Amino acid dipepetide frequency for Aquicella siphonis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.309AlaAla: 9.309 ± 0.148
1.21AlaCys: 1.21 ± 0.038
4.32AlaAsp: 4.32 ± 0.083
4.869AlaGlu: 4.869 ± 0.08
3.435AlaPhe: 3.435 ± 0.062
6.459AlaGly: 6.459 ± 0.108
1.909AlaHis: 1.909 ± 0.05
5.541AlaIle: 5.541 ± 0.088
4.32AlaLys: 4.32 ± 0.072
9.157AlaLeu: 9.157 ± 0.137
2.564AlaMet: 2.564 ± 0.052
3.345AlaAsn: 3.345 ± 0.068
3.008AlaPro: 3.008 ± 0.067
3.362AlaGln: 3.362 ± 0.084
4.864AlaArg: 4.864 ± 0.077
5.461AlaSer: 5.461 ± 0.077
3.539AlaThr: 3.539 ± 0.07
6.114AlaVal: 6.114 ± 0.097
1.02AlaTrp: 1.02 ± 0.041
2.843AlaTyr: 2.843 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.986CysAla: 0.986 ± 0.037
0.189CysCys: 0.189 ± 0.017
0.575CysAsp: 0.575 ± 0.033
0.664CysGlu: 0.664 ± 0.029
0.547CysPhe: 0.547 ± 0.031
0.968CysGly: 0.968 ± 0.043
0.355CysHis: 0.355 ± 0.023
0.647CysIle: 0.647 ± 0.03
0.509CysLys: 0.509 ± 0.028
1.224CysLeu: 1.224 ± 0.039
0.311CysMet: 0.311 ± 0.017
0.379CysAsn: 0.379 ± 0.021
0.502CysPro: 0.502 ± 0.025
0.443CysGln: 0.443 ± 0.026
0.62CysArg: 0.62 ± 0.026
0.689CysSer: 0.689 ± 0.033
0.492CysThr: 0.492 ± 0.03
0.762CysVal: 0.762 ± 0.031
0.131CysTrp: 0.131 ± 0.012
0.428CysTyr: 0.428 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.204AspAla: 4.204 ± 0.062
0.505AspCys: 0.505 ± 0.024
2.503AspAsp: 2.503 ± 0.057
3.41AspGlu: 3.41 ± 0.073
2.396AspPhe: 2.396 ± 0.053
2.84AspGly: 2.84 ± 0.068
1.28AspHis: 1.28 ± 0.04
3.918AspIle: 3.918 ± 0.072
3.08AspLys: 3.08 ± 0.075
5.218AspLeu: 5.218 ± 0.082
1.4AspMet: 1.4 ± 0.037
2.001AspAsn: 2.001 ± 0.051
2.362AspPro: 2.362 ± 0.052
2.028AspGln: 2.028 ± 0.05
2.465AspArg: 2.465 ± 0.054
2.911AspSer: 2.911 ± 0.058
2.582AspThr: 2.582 ± 0.064
3.2AspVal: 3.2 ± 0.059
0.755AspTrp: 0.755 ± 0.032
2.006AspTyr: 2.006 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
4.511GluAla: 4.511 ± 0.08
0.541GluCys: 0.541 ± 0.028
2.255GluAsp: 2.255 ± 0.061
3.41GluGlu: 3.41 ± 0.08
2.29GluPhe: 2.29 ± 0.053
2.862GluGly: 2.862 ± 0.064
1.374GluHis: 1.374 ± 0.041
4.397GluIle: 4.397 ± 0.075
4.33GluLys: 4.33 ± 0.096
5.564GluLeu: 5.564 ± 0.095
1.674GluMet: 1.674 ± 0.047
2.945GluAsn: 2.945 ± 0.057
1.781GluPro: 1.781 ± 0.047
2.717GluGln: 2.717 ± 0.068
3.182GluArg: 3.182 ± 0.069
3.497GluSer: 3.497 ± 0.071
2.979GluThr: 2.979 ± 0.064
3.311GluVal: 3.311 ± 0.076
0.671GluTrp: 0.671 ± 0.029
1.849GluTyr: 1.849 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.592PheAla: 3.592 ± 0.067
0.577PheCys: 0.577 ± 0.028
2.385PheAsp: 2.385 ± 0.052
1.952PheGlu: 1.952 ± 0.049
1.98PhePhe: 1.98 ± 0.059
2.761PheGly: 2.761 ± 0.069
1.089PheHis: 1.089 ± 0.034
3.14PheIle: 3.14 ± 0.074
1.894PheLys: 1.894 ± 0.046
4.205PheLeu: 4.205 ± 0.09
1.099PheMet: 1.099 ± 0.037
2.022PheAsn: 2.022 ± 0.051
1.755PhePro: 1.755 ± 0.049
1.423PheGln: 1.423 ± 0.049
1.897PheArg: 1.897 ± 0.048
3.287PheSer: 3.287 ± 0.061
2.427PheThr: 2.427 ± 0.05
2.43PheVal: 2.43 ± 0.057
0.505PheTrp: 0.505 ± 0.03
1.607PheTyr: 1.607 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
5.074GlyAla: 5.074 ± 0.091
0.874GlyCys: 0.874 ± 0.035
2.904GlyAsp: 2.904 ± 0.062
3.435GlyGlu: 3.435 ± 0.076
2.983GlyPhe: 2.983 ± 0.054
4.485GlyGly: 4.485 ± 0.102
1.555GlyHis: 1.555 ± 0.046
5.112GlyIle: 5.112 ± 0.09
4.166GlyLys: 4.166 ± 0.066
6.545GlyLeu: 6.545 ± 0.091
2.204GlyMet: 2.204 ± 0.05
2.469GlyAsn: 2.469 ± 0.056
1.877GlyPro: 1.877 ± 0.053
2.335GlyGln: 2.335 ± 0.055
3.136GlyArg: 3.136 ± 0.068
4.17GlySer: 4.17 ± 0.075
3.495GlyThr: 3.495 ± 0.065
4.531GlyVal: 4.531 ± 0.077
0.994GlyTrp: 0.994 ± 0.037
2.556GlyTyr: 2.556 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
2.422HisAla: 2.422 ± 0.062
0.346HisCys: 0.346 ± 0.02
1.436HisAsp: 1.436 ± 0.049
1.552HisGlu: 1.552 ± 0.044
1.265HisPhe: 1.265 ± 0.037
1.773HisGly: 1.773 ± 0.05
0.977HisHis: 0.977 ± 0.036
1.613HisIle: 1.613 ± 0.047
1.162HisLys: 1.162 ± 0.036
2.559HisLeu: 2.559 ± 0.051
0.57HisMet: 0.57 ± 0.025
0.728HisAsn: 0.728 ± 0.027
1.492HisPro: 1.492 ± 0.042
1.129HisGln: 1.129 ± 0.039
1.184HisArg: 1.184 ± 0.035
1.509HisSer: 1.509 ± 0.041
1.316HisThr: 1.316 ± 0.041
1.568HisVal: 1.568 ± 0.04
0.335HisTrp: 0.335 ± 0.022
1.037HisTyr: 1.037 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.103IleAla: 6.103 ± 0.089
0.84IleCys: 0.84 ± 0.034
3.834IleAsp: 3.834 ± 0.068
3.99IleGlu: 3.99 ± 0.08
2.682IlePhe: 2.682 ± 0.059
4.518IleGly: 4.518 ± 0.082
1.875IleHis: 1.875 ± 0.046
4.69IleIle: 4.69 ± 0.079
3.814IleLys: 3.814 ± 0.077
6.888IleLeu: 6.888 ± 0.104
1.639IleMet: 1.639 ± 0.046
3.175IleAsn: 3.175 ± 0.058
3.223IlePro: 3.223 ± 0.056
2.771IleGln: 2.771 ± 0.061
3.779IleArg: 3.779 ± 0.076
4.986IleSer: 4.986 ± 0.08
3.867IleThr: 3.867 ± 0.078
4.074IleVal: 4.074 ± 0.077
0.609IleTrp: 0.609 ± 0.027
2.239IleTyr: 2.239 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.13LysAla: 4.13 ± 0.083
0.403LysCys: 0.403 ± 0.025
2.525LysAsp: 2.525 ± 0.066
3.026LysGlu: 3.026 ± 0.067
1.639LysPhe: 1.639 ± 0.046
2.707LysGly: 2.707 ± 0.055
1.3LysHis: 1.3 ± 0.039
4.087LysIle: 4.087 ± 0.074
3.958LysLys: 3.958 ± 0.074
5.244LysLeu: 5.244 ± 0.092
1.635LysMet: 1.635 ± 0.044
3.006LysAsn: 3.006 ± 0.061
2.649LysPro: 2.649 ± 0.058
2.617LysGln: 2.617 ± 0.062
2.796LysArg: 2.796 ± 0.059
3.772LysSer: 3.772 ± 0.083
3.381LysThr: 3.381 ± 0.062
2.9LysVal: 2.9 ± 0.064
0.551LysTrp: 0.551 ± 0.024
1.68LysTyr: 1.68 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
9.606LeuAla: 9.606 ± 0.123
1.219LeuCys: 1.219 ± 0.039
5.314LeuAsp: 5.314 ± 0.088
5.44LeuGlu: 5.44 ± 0.098
4.767LeuPhe: 4.767 ± 0.084
6.639LeuGly: 6.639 ± 0.102
2.536LeuHis: 2.536 ± 0.056
7.085LeuIle: 7.085 ± 0.111
5.701LeuLys: 5.701 ± 0.101
10.715LeuLeu: 10.715 ± 0.154
2.538LeuMet: 2.538 ± 0.056
4.414LeuAsn: 4.414 ± 0.082
5.167LeuPro: 5.167 ± 0.088
4.305LeuGln: 4.305 ± 0.083
5.434LeuArg: 5.434 ± 0.094
7.753LeuSer: 7.753 ± 0.109
5.781LeuThr: 5.781 ± 0.089
6.0LeuVal: 6.0 ± 0.1
0.95LeuTrp: 0.95 ± 0.04
2.936LeuTyr: 2.936 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.226MetAla: 2.226 ± 0.052
0.212MetCys: 0.212 ± 0.015
1.319MetAsp: 1.319 ± 0.041
1.396MetGlu: 1.396 ± 0.046
0.815MetPhe: 0.815 ± 0.029
1.645MetGly: 1.645 ± 0.055
0.71MetHis: 0.71 ± 0.031
1.778MetIle: 1.778 ± 0.046
1.623MetLys: 1.623 ± 0.046
2.813MetLeu: 2.813 ± 0.062
0.792MetMet: 0.792 ± 0.031
1.349MetAsn: 1.349 ± 0.041
1.381MetPro: 1.381 ± 0.045
1.375MetGln: 1.375 ± 0.042
1.676MetArg: 1.676 ± 0.048
1.698MetSer: 1.698 ± 0.045
1.75MetThr: 1.75 ± 0.044
1.524MetVal: 1.524 ± 0.044
0.186MetTrp: 0.186 ± 0.015
0.589MetTyr: 0.589 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.443AsnAla: 3.443 ± 0.068
0.389AsnCys: 0.389 ± 0.021
2.144AsnAsp: 2.144 ± 0.052
2.414AsnGlu: 2.414 ± 0.065
1.531AsnPhe: 1.531 ± 0.043
2.621AsnGly: 2.621 ± 0.068
1.132AsnHis: 1.132 ± 0.038
3.074AsnIle: 3.074 ± 0.067
2.291AsnLys: 2.291 ± 0.055
4.107AsnLeu: 4.107 ± 0.065
1.072AsnMet: 1.072 ± 0.036
1.984AsnAsn: 1.984 ± 0.055
2.557AsnPro: 2.557 ± 0.054
2.083AsnGln: 2.083 ± 0.057
2.161AsnArg: 2.161 ± 0.055
2.304AsnSer: 2.304 ± 0.051
2.28AsnThr: 2.28 ± 0.06
2.39AsnVal: 2.39 ± 0.05
0.45AsnTrp: 0.45 ± 0.023
1.458AsnTyr: 1.458 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.422ProAla: 4.422 ± 0.077
0.44ProCys: 0.44 ± 0.021
3.062ProAsp: 3.062 ± 0.062
3.204ProGlu: 3.204 ± 0.052
1.846ProPhe: 1.846 ± 0.049
3.385ProGly: 3.385 ± 0.068
1.128ProHis: 1.128 ± 0.038
2.111ProIle: 2.111 ± 0.048
1.694ProLys: 1.694 ± 0.048
4.422ProLeu: 4.422 ± 0.083
0.93ProMet: 0.93 ± 0.032
1.35ProAsn: 1.35 ± 0.04
1.819ProPro: 1.819 ± 0.058
1.738ProGln: 1.738 ± 0.054
2.051ProArg: 2.051 ± 0.058
2.654ProSer: 2.654 ± 0.059
1.71ProThr: 1.71 ± 0.048
4.009ProVal: 4.009 ± 0.074
0.508ProTrp: 0.508 ± 0.027
1.532ProTyr: 1.532 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
4.136GlnAla: 4.136 ± 0.094
0.417GlnCys: 0.417 ± 0.023
2.104GlnAsp: 2.104 ± 0.055
2.336GlnGlu: 2.336 ± 0.054
1.698GlnPhe: 1.698 ± 0.046
2.621GlnGly: 2.621 ± 0.063
1.136GlnHis: 1.136 ± 0.038
2.871GlnIle: 2.871 ± 0.058
2.362GlnLys: 2.362 ± 0.049
4.281GlnLeu: 4.281 ± 0.076
1.048GlnMet: 1.048 ± 0.036
1.77GlnAsn: 1.77 ± 0.041
1.958GlnPro: 1.958 ± 0.065
2.097GlnGln: 2.097 ± 0.082
2.22GlnArg: 2.22 ± 0.055
2.836GlnSer: 2.836 ± 0.055
2.279GlnThr: 2.279 ± 0.048
2.44GlnVal: 2.44 ± 0.056
0.45GlnTrp: 0.45 ± 0.022
1.499GlnTyr: 1.499 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
3.892ArgAla: 3.892 ± 0.068
0.517ArgCys: 0.517 ± 0.024
2.908ArgAsp: 2.908 ± 0.057
3.693ArgGlu: 3.693 ± 0.072
2.393ArgPhe: 2.393 ± 0.057
2.854ArgGly: 2.854 ± 0.059
1.738ArgHis: 1.738 ± 0.043
3.855ArgIle: 3.855 ± 0.071
2.871ArgLys: 2.871 ± 0.06
6.093ArgLeu: 6.093 ± 0.093
1.453ArgMet: 1.453 ± 0.048
2.093ArgAsn: 2.093 ± 0.053
1.965ArgPro: 1.965 ± 0.052
2.733ArgGln: 2.733 ± 0.061
2.958ArgArg: 2.958 ± 0.069
2.808ArgSer: 2.808 ± 0.051
2.239ArgThr: 2.239 ± 0.049
3.164ArgVal: 3.164 ± 0.066
0.635ArgTrp: 0.635 ± 0.028
2.077ArgTyr: 2.077 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
5.658SerAla: 5.658 ± 0.086
0.76SerCys: 0.76 ± 0.032
3.433SerAsp: 3.433 ± 0.07
3.407SerGlu: 3.407 ± 0.067
2.716SerPhe: 2.716 ± 0.064
5.261SerGly: 5.261 ± 0.096
1.8SerHis: 1.8 ± 0.046
4.326SerIle: 4.326 ± 0.075
2.796SerLys: 2.796 ± 0.059
7.407SerLeu: 7.407 ± 0.099
1.799SerMet: 1.799 ± 0.045
2.284SerAsn: 2.284 ± 0.053
2.794SerPro: 2.794 ± 0.062
2.822SerGln: 2.822 ± 0.061
3.826SerArg: 3.826 ± 0.069
4.76SerSer: 4.76 ± 0.098
3.142SerThr: 3.142 ± 0.065
4.093SerVal: 4.093 ± 0.077
0.744SerTrp: 0.744 ± 0.031
2.111SerTyr: 2.111 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
4.69ThrAla: 4.69 ± 0.095
0.563ThrCys: 0.563 ± 0.03
2.588ThrAsp: 2.588 ± 0.055
2.543ThrGlu: 2.543 ± 0.058
2.015ThrPhe: 2.015 ± 0.055
4.241ThrGly: 4.241 ± 0.071
1.434ThrHis: 1.434 ± 0.044
3.344ThrIle: 3.344 ± 0.064
1.964ThrLys: 1.964 ± 0.046
6.081ThrLeu: 6.081 ± 0.091
1.149ThrMet: 1.149 ± 0.042
1.872ThrAsn: 1.872 ± 0.055
2.806ThrPro: 2.806 ± 0.06
2.093ThrGln: 2.093 ± 0.052
2.9ThrArg: 2.9 ± 0.057
3.35ThrSer: 3.35 ± 0.069
2.684ThrThr: 2.684 ± 0.07
3.582ThrVal: 3.582 ± 0.068
0.525ThrTrp: 0.525 ± 0.024
1.564ThrTyr: 1.564 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
4.817ValAla: 4.817 ± 0.082
0.821ValCys: 0.821 ± 0.03
3.181ValAsp: 3.181 ± 0.063
3.214ValGlu: 3.214 ± 0.072
2.765ValPhe: 2.765 ± 0.063
3.362ValGly: 3.362 ± 0.078
1.242ValHis: 1.242 ± 0.04
5.161ValIle: 5.161 ± 0.106
3.456ValLys: 3.456 ± 0.067
6.372ValLeu: 6.372 ± 0.099
1.936ValMet: 1.936 ± 0.057
2.979ValAsn: 2.979 ± 0.063
2.81ValPro: 2.81 ± 0.057
2.039ValGln: 2.039 ± 0.049
3.248ValArg: 3.248 ± 0.071
4.674ValSer: 4.674 ± 0.083
3.861ValThr: 3.861 ± 0.071
3.923ValVal: 3.923 ± 0.082
0.633ValTrp: 0.633 ± 0.03
2.094ValTyr: 2.094 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.687TrpAla: 0.687 ± 0.032
0.134TrpCys: 0.134 ± 0.012
0.563TrpAsp: 0.563 ± 0.028
0.581TrpGlu: 0.581 ± 0.025
0.534TrpPhe: 0.534 ± 0.025
0.702TrpGly: 0.702 ± 0.031
0.363TrpHis: 0.363 ± 0.018
0.824TrpIle: 0.824 ± 0.032
0.554TrpLys: 0.554 ± 0.027
1.455TrpLeu: 1.455 ± 0.045
0.338TrpMet: 0.338 ± 0.022
0.516TrpAsn: 0.516 ± 0.023
0.452TrpPro: 0.452 ± 0.023
0.577TrpGln: 0.577 ± 0.028
0.687TrpArg: 0.687 ± 0.03
0.641TrpSer: 0.641 ± 0.028
0.504TrpThr: 0.504 ± 0.023
0.683TrpVal: 0.683 ± 0.029
0.162TrpTrp: 0.162 ± 0.015
0.336TrpTyr: 0.336 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.743TyrAla: 2.743 ± 0.071
0.461TyrCys: 0.461 ± 0.028
1.709TyrAsp: 1.709 ± 0.048
1.603TyrGlu: 1.603 ± 0.042
1.733TyrPhe: 1.733 ± 0.045
2.196TyrGly: 2.196 ± 0.061
1.039TyrHis: 1.039 ± 0.032
2.022TyrIle: 2.022 ± 0.05
1.463TyrLys: 1.463 ± 0.045
3.95TyrLeu: 3.95 ± 0.079
0.703TyrMet: 0.703 ± 0.03
1.205TyrAsn: 1.205 ± 0.04
1.658TyrPro: 1.658 ± 0.041
1.871TyrGln: 1.871 ± 0.047
1.857TyrArg: 1.857 ± 0.048
2.177TyrSer: 2.177 ± 0.056
1.681TyrThr: 1.681 ± 0.049
1.892TyrVal: 1.892 ± 0.044
0.479TyrTrp: 0.479 ± 0.026
1.415TyrTyr: 1.415 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2580 proteins (845115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski