Amino acid dipepetide frequency for Cyclospora cayetanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.866AlaAla: 21.866 ± 0.22	2.303AlaCys: 2.303 ± 0.029	4.639AlaAsp: 4.639 ± 0.039	7.522AlaGlu: 7.522 ± 0.058	3.86AlaPhe: 3.86 ± 0.039	6.657AlaGly: 6.657 ± 0.055	2.061AlaHis: 2.061 ± 0.024	3.056AlaIle: 3.056 ± 0.029	3.718AlaLys: 3.718 ± 0.037	11.248AlaLeu: 11.248 ± 0.077	1.694AlaMet: 1.694 ± 0.02	2.18AlaAsn: 2.18 ± 0.027	6.403AlaPro: 6.403 ± 0.053	3.84AlaGln: 3.84 ± 0.037	5.529AlaArg: 5.529 ± 0.036	10.55AlaSer: 10.55 ± 0.073	6.06AlaThr: 6.06 ± 0.042	7.547AlaVal: 7.547 ± 0.055	0.992AlaTrp: 0.992 ± 0.017	1.74AlaTyr: 1.74 ± 0.025	0.003AlaXaa: 0.003 ± 0.001
Cys	1.902CysAla: 1.902 ± 0.025	1.164CysCys: 1.164 ± 0.024	0.796CysAsp: 0.796 ± 0.015	1.045CysGlu: 1.045 ± 0.019	0.903CysPhe: 0.903 ± 0.018	1.679CysGly: 1.679 ± 0.025	0.468CysHis: 0.468 ± 0.011	0.953CysIle: 0.953 ± 0.017	0.807CysLys: 0.807 ± 0.016	2.62CysLeu: 2.62 ± 0.034	0.504CysMet: 0.504 ± 0.011	0.61CysAsn: 0.61 ± 0.014	1.233CysPro: 1.233 ± 0.034	0.622CysGln: 0.622 ± 0.014	1.619CysArg: 1.619 ± 0.023	2.468CysSer: 2.468 ± 0.029	1.271CysThr: 1.271 ± 0.022	1.541CysVal: 1.541 ± 0.021	0.31CysTrp: 0.31 ± 0.01	0.411CysTyr: 0.411 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.362AspAla: 5.362 ± 0.042	1.02AspCys: 1.02 ± 0.018	2.03AspAsp: 2.03 ± 0.027	3.023AspGlu: 3.023 ± 0.028	1.635AspPhe: 1.635 ± 0.021	3.317AspGly: 3.317 ± 0.033	0.647AspHis: 0.647 ± 0.013	1.752AspIle: 1.752 ± 0.026	1.507AspLys: 1.507 ± 0.022	3.977AspLeu: 3.977 ± 0.033	0.835AspMet: 0.835 ± 0.017	0.858AspAsn: 0.858 ± 0.014	2.418AspPro: 2.418 ± 0.023	1.199AspGln: 1.199 ± 0.017	2.255AspArg: 2.255 ± 0.027	3.821AspSer: 3.821 ± 0.039	2.372AspThr: 2.372 ± 0.022	2.76AspVal: 2.76 ± 0.033	0.529AspTrp: 0.529 ± 0.012	0.758AspTyr: 0.758 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	9.273GluAla: 9.273 ± 0.062	1.055GluCys: 1.055 ± 0.023	3.514GluAsp: 3.514 ± 0.036	6.867GluGlu: 6.867 ± 0.069	1.574GluPhe: 1.574 ± 0.023	6.044GluGly: 6.044 ± 0.044	1.347GluHis: 1.347 ± 0.019	1.952GluIle: 1.952 ± 0.027	3.277GluLys: 3.277 ± 0.043	5.735GluLeu: 5.735 ± 0.05	1.157GluMet: 1.157 ± 0.017	1.642GluAsn: 1.642 ± 0.023	2.681GluPro: 2.681 ± 0.029	3.555GluGln: 3.555 ± 0.041	4.478GluArg: 4.478 ± 0.046	4.372GluSer: 4.372 ± 0.037	3.451GluThr: 3.451 ± 0.03	3.712GluVal: 3.712 ± 0.035	0.67GluTrp: 0.67 ± 0.015	0.975GluTyr: 0.975 ± 0.019	0.001GluXaa: 0.001 ± 0.0
Phe	3.129PheAla: 3.129 ± 0.028	0.935PheCys: 0.935 ± 0.017	1.481PheAsp: 1.481 ± 0.024	1.776PheGlu: 1.776 ± 0.023	1.516PhePhe: 1.516 ± 0.022	2.152PheGly: 2.152 ± 0.028	0.686PheHis: 0.686 ± 0.014	1.1PheIle: 1.1 ± 0.018	1.141PheLys: 1.141 ± 0.017	3.788PheLeu: 3.788 ± 0.038	0.585PheMet: 0.585 ± 0.014	0.741PheAsn: 0.741 ± 0.015	1.874PhePro: 1.874 ± 0.025	1.1PheGln: 1.1 ± 0.021	1.915PheArg: 1.915 ± 0.023	3.156PheSer: 3.156 ± 0.031	1.4PheThr: 1.4 ± 0.02	2.331PheVal: 2.331 ± 0.025	0.403PheTrp: 0.403 ± 0.012	0.743PheTyr: 0.743 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	7.503GlyAla: 7.503 ± 0.055	1.722GlyCys: 1.722 ± 0.025	3.256GlyAsp: 3.256 ± 0.029	4.76GlyGlu: 4.76 ± 0.04	2.219GlyPhe: 2.219 ± 0.024	7.602GlyGly: 7.602 ± 0.078	1.329GlyHis: 1.329 ± 0.02	2.459GlyIle: 2.459 ± 0.028	2.814GlyLys: 2.814 ± 0.03	5.857GlyLeu: 5.857 ± 0.045	1.228GlyMet: 1.228 ± 0.022	1.789GlyAsn: 1.789 ± 0.024	3.961GlyPro: 3.961 ± 0.051	2.125GlyGln: 2.125 ± 0.029	4.468GlyArg: 4.468 ± 0.04	7.013GlySer: 7.013 ± 0.059	3.512GlyThr: 3.512 ± 0.035	4.598GlyVal: 4.598 ± 0.038	0.787GlyTrp: 0.787 ± 0.016	1.224GlyTyr: 1.224 ± 0.025	0.006GlyXaa: 0.006 ± 0.001
His	2.606HisAla: 2.606 ± 0.031	0.579HisCys: 0.579 ± 0.015	0.872HisAsp: 0.872 ± 0.015	1.454HisGlu: 1.454 ± 0.022	0.851HisPhe: 0.851 ± 0.017	1.567HisGly: 1.567 ± 0.023	0.763HisHis: 0.763 ± 0.014	0.829HisIle: 0.829 ± 0.017	0.934HisLys: 0.934 ± 0.018	2.682HisLeu: 2.682 ± 0.025	0.47HisMet: 0.47 ± 0.011	0.538HisAsn: 0.538 ± 0.013	1.782HisPro: 1.782 ± 0.025	1.574HisGln: 1.574 ± 0.028	1.786HisArg: 1.786 ± 0.021	2.045HisSer: 2.045 ± 0.026	1.169HisThr: 1.169 ± 0.016	1.412HisVal: 1.412 ± 0.021	0.286HisTrp: 0.286 ± 0.007	0.452HisTyr: 0.452 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	2.99IleAla: 2.99 ± 0.03	0.873IleCys: 0.873 ± 0.017	1.547IleAsp: 1.547 ± 0.022	2.006IleGlu: 2.006 ± 0.025	1.131IlePhe: 1.131 ± 0.017	1.922IleGly: 1.922 ± 0.025	0.792IleHis: 0.792 ± 0.015	1.04IleIle: 1.04 ± 0.018	1.253IleLys: 1.253 ± 0.022	3.137IleLeu: 3.137 ± 0.036	0.52IleMet: 0.52 ± 0.012	0.795IleAsn: 0.795 ± 0.02	1.957IlePro: 1.957 ± 0.022	1.381IleGln: 1.381 ± 0.019	2.252IleArg: 2.252 ± 0.028	2.741IleSer: 2.741 ± 0.036	1.421IleThr: 1.421 ± 0.022	1.894IleVal: 1.894 ± 0.028	0.347IleTrp: 0.347 ± 0.011	0.648IleTyr: 0.648 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.541LysAla: 4.541 ± 0.04	0.662LysCys: 0.662 ± 0.019	1.911LysAsp: 1.911 ± 0.025	3.453LysGlu: 3.453 ± 0.037	0.868LysPhe: 0.868 ± 0.017	3.165LysGly: 3.165 ± 0.034	1.051LysHis: 1.051 ± 0.016	1.243LysIle: 1.243 ± 0.019	2.458LysLys: 2.458 ± 0.044	3.411LysLeu: 3.411 ± 0.036	0.685LysMet: 0.685 ± 0.014	1.115LysAsn: 1.115 ± 0.02	2.017LysPro: 2.017 ± 0.031	2.502LysGln: 2.502 ± 0.035	3.254LysArg: 3.254 ± 0.034	2.585LysSer: 2.585 ± 0.03	2.062LysThr: 2.062 ± 0.024	2.052LysVal: 2.052 ± 0.029	0.405LysTrp: 0.405 ± 0.01	0.76LysTyr: 0.76 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.955LeuAla: 8.955 ± 0.048	2.462LeuCys: 2.462 ± 0.034	3.98LeuAsp: 3.98 ± 0.035	6.454LeuGlu: 6.454 ± 0.051	3.39LeuPhe: 3.39 ± 0.037	5.744LeuGly: 5.744 ± 0.046	3.359LeuHis: 3.359 ± 0.037	2.704LeuIle: 2.704 ± 0.031	4.316LeuLys: 4.316 ± 0.042	14.867LeuLeu: 14.867 ± 0.124	1.951LeuMet: 1.951 ± 0.022	2.282LeuAsn: 2.282 ± 0.027	7.657LeuPro: 7.657 ± 0.051	7.873LeuGln: 7.873 ± 0.076	8.254LeuArg: 8.254 ± 0.061	8.546LeuSer: 8.546 ± 0.055	4.313LeuThr: 4.313 ± 0.036	5.571LeuVal: 5.571 ± 0.046	1.335LeuTrp: 1.335 ± 0.021	2.003LeuTyr: 2.003 ± 0.026	0.003LeuXaa: 0.003 ± 0.001
Met	1.674MetAla: 1.674 ± 0.023	0.336MetCys: 0.336 ± 0.01	0.738MetAsp: 0.738 ± 0.013	1.21MetGlu: 1.21 ± 0.017	0.405MetPhe: 0.405 ± 0.009	1.218MetGly: 1.218 ± 0.022	0.581MetHis: 0.581 ± 0.012	0.459MetIle: 0.459 ± 0.012	0.754MetLys: 0.754 ± 0.017	1.935MetLeu: 1.935 ± 0.024	0.373MetMet: 0.373 ± 0.012	0.44MetAsn: 0.44 ± 0.013	1.192MetPro: 1.192 ± 0.021	1.372MetGln: 1.372 ± 0.02	1.489MetArg: 1.489 ± 0.02	1.146MetSer: 1.146 ± 0.021	0.789MetThr: 0.789 ± 0.018	0.83MetVal: 0.83 ± 0.014	0.195MetTrp: 0.195 ± 0.006	0.328MetTyr: 0.328 ± 0.009	0.001MetXaa: 0.001 ± 0.0
Asn	2.621AsnAla: 2.621 ± 0.028	0.554AsnCys: 0.554 ± 0.013	0.966AsnAsp: 0.966 ± 0.018	1.43AsnGlu: 1.43 ± 0.022	0.793AsnPhe: 0.793 ± 0.017	1.705AsnGly: 1.705 ± 0.024	0.454AsnHis: 0.454 ± 0.011	0.948AsnIle: 0.948 ± 0.019	1.093AsnLys: 1.093 ± 0.019	2.005AsnLeu: 2.005 ± 0.024	0.478AsnMet: 0.478 ± 0.015	0.77AsnAsn: 0.77 ± 0.018	1.565AsnPro: 1.565 ± 0.021	0.821AsnGln: 0.821 ± 0.015	1.485AsnArg: 1.485 ± 0.02	2.278AsnSer: 2.278 ± 0.032	1.372AsnThr: 1.372 ± 0.022	1.366AsnVal: 1.366 ± 0.021	0.276AsnTrp: 0.276 ± 0.009	0.46AsnTyr: 0.46 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	5.924ProAla: 5.924 ± 0.057	1.334ProCys: 1.334 ± 0.023	2.151ProAsp: 2.151 ± 0.022	3.747ProGlu: 3.747 ± 0.035	2.165ProPhe: 2.165 ± 0.03	3.287ProGly: 3.287 ± 0.036	1.745ProHis: 1.745 ± 0.02	1.572ProIle: 1.572 ± 0.017	2.115ProLys: 2.115 ± 0.036	7.362ProLeu: 7.362 ± 0.045	0.949ProMet: 0.949 ± 0.017	1.27ProAsn: 1.27 ± 0.019	6.457ProPro: 6.457 ± 0.081	3.458ProGln: 3.458 ± 0.035	3.768ProArg: 3.768 ± 0.036	6.541ProSer: 6.541 ± 0.061	3.088ProThr: 3.088 ± 0.038	3.448ProVal: 3.448 ± 0.032	0.751ProTrp: 0.751 ± 0.013	1.073ProTyr: 1.073 ± 0.017	0.005ProXaa: 0.005 ± 0.001
Gln	4.06GlnAla: 4.06 ± 0.039	0.761GlnCys: 0.761 ± 0.016	1.743GlnAsp: 1.743 ± 0.024	4.059GlnGlu: 4.059 ± 0.046	0.998GlnPhe: 0.998 ± 0.016	3.091GlnGly: 3.091 ± 0.032	2.148GlnHis: 2.148 ± 0.033	1.323GlnIle: 1.323 ± 0.021	2.477GlnLys: 2.477 ± 0.026	5.865GlnLeu: 5.865 ± 0.054	0.922GlnMet: 0.922 ± 0.018	1.084GlnAsn: 1.084 ± 0.019	2.985GlnPro: 2.985 ± 0.032	8.554GlnGln: 8.554 ± 0.142	4.668GlnArg: 4.668 ± 0.047	2.917GlnSer: 2.917 ± 0.027	2.169GlnThr: 2.169 ± 0.023	2.293GlnVal: 2.293 ± 0.025	0.58GlnTrp: 0.58 ± 0.012	0.718GlnTyr: 0.718 ± 0.015	0.002GlnXaa: 0.002 ± 0.001
Arg	5.778ArgAla: 5.778 ± 0.048	1.609ArgCys: 1.609 ± 0.023	2.778ArgAsp: 2.778 ± 0.031	4.685ArgGlu: 4.685 ± 0.043	2.005ArgPhe: 2.005 ± 0.024	5.237ArgGly: 5.237 ± 0.048	2.027ArgHis: 2.027 ± 0.026	2.391ArgIle: 2.391 ± 0.027	3.105ArgLys: 3.105 ± 0.034	7.959ArgLeu: 7.959 ± 0.055	1.41ArgMet: 1.41 ± 0.017	1.708ArgAsn: 1.708 ± 0.02	3.126ArgPro: 3.126 ± 0.029	4.13ArgGln: 4.13 ± 0.037	6.518ArgArg: 6.518 ± 0.052	5.335ArgSer: 5.335 ± 0.04	2.801ArgThr: 2.801 ± 0.029	3.888ArgVal: 3.888 ± 0.034	0.844ArgTrp: 0.844 ± 0.017	1.172ArgTyr: 1.172 ± 0.017	0.002ArgXaa: 0.002 ± 0.001
Ser	9.445SerAla: 9.445 ± 0.063	2.252SerCys: 2.252 ± 0.032	3.424SerAsp: 3.424 ± 0.037	4.835SerGlu: 4.835 ± 0.045	2.959SerPhe: 2.959 ± 0.033	6.308SerGly: 6.308 ± 0.046	1.872SerHis: 1.872 ± 0.024	2.602SerIle: 2.602 ± 0.032	3.206SerLys: 3.206 ± 0.029	9.256SerLeu: 9.256 ± 0.059	1.387SerMet: 1.387 ± 0.021	2.342SerAsn: 2.342 ± 0.036	6.024SerPro: 6.024 ± 0.054	3.23SerGln: 3.23 ± 0.032	6.03SerArg: 6.03 ± 0.045	11.042SerSer: 11.042 ± 0.098	4.799SerThr: 4.799 ± 0.045	5.096SerVal: 5.096 ± 0.039	0.984SerTrp: 0.984 ± 0.016	1.314SerTyr: 1.314 ± 0.023	0.003SerXaa: 0.003 ± 0.001
Thr	6.592ThrAla: 6.592 ± 0.054	1.004ThrCys: 1.004 ± 0.023	2.224ThrAsp: 2.224 ± 0.026	3.29ThrGlu: 3.29 ± 0.03	1.466ThrPhe: 1.466 ± 0.023	3.388ThrGly: 3.388 ± 0.035	1.146ThrHis: 1.146 ± 0.02	1.387ThrIle: 1.387 ± 0.022	1.796ThrLys: 1.796 ± 0.025	4.624ThrLeu: 4.624 ± 0.044	0.724ThrMet: 0.724 ± 0.015	1.202ThrAsn: 1.202 ± 0.018	3.891ThrPro: 3.891 ± 0.038	2.074ThrGln: 2.074 ± 0.023	2.94ThrArg: 2.94 ± 0.029	4.223ThrSer: 4.223 ± 0.04	2.818ThrThr: 2.818 ± 0.035	2.964ThrVal: 2.964 ± 0.032	0.489ThrTrp: 0.489 ± 0.012	0.798ThrTyr: 0.798 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	6.83ValAla: 6.83 ± 0.048	1.551ValCys: 1.551 ± 0.022	2.78ValAsp: 2.78 ± 0.033	3.936ValGlu: 3.936 ± 0.04	2.192ValPhe: 2.192 ± 0.026	3.889ValGly: 3.889 ± 0.036	1.48ValHis: 1.48 ± 0.019	1.702ValIle: 1.702 ± 0.025	2.105ValLys: 2.105 ± 0.027	6.574ValLeu: 6.574 ± 0.048	0.944ValMet: 0.944 ± 0.019	1.254ValAsn: 1.254 ± 0.021	3.544ValPro: 3.544 ± 0.038	2.721ValGln: 2.721 ± 0.029	3.398ValArg: 3.398 ± 0.033	5.357ValSer: 5.357 ± 0.043	2.622ValThr: 2.622 ± 0.031	3.97ValVal: 3.97 ± 0.038	0.702ValTrp: 0.702 ± 0.014	1.434ValTyr: 1.434 ± 0.02	0.001ValXaa: 0.001 ± 0.0
Trp	0.808TrpAla: 0.808 ± 0.014	0.255TrpCys: 0.255 ± 0.008	0.431TrpAsp: 0.431 ± 0.01	0.733TrpGlu: 0.733 ± 0.015	0.31TrpPhe: 0.31 ± 0.008	0.997TrpGly: 0.997 ± 0.018	0.295TrpHis: 0.295 ± 0.009	0.451TrpIle: 0.451 ± 0.011	0.551TrpLys: 0.551 ± 0.013	1.334TrpLeu: 1.334 ± 0.021	0.268TrpMet: 0.268 ± 0.007	0.341TrpAsn: 0.341 ± 0.01	0.483TrpPro: 0.483 ± 0.012	0.612TrpGln: 0.612 ± 0.012	1.132TrpArg: 1.132 ± 0.016	0.794TrpSer: 0.794 ± 0.017	0.56TrpThr: 0.56 ± 0.013	0.605TrpVal: 0.605 ± 0.013	0.183TrpTrp: 0.183 ± 0.007	0.175TrpTyr: 0.175 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.605TyrAla: 1.605 ± 0.024	0.496TyrCys: 0.496 ± 0.016	0.814TyrAsp: 0.814 ± 0.017	1.05TyrGlu: 1.05 ± 0.019	0.715TyrPhe: 0.715 ± 0.014	1.253TyrGly: 1.253 ± 0.019	0.4TyrHis: 0.4 ± 0.01	0.72TyrIle: 0.72 ± 0.017	0.773TyrLys: 0.773 ± 0.016	1.784TyrLeu: 1.784 ± 0.027	0.38TyrMet: 0.38 ± 0.009	0.478TyrAsn: 0.478 ± 0.011	0.957TyrPro: 0.957 ± 0.017	0.672TyrGln: 0.672 ± 0.013	1.268TyrArg: 1.268 ± 0.018	1.479TyrSer: 1.479 ± 0.025	0.991TyrThr: 0.991 ± 0.016	1.104TyrVal: 1.104 ± 0.018	0.249TyrTrp: 0.249 ± 0.009	0.454TyrTyr: 0.454 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.008XaaGly: 0.008 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.037XaaXaa: 0.037 ± 0.009

Statistics based on 7151 proteins (3734096 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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