Amino acid dipepetide frequency for Cohnella sp. CIP 111063

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.953AlaAla: 10.953 ± 0.104
0.842AlaCys: 0.842 ± 0.021
5.226AlaAsp: 5.226 ± 0.058
6.8AlaGlu: 6.8 ± 0.066
3.725AlaPhe: 3.725 ± 0.043
7.976AlaGly: 7.976 ± 0.081
1.457AlaHis: 1.457 ± 0.026
5.458AlaIle: 5.458 ± 0.058
4.16AlaLys: 4.16 ± 0.043
9.633AlaLeu: 9.633 ± 0.076
2.406AlaMet: 2.406 ± 0.035
2.827AlaAsn: 2.827 ± 0.036
3.296AlaPro: 3.296 ± 0.048
2.751AlaGln: 2.751 ± 0.033
4.567AlaArg: 4.567 ± 0.045
6.103AlaSer: 6.103 ± 0.054
3.977AlaThr: 3.977 ± 0.069
7.061AlaVal: 7.061 ± 0.071
1.191AlaTrp: 1.191 ± 0.025
3.048AlaTyr: 3.048 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.637CysAla: 0.637 ± 0.019
0.122CysCys: 0.122 ± 0.008
0.372CysAsp: 0.372 ± 0.014
0.465CysGlu: 0.465 ± 0.014
0.28CysPhe: 0.28 ± 0.011
0.799CysGly: 0.799 ± 0.021
0.16CysHis: 0.16 ± 0.007
0.398CysIle: 0.398 ± 0.011
0.261CysLys: 0.261 ± 0.01
0.703CysLeu: 0.703 ± 0.017
0.185CysMet: 0.185 ± 0.009
0.205CysAsn: 0.205 ± 0.008
0.349CysPro: 0.349 ± 0.013
0.167CysGln: 0.167 ± 0.01
0.522CysArg: 0.522 ± 0.016
0.528CysSer: 0.528 ± 0.013
0.331CysThr: 0.331 ± 0.012
0.49CysVal: 0.49 ± 0.014
0.093CysTrp: 0.093 ± 0.006
0.24CysTyr: 0.24 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
4.467AspAla: 4.467 ± 0.043
0.398AspCys: 0.398 ± 0.013
2.712AspAsp: 2.712 ± 0.036
4.003AspGlu: 4.003 ± 0.043
2.088AspPhe: 2.088 ± 0.029
4.953AspGly: 4.953 ± 0.062
0.915AspHis: 0.915 ± 0.021
3.162AspIle: 3.162 ± 0.039
2.572AspLys: 2.572 ± 0.037
4.714AspLeu: 4.714 ± 0.045
1.217AspMet: 1.217 ± 0.024
1.847AspAsn: 1.847 ± 0.031
2.588AspPro: 2.588 ± 0.035
1.547AspGln: 1.547 ± 0.029
3.559AspArg: 3.559 ± 0.04
2.856AspSer: 2.856 ± 0.036
2.367AspThr: 2.367 ± 0.035
3.635AspVal: 3.635 ± 0.042
0.97AspTrp: 0.97 ± 0.021
2.135AspTyr: 2.135 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
7.114GluAla: 7.114 ± 0.064
0.376GluCys: 0.376 ± 0.012
3.169GluAsp: 3.169 ± 0.04
5.512GluGlu: 5.512 ± 0.064
2.154GluPhe: 2.154 ± 0.032
4.817GluGly: 4.817 ± 0.055
1.329GluHis: 1.329 ± 0.029
3.904GluIle: 3.904 ± 0.045
3.374GluLys: 3.374 ± 0.047
7.562GluLeu: 7.562 ± 0.064
1.866GluMet: 1.866 ± 0.026
2.123GluAsn: 2.123 ± 0.033
2.644GluPro: 2.644 ± 0.037
3.223GluGln: 3.223 ± 0.045
5.189GluArg: 5.189 ± 0.063
3.606GluSer: 3.606 ± 0.04
3.545GluThr: 3.545 ± 0.037
4.074GluVal: 4.074 ± 0.042
1.142GluTrp: 1.142 ± 0.022
1.96GluTyr: 1.96 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.774PheAla: 3.774 ± 0.048
0.329PheCys: 0.329 ± 0.012
2.296PheAsp: 2.296 ± 0.034
2.479PheGlu: 2.479 ± 0.033
1.708PhePhe: 1.708 ± 0.032
3.418PheGly: 3.418 ± 0.038
0.83PheHis: 0.83 ± 0.02
2.34PheIle: 2.34 ± 0.038
1.803PheLys: 1.803 ± 0.032
3.864PheLeu: 3.864 ± 0.055
0.99PheMet: 0.99 ± 0.024
1.496PheAsn: 1.496 ± 0.026
1.656PhePro: 1.656 ± 0.029
1.232PheGln: 1.232 ± 0.025
2.488PheArg: 2.488 ± 0.033
2.679PheSer: 2.679 ± 0.041
2.061PheThr: 2.061 ± 0.035
3.192PheVal: 3.192 ± 0.043
0.553PheTrp: 0.553 ± 0.015
1.471PheTyr: 1.471 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
6.848GlyAla: 6.848 ± 0.102
0.703GlyCys: 0.703 ± 0.017
4.016GlyAsp: 4.016 ± 0.05
5.356GlyGlu: 5.356 ± 0.053
3.335GlyPhe: 3.335 ± 0.04
6.458GlyGly: 6.458 ± 0.08
1.436GlyHis: 1.436 ± 0.025
5.25GlyIle: 5.25 ± 0.047
4.32GlyLys: 4.32 ± 0.051
7.615GlyLeu: 7.615 ± 0.066
2.409GlyMet: 2.409 ± 0.031
2.789GlyAsn: 2.789 ± 0.047
2.238GlyPro: 2.238 ± 0.067
2.686GlyGln: 2.686 ± 0.034
4.503GlyArg: 4.503 ± 0.053
5.188GlySer: 5.188 ± 0.067
4.498GlyThr: 4.498 ± 0.054
5.449GlyVal: 5.449 ± 0.051
1.327GlyTrp: 1.327 ± 0.025
3.029GlyTyr: 3.029 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
1.586HisAla: 1.586 ± 0.031
0.179HisCys: 0.179 ± 0.009
0.914HisAsp: 0.914 ± 0.021
1.144HisGlu: 1.144 ± 0.024
0.933HisPhe: 0.933 ± 0.02
1.485HisGly: 1.485 ± 0.028
0.491HisHis: 0.491 ± 0.015
1.023HisIle: 1.023 ± 0.023
0.638HisLys: 0.638 ± 0.018
1.965HisLeu: 1.965 ± 0.041
0.461HisMet: 0.461 ± 0.014
0.545HisAsn: 0.545 ± 0.016
1.183HisPro: 1.183 ± 0.022
0.573HisGln: 0.573 ± 0.012
1.228HisArg: 1.228 ± 0.024
1.095HisSer: 1.095 ± 0.022
0.857HisThr: 0.857 ± 0.019
1.231HisVal: 1.231 ± 0.024
0.347HisTrp: 0.347 ± 0.011
0.845HisTyr: 0.845 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.275IleAla: 6.275 ± 0.065
0.473IleCys: 0.473 ± 0.013
3.546IleAsp: 3.546 ± 0.038
3.894IleGlu: 3.894 ± 0.042
1.992IlePhe: 1.992 ± 0.036
5.36IleGly: 5.36 ± 0.06
1.165IleHis: 1.165 ± 0.025
2.897IleIle: 2.897 ± 0.05
2.274IleLys: 2.274 ± 0.037
4.809IleLeu: 4.809 ± 0.059
1.304IleMet: 1.304 ± 0.025
1.904IleAsn: 1.904 ± 0.036
2.898IlePro: 2.898 ± 0.039
1.913IleGln: 1.913 ± 0.028
4.142IleArg: 4.142 ± 0.048
3.605IleSer: 3.605 ± 0.043
2.855IleThr: 2.855 ± 0.04
5.5IleVal: 5.5 ± 0.058
0.681IleTrp: 0.681 ± 0.02
1.873IleTyr: 1.873 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.008LysAla: 4.008 ± 0.045
0.211LysCys: 0.211 ± 0.01
2.404LysAsp: 2.404 ± 0.038
3.534LysGlu: 3.534 ± 0.039
1.495LysPhe: 1.495 ± 0.024
3.104LysGly: 3.104 ± 0.044
0.953LysHis: 0.953 ± 0.023
2.582LysIle: 2.582 ± 0.04
2.481LysLys: 2.481 ± 0.037
5.32LysLeu: 5.32 ± 0.058
1.281LysMet: 1.281 ± 0.024
1.553LysAsn: 1.553 ± 0.026
2.227LysPro: 2.227 ± 0.031
1.936LysGln: 1.936 ± 0.029
2.881LysArg: 2.881 ± 0.036
2.567LysSer: 2.567 ± 0.03
2.468LysThr: 2.468 ± 0.036
3.024LysVal: 3.024 ± 0.039
0.693LysTrp: 0.693 ± 0.018
1.605LysTyr: 1.605 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
9.569LeuAla: 9.569 ± 0.087
0.776LeuCys: 0.776 ± 0.02
5.157LeuAsp: 5.157 ± 0.043
6.377LeuGlu: 6.377 ± 0.064
4.678LeuPhe: 4.678 ± 0.058
6.941LeuGly: 6.941 ± 0.055
1.947LeuHis: 1.947 ± 0.029
6.028LeuIle: 6.028 ± 0.069
4.774LeuLys: 4.774 ± 0.048
11.51LeuLeu: 11.51 ± 0.113
2.415LeuMet: 2.415 ± 0.033
3.72LeuAsn: 3.72 ± 0.043
4.869LeuPro: 4.869 ± 0.047
3.69LeuGln: 3.69 ± 0.037
5.871LeuArg: 5.871 ± 0.056
7.102LeuSer: 7.102 ± 0.061
5.593LeuThr: 5.593 ± 0.062
6.509LeuVal: 6.509 ± 0.06
1.14LeuTrp: 1.14 ± 0.025
3.292LeuTyr: 3.292 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.222MetAla: 2.222 ± 0.032
0.133MetCys: 0.133 ± 0.007
1.341MetAsp: 1.341 ± 0.026
1.653MetGlu: 1.653 ± 0.029
0.937MetPhe: 0.937 ± 0.021
1.628MetGly: 1.628 ± 0.029
0.424MetHis: 0.424 ± 0.013
1.681MetIle: 1.681 ± 0.03
1.686MetLys: 1.686 ± 0.024
2.789MetLeu: 2.789 ± 0.04
0.721MetMet: 0.721 ± 0.02
1.281MetAsn: 1.281 ± 0.026
1.147MetPro: 1.147 ± 0.025
0.831MetGln: 0.831 ± 0.018
1.533MetArg: 1.533 ± 0.022
1.715MetSer: 1.715 ± 0.027
1.678MetThr: 1.678 ± 0.026
1.411MetVal: 1.411 ± 0.028
0.241MetTrp: 0.241 ± 0.01
0.705MetTyr: 0.705 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.116AsnAla: 3.116 ± 0.036
0.205AsnCys: 0.205 ± 0.008
1.844AsnAsp: 1.844 ± 0.031
2.377AsnGlu: 2.377 ± 0.035
1.196AsnPhe: 1.196 ± 0.023
3.326AsnGly: 3.326 ± 0.05
0.65AsnHis: 0.65 ± 0.015
1.825AsnIle: 1.825 ± 0.032
1.594AsnLys: 1.594 ± 0.028
3.098AsnLeu: 3.098 ± 0.042
0.847AsnMet: 0.847 ± 0.021
1.293AsnAsn: 1.293 ± 0.033
1.948AsnPro: 1.948 ± 0.032
1.103AsnGln: 1.103 ± 0.023
2.242AsnArg: 2.242 ± 0.034
1.888AsnSer: 1.888 ± 0.032
1.678AsnThr: 1.678 ± 0.032
2.649AsnVal: 2.649 ± 0.036
0.519AsnTrp: 0.519 ± 0.017
1.283AsnTyr: 1.283 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
3.974ProAla: 3.974 ± 0.048
0.249ProCys: 0.249 ± 0.011
3.029ProAsp: 3.029 ± 0.04
3.685ProGlu: 3.685 ± 0.042
1.941ProPhe: 1.941 ± 0.032
3.441ProGly: 3.441 ± 0.046
0.871ProHis: 0.871 ± 0.02
2.553ProIle: 2.553 ± 0.036
1.547ProLys: 1.547 ± 0.023
4.23ProLeu: 4.23 ± 0.051
0.955ProMet: 0.955 ± 0.02
1.547ProAsn: 1.547 ± 0.029
1.551ProPro: 1.551 ± 0.028
1.375ProGln: 1.375 ± 0.029
1.791ProArg: 1.791 ± 0.033
2.977ProSer: 2.977 ± 0.04
2.002ProThr: 2.002 ± 0.059
3.269ProVal: 3.269 ± 0.04
0.595ProTrp: 0.595 ± 0.015
1.634ProTyr: 1.634 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.607GlnAla: 3.607 ± 0.045
0.177GlnCys: 0.177 ± 0.009
1.461GlnAsp: 1.461 ± 0.024
2.196GlnGlu: 2.196 ± 0.032
1.376GlnPhe: 1.376 ± 0.024
2.442GlnGly: 2.442 ± 0.034
0.576GlnHis: 0.576 ± 0.015
2.103GlnIle: 2.103 ± 0.034
1.415GlnLys: 1.415 ± 0.026
3.676GlnLeu: 3.676 ± 0.043
0.971GlnMet: 0.971 ± 0.021
1.013GlnAsn: 1.013 ± 0.022
1.544GlnPro: 1.544 ± 0.025
1.409GlnGln: 1.409 ± 0.029
1.876GlnArg: 1.876 ± 0.032
2.065GlnSer: 2.065 ± 0.032
1.874GlnThr: 1.874 ± 0.031
2.172GlnVal: 2.172 ± 0.03
0.59GlnTrp: 0.59 ± 0.017
1.262GlnTyr: 1.262 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
4.425ArgAla: 4.425 ± 0.052
0.399ArgCys: 0.399 ± 0.015
2.962ArgAsp: 2.962 ± 0.04
4.611ArgGlu: 4.611 ± 0.058
2.613ArgPhe: 2.613 ± 0.036
3.689ArgGly: 3.689 ± 0.047
1.246ArgHis: 1.246 ± 0.024
4.187ArgIle: 4.187 ± 0.041
3.272ArgLys: 3.272 ± 0.041
6.679ArgLeu: 6.679 ± 0.068
1.918ArgMet: 1.918 ± 0.031
2.159ArgAsn: 2.159 ± 0.033
2.179ArgPro: 2.179 ± 0.039
2.309ArgGln: 2.309 ± 0.034
3.699ArgArg: 3.699 ± 0.056
3.748ArgSer: 3.748 ± 0.042
3.184ArgThr: 3.184 ± 0.039
3.564ArgVal: 3.564 ± 0.048
0.854ArgTrp: 0.854 ± 0.02
2.18ArgTyr: 2.18 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
5.971SerAla: 5.971 ± 0.056
0.435SerCys: 0.435 ± 0.014
3.199SerAsp: 3.199 ± 0.037
3.893SerGlu: 3.893 ± 0.043
2.875SerPhe: 2.875 ± 0.041
6.082SerGly: 6.082 ± 0.065
1.126SerHis: 1.126 ± 0.025
3.661SerIle: 3.661 ± 0.043
2.609SerLys: 2.609 ± 0.036
6.376SerLeu: 6.376 ± 0.06
1.54SerMet: 1.54 ± 0.027
1.968SerAsn: 1.968 ± 0.032
2.962SerPro: 2.962 ± 0.041
1.79SerGln: 1.79 ± 0.029
3.553SerArg: 3.553 ± 0.042
4.248SerSer: 4.248 ± 0.052
2.708SerThr: 2.708 ± 0.039
4.701SerVal: 4.701 ± 0.054
0.917SerTrp: 0.917 ± 0.021
2.214SerTyr: 2.214 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
4.708ThrAla: 4.708 ± 0.056
0.299ThrCys: 0.299 ± 0.01
2.813ThrAsp: 2.813 ± 0.039
3.101ThrGlu: 3.101 ± 0.041
2.212ThrPhe: 2.212 ± 0.036
4.697ThrGly: 4.697 ± 0.137
0.841ThrHis: 0.841 ± 0.019
3.545ThrIle: 3.545 ± 0.048
2.04ThrLys: 2.04 ± 0.034
5.32ThrLeu: 5.32 ± 0.054
1.281ThrMet: 1.281 ± 0.025
1.762ThrAsn: 1.762 ± 0.03
2.419ThrPro: 2.419 ± 0.04
1.295ThrGln: 1.295 ± 0.026
2.374ThrArg: 2.374 ± 0.03
2.924ThrSer: 2.924 ± 0.034
2.596ThrThr: 2.596 ± 0.044
4.443ThrVal: 4.443 ± 0.059
0.625ThrTrp: 0.625 ± 0.019
1.758ThrTyr: 1.758 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
5.983ValAla: 5.983 ± 0.05
0.623ValCys: 0.623 ± 0.017
3.623ValAsp: 3.623 ± 0.035
4.256ValGlu: 4.256 ± 0.043
2.975ValPhe: 2.975 ± 0.043
4.977ValGly: 4.977 ± 0.043
1.385ValHis: 1.385 ± 0.028
4.067ValIle: 4.067 ± 0.051
3.369ValLys: 3.369 ± 0.043
7.163ValLeu: 7.163 ± 0.061
1.706ValMet: 1.706 ± 0.027
2.606ValAsn: 2.606 ± 0.036
3.393ValPro: 3.393 ± 0.045
2.436ValGln: 2.436 ± 0.035
4.463ValArg: 4.463 ± 0.05
4.901ValSer: 4.901 ± 0.044
4.233ValThr: 4.233 ± 0.056
5.348ValVal: 5.348 ± 0.053
0.978ValTrp: 0.978 ± 0.019
2.551ValTyr: 2.551 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.039TrpAla: 1.039 ± 0.023
0.104TrpCys: 0.104 ± 0.007
0.733TrpAsp: 0.733 ± 0.018
0.861TrpGlu: 0.861 ± 0.022
0.593TrpPhe: 0.593 ± 0.017
0.956TrpGly: 0.956 ± 0.022
0.295TrpHis: 0.295 ± 0.012
0.911TrpIle: 0.911 ± 0.022
0.789TrpLys: 0.789 ± 0.017
1.565TrpLeu: 1.565 ± 0.026
0.464TrpMet: 0.464 ± 0.013
0.762TrpAsn: 0.762 ± 0.019
0.486TrpPro: 0.486 ± 0.015
0.54TrpGln: 0.54 ± 0.016
0.838TrpArg: 0.838 ± 0.02
0.908TrpSer: 0.908 ± 0.019
0.893TrpThr: 0.893 ± 0.022
0.808TrpVal: 0.808 ± 0.018
0.198TrpTrp: 0.198 ± 0.01
0.454TrpTyr: 0.454 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.182TyrAla: 3.182 ± 0.041
0.274TyrCys: 0.274 ± 0.012
1.889TyrAsp: 1.889 ± 0.032
2.486TyrGlu: 2.486 ± 0.034
1.554TyrPhe: 1.554 ± 0.028
2.903TyrGly: 2.903 ± 0.035
0.627TyrHis: 0.627 ± 0.017
1.783TyrIle: 1.783 ± 0.031
1.349TyrLys: 1.349 ± 0.022
3.366TyrLeu: 3.366 ± 0.04
0.82TyrMet: 0.82 ± 0.019
1.28TyrAsn: 1.28 ± 0.029
1.639TyrPro: 1.639 ± 0.031
0.999TyrGln: 0.999 ± 0.019
2.559TyrArg: 2.559 ± 0.033
2.123TyrSer: 2.123 ± 0.031
1.656TyrThr: 1.656 ± 0.033
2.507TyrVal: 2.507 ± 0.039
0.544TyrTrp: 0.544 ± 0.016
1.376TyrTyr: 1.376 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6817 proteins (2409860 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski