Amino acid dipepetide frequency for Hubei tombus-like virus 12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.264AlaAla: 8.264 ± 8.286
1.377AlaCys: 1.377 ± 0.775
2.755AlaAsp: 2.755 ± 1.55
2.755AlaGlu: 2.755 ± 1.55
4.132AlaPhe: 4.132 ± 0.262
6.887AlaGly: 6.887 ± 9.061
0.0AlaHis: 0.0 ± 0.0
2.755AlaIle: 2.755 ± 1.55
2.755AlaLys: 2.755 ± 1.037
4.132AlaLeu: 4.132 ± 0.262
5.51AlaMet: 5.51 ± 3.1
1.377AlaAsn: 1.377 ± 0.775
2.755AlaPro: 2.755 ± 1.55
8.264AlaGln: 8.264 ± 3.111
9.642AlaArg: 9.642 ± 0.251
4.132AlaSer: 4.132 ± 0.262
2.755AlaThr: 2.755 ± 3.624
1.377AlaVal: 1.377 ± 1.812
0.0AlaTrp: 0.0 ± 0.0
1.377AlaTyr: 1.377 ± 0.775
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.377CysCys: 1.377 ± 0.775
0.0CysAsp: 0.0 ± 0.0
2.755CysGlu: 2.755 ± 1.55
4.132CysPhe: 4.132 ± 2.325
2.755CysGly: 2.755 ± 1.55
1.377CysHis: 1.377 ± 0.775
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.377CysLeu: 1.377 ± 0.775
0.0CysMet: 0.0 ± 0.0
1.377CysAsn: 1.377 ± 0.775
0.0CysPro: 0.0 ± 0.0
2.755CysGln: 2.755 ± 1.55
0.0CysArg: 0.0 ± 0.0
2.755CysSer: 2.755 ± 1.55
1.377CysThr: 1.377 ± 0.775
4.132CysVal: 4.132 ± 2.849
0.0CysTrp: 0.0 ± 0.0
1.377CysTyr: 1.377 ± 0.775
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
4.132AspCys: 4.132 ± 2.325
4.132AspAsp: 4.132 ± 2.325
2.755AspGlu: 2.755 ± 3.624
0.0AspPhe: 0.0 ± 0.0
4.132AspGly: 4.132 ± 2.325
1.377AspHis: 1.377 ± 1.812
5.51AspIle: 5.51 ± 0.513
1.377AspLys: 1.377 ± 0.775
8.264AspLeu: 8.264 ± 0.524
1.377AspMet: 1.377 ± 0.775
1.377AspAsn: 1.377 ± 0.775
5.51AspPro: 5.51 ± 3.1
0.0AspGln: 0.0 ± 0.0
2.755AspArg: 2.755 ± 1.037
2.755AspSer: 2.755 ± 1.55
1.377AspThr: 1.377 ± 0.775
5.51AspVal: 5.51 ± 2.074
1.377AspTrp: 1.377 ± 0.775
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
5.51GluAla: 5.51 ± 2.074
1.377GluCys: 1.377 ± 0.775
1.377GluAsp: 1.377 ± 1.812
5.51GluGlu: 5.51 ± 4.661
2.755GluPhe: 2.755 ± 1.55
1.377GluGly: 1.377 ± 1.812
4.132GluHis: 4.132 ± 2.325
0.0GluIle: 0.0 ± 0.0
5.51GluLys: 5.51 ± 0.513
5.51GluLeu: 5.51 ± 2.074
2.755GluMet: 2.755 ± 1.037
2.755GluAsn: 2.755 ± 1.55
1.377GluPro: 1.377 ± 0.775
2.755GluGln: 2.755 ± 1.55
0.0GluArg: 0.0 ± 0.0
1.377GluSer: 1.377 ± 0.775
1.377GluThr: 1.377 ± 0.775
4.132GluVal: 4.132 ± 0.262
2.755GluTrp: 2.755 ± 1.55
2.755GluTyr: 2.755 ± 1.037
0.0GluXaa: 0.0 ± 0.0
Phe
1.377PheAla: 1.377 ± 0.775
1.377PheCys: 1.377 ± 0.775
2.755PheAsp: 2.755 ± 1.55
4.132PheGlu: 4.132 ± 2.325
0.0PhePhe: 0.0 ± 0.0
1.377PheGly: 1.377 ± 0.775
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
1.377PheLys: 1.377 ± 0.775
2.755PheLeu: 2.755 ± 1.037
0.0PheMet: 0.0 ± 0.0
2.755PheAsn: 2.755 ± 1.037
0.0PhePro: 0.0 ± 0.0
2.755PheGln: 2.755 ± 1.55
0.0PheArg: 0.0 ± 0.0
2.755PheSer: 2.755 ± 1.55
1.377PheThr: 1.377 ± 0.775
2.755PheVal: 2.755 ± 1.55
1.377PheTrp: 1.377 ± 0.775
1.377PheTyr: 1.377 ± 0.775
0.0PheXaa: 0.0 ± 0.0
Gly
4.132GlyAla: 4.132 ± 0.262
1.377GlyCys: 1.377 ± 0.775
6.887GlyAsp: 6.887 ± 1.288
4.132GlyGlu: 4.132 ± 2.849
1.377GlyPhe: 1.377 ± 1.812
6.887GlyGly: 6.887 ± 3.886
0.0GlyHis: 0.0 ± 0.0
9.642GlyIle: 9.642 ± 0.251
0.0GlyLys: 0.0 ± 0.0
11.019GlyLeu: 11.019 ± 9.323
4.132GlyMet: 4.132 ± 2.325
1.377GlyAsn: 1.377 ± 0.775
2.755GlyPro: 2.755 ± 1.037
2.755GlyGln: 2.755 ± 1.55
6.887GlyArg: 6.887 ± 1.299
5.51GlySer: 5.51 ± 2.074
4.132GlyThr: 4.132 ± 0.262
6.887GlyVal: 6.887 ± 1.299
1.377GlyTrp: 1.377 ± 1.812
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.377HisCys: 1.377 ± 0.775
2.755HisAsp: 2.755 ± 1.037
2.755HisGlu: 2.755 ± 1.55
1.377HisPhe: 1.377 ± 0.775
2.755HisGly: 2.755 ± 1.55
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
4.132HisLeu: 4.132 ± 0.262
1.377HisMet: 1.377 ± 0.775
0.0HisAsn: 0.0 ± 0.0
1.377HisPro: 1.377 ± 1.812
0.0HisGln: 0.0 ± 0.0
5.51HisArg: 5.51 ± 3.1
1.377HisSer: 1.377 ± 0.775
0.0HisThr: 0.0 ± 0.0
1.377HisVal: 1.377 ± 0.775
2.755HisTrp: 2.755 ± 1.037
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.51IleAla: 5.51 ± 0.513
1.377IleCys: 1.377 ± 0.775
1.377IleAsp: 1.377 ± 1.812
2.755IleGlu: 2.755 ± 1.55
0.0IlePhe: 0.0 ± 0.0
5.51IleGly: 5.51 ± 0.513
0.0IleHis: 0.0 ± 0.0
0.0IleIle: 0.0 ± 0.0
2.755IleLys: 2.755 ± 1.037
1.377IleLeu: 1.377 ± 0.775
1.377IleMet: 1.377 ± 0.775
0.0IleAsn: 0.0 ± 0.0
2.755IlePro: 2.755 ± 1.55
4.132IleGln: 4.132 ± 2.325
1.377IleArg: 1.377 ± 0.775
0.0IleSer: 0.0 ± 0.0
4.132IleThr: 4.132 ± 0.262
4.132IleVal: 4.132 ± 2.325
0.0IleTrp: 0.0 ± 0.0
4.132IleTyr: 4.132 ± 0.262
0.0IleXaa: 0.0 ± 0.0
Lys
5.51LysAla: 5.51 ± 0.513
1.377LysCys: 1.377 ± 0.775
0.0LysAsp: 0.0 ± 0.0
0.0LysGlu: 0.0 ± 0.0
1.377LysPhe: 1.377 ± 0.775
2.755LysGly: 2.755 ± 1.55
2.755LysHis: 2.755 ± 1.55
2.755LysIle: 2.755 ± 1.037
0.0LysLys: 0.0 ± 0.0
4.132LysLeu: 4.132 ± 2.325
0.0LysMet: 0.0 ± 0.0
1.377LysAsn: 1.377 ± 1.812
1.377LysPro: 1.377 ± 1.812
0.0LysGln: 0.0 ± 0.0
2.755LysArg: 2.755 ± 1.037
0.0LysSer: 0.0 ± 0.0
2.755LysThr: 2.755 ± 1.037
8.264LysVal: 8.264 ± 0.524
1.377LysTrp: 1.377 ± 0.775
1.377LysTyr: 1.377 ± 0.775
0.0LysXaa: 0.0 ± 0.0
Leu
6.887LeuAla: 6.887 ± 1.288
0.0LeuCys: 0.0 ± 0.0
5.51LeuAsp: 5.51 ± 0.513
9.642LeuGlu: 9.642 ± 0.251
2.755LeuPhe: 2.755 ± 1.55
8.264LeuGly: 8.264 ± 3.111
2.755LeuHis: 2.755 ± 1.55
6.887LeuIle: 6.887 ± 1.288
2.755LeuLys: 2.755 ± 1.55
5.51LeuLeu: 5.51 ± 2.074
2.755LeuMet: 2.755 ± 1.228
4.132LeuAsn: 4.132 ± 2.849
5.51LeuPro: 5.51 ± 4.661
2.755LeuGln: 2.755 ± 1.037
9.642LeuArg: 9.642 ± 2.336
5.51LeuSer: 5.51 ± 0.513
2.755LeuThr: 2.755 ± 1.037
4.132LeuVal: 4.132 ± 2.849
2.755LeuTrp: 2.755 ± 1.55
2.755LeuTyr: 2.755 ± 1.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.755MetAla: 2.755 ± 1.55
1.377MetCys: 1.377 ± 0.775
1.377MetAsp: 1.377 ± 0.775
2.755MetGlu: 2.755 ± 1.55
2.755MetPhe: 2.755 ± 1.55
1.377MetGly: 1.377 ± 1.812
0.0MetHis: 0.0 ± 0.0
2.755MetIle: 2.755 ± 1.55
1.377MetLys: 1.377 ± 0.775
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
4.132MetAsn: 4.132 ± 2.325
0.0MetPro: 0.0 ± 0.0
2.755MetGln: 2.755 ± 1.55
0.0MetArg: 0.0 ± 0.0
2.755MetSer: 2.755 ± 1.037
1.377MetThr: 1.377 ± 0.775
1.377MetVal: 1.377 ± 0.775
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.377AsnAla: 1.377 ± 0.775
2.755AsnCys: 2.755 ± 1.55
2.755AsnAsp: 2.755 ± 1.55
0.0AsnGlu: 0.0 ± 0.0
0.0AsnPhe: 0.0 ± 0.0
4.132AsnGly: 4.132 ± 0.262
1.377AsnHis: 1.377 ± 1.812
2.755AsnIle: 2.755 ± 1.55
0.0AsnLys: 0.0 ± 0.0
2.755AsnLeu: 2.755 ± 1.037
2.755AsnMet: 2.755 ± 1.55
1.377AsnAsn: 1.377 ± 1.812
6.887AsnPro: 6.887 ± 3.876
2.755AsnGln: 2.755 ± 1.55
1.377AsnArg: 1.377 ± 0.775
0.0AsnSer: 0.0 ± 0.0
1.377AsnThr: 1.377 ± 0.775
2.755AsnVal: 2.755 ± 1.037
2.755AsnTrp: 2.755 ± 1.037
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
8.264ProAla: 8.264 ± 0.524
0.0ProCys: 0.0 ± 0.0
1.377ProAsp: 1.377 ± 0.775
1.377ProGlu: 1.377 ± 0.775
0.0ProPhe: 0.0 ± 0.0
5.51ProGly: 5.51 ± 3.1
0.0ProHis: 0.0 ± 0.0
2.755ProIle: 2.755 ± 1.55
0.0ProLys: 0.0 ± 0.0
4.132ProLeu: 4.132 ± 2.325
0.0ProMet: 0.0 ± 0.0
2.755ProAsn: 2.755 ± 1.55
4.132ProPro: 4.132 ± 0.262
2.755ProGln: 2.755 ± 1.037
5.51ProArg: 5.51 ± 3.1
5.51ProSer: 5.51 ± 7.249
6.887ProThr: 6.887 ± 1.299
2.755ProVal: 2.755 ± 1.55
1.377ProTrp: 1.377 ± 1.812
1.377ProTyr: 1.377 ± 0.775
0.0ProXaa: 0.0 ± 0.0
Gln
5.51GlnAla: 5.51 ± 2.074
0.0GlnCys: 0.0 ± 0.0
1.377GlnAsp: 1.377 ± 0.775
1.377GlnGlu: 1.377 ± 0.775
1.377GlnPhe: 1.377 ± 0.775
1.377GlnGly: 1.377 ± 1.812
2.755GlnHis: 2.755 ± 1.037
1.377GlnIle: 1.377 ± 0.775
4.132GlnLys: 4.132 ± 0.262
5.51GlnLeu: 5.51 ± 3.1
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
1.377GlnPro: 1.377 ± 1.812
1.377GlnGln: 1.377 ± 0.775
9.642GlnArg: 9.642 ± 2.839
6.887GlnSer: 6.887 ± 1.288
1.377GlnThr: 1.377 ± 0.775
0.0GlnVal: 0.0 ± 0.0
1.377GlnTrp: 1.377 ± 0.775
2.755GlnTyr: 2.755 ± 1.55
0.0GlnXaa: 0.0 ± 0.0
Arg
6.887ArgAla: 6.887 ± 1.288
1.377ArgCys: 1.377 ± 1.812
6.887ArgAsp: 6.887 ± 1.288
4.132ArgGlu: 4.132 ± 2.849
1.377ArgPhe: 1.377 ± 0.775
5.51ArgGly: 5.51 ± 4.661
2.755ArgHis: 2.755 ± 1.55
1.377ArgIle: 1.377 ± 0.775
2.755ArgLys: 2.755 ± 1.55
9.642ArgLeu: 9.642 ± 2.336
4.132ArgMet: 4.132 ± 2.325
1.377ArgAsn: 1.377 ± 0.775
2.755ArgPro: 2.755 ± 1.55
0.0ArgGln: 0.0 ± 0.0
9.642ArgArg: 9.642 ± 4.923
1.377ArgSer: 1.377 ± 1.812
4.132ArgThr: 4.132 ± 2.849
6.887ArgVal: 6.887 ± 1.288
5.51ArgTrp: 5.51 ± 2.074
1.377ArgTyr: 1.377 ± 0.775
0.0ArgXaa: 0.0 ± 0.0
Ser
0.0SerAla: 0.0 ± 0.0
1.377SerCys: 1.377 ± 0.775
1.377SerAsp: 1.377 ± 1.812
1.377SerGlu: 1.377 ± 1.812
2.755SerPhe: 2.755 ± 1.55
4.132SerGly: 4.132 ± 0.262
1.377SerHis: 1.377 ± 0.775
1.377SerIle: 1.377 ± 0.775
8.264SerLys: 8.264 ± 3.111
9.642SerLeu: 9.642 ± 0.251
0.0SerMet: 0.0 ± 0.0
4.132SerAsn: 4.132 ± 2.325
0.0SerPro: 0.0 ± 0.0
1.377SerGln: 1.377 ± 0.775
4.132SerArg: 4.132 ± 2.849
2.755SerSer: 2.755 ± 1.037
2.755SerThr: 2.755 ± 1.037
1.377SerVal: 1.377 ± 1.812
0.0SerTrp: 0.0 ± 0.0
1.377SerTyr: 1.377 ± 0.775
0.0SerXaa: 0.0 ± 0.0
Thr
4.132ThrAla: 4.132 ± 2.849
0.0ThrCys: 0.0 ± 0.0
5.51ThrAsp: 5.51 ± 2.074
2.755ThrGlu: 2.755 ± 1.55
1.377ThrPhe: 1.377 ± 0.775
2.755ThrGly: 2.755 ± 1.037
2.755ThrHis: 2.755 ± 1.037
0.0ThrIle: 0.0 ± 0.0
1.377ThrLys: 1.377 ± 0.775
2.755ThrLeu: 2.755 ± 1.55
1.377ThrMet: 1.377 ± 0.775
0.0ThrAsn: 0.0 ± 0.0
11.019ThrPro: 11.019 ± 1.561
1.377ThrGln: 1.377 ± 0.775
2.755ThrArg: 2.755 ± 3.624
1.377ThrSer: 1.377 ± 0.775
1.377ThrThr: 1.377 ± 0.775
4.132ThrVal: 4.132 ± 0.262
1.377ThrTrp: 1.377 ± 0.775
2.755ThrTyr: 2.755 ± 1.037
0.0ThrXaa: 0.0 ± 0.0
Val
6.887ValAla: 6.887 ± 6.474
2.755ValCys: 2.755 ± 1.55
2.755ValAsp: 2.755 ± 1.55
4.132ValGlu: 4.132 ± 0.262
2.755ValPhe: 2.755 ± 1.55
5.51ValGly: 5.51 ± 2.074
2.755ValHis: 2.755 ± 1.55
2.755ValIle: 2.755 ± 1.037
5.51ValLys: 5.51 ± 0.513
5.51ValLeu: 5.51 ± 0.513
0.0ValMet: 0.0 ± 0.0
4.132ValAsn: 4.132 ± 0.262
4.132ValPro: 4.132 ± 2.325
4.132ValGln: 4.132 ± 0.262
2.755ValArg: 2.755 ± 3.624
0.0ValSer: 0.0 ± 0.0
4.132ValThr: 4.132 ± 0.262
2.755ValVal: 2.755 ± 1.037
0.0ValTrp: 0.0 ± 0.0
1.377ValTyr: 1.377 ± 1.812
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
2.755TrpCys: 2.755 ± 1.037
1.377TrpAsp: 1.377 ± 0.775
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.377TrpGly: 1.377 ± 0.775
2.755TrpHis: 2.755 ± 1.55
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
4.132TrpLeu: 4.132 ± 2.849
0.0TrpMet: 0.0 ± 0.0
2.755TrpAsn: 2.755 ± 1.55
1.377TrpPro: 1.377 ± 0.775
0.0TrpGln: 0.0 ± 0.0
1.377TrpArg: 1.377 ± 0.775
1.377TrpSer: 1.377 ± 1.812
4.132TrpThr: 4.132 ± 0.262
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
2.755TrpTyr: 2.755 ± 1.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
1.377TyrAsp: 1.377 ± 0.775
0.0TyrGlu: 0.0 ± 0.0
0.0TyrPhe: 0.0 ± 0.0
6.887TyrGly: 6.887 ± 1.299
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
0.0TyrLys: 0.0 ± 0.0
1.377TyrLeu: 1.377 ± 0.775
0.0TyrMet: 0.0 ± 0.994
2.755TyrAsn: 2.755 ± 1.55
1.377TyrPro: 1.377 ± 0.775
6.887TyrGln: 6.887 ± 1.299
4.132TyrArg: 4.132 ± 0.262
1.377TyrSer: 1.377 ± 0.775
1.377TyrThr: 1.377 ± 0.775
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (727 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski