Amino acid dipepetide frequency for Tibeticola sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.058AlaAla: 21.058 ± 0.242	1.316AlaCys: 1.316 ± 0.039	6.339AlaAsp: 6.339 ± 0.1	8.13AlaGlu: 8.13 ± 0.116	4.12AlaPhe: 4.12 ± 0.084	10.227AlaGly: 10.227 ± 0.111	3.023AlaHis: 3.023 ± 0.067	4.939AlaIle: 4.939 ± 0.078	3.323AlaLys: 3.323 ± 0.078	17.337AlaLeu: 17.337 ± 0.222	3.264AlaMet: 3.264 ± 0.059	2.451AlaAsn: 2.451 ± 0.064	7.197AlaPro: 7.197 ± 0.136	6.632AlaGln: 6.632 ± 0.103	11.292AlaArg: 11.292 ± 0.155	6.449AlaSer: 6.449 ± 0.099	5.826AlaThr: 5.826 ± 0.108	9.617AlaVal: 9.617 ± 0.141	2.435AlaTrp: 2.435 ± 0.066	2.552AlaTyr: 2.552 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.279CysAla: 1.279 ± 0.04	0.108CysCys: 0.108 ± 0.011	0.515CysAsp: 0.515 ± 0.026	0.484CysGlu: 0.484 ± 0.026	0.265CysPhe: 0.265 ± 0.019	1.0CysGly: 1.0 ± 0.034	0.3CysHis: 0.3 ± 0.024	0.397CysIle: 0.397 ± 0.022	0.209CysLys: 0.209 ± 0.016	0.766CysLeu: 0.766 ± 0.03	0.195CysMet: 0.195 ± 0.016	0.218CysAsn: 0.218 ± 0.017	0.614CysPro: 0.614 ± 0.028	0.209CysGln: 0.209 ± 0.016	0.632CysArg: 0.632 ± 0.027	0.462CysSer: 0.462 ± 0.024	0.505CysThr: 0.505 ± 0.024	0.687CysVal: 0.687 ± 0.029	0.117CysTrp: 0.117 ± 0.011	0.191CysTyr: 0.191 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.847AspAla: 7.847 ± 0.127	0.448AspCys: 0.448 ± 0.023	2.36AspAsp: 2.36 ± 0.063	3.284AspGlu: 3.284 ± 0.065	1.893AspPhe: 1.893 ± 0.049	4.157AspGly: 4.157 ± 0.072	1.003AspHis: 1.003 ± 0.033	2.061AspIle: 2.061 ± 0.053	1.257AspLys: 1.257 ± 0.047	5.324AspLeu: 5.324 ± 0.091	0.97AspMet: 0.97 ± 0.036	0.862AspAsn: 0.862 ± 0.034	3.322AspPro: 3.322 ± 0.064	1.345AspGln: 1.345 ± 0.041	3.553AspArg: 3.553 ± 0.065	1.735AspSer: 1.735 ± 0.049	2.243AspThr: 2.243 ± 0.054	3.702AspVal: 3.702 ± 0.066	1.055AspTrp: 1.055 ± 0.043	1.279AspTyr: 1.279 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.616GluAla: 8.616 ± 0.135	0.391GluCys: 0.391 ± 0.024	2.42GluAsp: 2.42 ± 0.059	2.731GluGlu: 2.731 ± 0.079	1.687GluPhe: 1.687 ± 0.051	4.3GluGly: 4.3 ± 0.073	1.456GluHis: 1.456 ± 0.043	2.779GluIle: 2.779 ± 0.072	1.704GluLys: 1.704 ± 0.054	5.993GluLeu: 5.993 ± 0.085	1.174GluMet: 1.174 ± 0.044	1.117GluAsn: 1.117 ± 0.04	3.402GluPro: 3.402 ± 0.076	2.599GluGln: 2.599 ± 0.065	6.408GluArg: 6.408 ± 0.104	2.5GluSer: 2.5 ± 0.059	2.68GluThr: 2.68 ± 0.053	4.499GluVal: 4.499 ± 0.077	0.793GluTrp: 0.793 ± 0.032	0.952GluTyr: 0.952 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.08PheAla: 4.08 ± 0.077	0.386PheCys: 0.386 ± 0.024	2.486PheAsp: 2.486 ± 0.058	2.335PheGlu: 2.335 ± 0.058	1.354PhePhe: 1.354 ± 0.045	3.263PheGly: 3.263 ± 0.062	0.682PheHis: 0.682 ± 0.033	1.452PheIle: 1.452 ± 0.043	1.007PheLys: 1.007 ± 0.038	2.954PheLeu: 2.954 ± 0.067	0.707PheMet: 0.707 ± 0.032	0.918PheAsn: 0.918 ± 0.033	1.437PhePro: 1.437 ± 0.044	0.978PheGln: 0.978 ± 0.031	1.873PheArg: 1.873 ± 0.053	1.86PheSer: 1.86 ± 0.052	1.612PheThr: 1.612 ± 0.039	2.65PheVal: 2.65 ± 0.056	0.557PheTrp: 0.557 ± 0.029	0.817PheTyr: 0.817 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.739GlyAla: 9.739 ± 0.128	0.989GlyCys: 0.989 ± 0.032	3.588GlyAsp: 3.588 ± 0.069	4.458GlyGlu: 4.458 ± 0.072	3.143GlyPhe: 3.143 ± 0.069	6.546GlyGly: 6.546 ± 0.124	1.978GlyHis: 1.978 ± 0.051	3.658GlyIle: 3.658 ± 0.074	2.794GlyLys: 2.794 ± 0.069	9.247GlyLeu: 9.247 ± 0.123	2.103GlyMet: 2.103 ± 0.05	1.758GlyAsn: 1.758 ± 0.048	3.463GlyPro: 3.463 ± 0.056	3.163GlyGln: 3.163 ± 0.061	6.023GlyArg: 6.023 ± 0.083	4.261GlySer: 4.261 ± 0.081	3.908GlyThr: 3.908 ± 0.081	6.716GlyVal: 6.716 ± 0.103	1.562GlyTrp: 1.562 ± 0.042	2.196GlyTyr: 2.196 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	3.048HisAla: 3.048 ± 0.064	0.279HisCys: 0.279 ± 0.019	1.089HisAsp: 1.089 ± 0.035	1.201HisGlu: 1.201 ± 0.038	0.803HisPhe: 0.803 ± 0.03	2.174HisGly: 2.174 ± 0.05	0.624HisHis: 0.624 ± 0.029	0.949HisIle: 0.949 ± 0.035	0.497HisLys: 0.497 ± 0.027	2.219HisLeu: 2.219 ± 0.06	0.433HisMet: 0.433 ± 0.023	0.469HisAsn: 0.469 ± 0.025	1.712HisPro: 1.712 ± 0.048	0.686HisGln: 0.686 ± 0.028	1.752HisArg: 1.752 ± 0.047	0.902HisSer: 0.902 ± 0.036	1.113HisThr: 1.113 ± 0.036	1.531HisVal: 1.531 ± 0.041	0.432HisTrp: 0.432 ± 0.021	0.59HisTyr: 0.59 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.552IleAla: 5.552 ± 0.094	0.362IleCys: 0.362 ± 0.021	3.012IleAsp: 3.012 ± 0.06	3.723IleGlu: 3.723 ± 0.08	1.168IlePhe: 1.168 ± 0.042	3.866IleGly: 3.866 ± 0.082	0.883IleHis: 0.883 ± 0.031	1.45IleIle: 1.45 ± 0.048	1.256IleLys: 1.256 ± 0.044	3.37IleLeu: 3.37 ± 0.07	0.735IleMet: 0.735 ± 0.034	1.185IleAsn: 1.185 ± 0.041	1.946IlePro: 1.946 ± 0.052	1.216IleGln: 1.216 ± 0.035	2.769IleArg: 2.769 ± 0.057	1.974IleSer: 1.974 ± 0.05	2.071IleThr: 2.071 ± 0.051	3.414IleVal: 3.414 ± 0.069	0.509IleTrp: 0.509 ± 0.026	0.902IleTyr: 0.902 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.589LysAla: 3.589 ± 0.077	0.147LysCys: 0.147 ± 0.015	1.402LysAsp: 1.402 ± 0.041	1.314LysGlu: 1.314 ± 0.047	0.801LysPhe: 0.801 ± 0.036	2.129LysGly: 2.129 ± 0.063	0.539LysHis: 0.539 ± 0.023	1.326LysIle: 1.326 ± 0.046	1.326LysLys: 1.326 ± 0.046	2.992LysLeu: 2.992 ± 0.069	0.699LysMet: 0.699 ± 0.032	0.839LysAsn: 0.839 ± 0.037	1.984LysPro: 1.984 ± 0.055	0.907LysGln: 0.907 ± 0.034	2.056LysArg: 2.056 ± 0.059	1.456LysSer: 1.456 ± 0.048	1.658LysThr: 1.658 ± 0.046	2.151LysVal: 2.151 ± 0.075	0.28LysTrp: 0.28 ± 0.017	0.6LysTyr: 0.6 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	16.239LeuAla: 16.239 ± 0.199	1.007LeuCys: 1.007 ± 0.036	6.032LeuAsp: 6.032 ± 0.089	6.329LeuGlu: 6.329 ± 0.109	3.256LeuPhe: 3.256 ± 0.073	9.218LeuGly: 9.218 ± 0.137	2.435LeuHis: 2.435 ± 0.051	4.436LeuIle: 4.436 ± 0.073	3.251LeuLys: 3.251 ± 0.069	11.562LeuLeu: 11.562 ± 0.203	2.469LeuMet: 2.469 ± 0.064	2.394LeuAsn: 2.394 ± 0.058	6.382LeuPro: 6.382 ± 0.098	4.291LeuGln: 4.291 ± 0.083	9.078LeuArg: 9.078 ± 0.121	5.871LeuSer: 5.871 ± 0.092	5.135LeuThr: 5.135 ± 0.085	7.69LeuVal: 7.69 ± 0.108	1.588LeuTrp: 1.588 ± 0.055	2.015LeuTyr: 2.015 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.988MetAla: 2.988 ± 0.056	0.158MetCys: 0.158 ± 0.014	0.982MetAsp: 0.982 ± 0.043	0.972MetGlu: 0.972 ± 0.032	0.686MetPhe: 0.686 ± 0.03	1.739MetGly: 1.739 ± 0.053	0.505MetHis: 0.505 ± 0.023	0.865MetIle: 0.865 ± 0.035	0.975MetLys: 0.975 ± 0.037	2.392MetLeu: 2.392 ± 0.055	0.537MetMet: 0.537 ± 0.032	0.846MetAsn: 0.846 ± 0.029	1.38MetPro: 1.38 ± 0.043	0.899MetGln: 0.899 ± 0.035	1.652MetArg: 1.652 ± 0.047	1.419MetSer: 1.419 ± 0.037	1.39MetThr: 1.39 ± 0.049	1.492MetVal: 1.492 ± 0.049	0.191MetTrp: 0.191 ± 0.016	0.326MetTyr: 0.326 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.829AsnAla: 2.829 ± 0.062	0.279AsnCys: 0.279 ± 0.019	1.06AsnAsp: 1.06 ± 0.039	1.094AsnGlu: 1.094 ± 0.036	0.823AsnPhe: 0.823 ± 0.033	1.795AsnGly: 1.795 ± 0.044	0.434AsnHis: 0.434 ± 0.024	0.987AsnIle: 0.987 ± 0.036	0.651AsnLys: 0.651 ± 0.029	2.408AsnLeu: 2.408 ± 0.053	0.482AsnMet: 0.482 ± 0.024	0.561AsnAsn: 0.561 ± 0.029	1.835AsnPro: 1.835 ± 0.053	0.73AsnGln: 0.73 ± 0.036	1.565AsnArg: 1.565 ± 0.043	0.859AsnSer: 0.859 ± 0.034	1.221AsnThr: 1.221 ± 0.039	1.598AsnVal: 1.598 ± 0.048	0.362AsnTrp: 0.362 ± 0.018	0.546AsnTyr: 0.546 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.669ProAla: 7.669 ± 0.127	0.405ProCys: 0.405 ± 0.021	3.208ProAsp: 3.208 ± 0.065	4.447ProGlu: 4.447 ± 0.076	1.816ProPhe: 1.816 ± 0.053	4.771ProGly: 4.771 ± 0.082	1.167ProHis: 1.167 ± 0.039	2.03ProIle: 2.03 ± 0.05	1.656ProLys: 1.656 ± 0.046	5.79ProLeu: 5.79 ± 0.098	1.334ProMet: 1.334 ± 0.04	1.362ProAsn: 1.362 ± 0.046	3.252ProPro: 3.252 ± 0.086	2.356ProGln: 2.356 ± 0.059	3.646ProArg: 3.646 ± 0.081	2.952ProSer: 2.952 ± 0.056	2.639ProThr: 2.639 ± 0.056	4.336ProVal: 4.336 ± 0.072	1.007ProTrp: 1.007 ± 0.036	1.182ProTyr: 1.182 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.889GlnAla: 5.889 ± 0.107	0.262GlnCys: 0.262 ± 0.02	1.352GlnAsp: 1.352 ± 0.041	1.589GlnGlu: 1.589 ± 0.051	1.167GlnPhe: 1.167 ± 0.038	2.871GlnGly: 2.871 ± 0.066	0.882GlnHis: 0.882 ± 0.034	1.756GlnIle: 1.756 ± 0.05	1.061GlnLys: 1.061 ± 0.038	3.787GlnLeu: 3.787 ± 0.072	0.872GlnMet: 0.872 ± 0.033	0.817GlnAsn: 0.817 ± 0.033	2.346GlnPro: 2.346 ± 0.057	1.749GlnGln: 1.749 ± 0.05	3.914GlnArg: 3.914 ± 0.08	1.859GlnSer: 1.859 ± 0.053	2.072GlnThr: 2.072 ± 0.06	2.706GlnVal: 2.706 ± 0.059	0.722GlnTrp: 0.722 ± 0.031	0.667GlnTyr: 0.667 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	10.41ArgAla: 10.41 ± 0.127	0.68ArgCys: 0.68 ± 0.029	3.654ArgAsp: 3.654 ± 0.071	4.813ArgGlu: 4.813 ± 0.075	3.031ArgPhe: 3.031 ± 0.059	5.268ArgGly: 5.268 ± 0.083	1.983ArgHis: 1.983 ± 0.055	3.747ArgIle: 3.747 ± 0.071	1.877ArgLys: 1.877 ± 0.052	9.623ArgLeu: 9.623 ± 0.122	1.944ArgMet: 1.944 ± 0.049	1.522ArgAsn: 1.522 ± 0.043	4.016ArgPro: 4.016 ± 0.076	2.875ArgGln: 2.875 ± 0.065	6.466ArgArg: 6.466 ± 0.105	3.812ArgSer: 3.812 ± 0.065	3.302ArgThr: 3.302 ± 0.059	5.897ArgVal: 5.897 ± 0.088	1.627ArgTrp: 1.627 ± 0.055	2.006ArgTyr: 2.006 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.584SerAla: 6.584 ± 0.102	0.416SerCys: 0.416 ± 0.024	2.329SerAsp: 2.329 ± 0.049	2.532SerGlu: 2.532 ± 0.059	1.806SerPhe: 1.806 ± 0.05	4.999SerGly: 4.999 ± 0.09	0.989SerHis: 0.989 ± 0.035	2.012SerIle: 2.012 ± 0.052	1.242SerLys: 1.242 ± 0.042	5.14SerLeu: 5.14 ± 0.072	1.141SerMet: 1.141 ± 0.035	1.137SerAsn: 1.137 ± 0.041	2.773SerPro: 2.773 ± 0.062	1.452SerGln: 1.452 ± 0.045	3.282SerArg: 3.282 ± 0.059	2.565SerSer: 2.565 ± 0.079	2.574SerThr: 2.574 ± 0.056	3.796SerVal: 3.796 ± 0.071	0.645SerTrp: 0.645 ± 0.029	1.047SerTyr: 1.047 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.802ThrAla: 5.802 ± 0.085	0.357ThrCys: 0.357 ± 0.021	2.255ThrAsp: 2.255 ± 0.052	2.489ThrGlu: 2.489 ± 0.058	1.407ThrPhe: 1.407 ± 0.043	4.323ThrGly: 4.323 ± 0.085	1.112ThrHis: 1.112 ± 0.034	1.859ThrIle: 1.859 ± 0.054	1.028ThrLys: 1.028 ± 0.039	6.309ThrLeu: 6.309 ± 0.092	0.829ThrMet: 0.829 ± 0.033	1.056ThrAsn: 1.056 ± 0.04	3.839ThrPro: 3.839 ± 0.075	1.852ThrGln: 1.852 ± 0.049	3.375ThrArg: 3.375 ± 0.061	2.121ThrSer: 2.121 ± 0.056	2.366ThrThr: 2.366 ± 0.061	4.089ThrVal: 4.089 ± 0.068	0.611ThrTrp: 0.611 ± 0.031	0.922ThrTyr: 0.922 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.787ValAla: 9.787 ± 0.141	0.757ValCys: 0.757 ± 0.034	3.927ValAsp: 3.927 ± 0.07	4.49ValGlu: 4.49 ± 0.079	2.763ValPhe: 2.763 ± 0.058	5.629ValGly: 5.629 ± 0.089	1.694ValHis: 1.694 ± 0.049	3.145ValIle: 3.145 ± 0.068	2.107ValLys: 2.107 ± 0.057	8.766ValLeu: 8.766 ± 0.125	1.707ValMet: 1.707 ± 0.05	1.703ValAsn: 1.703 ± 0.047	4.122ValPro: 4.122 ± 0.079	2.884ValGln: 2.884 ± 0.062	5.814ValArg: 5.814 ± 0.092	3.61ValSer: 3.61 ± 0.068	3.688ValThr: 3.688 ± 0.068	6.153ValVal: 6.153 ± 0.107	1.183ValTrp: 1.183 ± 0.042	1.597ValTyr: 1.597 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.778TrpAla: 1.778 ± 0.056	0.182TrpCys: 0.182 ± 0.015	0.623TrpAsp: 0.623 ± 0.028	0.617TrpGlu: 0.617 ± 0.022	0.572TrpPhe: 0.572 ± 0.026	1.067TrpGly: 1.067 ± 0.038	0.363TrpHis: 0.363 ± 0.021	0.768TrpIle: 0.768 ± 0.032	0.412TrpLys: 0.412 ± 0.025	2.447TrpLeu: 2.447 ± 0.074	0.442TrpMet: 0.442 ± 0.023	0.368TrpAsn: 0.368 ± 0.021	0.883TrpPro: 0.883 ± 0.04	0.747TrpGln: 0.747 ± 0.03	1.629TrpArg: 1.629 ± 0.055	0.818TrpSer: 0.818 ± 0.034	0.735TrpThr: 0.735 ± 0.032	1.268TrpVal: 1.268 ± 0.046	0.314TrpTrp: 0.314 ± 0.02	0.296TrpTyr: 0.296 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.746TyrAla: 2.746 ± 0.062	0.223TyrCys: 0.223 ± 0.016	1.068TyrAsp: 1.068 ± 0.039	1.168TyrGlu: 1.168 ± 0.044	0.852TyrPhe: 0.852 ± 0.032	1.95TyrGly: 1.95 ± 0.053	0.449TyrHis: 0.449 ± 0.026	0.747TyrIle: 0.747 ± 0.033	0.564TyrLys: 0.564 ± 0.028	2.252TyrLeu: 2.252 ± 0.053	0.351TyrMet: 0.351 ± 0.022	0.538TyrAsn: 0.538 ± 0.026	1.119TyrPro: 1.119 ± 0.035	0.769TyrGln: 0.769 ± 0.031	1.771TyrArg: 1.771 ± 0.047	0.977TyrSer: 0.977 ± 0.033	1.263TyrThr: 1.263 ± 0.038	1.533TyrVal: 1.533 ± 0.038	0.339TyrTrp: 0.339 ± 0.02	0.543TyrTyr: 0.543 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2531 proteins (831099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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