Amino acid dipepetide frequency for Drosophila navojoa (Fruit fly)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.819AlaAla: 11.819 ± 0.146	1.217AlaCys: 1.217 ± 0.034	3.617AlaAsp: 3.617 ± 0.024	4.778AlaGlu: 4.778 ± 0.037	2.162AlaPhe: 2.162 ± 0.021	4.955AlaGly: 4.955 ± 0.045	1.837AlaHis: 1.837 ± 0.02	3.469AlaIle: 3.469 ± 0.024	4.123AlaLys: 4.123 ± 0.033	6.737AlaLeu: 6.737 ± 0.041	1.807AlaMet: 1.807 ± 0.016	3.658AlaAsn: 3.658 ± 0.026	4.245AlaPro: 4.245 ± 0.039	3.739AlaGln: 3.739 ± 0.028	3.491AlaArg: 3.491 ± 0.025	6.318AlaSer: 6.318 ± 0.046	5.769AlaThr: 5.769 ± 0.056	4.68AlaVal: 4.68 ± 0.03	0.602AlaTrp: 0.602 ± 0.011	1.862AlaTyr: 1.862 ± 0.018	0.002AlaXaa: 0.002 ± 0.0
Cys	1.315CysAla: 1.315 ± 0.027	0.531CysCys: 0.531 ± 0.01	1.094CysAsp: 1.094 ± 0.017	1.112CysGlu: 1.112 ± 0.021	0.692CysPhe: 0.692 ± 0.012	1.337CysGly: 1.337 ± 0.038	0.499CysHis: 0.499 ± 0.011	0.98CysIle: 0.98 ± 0.022	0.955CysLys: 0.955 ± 0.015	1.828CysLeu: 1.828 ± 0.028	0.425CysMet: 0.425 ± 0.009	0.952CysAsn: 0.952 ± 0.018	0.995CysPro: 0.995 ± 0.036	0.864CysGln: 0.864 ± 0.029	1.118CysArg: 1.118 ± 0.048	1.625CysSer: 1.625 ± 0.027	0.987CysThr: 0.987 ± 0.024	1.181CysVal: 1.181 ± 0.036	0.209CysTrp: 0.209 ± 0.005	0.598CysTyr: 0.598 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.886AspAla: 3.886 ± 0.024	1.028AspCys: 1.028 ± 0.021	4.048AspAsp: 4.048 ± 0.054	4.265AspGlu: 4.265 ± 0.037	2.015AspPhe: 2.015 ± 0.021	2.966AspGly: 2.966 ± 0.033	0.994AspHis: 0.994 ± 0.014	2.795AspIle: 2.795 ± 0.023	2.627AspLys: 2.627 ± 0.025	4.401AspLeu: 4.401 ± 0.029	1.313AspMet: 1.313 ± 0.015	2.44AspAsn: 2.44 ± 0.026	2.107AspPro: 2.107 ± 0.037	1.77AspGln: 1.77 ± 0.015	2.286AspArg: 2.286 ± 0.026	3.807AspSer: 3.807 ± 0.027	2.401AspThr: 2.401 ± 0.022	3.301AspVal: 3.301 ± 0.021	0.597AspTrp: 0.597 ± 0.012	1.844AspTyr: 1.844 ± 0.017	0.001AspXaa: 0.001 ± 0.0
Glu	4.518GluAla: 4.518 ± 0.035	1.129GluCys: 1.129 ± 0.041	3.536GluAsp: 3.536 ± 0.033	5.313GluGlu: 5.313 ± 0.059	2.018GluPhe: 2.018 ± 0.018	2.438GluGly: 2.438 ± 0.027	1.683GluHis: 1.683 ± 0.016	2.994GluIle: 2.994 ± 0.028	3.683GluLys: 3.683 ± 0.037	6.659GluLeu: 6.659 ± 0.044	1.504GluMet: 1.504 ± 0.015	2.664GluAsn: 2.664 ± 0.025	2.946GluPro: 2.946 ± 0.028	4.247GluGln: 4.247 ± 0.041	4.055GluArg: 4.055 ± 0.038	4.145GluSer: 4.145 ± 0.033	3.252GluThr: 3.252 ± 0.029	3.193GluVal: 3.193 ± 0.03	0.55GluTrp: 0.55 ± 0.009	1.747GluTyr: 1.747 ± 0.018	0.001GluXaa: 0.001 ± 0.0
Phe	2.281PheAla: 2.281 ± 0.018	0.721PheCys: 0.721 ± 0.012	1.979PheAsp: 1.979 ± 0.02	2.073PheGlu: 2.073 ± 0.021	1.322PhePhe: 1.322 ± 0.018	2.306PheGly: 2.306 ± 0.025	0.841PheHis: 0.841 ± 0.013	1.79PheIle: 1.79 ± 0.019	1.803PheLys: 1.803 ± 0.019	3.055PheLeu: 3.055 ± 0.025	0.889PheMet: 0.889 ± 0.013	1.664PheAsn: 1.664 ± 0.017	1.328PhePro: 1.328 ± 0.016	1.365PheGln: 1.365 ± 0.016	1.754PheArg: 1.754 ± 0.017	2.374PheSer: 2.374 ± 0.023	1.704PheThr: 1.704 ± 0.019	2.304PheVal: 2.304 ± 0.022	0.407PheTrp: 0.407 ± 0.008	1.279PheTyr: 1.279 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	4.51GlyAla: 4.51 ± 0.043	1.052GlyCys: 1.052 ± 0.022	2.805GlyAsp: 2.805 ± 0.029	2.83GlyGlu: 2.83 ± 0.026	1.988GlyPhe: 1.988 ± 0.022	5.686GlyGly: 5.686 ± 0.09	1.55GlyHis: 1.55 ± 0.017	2.845GlyIle: 2.845 ± 0.026	2.839GlyLys: 2.839 ± 0.028	4.456GlyLeu: 4.456 ± 0.038	1.257GlyMet: 1.257 ± 0.017	3.055GlyAsn: 3.055 ± 0.032	2.243GlyPro: 2.243 ± 0.037	2.379GlyGln: 2.379 ± 0.024	2.872GlyArg: 2.872 ± 0.028	5.37GlySer: 5.37 ± 0.043	2.975GlyThr: 2.975 ± 0.023	3.377GlyVal: 3.377 ± 0.026	0.608GlyTrp: 0.608 ± 0.012	2.046GlyTyr: 2.046 ± 0.025	0.001GlyXaa: 0.001 ± 0.0
His	1.721HisAla: 1.721 ± 0.017	0.598HisCys: 0.598 ± 0.012	1.093HisAsp: 1.093 ± 0.014	1.401HisGlu: 1.401 ± 0.015	0.983HisPhe: 0.983 ± 0.014	1.501HisGly: 1.501 ± 0.019	1.426HisHis: 1.426 ± 0.031	1.376HisIle: 1.376 ± 0.014	1.349HisLys: 1.349 ± 0.016	2.559HisLeu: 2.559 ± 0.024	0.742HisMet: 0.742 ± 0.012	1.283HisAsn: 1.283 ± 0.016	1.326HisPro: 1.326 ± 0.016	1.721HisGln: 1.721 ± 0.026	1.429HisArg: 1.429 ± 0.016	2.222HisSer: 2.222 ± 0.023	1.357HisThr: 1.357 ± 0.016	1.472HisVal: 1.472 ± 0.014	0.304HisTrp: 0.304 ± 0.006	0.898HisTyr: 0.898 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.524IleAla: 3.524 ± 0.022	1.202IleCys: 1.202 ± 0.023	2.737IleAsp: 2.737 ± 0.025	3.117IleGlu: 3.117 ± 0.031	1.993IlePhe: 1.993 ± 0.023	2.61IleGly: 2.61 ± 0.024	1.047IleHis: 1.047 ± 0.014	2.707IleIle: 2.707 ± 0.026	2.847IleLys: 2.847 ± 0.025	3.973IleLeu: 3.973 ± 0.03	1.155IleMet: 1.155 ± 0.014	2.51IleAsn: 2.51 ± 0.02	2.074IlePro: 2.074 ± 0.022	1.834IleGln: 1.834 ± 0.019	2.369IleArg: 2.369 ± 0.02	3.892IleSer: 3.892 ± 0.025	2.682IleThr: 2.682 ± 0.026	3.225IleVal: 3.225 ± 0.027	0.539IleTrp: 0.539 ± 0.01	1.768IleTyr: 1.768 ± 0.019	0.001IleXaa: 0.001 ± 0.0
Lys	3.548LysAla: 3.548 ± 0.028	1.125LysCys: 1.125 ± 0.025	2.648LysAsp: 2.648 ± 0.028	3.584LysGlu: 3.584 ± 0.035	1.779LysPhe: 1.779 ± 0.016	2.153LysGly: 2.153 ± 0.027	1.42LysHis: 1.42 ± 0.016	2.6LysIle: 2.6 ± 0.024	3.748LysLys: 3.748 ± 0.049	5.361LysLeu: 5.361 ± 0.038	1.353LysMet: 1.353 ± 0.014	2.197LysAsn: 2.197 ± 0.021	3.021LysPro: 3.021 ± 0.036	3.085LysGln: 3.085 ± 0.026	3.722LysArg: 3.722 ± 0.033	4.056LysSer: 4.056 ± 0.031	2.88LysThr: 2.88 ± 0.024	2.781LysVal: 2.781 ± 0.027	0.573LysTrp: 0.573 ± 0.01	1.764LysTyr: 1.764 ± 0.021	0.001LysXaa: 0.001 ± 0.0
Leu	6.97LeuAla: 6.97 ± 0.046	1.816LeuCys: 1.816 ± 0.021	4.74LeuAsp: 4.74 ± 0.029	5.943LeuGlu: 5.943 ± 0.042	2.911LeuPhe: 2.911 ± 0.026	4.709LeuGly: 4.709 ± 0.036	2.611LeuHis: 2.611 ± 0.021	4.286LeuIle: 4.286 ± 0.032	5.216LeuLys: 5.216 ± 0.035	9.801LeuLeu: 9.801 ± 0.07	2.162LeuMet: 2.162 ± 0.022	4.327LeuAsn: 4.327 ± 0.03	5.388LeuPro: 5.388 ± 0.034	5.673LeuGln: 5.673 ± 0.043	5.632LeuArg: 5.632 ± 0.04	6.974LeuSer: 6.974 ± 0.036	4.824LeuThr: 4.824 ± 0.03	4.85LeuVal: 4.85 ± 0.035	0.89LeuTrp: 0.89 ± 0.012	2.544LeuTyr: 2.544 ± 0.024	0.002LeuXaa: 0.002 ± 0.001
Met	1.865MetAla: 1.865 ± 0.019	0.435MetCys: 0.435 ± 0.009	1.362MetAsp: 1.362 ± 0.016	1.543MetGlu: 1.543 ± 0.017	0.768MetPhe: 0.768 ± 0.012	1.329MetGly: 1.329 ± 0.021	0.673MetHis: 0.673 ± 0.009	0.937MetIle: 0.937 ± 0.013	1.187MetLys: 1.187 ± 0.014	2.405MetLeu: 2.405 ± 0.022	0.61MetMet: 0.61 ± 0.011	0.981MetAsn: 0.981 ± 0.013	1.484MetPro: 1.484 ± 0.019	1.373MetGln: 1.373 ± 0.017	1.547MetArg: 1.547 ± 0.018	1.872MetSer: 1.872 ± 0.019	1.134MetThr: 1.134 ± 0.013	1.164MetVal: 1.164 ± 0.015	0.232MetTrp: 0.232 ± 0.006	0.622MetTyr: 0.622 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.793AsnAla: 3.793 ± 0.035	1.043AsnCys: 1.043 ± 0.014	2.419AsnAsp: 2.419 ± 0.027	2.963AsnGlu: 2.963 ± 0.024	1.737AsnPhe: 1.737 ± 0.019	3.456AsnGly: 3.456 ± 0.031	1.055AsnHis: 1.055 ± 0.018	2.554AsnIle: 2.554 ± 0.022	2.393AsnLys: 2.393 ± 0.021	3.927AsnLeu: 3.927 ± 0.032	1.267AsnMet: 1.267 ± 0.015	4.333AsnAsn: 4.333 ± 0.077	2.06AsnPro: 2.06 ± 0.029	1.819AsnGln: 1.819 ± 0.02	2.237AsnArg: 2.237 ± 0.018	4.737AsnSer: 4.737 ± 0.05	2.507AsnThr: 2.507 ± 0.02	2.919AsnVal: 2.919 ± 0.025	0.539AsnTrp: 0.539 ± 0.009	1.643AsnTyr: 1.643 ± 0.016	0.001AsnXaa: 0.001 ± 0.0
Pro	4.717ProAla: 4.717 ± 0.04	0.755ProCys: 0.755 ± 0.052	2.345ProAsp: 2.345 ± 0.02	3.217ProGlu: 3.217 ± 0.033	1.532ProPhe: 1.532 ± 0.019	2.739ProGly: 2.739 ± 0.047	1.456ProHis: 1.456 ± 0.017	2.39ProIle: 2.39 ± 0.021	2.88ProLys: 2.88 ± 0.028	4.509ProLeu: 4.509 ± 0.033	1.166ProMet: 1.166 ± 0.014	2.415ProAsn: 2.415 ± 0.025	4.685ProPro: 4.685 ± 0.066	2.972ProGln: 2.972 ± 0.03	2.453ProArg: 2.453 ± 0.024	4.191ProSer: 4.191 ± 0.044	3.645ProThr: 3.645 ± 0.04	3.104ProVal: 3.104 ± 0.028	0.439ProTrp: 0.439 ± 0.009	1.432ProTyr: 1.432 ± 0.018	0.001ProXaa: 0.001 ± 0.0
Gln	3.468GlnAla: 3.468 ± 0.032	0.871GlnCys: 0.871 ± 0.028	1.758GlnAsp: 1.758 ± 0.018	3.059GlnGlu: 3.059 ± 0.032	1.525GlnPhe: 1.525 ± 0.016	1.798GlnGly: 1.798 ± 0.02	2.185GlnHis: 2.185 ± 0.029	2.101GlnIle: 2.101 ± 0.02	2.501GlnLys: 2.501 ± 0.025	6.518GlnLeu: 6.518 ± 0.053	1.302GlnMet: 1.302 ± 0.016	1.908GlnAsn: 1.908 ± 0.018	3.378GlnPro: 3.378 ± 0.036	12.596GlnGln: 12.596 ± 0.244	3.71GlnArg: 3.71 ± 0.03	3.644GlnSer: 3.644 ± 0.029	2.562GlnThr: 2.562 ± 0.023	2.412GlnVal: 2.412 ± 0.021	0.462GlnTrp: 0.462 ± 0.009	1.299GlnTyr: 1.299 ± 0.015	0.003GlnXaa: 0.003 ± 0.001
Arg	3.574ArgAla: 3.574 ± 0.025	1.141ArgCys: 1.141 ± 0.023	2.709ArgAsp: 2.709 ± 0.026	3.465ArgGlu: 3.465 ± 0.035	1.938ArgPhe: 1.938 ± 0.018	2.667ArgGly: 2.667 ± 0.028	1.637ArgHis: 1.637 ± 0.021	2.753ArgIle: 2.753 ± 0.02	3.396ArgLys: 3.396 ± 0.027	5.266ArgLeu: 5.266 ± 0.038	1.259ArgMet: 1.259 ± 0.014	2.763ArgAsn: 2.763 ± 0.022	2.664ArgPro: 2.664 ± 0.026	3.129ArgGln: 3.129 ± 0.029	4.5ArgArg: 4.5 ± 0.044	4.365ArgSer: 4.365 ± 0.036	2.74ArgThr: 2.74 ± 0.021	2.791ArgVal: 2.791 ± 0.022	0.562ArgTrp: 0.562 ± 0.008	1.717ArgTyr: 1.717 ± 0.018	0.001ArgXaa: 0.001 ± 0.0
Ser	6.332SerAla: 6.332 ± 0.044	1.581SerCys: 1.581 ± 0.033	3.941SerAsp: 3.941 ± 0.03	4.295SerGlu: 4.295 ± 0.032	2.536SerPhe: 2.536 ± 0.026	5.267SerGly: 5.267 ± 0.042	1.926SerHis: 1.926 ± 0.02	3.71SerIle: 3.71 ± 0.023	3.996SerLys: 3.996 ± 0.029	6.597SerLeu: 6.597 ± 0.041	1.789SerMet: 1.789 ± 0.019	5.016SerAsn: 5.016 ± 0.05	4.226SerPro: 4.226 ± 0.044	3.427SerGln: 3.427 ± 0.028	3.851SerArg: 3.851 ± 0.037	11.016SerSer: 11.016 ± 0.139	5.337SerThr: 5.337 ± 0.044	4.274SerVal: 4.274 ± 0.027	0.741SerTrp: 0.741 ± 0.011	2.336SerTyr: 2.336 ± 0.024	0.002SerXaa: 0.002 ± 0.0
Thr	5.528ThrAla: 5.528 ± 0.048	0.969ThrCys: 0.969 ± 0.02	2.622ThrAsp: 2.622 ± 0.021	3.235ThrGlu: 3.235 ± 0.032	1.745ThrPhe: 1.745 ± 0.018	3.147ThrGly: 3.147 ± 0.027	1.356ThrHis: 1.356 ± 0.014	2.762ThrIle: 2.762 ± 0.023	2.755ThrLys: 2.755 ± 0.027	5.082ThrLeu: 5.082 ± 0.029	1.206ThrMet: 1.206 ± 0.012	2.568ThrAsn: 2.568 ± 0.025	3.991ThrPro: 3.991 ± 0.041	2.458ThrGln: 2.458 ± 0.021	2.579ThrArg: 2.579 ± 0.021	4.681ThrSer: 4.681 ± 0.039	5.522ThrThr: 5.522 ± 0.098	3.35ThrVal: 3.35 ± 0.027	0.472ThrTrp: 0.472 ± 0.01	1.488ThrTyr: 1.488 ± 0.017	0.002ThrXaa: 0.002 ± 0.001
Val	4.82ValAla: 4.82 ± 0.033	1.207ValCys: 1.207 ± 0.028	3.179ValAsp: 3.179 ± 0.022	3.693ValGlu: 3.693 ± 0.035	1.948ValPhe: 1.948 ± 0.02	3.29ValGly: 3.29 ± 0.024	1.463ValHis: 1.463 ± 0.015	2.779ValIle: 2.779 ± 0.024	2.968ValLys: 2.968 ± 0.026	5.298ValLeu: 5.298 ± 0.035	1.25ValMet: 1.25 ± 0.017	2.596ValAsn: 2.596 ± 0.023	3.139ValPro: 3.139 ± 0.025	2.651ValGln: 2.651 ± 0.025	3.026ValArg: 3.026 ± 0.023	4.021ValSer: 4.021 ± 0.025	3.091ValThr: 3.091 ± 0.028	3.746ValVal: 3.746 ± 0.032	0.577ValTrp: 0.577 ± 0.011	1.713ValTyr: 1.713 ± 0.019	0.002ValXaa: 0.002 ± 0.0
Trp	0.562TrpAla: 0.562 ± 0.01	0.194TrpCys: 0.194 ± 0.005	0.482TrpAsp: 0.482 ± 0.01	0.502TrpGlu: 0.502 ± 0.009	0.369TrpPhe: 0.369 ± 0.007	0.491TrpGly: 0.491 ± 0.01	0.305TrpHis: 0.305 ± 0.008	0.51TrpIle: 0.51 ± 0.009	0.526TrpLys: 0.526 ± 0.009	1.164TrpLeu: 1.164 ± 0.014	0.258TrpMet: 0.258 ± 0.006	0.474TrpAsn: 0.474 ± 0.009	0.436TrpPro: 0.436 ± 0.009	0.589TrpGln: 0.589 ± 0.01	0.702TrpArg: 0.702 ± 0.011	0.767TrpSer: 0.767 ± 0.012	0.543TrpThr: 0.543 ± 0.01	0.48TrpVal: 0.48 ± 0.01	0.155TrpTrp: 0.155 ± 0.005	0.306TrpTyr: 0.306 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.138TyrAla: 2.138 ± 0.021	0.681TyrCys: 0.681 ± 0.009	1.779TyrAsp: 1.779 ± 0.02	1.885TyrGlu: 1.885 ± 0.018	1.277TyrPhe: 1.277 ± 0.016	1.896TyrGly: 1.896 ± 0.025	0.797TyrHis: 0.797 ± 0.011	1.466TyrIle: 1.466 ± 0.016	1.607TyrLys: 1.607 ± 0.018	2.674TyrLeu: 2.674 ± 0.023	0.808TyrMet: 0.808 ± 0.012	1.596TyrAsn: 1.596 ± 0.018	1.302TyrPro: 1.302 ± 0.017	1.367TyrGln: 1.367 ± 0.018	1.705TyrArg: 1.705 ± 0.02	2.117TyrSer: 2.117 ± 0.019	1.605TyrThr: 1.605 ± 0.016	1.849TyrVal: 1.849 ± 0.019	0.357TyrTrp: 0.357 ± 0.009	1.299TyrTyr: 1.299 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.003XaaGln: 0.003 ± 0.001	0.001XaaArg: 0.001 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.155XaaXaa: 0.155 ± 0.028

Statistics based on 15505 proteins (7239635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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