Amino acid dipepetide frequency for Mycoplasma marinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.698AlaAla: 3.698 ± 0.168
0.239AlaCys: 0.239 ± 0.027
2.343AlaAsp: 2.343 ± 0.095
2.827AlaGlu: 2.827 ± 0.098
2.931AlaPhe: 2.931 ± 0.106
3.221AlaGly: 3.221 ± 0.119
0.925AlaHis: 0.925 ± 0.051
6.218AlaIle: 6.218 ± 0.199
6.107AlaLys: 6.107 ± 0.175
5.078AlaLeu: 5.078 ± 0.155
1.472AlaMet: 1.472 ± 0.08
3.206AlaAsn: 3.206 ± 0.091
1.481AlaPro: 1.481 ± 0.076
1.696AlaGln: 1.696 ± 0.086
1.988AlaArg: 1.988 ± 0.081
3.943AlaSer: 3.943 ± 0.143
3.618AlaThr: 3.618 ± 0.145
2.815AlaVal: 2.815 ± 0.108
0.552AlaTrp: 0.552 ± 0.046
1.615AlaTyr: 1.615 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.227CysAla: 0.227 ± 0.026
0.033CysCys: 0.033 ± 0.01
0.2CysAsp: 0.2 ± 0.028
0.263CysGlu: 0.263 ± 0.032
0.239CysPhe: 0.239 ± 0.027
0.499CysGly: 0.499 ± 0.042
0.096CysHis: 0.096 ± 0.017
0.415CysIle: 0.415 ± 0.035
0.406CysLys: 0.406 ± 0.041
0.322CysLeu: 0.322 ± 0.036
0.087CysMet: 0.087 ± 0.014
0.212CysAsn: 0.212 ± 0.025
0.149CysPro: 0.149 ± 0.025
0.122CysGln: 0.122 ± 0.017
0.093CysArg: 0.093 ± 0.016
0.346CysSer: 0.346 ± 0.033
0.146CysThr: 0.146 ± 0.022
0.227CysVal: 0.227 ± 0.028
0.06CysTrp: 0.06 ± 0.012
0.149CysTyr: 0.149 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.158AspAla: 3.158 ± 0.168
0.134AspCys: 0.134 ± 0.02
2.379AspAsp: 2.379 ± 0.097
3.603AspGlu: 3.603 ± 0.11
2.863AspPhe: 2.863 ± 0.101
3.179AspGly: 3.179 ± 0.153
0.663AspHis: 0.663 ± 0.044
4.74AspIle: 4.74 ± 0.136
5.809AspLys: 5.809 ± 0.176
4.531AspLeu: 4.531 ± 0.129
1.215AspMet: 1.215 ± 0.07
2.687AspAsn: 2.687 ± 0.096
1.469AspPro: 1.469 ± 0.08
1.26AspGln: 1.26 ± 0.072
1.367AspArg: 1.367 ± 0.064
3.561AspSer: 3.561 ± 0.121
2.275AspThr: 2.275 ± 0.092
3.2AspVal: 3.2 ± 0.122
0.591AspTrp: 0.591 ± 0.037
1.997AspTyr: 1.997 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
3.436GluAla: 3.436 ± 0.113
0.278GluCys: 0.278 ± 0.034
2.869GluAsp: 2.869 ± 0.096
5.376GluGlu: 5.376 ± 0.197
3.355GluPhe: 3.355 ± 0.113
3.098GluGly: 3.098 ± 0.099
0.955GluHis: 0.955 ± 0.054
7.003GluIle: 7.003 ± 0.148
7.498GluLys: 7.498 ± 0.197
6.188GluLeu: 6.188 ± 0.187
1.827GluMet: 1.827 ± 0.089
4.37GluAsn: 4.37 ± 0.148
1.331GluPro: 1.331 ± 0.072
2.173GluGln: 2.173 ± 0.087
2.179GluArg: 2.179 ± 0.086
3.304GluSer: 3.304 ± 0.114
3.349GluThr: 3.349 ± 0.099
3.91GluVal: 3.91 ± 0.134
0.797GluTrp: 0.797 ± 0.049
2.791GluTyr: 2.791 ± 0.115
0.0GluXaa: 0.0 ± 0.0
Phe
3.045PheAla: 3.045 ± 0.11
0.248PheCys: 0.248 ± 0.032
3.191PheAsp: 3.191 ± 0.11
3.448PheGlu: 3.448 ± 0.112
2.352PhePhe: 2.352 ± 0.103
3.236PheGly: 3.236 ± 0.114
0.585PheHis: 0.585 ± 0.037
5.313PheIle: 5.313 ± 0.155
5.176PheLys: 5.176 ± 0.125
4.2PheLeu: 4.2 ± 0.144
1.131PheMet: 1.131 ± 0.062
3.463PheAsn: 3.463 ± 0.111
1.406PhePro: 1.406 ± 0.079
1.176PheGln: 1.176 ± 0.061
1.281PheArg: 1.281 ± 0.055
3.94PheSer: 3.94 ± 0.142
2.803PheThr: 2.803 ± 0.094
3.224PheVal: 3.224 ± 0.1
0.621PheTrp: 0.621 ± 0.051
1.716PheTyr: 1.716 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
3.504GlyAla: 3.504 ± 0.138
0.221GlyCys: 0.221 ± 0.028
2.809GlyAsp: 2.809 ± 0.11
3.498GlyGlu: 3.498 ± 0.118
3.364GlyPhe: 3.364 ± 0.174
3.618GlyGly: 3.618 ± 0.142
1.093GlyHis: 1.093 ± 0.065
5.982GlyIle: 5.982 ± 0.142
5.851GlyLys: 5.851 ± 0.142
4.415GlyLeu: 4.415 ± 0.15
1.54GlyMet: 1.54 ± 0.069
2.719GlyAsn: 2.719 ± 0.082
1.158GlyPro: 1.158 ± 0.062
1.734GlyGln: 1.734 ± 0.069
1.916GlyArg: 1.916 ± 0.092
3.955GlySer: 3.955 ± 0.122
3.749GlyThr: 3.749 ± 0.219
3.991GlyVal: 3.991 ± 0.141
0.594GlyTrp: 0.594 ± 0.044
2.167GlyTyr: 2.167 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
0.848HisAla: 0.848 ± 0.058
0.075HisCys: 0.075 ± 0.015
0.797HisAsp: 0.797 ± 0.053
1.006HisGlu: 1.006 ± 0.055
0.782HisPhe: 0.782 ± 0.048
1.003HisGly: 1.003 ± 0.06
0.316HisHis: 0.316 ± 0.034
1.409HisIle: 1.409 ± 0.072
1.516HisLys: 1.516 ± 0.069
1.31HisLeu: 1.31 ± 0.068
0.31HisMet: 0.31 ± 0.033
0.896HisAsn: 0.896 ± 0.054
0.597HisPro: 0.597 ± 0.043
0.367HisGln: 0.367 ± 0.029
0.522HisArg: 0.522 ± 0.04
1.167HisSer: 1.167 ± 0.064
0.842HisThr: 0.842 ± 0.043
0.809HisVal: 0.809 ± 0.056
0.197HisTrp: 0.197 ± 0.023
0.567HisTyr: 0.567 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.934IleAla: 5.934 ± 0.161
0.534IleCys: 0.534 ± 0.043
5.684IleAsp: 5.684 ± 0.163
6.478IleGlu: 6.478 ± 0.196
5.406IlePhe: 5.406 ± 0.199
5.385IleGly: 5.385 ± 0.148
1.358IleHis: 1.358 ± 0.057
9.531IleIle: 9.531 ± 0.234
10.436IleLys: 10.436 ± 0.187
8.466IleLeu: 8.466 ± 0.228
2.26IleMet: 2.26 ± 0.091
7.287IleAsn: 7.287 ± 0.258
3.006IlePro: 3.006 ± 0.098
2.501IleGln: 2.501 ± 0.093
2.722IleArg: 2.722 ± 0.1
8.251IleSer: 8.251 ± 0.172
5.648IleThr: 5.648 ± 0.217
5.436IleVal: 5.436 ± 0.153
0.973IleTrp: 0.973 ± 0.056
3.182IleTyr: 3.182 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
5.43LysAla: 5.43 ± 0.164
0.299LysCys: 0.299 ± 0.034
5.884LysAsp: 5.884 ± 0.169
8.869LysGlu: 8.869 ± 0.192
4.206LysPhe: 4.206 ± 0.124
5.173LysGly: 5.173 ± 0.141
1.818LysHis: 1.818 ± 0.073
10.785LysIle: 10.785 ± 0.254
11.454LysLys: 11.454 ± 0.202
8.439LysLeu: 8.439 ± 0.15
3.104LysMet: 3.104 ± 0.103
8.31LysAsn: 8.31 ± 0.219
2.749LysPro: 2.749 ± 0.093
3.543LysGln: 3.543 ± 0.103
3.394LysArg: 3.394 ± 0.12
5.904LysSer: 5.904 ± 0.143
6.367LysThr: 6.367 ± 0.141
6.113LysVal: 6.113 ± 0.154
1.233LysTrp: 1.233 ± 0.063
4.588LysTyr: 4.588 ± 0.139
0.0LysXaa: 0.0 ± 0.0
Leu
4.722LeuAla: 4.722 ± 0.144
0.463LeuCys: 0.463 ± 0.036
4.457LeuAsp: 4.457 ± 0.119
5.46LeuGlu: 5.46 ± 0.19
4.845LeuPhe: 4.845 ± 0.181
4.785LeuGly: 4.785 ± 0.141
1.269LeuHis: 1.269 ± 0.063
8.149LeuIle: 8.149 ± 0.215
8.573LeuLys: 8.573 ± 0.176
7.021LeuLeu: 7.021 ± 0.212
2.11LeuMet: 2.11 ± 0.093
5.442LeuAsn: 5.442 ± 0.151
2.764LeuPro: 2.764 ± 0.111
1.994LeuGln: 1.994 ± 0.079
2.675LeuArg: 2.675 ± 0.094
6.537LeuSer: 6.537 ± 0.147
4.692LeuThr: 4.692 ± 0.194
4.806LeuVal: 4.806 ± 0.142
0.797LeuTrp: 0.797 ± 0.052
2.427LeuTyr: 2.427 ± 0.104
0.0LeuXaa: 0.0 ± 0.0
Met
1.466MetAla: 1.466 ± 0.071
0.134MetCys: 0.134 ± 0.019
1.176MetAsp: 1.176 ± 0.064
1.475MetGlu: 1.475 ± 0.082
1.254MetPhe: 1.254 ± 0.077
1.442MetGly: 1.442 ± 0.063
0.43MetHis: 0.43 ± 0.04
2.325MetIle: 2.325 ± 0.096
2.69MetLys: 2.69 ± 0.091
2.06MetLeu: 2.06 ± 0.098
0.558MetMet: 0.558 ± 0.045
1.693MetAsn: 1.693 ± 0.073
0.934MetPro: 0.934 ± 0.059
0.827MetGln: 0.827 ± 0.046
0.654MetArg: 0.654 ± 0.049
1.579MetSer: 1.579 ± 0.075
1.212MetThr: 1.212 ± 0.071
1.328MetVal: 1.328 ± 0.068
0.257MetTrp: 0.257 ± 0.026
0.654MetTyr: 0.654 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.415AsnAla: 3.415 ± 0.134
0.191AsnCys: 0.191 ± 0.024
3.463AsnAsp: 3.463 ± 0.13
4.215AsnGlu: 4.215 ± 0.121
3.161AsnPhe: 3.161 ± 0.106
4.191AsnGly: 4.191 ± 0.165
0.904AsnHis: 0.904 ± 0.058
6.66AsnIle: 6.66 ± 0.206
8.421AsnLys: 8.421 ± 0.189
4.878AsnLeu: 4.878 ± 0.151
1.179AsnMet: 1.179 ± 0.065
4.812AsnAsn: 4.812 ± 0.203
2.212AsnPro: 2.212 ± 0.089
1.755AsnGln: 1.755 ± 0.069
1.681AsnArg: 1.681 ± 0.076
4.525AsnSer: 4.525 ± 0.132
3.176AsnThr: 3.176 ± 0.132
3.391AsnVal: 3.391 ± 0.111
0.77AsnTrp: 0.77 ± 0.053
2.358AsnTyr: 2.358 ± 0.11
0.0AsnXaa: 0.0 ± 0.0
Pro
1.448ProAla: 1.448 ± 0.085
0.11ProCys: 0.11 ± 0.017
1.087ProAsp: 1.087 ± 0.062
1.916ProGlu: 1.916 ± 0.089
1.513ProPhe: 1.513 ± 0.084
1.698ProGly: 1.698 ± 0.095
0.606ProHis: 0.606 ± 0.037
2.907ProIle: 2.907 ± 0.098
2.922ProLys: 2.922 ± 0.141
2.361ProLeu: 2.361 ± 0.093
0.597ProMet: 0.597 ± 0.041
1.806ProAsn: 1.806 ± 0.088
0.499ProPro: 0.499 ± 0.037
0.884ProGln: 0.884 ± 0.05
0.761ProArg: 0.761 ± 0.048
2.027ProSer: 2.027 ± 0.095
1.842ProThr: 1.842 ± 0.074
1.546ProVal: 1.546 ± 0.071
0.436ProTrp: 0.436 ± 0.038
1.045ProTyr: 1.045 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
1.627GlnAla: 1.627 ± 0.063
0.051GlnCys: 0.051 ± 0.011
1.469GlnAsp: 1.469 ± 0.073
2.155GlnGlu: 2.155 ± 0.085
1.278GlnPhe: 1.278 ± 0.063
1.51GlnGly: 1.51 ± 0.07
0.385GlnHis: 0.385 ± 0.033
2.878GlnIle: 2.878 ± 0.108
3.209GlnLys: 3.209 ± 0.103
2.257GlnLeu: 2.257 ± 0.082
0.776GlnMet: 0.776 ± 0.044
1.887GlnAsn: 1.887 ± 0.087
0.693GlnPro: 0.693 ± 0.047
0.845GlnGln: 0.845 ± 0.054
1.107GlnArg: 1.107 ± 0.062
1.403GlnSer: 1.403 ± 0.063
1.672GlnThr: 1.672 ± 0.081
1.63GlnVal: 1.63 ± 0.065
0.337GlnTrp: 0.337 ± 0.033
0.994GlnTyr: 0.994 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
1.612ArgAla: 1.612 ± 0.078
0.146ArgCys: 0.146 ± 0.025
1.552ArgAsp: 1.552 ± 0.069
2.316ArgGlu: 2.316 ± 0.094
1.478ArgPhe: 1.478 ± 0.068
1.86ArgGly: 1.86 ± 0.082
0.475ArgHis: 0.475 ± 0.041
2.949ArgIle: 2.949 ± 0.095
3.337ArgLys: 3.337 ± 0.099
2.37ArgLeu: 2.37 ± 0.109
0.955ArgMet: 0.955 ± 0.054
1.872ArgAsn: 1.872 ± 0.074
0.791ArgPro: 0.791 ± 0.048
1.033ArgGln: 1.033 ± 0.059
1.337ArgArg: 1.337 ± 0.078
1.615ArgSer: 1.615 ± 0.067
1.758ArgThr: 1.758 ± 0.078
2.057ArgVal: 2.057 ± 0.086
0.331ArgTrp: 0.331 ± 0.028
1.116ArgTyr: 1.116 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.46SerAla: 3.46 ± 0.11
0.424SerCys: 0.424 ± 0.04
3.113SerAsp: 3.113 ± 0.094
3.758SerGlu: 3.758 ± 0.121
3.812SerPhe: 3.812 ± 0.105
4.203SerGly: 4.203 ± 0.153
1.116SerHis: 1.116 ± 0.053
7.236SerIle: 7.236 ± 0.187
7.857SerLys: 7.857 ± 0.161
6.352SerLeu: 6.352 ± 0.146
1.481SerMet: 1.481 ± 0.069
4.612SerAsn: 4.612 ± 0.133
1.654SerPro: 1.654 ± 0.077
1.872SerGln: 1.872 ± 0.073
2.361SerArg: 2.361 ± 0.096
5.182SerSer: 5.182 ± 0.146
3.836SerThr: 3.836 ± 0.128
3.594SerVal: 3.594 ± 0.136
0.904SerTrp: 0.904 ± 0.075
2.188SerTyr: 2.188 ± 0.093
0.0SerXaa: 0.0 ± 0.0
Thr
2.848ThrAla: 2.848 ± 0.15
0.209ThrCys: 0.209 ± 0.031
2.645ThrAsp: 2.645 ± 0.15
2.513ThrGlu: 2.513 ± 0.083
3.087ThrPhe: 3.087 ± 0.119
3.63ThrGly: 3.63 ± 0.234
0.958ThrHis: 0.958 ± 0.055
5.991ThrIle: 5.991 ± 0.157
5.994ThrLys: 5.994 ± 0.168
5.4ThrLeu: 5.4 ± 0.155
1.155ThrMet: 1.155 ± 0.048
3.594ThrAsn: 3.594 ± 0.123
2.081ThrPro: 2.081 ± 0.104
1.761ThrGln: 1.761 ± 0.082
1.743ThrArg: 1.743 ± 0.072
4.206ThrSer: 4.206 ± 0.117
3.839ThrThr: 3.839 ± 0.155
2.83ThrVal: 2.83 ± 0.17
0.678ThrTrp: 0.678 ± 0.053
1.785ThrTyr: 1.785 ± 0.078
0.0ThrXaa: 0.0 ± 0.0
Val
3.713ValAla: 3.713 ± 0.123
0.316ValCys: 0.316 ± 0.034
3.087ValAsp: 3.087 ± 0.112
3.922ValGlu: 3.922 ± 0.124
2.931ValPhe: 2.931 ± 0.105
3.406ValGly: 3.406 ± 0.112
0.839ValHis: 0.839 ± 0.051
5.573ValIle: 5.573 ± 0.13
5.224ValLys: 5.224 ± 0.156
4.633ValLeu: 4.633 ± 0.133
1.254ValMet: 1.254 ± 0.071
3.451ValAsn: 3.451 ± 0.147
1.77ValPro: 1.77 ± 0.083
1.487ValGln: 1.487 ± 0.072
1.648ValArg: 1.648 ± 0.074
4.331ValSer: 4.331 ± 0.138
3.442ValThr: 3.442 ± 0.163
4.006ValVal: 4.006 ± 0.145
0.537ValTrp: 0.537 ± 0.044
1.773ValTyr: 1.773 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.585TrpAla: 0.585 ± 0.043
0.054TrpCys: 0.054 ± 0.014
0.567TrpAsp: 0.567 ± 0.042
0.701TrpGlu: 0.701 ± 0.045
0.684TrpPhe: 0.684 ± 0.05
0.588TrpGly: 0.588 ± 0.039
0.149TrpHis: 0.149 ± 0.025
1.209TrpIle: 1.209 ± 0.07
1.152TrpLys: 1.152 ± 0.059
0.907TrpLeu: 0.907 ± 0.053
0.299TrpMet: 0.299 ± 0.028
0.815TrpAsn: 0.815 ± 0.059
0.269TrpPro: 0.269 ± 0.027
0.221TrpGln: 0.221 ± 0.025
0.358TrpArg: 0.358 ± 0.044
0.621TrpSer: 0.621 ± 0.052
0.91TrpThr: 0.91 ± 0.1
0.627TrpVal: 0.627 ± 0.044
0.158TrpTrp: 0.158 ± 0.022
0.406TrpTyr: 0.406 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.797TyrAla: 1.797 ± 0.079
0.131TyrCys: 0.131 ± 0.022
1.91TyrAsp: 1.91 ± 0.081
2.29TyrGlu: 2.29 ± 0.103
2.015TyrPhe: 2.015 ± 0.095
2.155TyrGly: 2.155 ± 0.095
0.397TyrHis: 0.397 ± 0.038
3.206TyrIle: 3.206 ± 0.115
4.03TyrLys: 4.03 ± 0.129
2.8TyrLeu: 2.8 ± 0.099
0.836TyrMet: 0.836 ± 0.055
2.227TyrAsn: 2.227 ± 0.081
1.0TyrPro: 1.0 ± 0.057
0.91TyrGln: 0.91 ± 0.057
1.173TyrArg: 1.173 ± 0.061
2.615TyrSer: 2.615 ± 0.1
1.77TyrThr: 1.77 ± 0.076
1.803TyrVal: 1.803 ± 0.076
0.457TyrTrp: 0.457 ± 0.037
1.328TyrTyr: 1.328 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 986 proteins (335004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski