Amino acid dipepetide frequency for Pluralibacter gergoviae (Enterobacter gergoviae)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.959AlaAla: 12.959 ± 0.144	1.293AlaCys: 1.293 ± 0.033	5.819AlaAsp: 5.819 ± 0.089	6.019AlaGlu: 6.019 ± 0.064	3.758AlaPhe: 3.758 ± 0.061	9.152AlaGly: 9.152 ± 0.158	1.977AlaHis: 1.977 ± 0.038	5.89AlaIle: 5.89 ± 0.074	3.643AlaLys: 3.643 ± 0.061	13.352AlaLeu: 13.352 ± 0.138	3.072AlaMet: 3.072 ± 0.044	2.84AlaAsn: 2.84 ± 0.05	4.325AlaPro: 4.325 ± 0.063	4.542AlaGln: 4.542 ± 0.07	6.802AlaArg: 6.802 ± 0.09	5.773AlaSer: 5.773 ± 0.069	4.863AlaThr: 4.863 ± 0.076	7.46AlaVal: 7.46 ± 0.075	1.851AlaTrp: 1.851 ± 0.037	1.996AlaTyr: 1.996 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.124CysAla: 1.124 ± 0.029	0.193CysCys: 0.193 ± 0.011	0.648CysAsp: 0.648 ± 0.02	0.563CysGlu: 0.563 ± 0.02	0.412CysPhe: 0.412 ± 0.016	1.155CysGly: 1.155 ± 0.027	0.31CysHis: 0.31 ± 0.015	0.55CysIle: 0.55 ± 0.022	0.298CysLys: 0.298 ± 0.015	1.027CysLeu: 1.027 ± 0.026	0.241CysMet: 0.241 ± 0.012	0.29CysAsn: 0.29 ± 0.013	0.523CysPro: 0.523 ± 0.023	0.406CysGln: 0.406 ± 0.018	0.731CysArg: 0.731 ± 0.022	0.659CysSer: 0.659 ± 0.02	0.473CysThr: 0.473 ± 0.018	0.708CysVal: 0.708 ± 0.023	0.194CysTrp: 0.194 ± 0.01	0.325CysTyr: 0.325 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.002AspAla: 6.002 ± 0.068	0.503AspCys: 0.503 ± 0.018	3.131AspAsp: 3.131 ± 0.061	3.453AspGlu: 3.453 ± 0.06	2.059AspPhe: 2.059 ± 0.037	4.294AspGly: 4.294 ± 0.075	0.916AspHis: 0.916 ± 0.026	3.304AspIle: 3.304 ± 0.049	2.347AspLys: 2.347 ± 0.043	4.84AspLeu: 4.84 ± 0.067	1.281AspMet: 1.281 ± 0.028	1.989AspAsn: 1.989 ± 0.043	2.402AspPro: 2.402 ± 0.042	1.406AspGln: 1.406 ± 0.033	3.085AspArg: 3.085 ± 0.039	2.865AspSer: 2.865 ± 0.044	2.516AspThr: 2.516 ± 0.053	3.728AspVal: 3.728 ± 0.071	0.803AspTrp: 0.803 ± 0.023	1.836AspTyr: 1.836 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.85GluAla: 5.85 ± 0.078	0.453GluCys: 0.453 ± 0.017	2.248GluAsp: 2.248 ± 0.039	3.228GluGlu: 3.228 ± 0.065	1.657GluPhe: 1.657 ± 0.036	3.709GluGly: 3.709 ± 0.055	1.36GluHis: 1.36 ± 0.032	3.104GluIle: 3.104 ± 0.057	2.992GluLys: 2.992 ± 0.05	5.585GluLeu: 5.585 ± 0.067	1.796GluMet: 1.796 ± 0.039	2.091GluAsn: 2.091 ± 0.041	2.125GluPro: 2.125 ± 0.043	3.087GluGln: 3.087 ± 0.055	3.673GluArg: 3.673 ± 0.055	2.921GluSer: 2.921 ± 0.049	2.716GluThr: 2.716 ± 0.045	3.785GluVal: 3.785 ± 0.059	0.741GluTrp: 0.741 ± 0.022	1.42GluTyr: 1.42 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.817PheAla: 3.817 ± 0.06	0.528PheCys: 0.528 ± 0.019	2.298PheAsp: 2.298 ± 0.043	1.604PheGlu: 1.604 ± 0.037	1.622PhePhe: 1.622 ± 0.038	3.198PheGly: 3.198 ± 0.056	0.77PheHis: 0.77 ± 0.024	2.464PheIle: 2.464 ± 0.042	1.128PheLys: 1.128 ± 0.028	3.154PheLeu: 3.154 ± 0.058	0.975PheMet: 0.975 ± 0.027	1.589PheAsn: 1.589 ± 0.032	1.542PhePro: 1.542 ± 0.032	1.061PheGln: 1.061 ± 0.027	1.98PheArg: 1.98 ± 0.041	3.102PheSer: 3.102 ± 0.044	2.351PheThr: 2.351 ± 0.037	2.361PheVal: 2.361 ± 0.048	0.653PheTrp: 0.653 ± 0.024	1.116PheTyr: 1.116 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.212GlyAla: 7.212 ± 0.085	1.047GlyCys: 1.047 ± 0.028	4.068GlyAsp: 4.068 ± 0.08	4.864GlyGlu: 4.864 ± 0.063	3.35GlyPhe: 3.35 ± 0.052	6.126GlyGly: 6.126 ± 0.092	1.721GlyHis: 1.721 ± 0.037	4.98GlyIle: 4.98 ± 0.065	3.793GlyLys: 3.793 ± 0.062	7.981GlyLeu: 7.981 ± 0.088	2.403GlyMet: 2.403 ± 0.044	2.641GlyAsn: 2.641 ± 0.097	2.283GlyPro: 2.283 ± 0.042	3.053GlyGln: 3.053 ± 0.063	4.533GlyArg: 4.533 ± 0.054	4.673GlySer: 4.673 ± 0.067	3.83GlyThr: 3.83 ± 0.079	5.914GlyVal: 5.914 ± 0.063	1.456GlyTrp: 1.456 ± 0.036	2.657GlyTyr: 2.657 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.946HisAla: 1.946 ± 0.032	0.293HisCys: 0.293 ± 0.013	1.182HisAsp: 1.182 ± 0.034	1.002HisGlu: 1.002 ± 0.028	0.999HisPhe: 0.999 ± 0.028	1.77HisGly: 1.77 ± 0.034	0.699HisHis: 0.699 ± 0.023	1.213HisIle: 1.213 ± 0.03	0.69HisLys: 0.69 ± 0.022	2.249HisLeu: 2.249 ± 0.041	0.493HisMet: 0.493 ± 0.017	0.748HisAsn: 0.748 ± 0.023	1.355HisPro: 1.355 ± 0.035	1.024HisGln: 1.024 ± 0.028	1.41HisArg: 1.41 ± 0.034	1.18HisSer: 1.18 ± 0.03	0.991HisThr: 0.991 ± 0.026	1.235HisVal: 1.235 ± 0.028	0.375HisTrp: 0.375 ± 0.014	0.881HisTyr: 0.881 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.828IleAla: 6.828 ± 0.077	0.662IleCys: 0.662 ± 0.022	3.47IleAsp: 3.47 ± 0.06	3.004IleGlu: 3.004 ± 0.053	1.94IlePhe: 1.94 ± 0.044	4.623IleGly: 4.623 ± 0.061	1.111IleHis: 1.111 ± 0.028	3.129IleIle: 3.129 ± 0.058	2.069IleLys: 2.069 ± 0.039	4.558IleLeu: 4.558 ± 0.053	1.184IleMet: 1.184 ± 0.032	2.434IleAsn: 2.434 ± 0.071	2.563IlePro: 2.563 ± 0.042	1.607IleGln: 1.607 ± 0.035	3.026IleArg: 3.026 ± 0.047	3.559IleSer: 3.559 ± 0.052	3.205IleThr: 3.205 ± 0.049	3.888IleVal: 3.888 ± 0.051	0.669IleTrp: 0.669 ± 0.023	1.444IleTyr: 1.444 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.169LysAla: 4.169 ± 0.066	0.249LysCys: 0.249 ± 0.013	1.822LysAsp: 1.822 ± 0.041	2.274LysGlu: 2.274 ± 0.044	1.003LysPhe: 1.003 ± 0.025	2.825LysGly: 2.825 ± 0.043	0.781LysHis: 0.781 ± 0.024	2.143LysIle: 2.143 ± 0.043	2.03LysLys: 2.03 ± 0.05	3.721LysLeu: 3.721 ± 0.062	1.17LysMet: 1.17 ± 0.029	1.473LysAsn: 1.473 ± 0.032	1.908LysPro: 1.908 ± 0.04	1.698LysGln: 1.698 ± 0.038	2.297LysArg: 2.297 ± 0.048	2.158LysSer: 2.158 ± 0.042	2.36LysThr: 2.36 ± 0.042	2.876LysVal: 2.876 ± 0.055	0.431LysTrp: 0.431 ± 0.017	1.036LysTyr: 1.036 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.571LeuAla: 12.571 ± 0.128	1.326LeuCys: 1.326 ± 0.032	5.458LeuAsp: 5.458 ± 0.068	5.264LeuGlu: 5.264 ± 0.077	4.235LeuPhe: 4.235 ± 0.062	7.663LeuGly: 7.663 ± 0.091	2.282LeuHis: 2.282 ± 0.044	5.568LeuIle: 5.568 ± 0.07	4.226LeuLys: 4.226 ± 0.056	12.322LeuLeu: 12.322 ± 0.166	2.907LeuMet: 2.907 ± 0.047	3.975LeuAsn: 3.975 ± 0.06	5.832LeuPro: 5.832 ± 0.072	3.961LeuGln: 3.961 ± 0.06	6.763LeuArg: 6.763 ± 0.089	7.3LeuSer: 7.3 ± 0.078	6.368LeuThr: 6.368 ± 0.073	7.005LeuVal: 7.005 ± 0.088	1.51LeuTrp: 1.51 ± 0.037	2.524LeuTyr: 2.524 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.013MetAla: 3.013 ± 0.051	0.192MetCys: 0.192 ± 0.011	1.153MetAsp: 1.153 ± 0.03	1.177MetGlu: 1.177 ± 0.031	0.824MetPhe: 0.824 ± 0.025	1.899MetGly: 1.899 ± 0.039	0.519MetHis: 0.519 ± 0.017	1.425MetIle: 1.425 ± 0.035	1.326MetLys: 1.326 ± 0.031	3.113MetLeu: 3.113 ± 0.051	0.81MetMet: 0.81 ± 0.025	1.031MetAsn: 1.031 ± 0.026	1.382MetPro: 1.382 ± 0.033	1.155MetGln: 1.155 ± 0.03	1.563MetArg: 1.563 ± 0.03	1.854MetSer: 1.854 ± 0.039	1.772MetThr: 1.772 ± 0.035	1.866MetVal: 1.866 ± 0.037	0.235MetTrp: 0.235 ± 0.012	0.498MetTyr: 0.498 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.424AsnAla: 3.424 ± 0.064	0.326AsnCys: 0.326 ± 0.015	1.832AsnAsp: 1.832 ± 0.034	1.577AsnGlu: 1.577 ± 0.032	1.187AsnPhe: 1.187 ± 0.029	2.86AsnGly: 2.86 ± 0.092	0.733AsnHis: 0.733 ± 0.023	2.078AsnIle: 2.078 ± 0.041	1.352AsnLys: 1.352 ± 0.031	3.337AsnLeu: 3.337 ± 0.048	0.878AsnMet: 0.878 ± 0.024	1.36AsnAsn: 1.36 ± 0.027	1.976AsnPro: 1.976 ± 0.038	1.387AsnGln: 1.387 ± 0.029	1.978AsnArg: 1.978 ± 0.037	1.804AsnSer: 1.804 ± 0.051	1.82AsnThr: 1.82 ± 0.046	2.366AsnVal: 2.366 ± 0.055	0.485AsnTrp: 0.485 ± 0.019	1.084AsnTyr: 1.084 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.295ProAla: 5.295 ± 0.062	0.379ProCys: 0.379 ± 0.015	2.987ProAsp: 2.987 ± 0.042	3.306ProGlu: 3.306 ± 0.051	1.823ProPhe: 1.823 ± 0.04	3.878ProGly: 3.878 ± 0.055	1.041ProHis: 1.041 ± 0.029	1.696ProIle: 1.696 ± 0.036	1.394ProLys: 1.394 ± 0.035	5.428ProLeu: 5.428 ± 0.069	1.079ProMet: 1.079 ± 0.029	1.187ProAsn: 1.187 ± 0.03	1.885ProPro: 1.885 ± 0.042	2.485ProGln: 2.485 ± 0.048	2.213ProArg: 2.213 ± 0.039	2.056ProSer: 2.056 ± 0.033	1.98ProThr: 1.98 ± 0.038	3.965ProVal: 3.965 ± 0.049	0.837ProTrp: 0.837 ± 0.028	1.151ProTyr: 1.151 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.772GlnAla: 4.772 ± 0.061	0.347GlnCys: 0.347 ± 0.017	1.716GlnAsp: 1.716 ± 0.034	2.054GlnGlu: 2.054 ± 0.039	1.419GlnPhe: 1.419 ± 0.034	2.917GlnGly: 2.917 ± 0.046	1.097GlnHis: 1.097 ± 0.034	2.172GlnIle: 2.172 ± 0.036	1.649GlnLys: 1.649 ± 0.04	4.627GlnLeu: 4.627 ± 0.073	1.233GlnMet: 1.233 ± 0.03	1.246GlnAsn: 1.246 ± 0.032	2.166GlnPro: 2.166 ± 0.05	3.106GlnGln: 3.106 ± 0.059	3.116GlnArg: 3.116 ± 0.051	2.22GlnSer: 2.22 ± 0.039	2.069GlnThr: 2.069 ± 0.037	2.864GlnVal: 2.864 ± 0.047	0.636GlnTrp: 0.636 ± 0.022	1.057GlnTyr: 1.057 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.73ArgAla: 5.73 ± 0.067	0.648ArgCys: 0.648 ± 0.021	3.315ArgAsp: 3.315 ± 0.042	4.054ArgGlu: 4.054 ± 0.066	2.646ArgPhe: 2.646 ± 0.045	3.956ArgGly: 3.956 ± 0.058	1.605ArgHis: 1.605 ± 0.039	3.434ArgIle: 3.434 ± 0.043	2.167ArgLys: 2.167 ± 0.041	7.232ArgLeu: 7.232 ± 0.093	1.602ArgMet: 1.602 ± 0.032	1.846ArgAsn: 1.846 ± 0.04	2.672ArgPro: 2.672 ± 0.04	3.262ArgGln: 3.262 ± 0.058	4.614ArgArg: 4.614 ± 0.074	3.063ArgSer: 3.063 ± 0.05	2.585ArgThr: 2.585 ± 0.04	4.109ArgVal: 4.109 ± 0.058	1.186ArgTrp: 1.186 ± 0.033	2.307ArgTyr: 2.307 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.306SerAla: 6.306 ± 0.092	0.575SerCys: 0.575 ± 0.019	3.171SerAsp: 3.171 ± 0.049	3.142SerGlu: 3.142 ± 0.053	2.17SerPhe: 2.17 ± 0.042	5.711SerGly: 5.711 ± 0.086	1.335SerHis: 1.335 ± 0.031	2.796SerIle: 2.796 ± 0.042	1.824SerLys: 1.824 ± 0.033	6.511SerLeu: 6.511 ± 0.077	1.454SerMet: 1.454 ± 0.028	1.688SerAsn: 1.688 ± 0.041	2.675SerPro: 2.675 ± 0.042	2.353SerGln: 2.353 ± 0.046	3.833SerArg: 3.833 ± 0.057	3.358SerSer: 3.358 ± 0.065	2.76SerThr: 2.76 ± 0.046	4.265SerVal: 4.265 ± 0.076	1.03SerTrp: 1.03 ± 0.031	1.563SerTyr: 1.563 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.311ThrAla: 5.311 ± 0.087	0.525ThrCys: 0.525 ± 0.019	2.582ThrAsp: 2.582 ± 0.047	2.356ThrGlu: 2.356 ± 0.049	2.05ThrPhe: 2.05 ± 0.039	4.597ThrGly: 4.597 ± 0.07	1.098ThrHis: 1.098 ± 0.026	2.662ThrIle: 2.662 ± 0.08	1.296ThrLys: 1.296 ± 0.03	7.351ThrLeu: 7.351 ± 0.081	1.085ThrMet: 1.085 ± 0.026	1.318ThrAsn: 1.318 ± 0.031	3.151ThrPro: 3.151 ± 0.046	1.877ThrGln: 1.877 ± 0.035	3.19ThrArg: 3.19 ± 0.055	2.733ThrSer: 2.733 ± 0.045	2.67ThrThr: 2.67 ± 0.07	3.974ThrVal: 3.974 ± 0.182	0.829ThrTrp: 0.829 ± 0.031	1.126ThrTyr: 1.126 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	7.385ValAla: 7.385 ± 0.073	0.765ValCys: 0.765 ± 0.026	3.715ValAsp: 3.715 ± 0.07	3.832ValGlu: 3.832 ± 0.061	2.445ValPhe: 2.445 ± 0.047	5.024ValGly: 5.024 ± 0.063	1.226ValHis: 1.226 ± 0.027	4.321ValIle: 4.321 ± 0.065	2.855ValLys: 2.855 ± 0.044	7.245ValLeu: 7.245 ± 0.081	2.164ValMet: 2.164 ± 0.041	2.712ValAsn: 2.712 ± 0.049	3.251ValPro: 3.251 ± 0.059	2.366ValGln: 2.366 ± 0.034	3.946ValArg: 3.946 ± 0.054	4.695ValSer: 4.695 ± 0.068	4.385ValThr: 4.385 ± 0.187	5.36ValVal: 5.36 ± 0.07	0.985ValTrp: 0.985 ± 0.029	1.641ValTyr: 1.641 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.086TrpAla: 1.086 ± 0.03	0.186TrpCys: 0.186 ± 0.01	0.641TrpAsp: 0.641 ± 0.018	0.591TrpGlu: 0.591 ± 0.018	0.668TrpPhe: 0.668 ± 0.024	1.004TrpGly: 1.004 ± 0.03	0.471TrpHis: 0.471 ± 0.018	0.73TrpIle: 0.73 ± 0.024	0.495TrpLys: 0.495 ± 0.018	2.476TrpLeu: 2.476 ± 0.052	0.417TrpMet: 0.417 ± 0.017	0.485TrpAsn: 0.485 ± 0.017	0.7TrpPro: 0.7 ± 0.017	1.252TrpGln: 1.252 ± 0.035	1.261TrpArg: 1.261 ± 0.036	0.868TrpSer: 0.868 ± 0.038	0.648TrpThr: 0.648 ± 0.029	0.927TrpVal: 0.927 ± 0.025	0.232TrpTrp: 0.232 ± 0.013	0.426TrpTyr: 0.426 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.586TyrAla: 2.586 ± 0.043	0.337TyrCys: 0.337 ± 0.014	1.507TyrAsp: 1.507 ± 0.038	1.177TyrGlu: 1.177 ± 0.026	1.047TyrPhe: 1.047 ± 0.027	2.226TyrGly: 2.226 ± 0.048	0.685TyrHis: 0.685 ± 0.022	1.311TyrIle: 1.311 ± 0.03	0.851TyrLys: 0.851 ± 0.024	2.953TyrLeu: 2.953 ± 0.052	0.557TyrMet: 0.557 ± 0.021	0.902TyrAsn: 0.902 ± 0.026	1.348TyrPro: 1.348 ± 0.029	1.396TyrGln: 1.396 ± 0.033	2.017TyrArg: 2.017 ± 0.037	1.677TyrSer: 1.677 ± 0.034	1.42TyrThr: 1.42 ± 0.044	1.664TyrVal: 1.664 ± 0.033	0.423TyrTrp: 0.423 ± 0.019	0.895TyrTyr: 0.895 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4977 proteins (1595228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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