Amino acid dipepetide frequency for Georhizobium profundi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.575AlaAla: 16.575 ± 0.154	0.995AlaCys: 0.995 ± 0.031	7.281AlaAsp: 7.281 ± 0.085	8.156AlaGlu: 8.156 ± 0.109	4.764AlaPhe: 4.764 ± 0.062	10.386AlaGly: 10.386 ± 0.113	2.226AlaHis: 2.226 ± 0.043	7.27AlaIle: 7.27 ± 0.078	3.678AlaLys: 3.678 ± 0.066	13.211AlaLeu: 13.211 ± 0.108	3.713AlaMet: 3.713 ± 0.062	2.974AlaAsn: 2.974 ± 0.055	5.264AlaPro: 5.264 ± 0.087	3.701AlaGln: 3.701 ± 0.068	8.405AlaArg: 8.405 ± 0.096	6.824AlaSer: 6.824 ± 0.077	6.001AlaThr: 6.001 ± 0.079	8.639AlaVal: 8.639 ± 0.088	1.429AlaTrp: 1.429 ± 0.035	2.5AlaTyr: 2.5 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.9CysAla: 0.9 ± 0.03	0.088CysCys: 0.088 ± 0.009	0.503CysAsp: 0.503 ± 0.019	0.401CysGlu: 0.401 ± 0.017	0.332CysPhe: 0.332 ± 0.017	0.874CysGly: 0.874 ± 0.032	0.246CysHis: 0.246 ± 0.015	0.362CysIle: 0.362 ± 0.018	0.162CysLys: 0.162 ± 0.01	0.75CysLeu: 0.75 ± 0.025	0.17CysMet: 0.17 ± 0.013	0.188CysAsn: 0.188 ± 0.011	0.406CysPro: 0.406 ± 0.02	0.214CysGln: 0.214 ± 0.013	0.585CysArg: 0.585 ± 0.022	0.458CysSer: 0.458 ± 0.02	0.352CysThr: 0.352 ± 0.017	0.537CysVal: 0.537 ± 0.022	0.094CysTrp: 0.094 ± 0.008	0.175CysTyr: 0.175 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.471AspAla: 7.471 ± 0.101	0.492AspCys: 0.492 ± 0.023	3.73AspAsp: 3.73 ± 0.088	3.849AspGlu: 3.849 ± 0.059	2.337AspPhe: 2.337 ± 0.044	5.476AspGly: 5.476 ± 0.076	1.433AspHis: 1.433 ± 0.039	3.422AspIle: 3.422 ± 0.046	1.6AspLys: 1.6 ± 0.034	6.056AspLeu: 6.056 ± 0.075	1.519AspMet: 1.519 ± 0.036	1.395AspAsn: 1.395 ± 0.034	3.406AspPro: 3.406 ± 0.053	1.92AspGln: 1.92 ± 0.04	4.849AspArg: 4.849 ± 0.078	2.029AspSer: 2.029 ± 0.041	2.839AspThr: 2.839 ± 0.053	4.328AspVal: 4.328 ± 0.065	0.951AspTrp: 0.951 ± 0.027	1.497AspTyr: 1.497 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.08GluAla: 8.08 ± 0.084	0.347GluCys: 0.347 ± 0.017	3.2GluAsp: 3.2 ± 0.055	3.684GluGlu: 3.684 ± 0.064	1.859GluPhe: 1.859 ± 0.041	4.745GluGly: 4.745 ± 0.068	1.2GluHis: 1.2 ± 0.034	3.777GluIle: 3.777 ± 0.058	2.196GluLys: 2.196 ± 0.043	5.353GluLeu: 5.353 ± 0.069	1.638GluMet: 1.638 ± 0.036	1.805GluAsn: 1.805 ± 0.039	2.859GluPro: 2.859 ± 0.057	2.134GluGln: 2.134 ± 0.047	5.573GluArg: 5.573 ± 0.081	2.483GluSer: 2.483 ± 0.043	3.969GluThr: 3.969 ± 0.062	3.687GluVal: 3.687 ± 0.053	0.685GluTrp: 0.685 ± 0.02	0.959GluTyr: 0.959 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.71PheAla: 4.71 ± 0.066	0.407PheCys: 0.407 ± 0.019	2.876PheAsp: 2.876 ± 0.043	2.366PheGlu: 2.366 ± 0.046	1.608PhePhe: 1.608 ± 0.038	3.883PheGly: 3.883 ± 0.062	0.76PheHis: 0.76 ± 0.024	1.916PheIle: 1.916 ± 0.039	0.948PheLys: 0.948 ± 0.027	3.494PheLeu: 3.494 ± 0.063	0.928PheMet: 0.928 ± 0.031	1.064PheAsn: 1.064 ± 0.032	1.544PhePro: 1.544 ± 0.043	1.119PheGln: 1.119 ± 0.03	2.233PheArg: 2.233 ± 0.042	2.277PheSer: 2.277 ± 0.037	1.968PheThr: 1.968 ± 0.039	3.011PheVal: 3.011 ± 0.054	0.536PheTrp: 0.536 ± 0.02	0.895PheTyr: 0.895 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.246GlyAla: 9.246 ± 0.101	0.784GlyCys: 0.784 ± 0.027	4.706GlyAsp: 4.706 ± 0.089	5.047GlyGlu: 5.047 ± 0.074	3.744GlyPhe: 3.744 ± 0.056	7.128GlyGly: 7.128 ± 0.106	1.911GlyHis: 1.911 ± 0.04	4.865GlyIle: 4.865 ± 0.076	2.953GlyLys: 2.953 ± 0.058	8.684GlyLeu: 8.684 ± 0.092	2.357GlyMet: 2.357 ± 0.042	2.263GlyAsn: 2.263 ± 0.057	3.331GlyPro: 3.331 ± 0.053	2.874GlyGln: 2.874 ± 0.051	6.045GlyArg: 6.045 ± 0.07	4.844GlySer: 4.844 ± 0.068	4.623GlyThr: 4.623 ± 0.061	5.95GlyVal: 5.95 ± 0.082	1.181GlyTrp: 1.181 ± 0.033	2.207GlyTyr: 2.207 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.277HisAla: 2.277 ± 0.045	0.252HisCys: 0.252 ± 0.015	1.242HisAsp: 1.242 ± 0.036	1.11HisGlu: 1.11 ± 0.024	0.844HisPhe: 0.844 ± 0.026	1.883HisGly: 1.883 ± 0.038	0.649HisHis: 0.649 ± 0.029	0.93HisIle: 0.93 ± 0.03	0.444HisLys: 0.444 ± 0.017	2.085HisLeu: 2.085 ± 0.047	0.518HisMet: 0.518 ± 0.021	0.421HisAsn: 0.421 ± 0.019	1.239HisPro: 1.239 ± 0.034	0.619HisGln: 0.619 ± 0.023	1.495HisArg: 1.495 ± 0.036	0.998HisSer: 0.998 ± 0.031	0.798HisThr: 0.798 ± 0.023	1.569HisVal: 1.569 ± 0.038	0.307HisTrp: 0.307 ± 0.016	0.606HisTyr: 0.606 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.116IleAla: 8.116 ± 0.081	0.483IleCys: 0.483 ± 0.02	4.152IleAsp: 4.152 ± 0.058	3.983IleGlu: 3.983 ± 0.06	2.013IlePhe: 2.013 ± 0.045	5.487IleGly: 5.487 ± 0.075	1.011IleHis: 1.011 ± 0.03	2.731IleIle: 2.731 ± 0.061	1.359IleLys: 1.359 ± 0.035	4.627IleLeu: 4.627 ± 0.07	1.124IleMet: 1.124 ± 0.028	1.508IleAsn: 1.508 ± 0.032	2.296IlePro: 2.296 ± 0.047	1.347IleGln: 1.347 ± 0.034	3.362IleArg: 3.362 ± 0.051	3.007IleSer: 3.007 ± 0.051	2.733IleThr: 2.733 ± 0.044	4.92IleVal: 4.92 ± 0.066	0.626IleTrp: 0.626 ± 0.02	1.203IleTyr: 1.203 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.019LysAla: 4.019 ± 0.068	0.142LysCys: 0.142 ± 0.011	1.654LysAsp: 1.654 ± 0.039	1.42LysGlu: 1.42 ± 0.035	0.768LysPhe: 0.768 ± 0.023	2.352LysGly: 2.352 ± 0.051	0.597LysHis: 0.597 ± 0.023	1.728LysIle: 1.728 ± 0.042	1.181LysLys: 1.181 ± 0.041	3.018LysLeu: 3.018 ± 0.054	0.673LysMet: 0.673 ± 0.028	0.765LysAsn: 0.765 ± 0.027	1.955LysPro: 1.955 ± 0.044	0.884LysGln: 0.884 ± 0.027	2.573LysArg: 2.573 ± 0.055	1.841LysSer: 1.841 ± 0.041	1.891LysThr: 1.891 ± 0.039	2.131LysVal: 2.131 ± 0.048	0.297LysTrp: 0.297 ± 0.014	0.46LysTyr: 0.46 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	12.887LeuAla: 12.887 ± 0.116	0.76LeuCys: 0.76 ± 0.026	6.121LeuAsp: 6.121 ± 0.083	5.363LeuGlu: 5.363 ± 0.072	3.622LeuPhe: 3.622 ± 0.063	7.844LeuGly: 7.844 ± 0.083	1.721LeuHis: 1.721 ± 0.037	5.407LeuIle: 5.407 ± 0.085	3.629LeuLys: 3.629 ± 0.059	9.003LeuLeu: 9.003 ± 0.118	2.446LeuMet: 2.446 ± 0.048	2.576LeuAsn: 2.576 ± 0.05	5.194LeuPro: 5.194 ± 0.064	2.713LeuGln: 2.713 ± 0.048	6.204LeuArg: 6.204 ± 0.075	6.649LeuSer: 6.649 ± 0.07	5.507LeuThr: 5.507 ± 0.063	7.48LeuVal: 7.48 ± 0.085	1.069LeuTrp: 1.069 ± 0.027	2.01LeuTyr: 2.01 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.331MetAla: 3.331 ± 0.054	0.149MetCys: 0.149 ± 0.012	1.33MetAsp: 1.33 ± 0.033	1.311MetGlu: 1.311 ± 0.034	0.738MetPhe: 0.738 ± 0.026	1.903MetGly: 1.903 ± 0.045	0.495MetHis: 0.495 ± 0.019	1.57MetIle: 1.57 ± 0.038	0.969MetLys: 0.969 ± 0.028	2.519MetLeu: 2.519 ± 0.049	0.744MetMet: 0.744 ± 0.024	0.834MetAsn: 0.834 ± 0.024	1.567MetPro: 1.567 ± 0.037	0.874MetGln: 0.874 ± 0.026	1.988MetArg: 1.988 ± 0.04	1.718MetSer: 1.718 ± 0.037	1.913MetThr: 1.913 ± 0.042	1.8MetVal: 1.8 ± 0.042	0.173MetTrp: 0.173 ± 0.012	0.283MetTyr: 0.283 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.331AsnAla: 3.331 ± 0.052	0.216AsnCys: 0.216 ± 0.014	1.591AsnAsp: 1.591 ± 0.038	1.447AsnGlu: 1.447 ± 0.031	1.005AsnPhe: 1.005 ± 0.027	2.503AsnGly: 2.503 ± 0.057	0.519AsnHis: 0.519 ± 0.02	1.319AsnIle: 1.319 ± 0.033	0.589AsnLys: 0.589 ± 0.023	2.416AsnLeu: 2.416 ± 0.045	0.624AsnMet: 0.624 ± 0.021	0.662AsnAsn: 0.662 ± 0.028	1.655AsnPro: 1.655 ± 0.04	0.79AsnGln: 0.79 ± 0.025	1.934AsnArg: 1.934 ± 0.04	1.231AsnSer: 1.231 ± 0.036	1.182AsnThr: 1.182 ± 0.033	1.975AsnVal: 1.975 ± 0.046	0.446AsnTrp: 0.446 ± 0.021	0.632AsnTyr: 0.632 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.874ProAla: 5.874 ± 0.093	0.3ProCys: 0.3 ± 0.016	3.474ProAsp: 3.474 ± 0.056	3.637ProGlu: 3.637 ± 0.059	2.041ProPhe: 2.041 ± 0.04	4.048ProGly: 4.048 ± 0.06	1.0ProHis: 1.0 ± 0.027	2.589ProIle: 2.589 ± 0.044	1.524ProLys: 1.524 ± 0.038	4.454ProLeu: 4.454 ± 0.055	1.206ProMet: 1.206 ± 0.035	1.309ProAsn: 1.309 ± 0.036	2.143ProPro: 2.143 ± 0.049	1.605ProGln: 1.605 ± 0.035	2.732ProArg: 2.732 ± 0.053	2.761ProSer: 2.761 ± 0.05	2.488ProThr: 2.488 ± 0.042	4.053ProVal: 4.053 ± 0.062	0.579ProTrp: 0.579 ± 0.02	1.131ProTyr: 1.131 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.104GlnAla: 4.104 ± 0.062	0.214GlnCys: 0.214 ± 0.013	1.491GlnAsp: 1.491 ± 0.034	1.604GlnGlu: 1.604 ± 0.044	1.104GlnPhe: 1.104 ± 0.03	2.293GlnGly: 2.293 ± 0.045	0.582GlnHis: 0.582 ± 0.026	1.887GlnIle: 1.887 ± 0.043	0.963GlnLys: 0.963 ± 0.028	2.816GlnLeu: 2.816 ± 0.049	1.0GlnMet: 1.0 ± 0.027	0.855GlnAsn: 0.855 ± 0.027	1.814GlnPro: 1.814 ± 0.041	1.189GlnGln: 1.189 ± 0.032	2.398GlnArg: 2.398 ± 0.051	1.955GlnSer: 1.955 ± 0.039	1.814GlnThr: 1.814 ± 0.043	2.1GlnVal: 2.1 ± 0.045	0.351GlnTrp: 0.351 ± 0.016	0.506GlnTyr: 0.506 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.689ArgAla: 7.689 ± 0.089	0.488ArgCys: 0.488 ± 0.022	4.278ArgAsp: 4.278 ± 0.07	4.244ArgGlu: 4.244 ± 0.07	3.069ArgPhe: 3.069 ± 0.043	4.721ArgGly: 4.721 ± 0.075	1.769ArgHis: 1.769 ± 0.039	4.092ArgIle: 4.092 ± 0.059	2.171ArgLys: 2.171 ± 0.045	7.697ArgLeu: 7.697 ± 0.081	2.0ArgMet: 2.0 ± 0.039	1.846ArgAsn: 1.846 ± 0.039	3.456ArgPro: 3.456 ± 0.052	2.732ArgGln: 2.732 ± 0.048	5.668ArgArg: 5.668 ± 0.088	4.101ArgSer: 4.101 ± 0.064	3.441ArgThr: 3.441 ± 0.056	4.57ArgVal: 4.57 ± 0.062	0.93ArgTrp: 0.93 ± 0.03	1.696ArgTyr: 1.696 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.585SerAla: 6.585 ± 0.085	0.36SerCys: 0.36 ± 0.016	3.328SerAsp: 3.328 ± 0.056	3.183SerGlu: 3.183 ± 0.053	2.359SerPhe: 2.359 ± 0.042	5.736SerGly: 5.736 ± 0.068	1.09SerHis: 1.09 ± 0.028	3.179SerIle: 3.179 ± 0.051	1.546SerLys: 1.546 ± 0.034	5.408SerLeu: 5.408 ± 0.078	1.482SerMet: 1.482 ± 0.032	1.427SerAsn: 1.427 ± 0.039	2.54SerPro: 2.54 ± 0.044	1.659SerGln: 1.659 ± 0.041	3.772SerArg: 3.772 ± 0.058	3.109SerSer: 3.109 ± 0.058	2.772SerThr: 2.772 ± 0.049	4.128SerVal: 4.128 ± 0.056	0.683SerTrp: 0.683 ± 0.022	1.279SerTyr: 1.279 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.217ThrAla: 6.217 ± 0.071	0.379ThrCys: 0.379 ± 0.017	2.985ThrAsp: 2.985 ± 0.046	2.86ThrGlu: 2.86 ± 0.05	2.025ThrPhe: 2.025 ± 0.041	5.109ThrGly: 5.109 ± 0.062	0.994ThrHis: 0.994 ± 0.029	3.312ThrIle: 3.312 ± 0.056	1.395ThrLys: 1.395 ± 0.035	5.73ThrLeu: 5.73 ± 0.085	1.369ThrMet: 1.369 ± 0.033	1.337ThrAsn: 1.337 ± 0.037	3.036ThrPro: 3.036 ± 0.049	1.4ThrGln: 1.4 ± 0.033	3.298ThrArg: 3.298 ± 0.044	2.933ThrSer: 2.933 ± 0.049	2.859ThrThr: 2.859 ± 0.048	4.38ThrVal: 4.38 ± 0.066	0.603ThrTrp: 0.603 ± 0.025	1.182ThrTyr: 1.182 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.045ValAla: 9.045 ± 0.089	0.603ValCys: 0.603 ± 0.024	4.593ValAsp: 4.593 ± 0.062	4.802ValGlu: 4.802 ± 0.07	2.917ValPhe: 2.917 ± 0.051	5.497ValGly: 5.497 ± 0.073	1.326ValHis: 1.326 ± 0.033	4.191ValIle: 4.191 ± 0.055	2.126ValLys: 2.126 ± 0.048	7.062ValLeu: 7.062 ± 0.089	1.911ValMet: 1.911 ± 0.04	1.884ValAsn: 1.884 ± 0.034	3.55ValPro: 3.55 ± 0.065	1.982ValGln: 1.982 ± 0.037	4.752ValArg: 4.752 ± 0.06	4.448ValSer: 4.448 ± 0.055	4.507ValThr: 4.507 ± 0.065	5.767ValVal: 5.767 ± 0.082	0.823ValTrp: 0.823 ± 0.029	1.553ValTyr: 1.553 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.147TrpAla: 1.147 ± 0.03	0.115TrpCys: 0.115 ± 0.009	0.596TrpAsp: 0.596 ± 0.023	0.531TrpGlu: 0.531 ± 0.02	0.48TrpPhe: 0.48 ± 0.02	0.8TrpGly: 0.8 ± 0.024	0.29TrpHis: 0.29 ± 0.014	0.668TrpIle: 0.668 ± 0.023	0.409TrpLys: 0.409 ± 0.02	1.502TrpLeu: 1.502 ± 0.037	0.354TrpMet: 0.354 ± 0.017	0.426TrpAsn: 0.426 ± 0.018	0.633TrpPro: 0.633 ± 0.026	0.568TrpGln: 0.568 ± 0.02	1.005TrpArg: 1.005 ± 0.03	0.792TrpSer: 0.792 ± 0.022	0.714TrpThr: 0.714 ± 0.026	0.758TrpVal: 0.758 ± 0.028	0.206TrpTrp: 0.206 ± 0.014	0.294TrpTyr: 0.294 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.39TyrAla: 2.39 ± 0.044	0.223TyrCys: 0.223 ± 0.015	1.467TyrAsp: 1.467 ± 0.034	1.233TyrGlu: 1.233 ± 0.03	0.914TyrPhe: 0.914 ± 0.027	2.071TyrGly: 2.071 ± 0.042	0.468TyrHis: 0.468 ± 0.018	0.874TyrIle: 0.874 ± 0.023	0.51TyrLys: 0.51 ± 0.02	2.319TyrLeu: 2.319 ± 0.05	0.434TyrMet: 0.434 ± 0.018	0.527TyrAsn: 0.527 ± 0.019	1.064TyrPro: 1.064 ± 0.035	0.717TyrGln: 0.717 ± 0.03	1.785TyrArg: 1.785 ± 0.04	1.166TyrSer: 1.166 ± 0.03	1.031TyrThr: 1.031 ± 0.029	1.557TyrVal: 1.557 ± 0.032	0.32TyrTrp: 0.32 ± 0.017	0.51TyrTyr: 0.51 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4118 proteins (1291389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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