Amino acid dipepetide frequency for Sewage-associated circular DNA virus-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.868AlaAla: 9.868 ± 2.107
0.0AlaCys: 0.0 ± 0.0
2.193AlaAsp: 2.193 ± 2.049
2.193AlaGlu: 2.193 ± 1.424
2.193AlaPhe: 2.193 ± 1.424
7.675AlaGly: 7.675 ± 3.739
0.0AlaHis: 0.0 ± 0.0
1.096AlaIle: 1.096 ± 0.712
3.289AlaLys: 3.289 ± 2.192
3.289AlaLeu: 3.289 ± 1.116
1.096AlaMet: 1.096 ± 0.85
6.579AlaAsn: 6.579 ± 2.566
4.386AlaPro: 4.386 ± 1.692
0.0AlaGln: 0.0 ± 0.0
4.386AlaArg: 4.386 ± 2.094
8.772AlaSer: 8.772 ± 1.195
1.096AlaThr: 1.096 ± 1.024
2.193AlaVal: 2.193 ± 1.348
1.096AlaTrp: 1.096 ± 1.024
5.482AlaTyr: 5.482 ± 1.807
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
1.096CysHis: 1.096 ± 0.712
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
2.193CysLeu: 2.193 ± 2.498
0.0CysMet: 0.0 ± 0.0
1.096CysAsn: 1.096 ± 1.249
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.096CysSer: 1.096 ± 1.024
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.193AspAla: 2.193 ± 2.049
0.0AspCys: 0.0 ± 0.0
7.675AspAsp: 7.675 ± 2.818
2.193AspGlu: 2.193 ± 0.8
1.096AspPhe: 1.096 ± 0.712
5.482AspGly: 5.482 ± 2.327
1.096AspHis: 1.096 ± 1.024
5.482AspIle: 5.482 ± 2.445
0.0AspLys: 0.0 ± 0.0
2.193AspLeu: 2.193 ± 1.424
1.096AspMet: 1.096 ± 0.712
2.193AspAsn: 2.193 ± 1.424
4.386AspPro: 4.386 ± 1.37
2.193AspGln: 2.193 ± 0.8
1.096AspArg: 1.096 ± 1.024
2.193AspSer: 2.193 ± 1.424
2.193AspThr: 2.193 ± 1.348
2.193AspVal: 2.193 ± 0.8
3.289AspTrp: 3.289 ± 1.695
4.386AspTyr: 4.386 ± 1.692
0.0AspXaa: 0.0 ± 0.0
Glu
5.482GluAla: 5.482 ± 0.848
0.0GluCys: 0.0 ± 0.0
2.193GluAsp: 2.193 ± 1.348
1.096GluGlu: 1.096 ± 1.024
4.386GluPhe: 4.386 ± 0.268
3.289GluGly: 3.289 ± 2.136
1.096GluHis: 1.096 ± 1.024
0.0GluIle: 0.0 ± 0.0
1.096GluLys: 1.096 ± 0.712
5.482GluLeu: 5.482 ± 2.001
1.096GluMet: 1.096 ± 0.712
0.0GluAsn: 0.0 ± 0.0
2.193GluPro: 2.193 ± 1.424
4.386GluGln: 4.386 ± 2.848
2.193GluArg: 2.193 ± 0.8
3.289GluSer: 3.289 ± 2.388
4.386GluThr: 4.386 ± 1.37
2.193GluVal: 2.193 ± 0.8
0.0GluTrp: 0.0 ± 0.0
1.096GluTyr: 1.096 ± 0.712
0.0GluXaa: 0.0 ± 0.0
Phe
1.096PheAla: 1.096 ± 0.712
2.193PheCys: 2.193 ± 2.498
4.386PheAsp: 4.386 ± 1.792
1.096PheGlu: 1.096 ± 1.024
4.386PhePhe: 4.386 ± 3.411
6.579PheGly: 6.579 ± 1.302
2.193PheHis: 2.193 ± 1.424
1.096PheIle: 1.096 ± 1.249
1.096PheLys: 1.096 ± 1.249
4.386PheLeu: 4.386 ± 1.832
2.193PheMet: 2.193 ± 1.047
2.193PheAsn: 2.193 ± 1.047
1.096PhePro: 1.096 ± 1.249
4.386PheGln: 4.386 ± 1.792
3.289PheArg: 3.289 ± 0.662
4.386PheSer: 4.386 ± 1.832
2.193PheThr: 2.193 ± 0.8
2.193PheVal: 2.193 ± 1.047
1.096PheTrp: 1.096 ± 1.024
1.096PheTyr: 1.096 ± 0.712
0.0PheXaa: 0.0 ± 0.0
Gly
4.386GlyAla: 4.386 ± 2.094
0.0GlyCys: 0.0 ± 0.0
5.482GlyAsp: 5.482 ± 2.344
1.096GlyGlu: 1.096 ± 0.712
4.386GlyPhe: 4.386 ± 0.268
8.772GlyGly: 8.772 ± 4.413
1.096GlyHis: 1.096 ± 1.024
2.193GlyIle: 2.193 ± 1.348
5.482GlyLys: 5.482 ± 1.807
4.386GlyLeu: 4.386 ± 2.848
0.0GlyMet: 0.0 ± 0.0
1.096GlyAsn: 1.096 ± 1.024
4.386GlyPro: 4.386 ± 2.848
3.289GlyGln: 3.289 ± 1.116
7.675GlyArg: 7.675 ± 2.562
10.965GlySer: 10.965 ± 1.562
9.868GlyThr: 9.868 ± 1.038
5.482GlyVal: 5.482 ± 2.231
2.193GlyTrp: 2.193 ± 1.424
4.386GlyTyr: 4.386 ± 1.692
0.0GlyXaa: 0.0 ± 0.0
His
1.096HisAla: 1.096 ± 0.712
0.0HisCys: 0.0 ± 0.0
1.096HisAsp: 1.096 ± 0.712
1.096HisGlu: 1.096 ± 1.024
1.096HisPhe: 1.096 ± 1.024
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
2.193HisIle: 2.193 ± 0.8
1.096HisLys: 1.096 ± 1.249
2.193HisLeu: 2.193 ± 0.8
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.096HisArg: 1.096 ± 1.249
0.0HisSer: 0.0 ± 0.0
1.096HisThr: 1.096 ± 0.712
3.289HisVal: 3.289 ± 1.695
1.096HisTrp: 1.096 ± 1.024
1.096HisTyr: 1.096 ± 0.712
0.0HisXaa: 0.0 ± 0.0
Ile
4.386IleAla: 4.386 ± 0.268
0.0IleCys: 0.0 ± 0.0
6.579IleAsp: 6.579 ± 1.794
5.482IleGlu: 5.482 ± 0.772
3.289IlePhe: 3.289 ± 2.388
2.193IleGly: 2.193 ± 1.424
0.0IleHis: 0.0 ± 0.0
0.0IleIle: 0.0 ± 0.0
1.096IleLys: 1.096 ± 0.712
3.289IleLeu: 3.289 ± 1.283
0.0IleMet: 0.0 ± 0.0
0.0IleAsn: 0.0 ± 0.0
2.193IlePro: 2.193 ± 0.8
1.096IleGln: 1.096 ± 0.712
4.386IleArg: 4.386 ± 1.6
1.096IleSer: 1.096 ± 1.249
4.386IleThr: 4.386 ± 2.937
1.096IleVal: 1.096 ± 1.024
2.193IleTrp: 2.193 ± 2.049
1.096IleTyr: 1.096 ± 0.712
0.0IleXaa: 0.0 ± 0.0
Lys
1.096LysAla: 1.096 ± 0.712
0.0LysCys: 0.0 ± 0.0
2.193LysAsp: 2.193 ± 2.049
1.096LysGlu: 1.096 ± 0.712
4.386LysPhe: 4.386 ± 1.692
3.289LysGly: 3.289 ± 0.662
0.0LysHis: 0.0 ± 0.0
3.289LysIle: 3.289 ± 1.283
4.386LysLys: 4.386 ± 2.848
3.289LysLeu: 3.289 ± 1.116
3.289LysMet: 3.289 ± 1.116
2.193LysAsn: 2.193 ± 1.348
2.193LysPro: 2.193 ± 1.047
3.289LysGln: 3.289 ± 1.116
4.386LysArg: 4.386 ± 2.848
3.289LysSer: 3.289 ± 2.043
4.386LysThr: 4.386 ± 1.37
7.675LysVal: 7.675 ± 3.715
1.096LysTrp: 1.096 ± 0.712
2.193LysTyr: 2.193 ± 1.047
0.0LysXaa: 0.0 ± 0.0
Leu
5.482LeuAla: 5.482 ± 2.344
0.0LeuCys: 0.0 ± 0.0
3.289LeuAsp: 3.289 ± 1.116
8.772LeuGlu: 8.772 ± 2.658
3.289LeuPhe: 3.289 ± 2.192
3.289LeuGly: 3.289 ± 0.662
2.193LeuHis: 2.193 ± 1.047
2.193LeuIle: 2.193 ± 1.047
5.482LeuLys: 5.482 ± 2.344
7.675LeuLeu: 7.675 ± 0.716
1.096LeuMet: 1.096 ± 0.792
5.482LeuAsn: 5.482 ± 3.064
4.386LeuPro: 4.386 ± 3.565
3.289LeuGln: 3.289 ± 0.662
5.482LeuArg: 5.482 ± 3.306
4.386LeuSer: 4.386 ± 1.37
4.386LeuThr: 4.386 ± 2.696
4.386LeuVal: 4.386 ± 0.268
4.386LeuTrp: 4.386 ± 0.268
2.193LeuTyr: 2.193 ± 1.348
0.0LeuXaa: 0.0 ± 0.0
Met
2.193MetAla: 2.193 ± 1.047
0.0MetCys: 0.0 ± 0.0
2.193MetAsp: 2.193 ± 0.8
1.096MetGlu: 1.096 ± 0.712
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.096MetLys: 1.096 ± 0.712
2.193MetLeu: 2.193 ± 2.049
1.096MetMet: 1.096 ± 0.712
1.096MetAsn: 1.096 ± 0.712
2.193MetPro: 2.193 ± 1.424
1.096MetGln: 1.096 ± 1.024
1.096MetArg: 1.096 ± 0.712
2.193MetSer: 2.193 ± 1.348
0.0MetThr: 0.0 ± 0.0
2.193MetVal: 2.193 ± 1.424
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.096AsnAla: 1.096 ± 1.249
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
4.386AsnGlu: 4.386 ± 1.792
1.096AsnPhe: 1.096 ± 1.249
3.289AsnGly: 3.289 ± 2.136
1.096AsnHis: 1.096 ± 1.249
3.289AsnIle: 3.289 ± 1.695
3.289AsnLys: 3.289 ± 2.136
2.193AsnLeu: 2.193 ± 1.348
0.0AsnMet: 0.0 ± 0.0
3.289AsnAsn: 3.289 ± 1.283
1.096AsnPro: 1.096 ± 1.024
0.0AsnGln: 0.0 ± 0.0
5.482AsnArg: 5.482 ± 2.231
7.675AsnSer: 7.675 ± 1.545
2.193AsnThr: 2.193 ± 2.498
3.289AsnVal: 3.289 ± 1.283
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
6.579ProAla: 6.579 ± 1.543
0.0ProCys: 0.0 ± 0.0
0.0ProAsp: 0.0 ± 0.0
3.289ProGlu: 3.289 ± 1.283
1.096ProPhe: 1.096 ± 0.712
9.868ProGly: 9.868 ± 3.849
0.0ProHis: 0.0 ± 0.0
2.193ProIle: 2.193 ± 1.348
6.579ProLys: 6.579 ± 0.573
5.482ProLeu: 5.482 ± 3.306
0.0ProMet: 0.0 ± 0.0
3.289ProAsn: 3.289 ± 2.192
4.386ProPro: 4.386 ± 1.832
0.0ProGln: 0.0 ± 0.0
5.482ProArg: 5.482 ± 0.772
3.289ProSer: 3.289 ± 2.192
1.096ProThr: 1.096 ± 1.024
2.193ProVal: 2.193 ± 1.348
0.0ProTrp: 0.0 ± 0.0
2.193ProTyr: 2.193 ± 0.8
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
2.193GlnAsp: 2.193 ± 2.049
1.096GlnGlu: 1.096 ± 1.024
0.0GlnPhe: 0.0 ± 0.0
4.386GlnGly: 4.386 ± 1.692
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
3.289GlnLys: 3.289 ± 2.136
4.386GlnLeu: 4.386 ± 2.937
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
2.193GlnPro: 2.193 ± 1.047
2.193GlnGln: 2.193 ± 1.424
2.193GlnArg: 2.193 ± 1.424
3.289GlnSer: 3.289 ± 2.136
1.096GlnThr: 1.096 ± 0.712
5.482GlnVal: 5.482 ± 2.406
1.096GlnTrp: 1.096 ± 1.024
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
6.579ArgAla: 6.579 ± 1.323
0.0ArgCys: 0.0 ± 0.0
2.193ArgAsp: 2.193 ± 0.8
2.193ArgGlu: 2.193 ± 1.424
3.289ArgPhe: 3.289 ± 2.388
7.675ArgGly: 7.675 ± 2.818
0.0ArgHis: 0.0 ± 0.0
5.482ArgIle: 5.482 ± 1.807
2.193ArgLys: 2.193 ± 1.424
6.579ArgLeu: 6.579 ± 2.662
0.0ArgMet: 0.0 ± 0.0
3.289ArgAsn: 3.289 ± 2.136
2.193ArgPro: 2.193 ± 2.049
1.096ArgGln: 1.096 ± 1.024
9.868ArgArg: 9.868 ± 1.646
5.482ArgSer: 5.482 ± 0.772
7.675ArgThr: 7.675 ± 0.716
2.193ArgVal: 2.193 ± 0.8
0.0ArgTrp: 0.0 ± 0.0
5.482ArgTyr: 5.482 ± 2.445
0.0ArgXaa: 0.0 ± 0.0
Ser
5.482SerAla: 5.482 ± 0.772
3.289SerCys: 3.289 ± 0.662
1.096SerAsp: 1.096 ± 0.712
0.0SerGlu: 0.0 ± 0.0
4.386SerPhe: 4.386 ± 1.832
6.579SerGly: 6.579 ± 1.543
3.289SerHis: 3.289 ± 1.695
4.386SerIle: 4.386 ± 2.094
4.386SerLys: 4.386 ± 1.6
6.579SerLeu: 6.579 ± 2.662
3.289SerMet: 3.289 ± 1.027
3.289SerAsn: 3.289 ± 0.662
4.386SerPro: 4.386 ± 3.411
1.096SerGln: 1.096 ± 1.024
3.289SerArg: 3.289 ± 2.043
6.579SerSer: 6.579 ± 1.543
4.386SerThr: 4.386 ± 3.565
8.772SerVal: 8.772 ± 2.957
0.0SerTrp: 0.0 ± 0.0
1.096SerTyr: 1.096 ± 1.249
0.0SerXaa: 0.0 ± 0.0
Thr
4.386ThrAla: 4.386 ± 1.6
0.0ThrCys: 0.0 ± 0.0
2.193ThrAsp: 2.193 ± 0.8
3.289ThrGlu: 3.289 ± 2.192
8.772ThrPhe: 8.772 ± 6.821
8.772ThrGly: 8.772 ± 2.894
1.096ThrHis: 1.096 ± 1.024
2.193ThrIle: 2.193 ± 1.348
4.386ThrLys: 4.386 ± 1.37
5.482ThrLeu: 5.482 ± 4.645
0.0ThrMet: 0.0 ± 0.0
1.096ThrAsn: 1.096 ± 0.712
5.482ThrPro: 5.482 ± 1.421
0.0ThrGln: 0.0 ± 0.0
3.289ThrArg: 3.289 ± 3.073
2.193ThrSer: 2.193 ± 1.348
4.386ThrThr: 4.386 ± 3.565
2.193ThrVal: 2.193 ± 2.049
2.193ThrTrp: 2.193 ± 1.047
1.096ThrTyr: 1.096 ± 1.024
0.0ThrXaa: 0.0 ± 0.0
Val
1.096ValAla: 1.096 ± 0.712
0.0ValCys: 0.0 ± 0.0
4.386ValAsp: 4.386 ± 1.6
4.386ValGlu: 4.386 ± 1.692
4.386ValPhe: 4.386 ± 2.848
3.289ValGly: 3.289 ± 2.136
1.096ValHis: 1.096 ± 1.024
4.386ValIle: 4.386 ± 2.684
2.193ValLys: 2.193 ± 0.8
4.386ValLeu: 4.386 ± 1.37
0.0ValMet: 0.0 ± 0.0
2.193ValAsn: 2.193 ± 1.047
5.482ValPro: 5.482 ± 2.231
3.289ValGln: 3.289 ± 2.136
6.579ValArg: 6.579 ± 1.794
2.193ValSer: 2.193 ± 1.424
6.579ValThr: 6.579 ± 3.141
5.482ValVal: 5.482 ± 2.344
1.096ValTrp: 1.096 ± 1.024
2.193ValTyr: 2.193 ± 1.348
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
2.193TrpAsp: 2.193 ± 2.049
1.096TrpGlu: 1.096 ± 1.024
1.096TrpPhe: 1.096 ± 0.712
1.096TrpGly: 1.096 ± 1.024
0.0TrpHis: 0.0 ± 0.0
1.096TrpIle: 1.096 ± 1.024
4.386TrpLys: 4.386 ± 2.937
2.193TrpLeu: 2.193 ± 0.8
2.193TrpMet: 2.193 ± 0.8
2.193TrpAsn: 2.193 ± 1.424
0.0TrpPro: 0.0 ± 0.0
2.193TrpGln: 2.193 ± 1.348
1.096TrpArg: 1.096 ± 0.712
1.096TrpSer: 1.096 ± 0.712
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.096TrpTyr: 1.096 ± 1.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.482TyrAla: 5.482 ± 2.406
0.0TyrCys: 0.0 ± 0.0
1.096TyrAsp: 1.096 ± 0.712
0.0TyrGlu: 0.0 ± 0.0
0.0TyrPhe: 0.0 ± 0.0
1.096TyrGly: 1.096 ± 0.712
2.193TyrHis: 2.193 ± 1.424
3.289TyrIle: 3.289 ± 1.116
2.193TyrLys: 2.193 ± 1.424
3.289TyrLeu: 3.289 ± 0.662
2.193TyrMet: 2.193 ± 0.8
2.193TyrAsn: 2.193 ± 0.8
4.386TyrPro: 4.386 ± 2.937
0.0TyrGln: 0.0 ± 0.0
1.096TyrArg: 1.096 ± 1.024
2.193TyrSer: 2.193 ± 1.047
1.096TyrThr: 1.096 ± 0.712
2.193TyrVal: 2.193 ± 2.049
2.193TyrTrp: 2.193 ± 2.049
3.289TyrTyr: 3.289 ± 1.116
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (913 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski