Amino acid dipepetide frequency for Streptococcus sp. 28462

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.69AlaAla: 5.69 ± 0.163
0.468AlaCys: 0.468 ± 0.029
4.303AlaAsp: 4.303 ± 0.095
5.787AlaGlu: 5.787 ± 0.128
3.386AlaPhe: 3.386 ± 0.094
5.433AlaGly: 5.433 ± 0.13
1.296AlaHis: 1.296 ± 0.053
5.958AlaIle: 5.958 ± 0.114
5.451AlaLys: 5.451 ± 0.106
7.569AlaLeu: 7.569 ± 0.132
2.0AlaMet: 2.0 ± 0.065
3.108AlaAsn: 3.108 ± 0.078
2.208AlaPro: 2.208 ± 0.07
3.118AlaGln: 3.118 ± 0.081
2.799AlaArg: 2.799 ± 0.059
4.392AlaSer: 4.392 ± 0.084
4.642AlaThr: 4.642 ± 0.109
5.586AlaVal: 5.586 ± 0.119
0.652AlaTrp: 0.652 ± 0.03
2.868AlaTyr: 2.868 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.335CysAla: 0.335 ± 0.025
0.059CysCys: 0.059 ± 0.011
0.315CysAsp: 0.315 ± 0.027
0.267CysGlu: 0.267 ± 0.022
0.251CysPhe: 0.251 ± 0.019
0.501CysGly: 0.501 ± 0.032
0.178CysHis: 0.178 ± 0.019
0.278CysIle: 0.278 ± 0.023
0.206CysLys: 0.206 ± 0.02
0.597CysLeu: 0.597 ± 0.034
0.114CysMet: 0.114 ± 0.014
0.235CysAsn: 0.235 ± 0.02
0.258CysPro: 0.258 ± 0.025
0.303CysGln: 0.303 ± 0.024
0.278CysArg: 0.278 ± 0.023
0.357CysSer: 0.357 ± 0.028
0.218CysThr: 0.218 ± 0.019
0.337CysVal: 0.337 ± 0.025
0.057CysTrp: 0.057 ± 0.011
0.238CysTyr: 0.238 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.72AspAla: 3.72 ± 0.091
0.319AspCys: 0.319 ± 0.026
3.272AspAsp: 3.272 ± 0.094
4.239AspGlu: 4.239 ± 0.093
3.328AspPhe: 3.328 ± 0.086
4.035AspGly: 4.035 ± 0.093
0.93AspHis: 0.93 ± 0.04
4.476AspIle: 4.476 ± 0.096
4.451AspLys: 4.451 ± 0.091
5.643AspLeu: 5.643 ± 0.107
1.581AspMet: 1.581 ± 0.051
2.667AspAsn: 2.667 ± 0.068
1.494AspPro: 1.494 ± 0.056
1.681AspGln: 1.681 ± 0.052
2.092AspArg: 2.092 ± 0.061
3.007AspSer: 3.007 ± 0.075
3.153AspThr: 3.153 ± 0.086
4.037AspVal: 4.037 ± 0.086
0.684AspTrp: 0.684 ± 0.035
3.027AspTyr: 3.027 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.753GluAla: 5.753 ± 0.113
0.253GluCys: 0.253 ± 0.022
3.814GluAsp: 3.814 ± 0.074
6.11GluGlu: 6.11 ± 0.127
2.607GluPhe: 2.607 ± 0.07
3.842GluGly: 3.842 ± 0.084
1.361GluHis: 1.361 ± 0.05
5.22GluIle: 5.22 ± 0.092
6.236GluLys: 6.236 ± 0.12
7.455GluLeu: 7.455 ± 0.125
1.933GluMet: 1.933 ± 0.055
3.929GluAsn: 3.929 ± 0.08
1.755GluPro: 1.755 ± 0.055
2.929GluGln: 2.929 ± 0.063
3.219GluArg: 3.219 ± 0.097
3.148GluSer: 3.148 ± 0.076
4.535GluThr: 4.535 ± 0.098
5.287GluVal: 5.287 ± 0.126
0.609GluTrp: 0.609 ± 0.026
2.075GluTyr: 2.075 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.276PheAla: 3.276 ± 0.074
0.256PheCys: 0.256 ± 0.022
3.091PheAsp: 3.091 ± 0.085
3.225PheGlu: 3.225 ± 0.082
2.057PhePhe: 2.057 ± 0.075
3.426PheGly: 3.426 ± 0.083
0.863PheHis: 0.863 ± 0.035
2.945PheIle: 2.945 ± 0.083
2.551PheLys: 2.551 ± 0.062
4.285PheLeu: 4.285 ± 0.116
1.143PheMet: 1.143 ± 0.043
2.059PheAsn: 2.059 ± 0.054
1.547PhePro: 1.547 ± 0.047
1.455PheGln: 1.455 ± 0.045
1.519PheArg: 1.519 ± 0.058
3.281PheSer: 3.281 ± 0.089
2.536PheThr: 2.536 ± 0.071
3.031PheVal: 3.031 ± 0.079
0.503PheTrp: 0.503 ± 0.03
1.918PheTyr: 1.918 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.714GlyAla: 4.714 ± 0.113
0.438GlyCys: 0.438 ± 0.028
3.623GlyAsp: 3.623 ± 0.079
4.114GlyGlu: 4.114 ± 0.086
3.301GlyPhe: 3.301 ± 0.077
4.295GlyGly: 4.295 ± 0.107
1.422GlyHis: 1.422 ± 0.052
5.348GlyIle: 5.348 ± 0.108
4.768GlyLys: 4.768 ± 0.098
6.625GlyLeu: 6.625 ± 0.122
1.861GlyMet: 1.861 ± 0.068
2.965GlyAsn: 2.965 ± 0.08
1.284GlyPro: 1.284 ± 0.053
2.888GlyGln: 2.888 ± 0.076
2.685GlyArg: 2.685 ± 0.082
3.601GlySer: 3.601 ± 0.083
3.919GlyThr: 3.919 ± 0.086
4.858GlyVal: 4.858 ± 0.099
0.669GlyTrp: 0.669 ± 0.034
2.838GlyTyr: 2.838 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.148HisAla: 1.148 ± 0.042
0.142HisCys: 0.142 ± 0.016
1.059HisAsp: 1.059 ± 0.044
1.14HisGlu: 1.14 ± 0.046
1.162HisPhe: 1.162 ± 0.043
1.242HisGly: 1.242 ± 0.052
0.515HisHis: 0.515 ± 0.033
1.383HisIle: 1.383 ± 0.048
0.982HisLys: 0.982 ± 0.04
2.109HisLeu: 2.109 ± 0.063
0.444HisMet: 0.444 ± 0.031
0.756HisAsn: 0.756 ± 0.035
0.865HisPro: 0.865 ± 0.038
0.942HisGln: 0.942 ± 0.04
0.863HisArg: 0.863 ± 0.038
0.969HisSer: 0.969 ± 0.042
0.969HisThr: 0.969 ± 0.041
1.17HisVal: 1.17 ± 0.048
0.191HisTrp: 0.191 ± 0.017
0.969HisTyr: 0.969 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.238IleAla: 6.238 ± 0.114
0.508IleCys: 0.508 ± 0.031
4.352IleAsp: 4.352 ± 0.088
4.825IleGlu: 4.825 ± 0.099
3.276IlePhe: 3.276 ± 0.093
4.856IleGly: 4.856 ± 0.112
1.177IleHis: 1.177 ± 0.042
4.887IleIle: 4.887 ± 0.113
4.395IleLys: 4.395 ± 0.095
6.969IleLeu: 6.969 ± 0.138
1.586IleMet: 1.586 ± 0.052
3.031IleAsn: 3.031 ± 0.077
2.771IlePro: 2.771 ± 0.079
2.157IleGln: 2.157 ± 0.063
2.721IleArg: 2.721 ± 0.077
4.892IleSer: 4.892 ± 0.106
4.159IleThr: 4.159 ± 0.087
4.811IleVal: 4.811 ± 0.078
0.679IleTrp: 0.679 ± 0.033
2.526IleTyr: 2.526 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
5.596LysAla: 5.596 ± 0.114
0.235LysCys: 0.235 ± 0.02
3.797LysAsp: 3.797 ± 0.096
5.777LysGlu: 5.777 ± 0.096
2.027LysPhe: 2.027 ± 0.065
4.008LysGly: 4.008 ± 0.079
1.235LysHis: 1.235 ± 0.043
4.583LysIle: 4.583 ± 0.092
5.108LysLys: 5.108 ± 0.109
5.847LysLeu: 5.847 ± 0.102
1.955LysMet: 1.955 ± 0.062
3.262LysAsn: 3.262 ± 0.079
2.246LysPro: 2.246 ± 0.073
2.691LysGln: 2.691 ± 0.076
2.987LysArg: 2.987 ± 0.083
3.887LysSer: 3.887 ± 0.076
4.285LysThr: 4.285 ± 0.091
4.912LysVal: 4.912 ± 0.103
0.647LysTrp: 0.647 ± 0.033
2.164LysTyr: 2.164 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
8.635LeuAla: 8.635 ± 0.162
0.488LeuCys: 0.488 ± 0.028
5.847LeuAsp: 5.847 ± 0.1
7.284LeuGlu: 7.284 ± 0.119
4.241LeuPhe: 4.241 ± 0.103
6.689LeuGly: 6.689 ± 0.132
1.582LeuHis: 1.582 ± 0.052
6.57LeuIle: 6.57 ± 0.134
6.164LeuLys: 6.164 ± 0.112
9.854LeuLeu: 9.854 ± 0.2
2.489LeuMet: 2.489 ± 0.069
4.043LeuAsn: 4.043 ± 0.085
4.047LeuPro: 4.047 ± 0.08
3.162LeuGln: 3.162 ± 0.086
3.711LeuArg: 3.711 ± 0.083
7.356LeuSer: 7.356 ± 0.138
6.586LeuThr: 6.586 ± 0.105
6.972LeuVal: 6.972 ± 0.126
0.816LeuTrp: 0.816 ± 0.035
3.108LeuTyr: 3.108 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.23MetAla: 2.23 ± 0.062
0.116MetCys: 0.116 ± 0.013
1.318MetAsp: 1.318 ± 0.049
1.467MetGlu: 1.467 ± 0.051
0.84MetPhe: 0.84 ± 0.041
1.675MetGly: 1.675 ± 0.055
0.349MetHis: 0.349 ± 0.021
1.876MetIle: 1.876 ± 0.06
1.836MetLys: 1.836 ± 0.057
2.261MetLeu: 2.261 ± 0.067
0.712MetMet: 0.712 ± 0.04
1.095MetAsn: 1.095 ± 0.049
0.897MetPro: 0.897 ± 0.038
0.815MetGln: 0.815 ± 0.037
1.034MetArg: 1.034 ± 0.041
1.673MetSer: 1.673 ± 0.055
2.288MetThr: 2.288 ± 0.067
1.727MetVal: 1.727 ± 0.056
0.178MetTrp: 0.178 ± 0.017
0.597MetTyr: 0.597 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.044AsnAla: 3.044 ± 0.078
0.277AsnCys: 0.277 ± 0.024
2.419AsnAsp: 2.419 ± 0.065
2.538AsnGlu: 2.538 ± 0.068
1.988AsnPhe: 1.988 ± 0.061
3.48AsnGly: 3.48 ± 0.081
1.135AsnHis: 1.135 ± 0.043
3.16AsnIle: 3.16 ± 0.085
2.6AsnLys: 2.6 ± 0.087
4.281AsnLeu: 4.281 ± 0.081
1.085AsnMet: 1.085 ± 0.044
1.896AsnAsn: 1.896 ± 0.059
2.24AsnPro: 2.24 ± 0.069
2.191AsnGln: 2.191 ± 0.065
2.047AsnArg: 2.047 ± 0.066
2.322AsnSer: 2.322 ± 0.065
2.238AsnThr: 2.238 ± 0.063
2.799AsnVal: 2.799 ± 0.076
0.538AsnTrp: 0.538 ± 0.029
1.934AsnTyr: 1.934 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
2.377ProAla: 2.377 ± 0.067
0.158ProCys: 0.158 ± 0.019
2.102ProAsp: 2.102 ± 0.058
3.074ProGlu: 3.074 ± 0.083
1.655ProPhe: 1.655 ± 0.06
1.772ProGly: 1.772 ± 0.067
0.655ProHis: 0.655 ± 0.035
2.379ProIle: 2.379 ± 0.075
2.248ProLys: 2.248 ± 0.067
3.135ProLeu: 3.135 ± 0.071
0.761ProMet: 0.761 ± 0.04
1.767ProAsn: 1.767 ± 0.056
0.612ProPro: 0.612 ± 0.048
1.259ProGln: 1.259 ± 0.05
1.123ProArg: 1.123 ± 0.042
2.04ProSer: 2.04 ± 0.056
2.136ProThr: 2.136 ± 0.073
2.679ProVal: 2.679 ± 0.069
0.272ProTrp: 0.272 ± 0.023
1.324ProTyr: 1.324 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.369GlnAla: 3.369 ± 0.092
0.117GlnCys: 0.117 ± 0.014
1.879GlnAsp: 1.879 ± 0.054
3.128GlnGlu: 3.128 ± 0.088
1.68GlnPhe: 1.68 ± 0.057
2.186GlnGly: 2.186 ± 0.064
0.655GlnHis: 0.655 ± 0.032
2.647GlnIle: 2.647 ± 0.064
2.91GlnLys: 2.91 ± 0.073
4.234GlnLeu: 4.234 ± 0.109
1.007GlnMet: 1.007 ± 0.041
1.728GlnAsn: 1.728 ± 0.062
1.187GlnPro: 1.187 ± 0.047
1.485GlnGln: 1.485 ± 0.063
1.396GlnArg: 1.396 ± 0.051
2.196GlnSer: 2.196 ± 0.069
2.325GlnThr: 2.325 ± 0.071
2.982GlnVal: 2.982 ± 0.067
0.324GlnTrp: 0.324 ± 0.025
1.292GlnTyr: 1.292 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.555ArgAla: 2.555 ± 0.072
0.169ArgCys: 0.169 ± 0.019
2.35ArgAsp: 2.35 ± 0.071
3.173ArgGlu: 3.173 ± 0.075
1.978ArgPhe: 1.978 ± 0.064
2.315ArgGly: 2.315 ± 0.064
0.907ArgHis: 0.907 ± 0.04
2.706ArgIle: 2.706 ± 0.085
2.737ArgLys: 2.737 ± 0.066
4.191ArgLeu: 4.191 ± 0.105
1.064ArgMet: 1.064 ± 0.043
1.636ArgAsn: 1.636 ± 0.048
1.286ArgPro: 1.286 ± 0.05
2.06ArgGln: 2.06 ± 0.064
2.077ArgArg: 2.077 ± 0.07
1.978ArgSer: 1.978 ± 0.055
1.879ArgThr: 1.879 ± 0.061
2.764ArgVal: 2.764 ± 0.069
0.347ArgTrp: 0.347 ± 0.025
1.713ArgTyr: 1.713 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.04SerAla: 4.04 ± 0.1
0.329SerCys: 0.329 ± 0.03
3.753SerAsp: 3.753 ± 0.088
4.057SerGlu: 4.057 ± 0.105
2.835SerPhe: 2.835 ± 0.065
4.55SerGly: 4.55 ± 0.085
1.303SerHis: 1.303 ± 0.045
3.844SerIle: 3.844 ± 0.087
3.68SerLys: 3.68 ± 0.081
6.402SerLeu: 6.402 ± 0.144
1.274SerMet: 1.274 ± 0.046
2.468SerAsn: 2.468 ± 0.064
1.975SerPro: 1.975 ± 0.065
2.888SerGln: 2.888 ± 0.08
2.389SerArg: 2.389 ± 0.068
3.75SerSer: 3.75 ± 0.094
3.126SerThr: 3.126 ± 0.085
4.023SerVal: 4.023 ± 0.078
0.614SerTrp: 0.614 ± 0.033
2.52SerTyr: 2.52 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
4.553ThrAla: 4.553 ± 0.117
0.325ThrCys: 0.325 ± 0.024
3.493ThrAsp: 3.493 ± 0.085
4.095ThrGlu: 4.095 ± 0.113
2.903ThrPhe: 2.903 ± 0.07
4.171ThrGly: 4.171 ± 0.089
1.17ThrHis: 1.17 ± 0.044
4.521ThrIle: 4.521 ± 0.09
3.676ThrLys: 3.676 ± 0.094
6.016ThrLeu: 6.016 ± 0.109
1.214ThrMet: 1.214 ± 0.042
2.437ThrAsn: 2.437 ± 0.056
2.701ThrPro: 2.701 ± 0.08
1.973ThrGln: 1.973 ± 0.061
2.028ThrArg: 2.028 ± 0.065
3.602ThrSer: 3.602 ± 0.091
3.846ThrThr: 3.846 ± 0.131
5.032ThrVal: 5.032 ± 0.11
0.578ThrTrp: 0.578 ± 0.033
2.411ThrTyr: 2.411 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
6.206ValAla: 6.206 ± 0.126
0.406ValCys: 0.406 ± 0.03
4.097ValAsp: 4.097 ± 0.086
4.734ValGlu: 4.734 ± 0.1
3.017ValPhe: 3.017 ± 0.07
4.55ValGly: 4.55 ± 0.098
1.127ValHis: 1.127 ± 0.051
5.172ValIle: 5.172 ± 0.087
4.608ValLys: 4.608 ± 0.079
6.798ValLeu: 6.798 ± 0.138
1.782ValMet: 1.782 ± 0.057
2.965ValAsn: 2.965 ± 0.073
2.583ValPro: 2.583 ± 0.065
2.075ValGln: 2.075 ± 0.065
2.655ValArg: 2.655 ± 0.07
4.717ValSer: 4.717 ± 0.101
5.351ValThr: 5.351 ± 0.123
5.202ValVal: 5.202 ± 0.106
0.538ValTrp: 0.538 ± 0.03
2.327ValTyr: 2.327 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.657TrpAla: 0.657 ± 0.034
0.064TrpCys: 0.064 ± 0.01
0.516TrpAsp: 0.516 ± 0.031
0.655TrpGlu: 0.655 ± 0.035
0.464TrpPhe: 0.464 ± 0.032
0.647TrpGly: 0.647 ± 0.036
0.22TrpHis: 0.22 ± 0.019
0.587TrpIle: 0.587 ± 0.037
0.563TrpLys: 0.563 ± 0.033
1.096TrpLeu: 1.096 ± 0.044
0.24TrpMet: 0.24 ± 0.02
0.521TrpAsn: 0.521 ± 0.04
0.154TrpPro: 0.154 ± 0.015
0.513TrpGln: 0.513 ± 0.031
0.404TrpArg: 0.404 ± 0.025
0.56TrpSer: 0.56 ± 0.03
0.557TrpThr: 0.557 ± 0.027
0.521TrpVal: 0.521 ± 0.029
0.129TrpTrp: 0.129 ± 0.014
0.36TrpTyr: 0.36 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.578TyrAla: 2.578 ± 0.071
0.258TyrCys: 0.258 ± 0.023
2.434TyrAsp: 2.434 ± 0.061
2.38TyrGlu: 2.38 ± 0.061
1.973TyrPhe: 1.973 ± 0.057
2.541TyrGly: 2.541 ± 0.065
0.942TyrHis: 0.942 ± 0.043
2.276TyrIle: 2.276 ± 0.067
2.077TyrLys: 2.077 ± 0.053
4.28TyrLeu: 4.28 ± 0.094
0.734TyrMet: 0.734 ± 0.037
1.643TyrAsn: 1.643 ± 0.057
1.418TyrPro: 1.418 ± 0.05
2.144TyrGln: 2.144 ± 0.075
1.857TyrArg: 1.857 ± 0.059
2.089TyrSer: 2.089 ± 0.062
2.0TyrThr: 2.0 ± 0.073
2.179TyrVal: 2.179 ± 0.071
0.406TyrTrp: 0.406 ± 0.029
1.641TyrTyr: 1.641 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1977 proteins (596538 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski