Amino acid dipepetide frequency for Megasphaera micronuciformis F0359

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.585AlaAla: 9.585 ± 0.183	1.165AlaCys: 1.165 ± 0.048	5.431AlaAsp: 5.431 ± 0.109	5.777AlaGlu: 5.777 ± 0.115	3.497AlaPhe: 3.497 ± 0.101	7.0AlaGly: 7.0 ± 0.136	1.554AlaHis: 1.554 ± 0.058	4.533AlaIle: 4.533 ± 0.112	4.855AlaLys: 4.855 ± 0.109	8.453AlaLeu: 8.453 ± 0.146	2.53AlaMet: 2.53 ± 0.081	2.499AlaAsn: 2.499 ± 0.089	2.506AlaPro: 2.506 ± 0.073	2.704AlaGln: 2.704 ± 0.073	3.656AlaArg: 3.656 ± 0.098	4.152AlaSer: 4.152 ± 0.097	4.288AlaThr: 4.288 ± 0.122	9.018AlaVal: 9.018 ± 0.151	0.67AlaTrp: 0.67 ± 0.04	3.28AlaTyr: 3.28 ± 0.081	0.0AlaXaa: 0.0 ± 0.0
Cys	0.924CysAla: 0.924 ± 0.046	0.223CysCys: 0.223 ± 0.022	0.673CysAsp: 0.673 ± 0.034	0.772CysGlu: 0.772 ± 0.041	0.432CysPhe: 0.432 ± 0.03	1.259CysGly: 1.259 ± 0.06	0.318CysHis: 0.318 ± 0.029	0.909CysIle: 0.909 ± 0.039	0.638CysLys: 0.638 ± 0.034	1.167CysLeu: 1.167 ± 0.045	0.333CysMet: 0.333 ± 0.025	0.37CysAsn: 0.37 ± 0.027	0.66CysPro: 0.66 ± 0.039	0.236CysGln: 0.236 ± 0.021	0.911CysArg: 0.911 ± 0.047	0.684CysSer: 0.684 ± 0.04	0.683CysThr: 0.683 ± 0.036	0.81CysVal: 0.81 ± 0.042	0.099CysTrp: 0.099 ± 0.015	0.352CysTyr: 0.352 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.335AspAla: 4.335 ± 0.095	0.737AspCys: 0.737 ± 0.041	3.172AspAsp: 3.172 ± 0.081	4.472AspGlu: 4.472 ± 0.11	2.474AspPhe: 2.474 ± 0.071	5.006AspGly: 5.006 ± 0.151	0.918AspHis: 0.918 ± 0.041	4.488AspIle: 4.488 ± 0.095	3.77AspLys: 3.77 ± 0.082	5.212AspLeu: 5.212 ± 0.118	1.793AspMet: 1.793 ± 0.074	2.024AspAsn: 2.024 ± 0.073	1.898AspPro: 1.898 ± 0.064	0.978AspGln: 0.978 ± 0.047	2.607AspArg: 2.607 ± 0.078	2.949AspSer: 2.949 ± 0.075	3.31AspThr: 3.31 ± 0.081	4.363AspVal: 4.363 ± 0.094	0.531AspTrp: 0.531 ± 0.033	2.405AspTyr: 2.405 ± 0.071	0.0AspXaa: 0.0 ± 0.0
Glu	6.381GluAla: 6.381 ± 0.143	0.679GluCys: 0.679 ± 0.039	3.656GluAsp: 3.656 ± 0.093	5.784GluGlu: 5.784 ± 0.135	2.321GluPhe: 2.321 ± 0.064	4.531GluGly: 4.531 ± 0.089	1.341GluHis: 1.341 ± 0.047	4.122GluIle: 4.122 ± 0.096	5.56GluLys: 5.56 ± 0.131	5.91GluLeu: 5.91 ± 0.122	1.876GluMet: 1.876 ± 0.061	2.805GluAsn: 2.805 ± 0.07	1.81GluPro: 1.81 ± 0.067	2.091GluGln: 2.091 ± 0.074	4.103GluArg: 4.103 ± 0.109	3.185GluSer: 3.185 ± 0.078	3.737GluThr: 3.737 ± 0.089	4.397GluVal: 4.397 ± 0.096	0.58GluTrp: 0.58 ± 0.029	2.332GluTyr: 2.332 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	3.196PheAla: 3.196 ± 0.079	0.569PheCys: 0.569 ± 0.033	2.358PheAsp: 2.358 ± 0.061	1.995PheGlu: 1.995 ± 0.064	1.857PhePhe: 1.857 ± 0.074	3.157PheGly: 3.157 ± 0.086	0.75PheHis: 0.75 ± 0.041	2.972PheIle: 2.972 ± 0.088	1.98PheLys: 1.98 ± 0.061	3.671PheLeu: 3.671 ± 0.094	1.116PheMet: 1.116 ± 0.05	1.457PheAsn: 1.457 ± 0.054	1.393PhePro: 1.393 ± 0.048	0.915PheGln: 0.915 ± 0.044	1.689PheArg: 1.689 ± 0.057	2.706PheSer: 2.706 ± 0.077	2.598PheThr: 2.598 ± 0.067	2.908PheVal: 2.908 ± 0.084	0.396PheTrp: 0.396 ± 0.029	1.442PheTyr: 1.442 ± 0.064	0.0PheXaa: 0.0 ± 0.0
Gly	6.387GlyAla: 6.387 ± 0.141	1.103GlyCys: 1.103 ± 0.046	3.924GlyAsp: 3.924 ± 0.092	4.436GlyGlu: 4.436 ± 0.097	2.96GlyPhe: 2.96 ± 0.072	5.762GlyGly: 5.762 ± 0.165	1.642GlyHis: 1.642 ± 0.055	6.029GlyIle: 6.029 ± 0.118	5.494GlyLys: 5.494 ± 0.099	6.753GlyLeu: 6.753 ± 0.119	2.422GlyMet: 2.422 ± 0.063	3.005GlyAsn: 3.005 ± 0.125	2.003GlyPro: 2.003 ± 0.06	2.293GlyGln: 2.293 ± 0.068	4.025GlyArg: 4.025 ± 0.091	4.342GlySer: 4.342 ± 0.12	5.165GlyThr: 5.165 ± 0.121	5.478GlyVal: 5.478 ± 0.124	0.595GlyTrp: 0.595 ± 0.039	2.807GlyTyr: 2.807 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	1.483HisAla: 1.483 ± 0.05	0.318HisCys: 0.318 ± 0.026	1.137HisAsp: 1.137 ± 0.046	1.298HisGlu: 1.298 ± 0.044	0.812HisPhe: 0.812 ± 0.041	1.668HisGly: 1.668 ± 0.051	0.527HisHis: 0.527 ± 0.035	1.685HisIle: 1.685 ± 0.056	1.225HisLys: 1.225 ± 0.055	1.85HisLeu: 1.85 ± 0.067	0.58HisMet: 0.58 ± 0.03	0.825HisAsn: 0.825 ± 0.038	0.935HisPro: 0.935 ± 0.042	0.466HisGln: 0.466 ± 0.028	1.047HisArg: 1.047 ± 0.053	1.015HisSer: 1.015 ± 0.042	1.255HisThr: 1.255 ± 0.053	1.586HisVal: 1.586 ± 0.053	0.213HisTrp: 0.213 ± 0.021	0.709HisTyr: 0.709 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	5.661IleAla: 5.661 ± 0.099	0.98IleCys: 0.98 ± 0.045	4.04IleAsp: 4.04 ± 0.095	4.004IleGlu: 4.004 ± 0.091	2.446IlePhe: 2.446 ± 0.075	5.511IleGly: 5.511 ± 0.143	1.455IleHis: 1.455 ± 0.051	4.655IleIle: 4.655 ± 0.12	3.456IleLys: 3.456 ± 0.079	5.919IleLeu: 5.919 ± 0.128	1.846IleMet: 1.846 ± 0.067	2.506IleAsn: 2.506 ± 0.076	3.069IlePro: 3.069 ± 0.081	1.915IleGln: 1.915 ± 0.055	3.439IleArg: 3.439 ± 0.093	3.89IleSer: 3.89 ± 0.099	4.09IleThr: 4.09 ± 0.105	5.046IleVal: 5.046 ± 0.124	0.484IleTrp: 0.484 ± 0.028	2.237IleTyr: 2.237 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	5.635LysAla: 5.635 ± 0.116	0.456LysCys: 0.456 ± 0.029	4.126LysAsp: 4.126 ± 0.103	5.717LysGlu: 5.717 ± 0.118	1.614LysPhe: 1.614 ± 0.07	4.46LysGly: 4.46 ± 0.1	1.189LysHis: 1.189 ± 0.049	3.922LysIle: 3.922 ± 0.084	5.098LysLys: 5.098 ± 0.114	4.586LysLeu: 4.586 ± 0.114	1.672LysMet: 1.672 ± 0.06	2.906LysAsn: 2.906 ± 0.081	1.975LysPro: 1.975 ± 0.065	1.917LysGln: 1.917 ± 0.056	3.306LysArg: 3.306 ± 0.095	3.168LysSer: 3.168 ± 0.08	3.733LysThr: 3.733 ± 0.076	4.212LysVal: 4.212 ± 0.114	0.516LysTrp: 0.516 ± 0.036	2.147LysTyr: 2.147 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	8.174LeuAla: 8.174 ± 0.15	1.219LeuCys: 1.219 ± 0.049	4.804LeuAsp: 4.804 ± 0.097	5.208LeuGlu: 5.208 ± 0.127	3.879LeuPhe: 3.879 ± 0.105	6.218LeuGly: 6.218 ± 0.133	2.057LeuHis: 2.057 ± 0.067	5.966LeuIle: 5.966 ± 0.14	5.618LeuLys: 5.618 ± 0.11	8.217LeuLeu: 8.217 ± 0.152	2.377LeuMet: 2.377 ± 0.073	3.228LeuAsn: 3.228 ± 0.089	3.961LeuPro: 3.961 ± 0.089	3.219LeuGln: 3.219 ± 0.097	4.573LeuArg: 4.573 ± 0.101	6.033LeuSer: 6.033 ± 0.123	5.936LeuThr: 5.936 ± 0.112	5.979LeuVal: 5.979 ± 0.13	0.754LeuTrp: 0.754 ± 0.042	3.17LeuTyr: 3.17 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.596MetAla: 2.596 ± 0.068	0.249MetCys: 0.249 ± 0.02	1.449MetAsp: 1.449 ± 0.05	1.936MetGlu: 1.936 ± 0.06	0.763MetPhe: 0.763 ± 0.041	1.977MetGly: 1.977 ± 0.06	0.559MetHis: 0.559 ± 0.033	1.679MetIle: 1.679 ± 0.059	2.351MetLys: 2.351 ± 0.066	2.188MetLeu: 2.188 ± 0.071	0.778MetMet: 0.778 ± 0.037	1.453MetAsn: 1.453 ± 0.054	1.27MetPro: 1.27 ± 0.047	0.819MetGln: 0.819 ± 0.035	1.461MetArg: 1.461 ± 0.044	1.754MetSer: 1.754 ± 0.062	1.979MetThr: 1.979 ± 0.064	1.554MetVal: 1.554 ± 0.068	0.168MetTrp: 0.168 ± 0.017	0.918MetTyr: 0.918 ± 0.042	0.0MetXaa: 0.0 ± 0.0
Asn	2.831AsnAla: 2.831 ± 0.08	0.43AsnCys: 0.43 ± 0.032	1.999AsnAsp: 1.999 ± 0.061	2.401AsnGlu: 2.401 ± 0.068	1.38AsnPhe: 1.38 ± 0.054	3.046AsnGly: 3.046 ± 0.113	0.748AsnHis: 0.748 ± 0.04	2.745AsnIle: 2.745 ± 0.071	2.343AsnLys: 2.343 ± 0.086	3.269AsnLeu: 3.269 ± 0.086	1.092AsnMet: 1.092 ± 0.046	1.535AsnAsn: 1.535 ± 0.078	1.857AsnPro: 1.857 ± 0.066	0.916AsnGln: 0.916 ± 0.038	2.231AsnArg: 2.231 ± 0.068	1.956AsnSer: 1.956 ± 0.085	2.123AsnThr: 2.123 ± 0.091	2.779AsnVal: 2.779 ± 0.1	0.361AsnTrp: 0.361 ± 0.026	1.285AsnTyr: 1.285 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.841ProAla: 2.841 ± 0.074	0.398ProCys: 0.398 ± 0.029	2.422ProAsp: 2.422 ± 0.071	3.082ProGlu: 3.082 ± 0.082	1.724ProPhe: 1.724 ± 0.054	2.521ProGly: 2.521 ± 0.073	0.892ProHis: 0.892 ± 0.043	1.937ProIle: 1.937 ± 0.058	1.78ProLys: 1.78 ± 0.06	3.613ProLeu: 3.613 ± 0.08	0.873ProMet: 0.873 ± 0.039	1.156ProAsn: 1.156 ± 0.049	0.963ProPro: 0.963 ± 0.044	1.333ProGln: 1.333 ± 0.049	1.277ProArg: 1.277 ± 0.049	1.969ProSer: 1.969 ± 0.064	2.04ProThr: 2.04 ± 0.057	3.772ProVal: 3.772 ± 0.081	0.363ProTrp: 0.363 ± 0.026	1.625ProTyr: 1.625 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.964GlnAla: 2.964 ± 0.087	0.324GlnCys: 0.324 ± 0.025	1.567GlnAsp: 1.567 ± 0.047	2.274GlnGlu: 2.274 ± 0.071	0.952GlnPhe: 0.952 ± 0.042	2.19GlnGly: 2.19 ± 0.066	0.539GlnHis: 0.539 ± 0.034	2.065GlnIle: 2.065 ± 0.067	2.04GlnLys: 2.04 ± 0.066	2.542GlnLeu: 2.542 ± 0.071	0.911GlnMet: 0.911 ± 0.045	1.032GlnAsn: 1.032 ± 0.046	1.023GlnPro: 1.023 ± 0.044	1.122GlnGln: 1.122 ± 0.053	1.567GlnArg: 1.567 ± 0.062	1.597GlnSer: 1.597 ± 0.05	1.681GlnThr: 1.681 ± 0.056	2.117GlnVal: 2.117 ± 0.062	0.325GlnTrp: 0.325 ± 0.026	1.171GlnTyr: 1.171 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	3.598ArgAla: 3.598 ± 0.096	0.606ArgCys: 0.606 ± 0.04	2.48ArgAsp: 2.48 ± 0.075	3.338ArgGlu: 3.338 ± 0.098	2.252ArgPhe: 2.252 ± 0.067	2.901ArgGly: 2.901 ± 0.079	1.259ArgHis: 1.259 ± 0.051	4.013ArgIle: 4.013 ± 0.108	3.372ArgLys: 3.372 ± 0.101	5.092ArgLeu: 5.092 ± 0.113	1.5ArgMet: 1.5 ± 0.058	2.121ArgAsn: 2.121 ± 0.065	1.859ArgPro: 1.859 ± 0.054	2.119ArgGln: 2.119 ± 0.065	3.355ArgArg: 3.355 ± 0.105	2.601ArgSer: 2.601 ± 0.074	2.83ArgThr: 2.83 ± 0.07	3.363ArgVal: 3.363 ± 0.084	0.475ArgTrp: 0.475 ± 0.028	1.812ArgTyr: 1.812 ± 0.061	0.0ArgXaa: 0.0 ± 0.0
Ser	4.548SerAla: 4.548 ± 0.119	0.628SerCys: 0.628 ± 0.034	3.149SerAsp: 3.149 ± 0.094	3.333SerGlu: 3.333 ± 0.084	2.469SerPhe: 2.469 ± 0.07	4.683SerGly: 4.683 ± 0.094	1.259SerHis: 1.259 ± 0.056	3.205SerIle: 3.205 ± 0.087	2.796SerLys: 2.796 ± 0.077	5.739SerLeu: 5.739 ± 0.114	1.492SerMet: 1.492 ± 0.051	1.659SerAsn: 1.659 ± 0.075	2.022SerPro: 2.022 ± 0.066	1.713SerGln: 1.713 ± 0.065	2.816SerArg: 2.816 ± 0.086	2.996SerSer: 2.996 ± 0.095	2.914SerThr: 2.914 ± 0.089	4.978SerVal: 4.978 ± 0.1	0.529SerTrp: 0.529 ± 0.04	2.106SerTyr: 2.106 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	6.084ThrAla: 6.084 ± 0.145	0.64ThrCys: 0.64 ± 0.035	3.778ThrAsp: 3.778 ± 0.092	3.884ThrGlu: 3.884 ± 0.089	2.166ThrPhe: 2.166 ± 0.067	5.442ThrGly: 5.442 ± 0.134	1.143ThrHis: 1.143 ± 0.047	3.385ThrIle: 3.385 ± 0.081	2.835ThrLys: 2.835 ± 0.07	5.33ThrLeu: 5.33 ± 0.1	1.388ThrMet: 1.388 ± 0.053	1.945ThrAsn: 1.945 ± 0.096	2.506ThrPro: 2.506 ± 0.077	1.567ThrGln: 1.567 ± 0.056	2.454ThrArg: 2.454 ± 0.063	2.931ThrSer: 2.931 ± 0.093	3.258ThrThr: 3.258 ± 0.101	5.885ThrVal: 5.885 ± 0.122	0.542ThrTrp: 0.542 ± 0.032	2.164ThrTyr: 2.164 ± 0.068	0.0ThrXaa: 0.0 ± 0.0
Val	6.342ValAla: 6.342 ± 0.129	1.122ValCys: 1.122 ± 0.049	4.318ValAsp: 4.318 ± 0.106	4.522ValGlu: 4.522 ± 0.104	3.226ValPhe: 3.226 ± 0.084	5.493ValGly: 5.493 ± 0.141	1.515ValHis: 1.515 ± 0.056	5.255ValIle: 5.255 ± 0.105	4.393ValLys: 4.393 ± 0.104	7.12ValLeu: 7.12 ± 0.14	2.132ValMet: 2.132 ± 0.068	2.884ValAsn: 2.884 ± 0.119	3.192ValPro: 3.192 ± 0.081	2.396ValGln: 2.396 ± 0.069	4.116ValArg: 4.116 ± 0.097	4.67ValSer: 4.67 ± 0.092	5.061ValThr: 5.061 ± 0.141	6.003ValVal: 6.003 ± 0.121	0.634ValTrp: 0.634 ± 0.04	2.942ValTyr: 2.942 ± 0.079	0.0ValXaa: 0.0 ± 0.0
Trp	0.634TrpAla: 0.634 ± 0.036	0.075TrpCys: 0.075 ± 0.013	0.494TrpAsp: 0.494 ± 0.033	0.497TrpGlu: 0.497 ± 0.033	0.406TrpPhe: 0.406 ± 0.03	0.563TrpGly: 0.563 ± 0.03	0.217TrpHis: 0.217 ± 0.018	0.535TrpIle: 0.535 ± 0.04	0.557TrpLys: 0.557 ± 0.035	0.847TrpLeu: 0.847 ± 0.038	0.239TrpMet: 0.239 ± 0.021	0.439TrpAsn: 0.439 ± 0.029	0.329TrpPro: 0.329 ± 0.025	0.499TrpGln: 0.499 ± 0.032	0.475TrpArg: 0.475 ± 0.031	0.462TrpSer: 0.462 ± 0.037	0.434TrpThr: 0.434 ± 0.029	0.514TrpVal: 0.514 ± 0.033	0.086TrpTrp: 0.086 ± 0.012	0.365TrpTyr: 0.365 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.955TyrAla: 2.955 ± 0.068	0.531TyrCys: 0.531 ± 0.035	2.467TyrAsp: 2.467 ± 0.07	2.469TyrGlu: 2.469 ± 0.074	1.496TyrPhe: 1.496 ± 0.06	3.237TyrGly: 3.237 ± 0.084	0.752TyrHis: 0.752 ± 0.04	2.547TyrIle: 2.547 ± 0.068	2.192TyrLys: 2.192 ± 0.071	3.112TyrLeu: 3.112 ± 0.077	0.948TyrMet: 0.948 ± 0.042	1.481TyrAsn: 1.481 ± 0.055	1.352TyrPro: 1.352 ± 0.047	0.785TyrGln: 0.785 ± 0.038	1.836TyrArg: 1.836 ± 0.06	1.973TyrSer: 1.973 ± 0.066	2.214TyrThr: 2.214 ± 0.065	2.573TyrVal: 2.573 ± 0.073	0.346TyrTrp: 0.346 ± 0.027	1.384TyrTyr: 1.384 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1771 proteins (534718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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