1.111GlnTyr: 1.111 ± 0.326
0.0GlnXaa: 0.0 ± 0.0
Arg
5.408ArgAla: 5.408 ± 0.614
0.889ArgCys: 0.889 ± 0.254
3.408ArgAsp: 3.408 ± 0.549
4.667ArgGlu: 4.667 ± 0.757
1.333ArgPhe: 1.333 ± 0.319
3.852ArgGly: 3.852 ± 0.442
1.259ArgHis: 1.259 ± 0.295
3.408ArgIle: 3.408 ± 0.522
3.334ArgLys: 3.334 ± 0.647
5.63ArgLeu: 5.63 ± 0.742
2.371ArgMet: 2.371 ± 0.327
2.371ArgAsn: 2.371 ± 0.375
2.815ArgPro: 2.815 ± 0.533
2.371ArgGln: 2.371 ± 0.417
4.223ArgArg: 4.223 ± 0.729
3.111ArgSer: 3.111 ± 0.449
2.222ArgThr: 2.222 ± 0.543
3.63ArgVal: 3.63 ± 0.459
1.259ArgTrp: 1.259 ± 0.356
2.593ArgTyr: 2.593 ± 0.509
0.0ArgXaa: 0.0 ± 0.0
Ser
6.371SerAla: 6.371 ± 0.681
0.889SerCys: 0.889 ± 0.282
4.074SerAsp: 4.074 ± 0.511
4.519SerGlu: 4.519 ± 0.492
2.519SerPhe: 2.519 ± 0.388
6.0SerGly: 6.0 ± 0.712
1.482SerHis: 1.482 ± 0.29
3.63SerIle: 3.63 ± 0.351
3.26SerLys: 3.26 ± 0.65
5.037SerLeu: 5.037 ± 0.685
1.556SerMet: 1.556 ± 0.331
3.111SerAsn: 3.111 ± 0.522
3.778SerPro: 3.778 ± 0.59
3.111SerGln: 3.111 ± 0.748
3.704SerArg: 3.704 ± 0.445
4.148SerSer: 4.148 ± 0.67
3.26SerThr: 3.26 ± 0.519
4.815SerVal: 4.815 ± 0.496
0.741SerTrp: 0.741 ± 0.257
1.704SerTyr: 1.704 ± 0.33
0.0SerXaa: 0.0 ± 0.0
Thr
6.741ThrAla: 6.741 ± 0.801
0.667ThrCys: 0.667 ± 0.261
4.0ThrAsp: 4.0 ± 0.596
2.815ThrGlu: 2.815 ± 0.393
2.222ThrPhe: 2.222 ± 0.419
4.667ThrGly: 4.667 ± 0.54
0.815ThrHis: 0.815 ± 0.256
3.408ThrIle: 3.408 ± 0.677
2.519ThrLys: 2.519 ± 0.399
4.741ThrLeu: 4.741 ± 0.646
0.667ThrMet: 0.667 ± 0.188
2.519ThrAsn: 2.519 ± 0.356
3.037ThrPro: 3.037 ± 0.405
1.926ThrGln: 1.926 ± 0.399
2.963ThrArg: 2.963 ± 0.546
4.223ThrSer: 4.223 ± 0.831
3.926ThrThr: 3.926 ± 0.696
3.926ThrVal: 3.926 ± 0.589
0.963ThrTrp: 0.963 ± 0.278
1.185ThrTyr: 1.185 ± 0.269
0.0ThrXaa: 0.0 ± 0.0
Val
5.63ValAla: 5.63 ± 0.982
0.815ValCys: 0.815 ± 0.236
4.148ValAsp: 4.148 ± 0.485
4.445ValGlu: 4.445 ± 0.486
2.371ValPhe: 2.371 ± 0.409
4.297ValGly: 4.297 ± 0.608
0.963ValHis: 0.963 ± 0.253
4.148ValIle: 4.148 ± 0.464
3.26ValLys: 3.26 ± 0.571
4.889ValLeu: 4.889 ± 0.564
1.852ValMet: 1.852 ± 0.316
4.297ValAsn: 4.297 ± 0.574
2.074ValPro: 2.074 ± 0.441
2.963ValGln: 2.963 ± 0.51
3.556ValArg: 3.556 ± 0.549
4.074ValSer: 4.074 ± 0.662
4.148ValThr: 4.148 ± 0.508
5.186ValVal: 5.186 ± 0.708
1.037ValTrp: 1.037 ± 0.313
1.704ValTyr: 1.704 ± 0.281
0.0ValXaa: 0.0 ± 0.0
Trp
0.815TrpAla: 0.815 ± 0.293
0.222TrpCys: 0.222 ± 0.135
0.815TrpAsp: 0.815 ± 0.226
0.889TrpGlu: 0.889 ± 0.27
0.963TrpPhe: 0.963 ± 0.292
0.667TrpGly: 0.667 ± 0.229
0.148TrpHis: 0.148 ± 0.102
0.741TrpIle: 0.741 ± 0.257
1.111TrpLys: 1.111 ± 0.374
1.704TrpLeu: 1.704 ± 0.382
0.296TrpMet: 0.296 ± 0.133
1.259TrpAsn: 1.259 ± 0.313
0.667TrpPro: 0.667 ± 0.299
0.963TrpGln: 0.963 ± 0.224
2.0TrpArg: 2.0 ± 0.389
0.667TrpSer: 0.667 ± 0.25
0.741TrpThr: 0.741 ± 0.258
1.852TrpVal: 1.852 ± 0.4
0.074TrpTrp: 0.074 ± 0.076
0.593TrpTyr: 0.593 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.334TyrAla: 3.334 ± 0.428
0.37TyrCys: 0.37 ± 0.18
1.704TyrAsp: 1.704 ± 0.41
1.408TyrGlu: 1.408 ± 0.302
1.185TyrPhe: 1.185 ± 0.366
2.667TyrGly: 2.667 ± 0.374
0.519TyrHis: 0.519 ± 0.189
1.704TyrIle: 1.704 ± 0.367
1.704TyrLys: 1.704 ± 0.362
2.0TyrLeu: 2.0 ± 0.394
0.519TyrMet: 0.519 ± 0.168
1.556TyrAsn: 1.556 ± 0.324
1.852TyrPro: 1.852 ± 0.404
1.556TyrGln: 1.556 ± 0.338
2.296TyrArg: 2.296 ± 0.424
2.074TyrSer: 2.074 ± 0.318
2.148TyrThr: 2.148 ± 0.361
1.704TyrVal: 1.704 ± 0.415
0.593TyrTrp: 0.593 ± 0.232
0.741TyrTyr: 0.741 ± 0.251
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (13500 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski