Amino acid dipepetide frequency for Caldimicrobium thiodismutans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.036AlaAla: 2.036 ± 0.08
0.92AlaCys: 0.92 ± 0.049
2.174AlaAsp: 2.174 ± 0.059
5.031AlaGlu: 5.031 ± 0.109
3.558AlaPhe: 3.558 ± 0.083
4.534AlaGly: 4.534 ± 0.104
1.086AlaHis: 1.086 ± 0.039
4.55AlaIle: 4.55 ± 0.114
5.144AlaLys: 5.144 ± 0.102
9.832AlaLeu: 9.832 ± 0.141
1.371AlaMet: 1.371 ± 0.052
1.547AlaAsn: 1.547 ± 0.051
1.953AlaPro: 1.953 ± 0.059
2.049AlaGln: 2.049 ± 0.072
3.025AlaArg: 3.025 ± 0.086
3.202AlaSer: 3.202 ± 0.079
2.407AlaThr: 2.407 ± 0.074
3.531AlaVal: 3.531 ± 0.093
0.54AlaTrp: 0.54 ± 0.029
2.382AlaTyr: 2.382 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.734CysAla: 0.734 ± 0.042
0.152CysCys: 0.152 ± 0.017
0.372CysAsp: 0.372 ± 0.029
0.685CysGlu: 0.685 ± 0.037
0.47CysPhe: 0.47 ± 0.027
1.165CysGly: 1.165 ± 0.051
0.318CysHis: 0.318 ± 0.039
0.558CysIle: 0.558 ± 0.033
0.766CysLys: 0.766 ± 0.039
0.927CysLeu: 0.927 ± 0.04
0.181CysMet: 0.181 ± 0.017
0.289CysAsn: 0.289 ± 0.027
0.797CysPro: 0.797 ± 0.047
0.298CysGln: 0.298 ± 0.025
0.41CysArg: 0.41 ± 0.028
0.584CysSer: 0.584 ± 0.037
0.354CysThr: 0.354 ± 0.034
0.567CysVal: 0.567 ± 0.032
0.085CysTrp: 0.085 ± 0.012
0.419CysTyr: 0.419 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
1.895AspAla: 1.895 ± 0.065
0.412AspCys: 0.412 ± 0.031
1.229AspAsp: 1.229 ± 0.05
3.285AspGlu: 3.285 ± 0.078
3.196AspPhe: 3.196 ± 0.086
2.152AspGly: 2.152 ± 0.059
0.622AspHis: 0.622 ± 0.028
3.28AspIle: 3.28 ± 0.079
2.969AspLys: 2.969 ± 0.077
6.595AspLeu: 6.595 ± 0.114
0.651AspMet: 0.651 ± 0.03
1.07AspAsn: 1.07 ± 0.053
2.479AspPro: 2.479 ± 0.068
0.831AspGln: 0.831 ± 0.043
1.971AspArg: 1.971 ± 0.06
1.67AspSer: 1.67 ± 0.063
1.798AspThr: 1.798 ± 0.059
2.221AspVal: 2.221 ± 0.066
0.594AspTrp: 0.594 ± 0.031
1.926AspTyr: 1.926 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.405GluAla: 5.405 ± 0.108
0.513GluCys: 0.513 ± 0.034
3.984GluAsp: 3.984 ± 0.083
10.16GluGlu: 10.16 ± 0.189
3.374GluPhe: 3.374 ± 0.077
6.001GluGly: 6.001 ± 0.122
1.005GluHis: 1.005 ± 0.051
8.778GluIle: 8.778 ± 0.144
9.873GluLys: 9.873 ± 0.179
9.241GluLeu: 9.241 ± 0.147
1.583GluMet: 1.583 ± 0.052
3.309GluAsn: 3.309 ± 0.079
2.457GluPro: 2.457 ± 0.065
1.156GluGln: 1.156 ± 0.059
5.766GluArg: 5.766 ± 0.124
3.14GluSer: 3.14 ± 0.079
3.639GluThr: 3.639 ± 0.086
6.711GluVal: 6.711 ± 0.125
0.764GluTrp: 0.764 ± 0.038
2.239GluTyr: 2.239 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.647PheAla: 2.647 ± 0.087
0.629PheCys: 0.629 ± 0.035
2.257PheAsp: 2.257 ± 0.058
4.371PheGlu: 4.371 ± 0.096
3.569PhePhe: 3.569 ± 0.115
3.254PheGly: 3.254 ± 0.079
0.914PheHis: 0.914 ± 0.045
3.955PheIle: 3.955 ± 0.098
4.429PheLys: 4.429 ± 0.094
8.128PheLeu: 8.128 ± 0.174
0.967PheMet: 0.967 ± 0.044
1.796PheAsn: 1.796 ± 0.059
2.403PhePro: 2.403 ± 0.061
1.849PheGln: 1.849 ± 0.058
2.201PheArg: 2.201 ± 0.066
3.838PheSer: 3.838 ± 0.101
2.497PheThr: 2.497 ± 0.072
2.81PheVal: 2.81 ± 0.073
0.746PheTrp: 0.746 ± 0.037
2.797PheTyr: 2.797 ± 0.085
0.0PheXaa: 0.0 ± 0.0
Gly
4.266GlyAla: 4.266 ± 0.112
0.753GlyCys: 0.753 ± 0.043
2.916GlyAsp: 2.916 ± 0.078
5.267GlyGlu: 5.267 ± 0.109
3.881GlyPhe: 3.881 ± 0.086
4.584GlyGly: 4.584 ± 0.138
1.109GlyHis: 1.109 ± 0.047
5.892GlyIle: 5.892 ± 0.1
5.927GlyLys: 5.927 ± 0.095
7.967GlyLeu: 7.967 ± 0.136
1.193GlyMet: 1.193 ± 0.044
1.957GlyAsn: 1.957 ± 0.074
2.035GlyPro: 2.035 ± 0.065
1.456GlyGln: 1.456 ± 0.051
3.086GlyArg: 3.086 ± 0.083
3.048GlySer: 3.048 ± 0.065
3.005GlyThr: 3.005 ± 0.071
4.467GlyVal: 4.467 ± 0.107
0.575GlyTrp: 0.575 ± 0.032
2.77GlyTyr: 2.77 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
0.858HisAla: 0.858 ± 0.039
0.179HisCys: 0.179 ± 0.022
0.421HisAsp: 0.421 ± 0.029
0.791HisGlu: 0.791 ± 0.035
0.99HisPhe: 0.99 ± 0.044
0.983HisGly: 0.983 ± 0.045
0.388HisHis: 0.388 ± 0.032
1.09HisIle: 1.09 ± 0.045
1.07HisLys: 1.07 ± 0.043
2.438HisLeu: 2.438 ± 0.076
0.231HisMet: 0.231 ± 0.019
0.488HisAsn: 0.488 ± 0.032
1.231HisPro: 1.231 ± 0.045
0.542HisGln: 0.542 ± 0.034
0.791HisArg: 0.791 ± 0.039
0.889HisSer: 0.889 ± 0.049
0.77HisThr: 0.77 ± 0.035
0.625HisVal: 0.625 ± 0.035
0.145HisTrp: 0.145 ± 0.017
0.726HisTyr: 0.726 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
4.796IleAla: 4.796 ± 0.103
0.831IleCys: 0.831 ± 0.049
3.184IleAsp: 3.184 ± 0.075
6.144IleGlu: 6.144 ± 0.117
4.514IlePhe: 4.514 ± 0.098
4.362IleGly: 4.362 ± 0.1
1.243IleHis: 1.243 ± 0.049
5.462IleIle: 5.462 ± 0.116
6.904IleLys: 6.904 ± 0.121
10.157IleLeu: 10.157 ± 0.167
1.214IleMet: 1.214 ± 0.054
2.794IleAsn: 2.794 ± 0.09
3.975IlePro: 3.975 ± 0.094
1.942IleGln: 1.942 ± 0.067
3.195IleArg: 3.195 ± 0.088
4.765IleSer: 4.765 ± 0.091
3.836IleThr: 3.836 ± 0.087
4.013IleVal: 4.013 ± 0.1
0.676IleTrp: 0.676 ± 0.039
2.951IleTyr: 2.951 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
5.898LysAla: 5.898 ± 0.112
0.531LysCys: 0.531 ± 0.034
4.217LysAsp: 4.217 ± 0.089
10.484LysGlu: 10.484 ± 0.18
3.198LysPhe: 3.198 ± 0.085
6.369LysGly: 6.369 ± 0.107
0.978LysHis: 0.978 ± 0.044
7.969LysIle: 7.969 ± 0.126
8.377LysLys: 8.377 ± 0.15
7.858LysLeu: 7.858 ± 0.116
1.521LysMet: 1.521 ± 0.055
3.899LysAsn: 3.899 ± 0.095
3.321LysPro: 3.321 ± 0.083
1.321LysGln: 1.321 ± 0.05
5.036LysArg: 5.036 ± 0.101
3.798LysSer: 3.798 ± 0.082
3.943LysThr: 3.943 ± 0.087
5.771LysVal: 5.771 ± 0.105
0.652LysTrp: 0.652 ± 0.035
2.653LysTyr: 2.653 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
7.974LeuAla: 7.974 ± 0.137
1.156LeuCys: 1.156 ± 0.053
4.689LeuAsp: 4.689 ± 0.086
10.601LeuGlu: 10.601 ± 0.17
7.024LeuPhe: 7.024 ± 0.158
7.578LeuGly: 7.578 ± 0.135
1.624LeuHis: 1.624 ± 0.062
8.97LeuIle: 8.97 ± 0.148
13.362LeuLys: 13.362 ± 0.196
13.738LeuLeu: 13.738 ± 0.24
2.082LeuMet: 2.082 ± 0.064
4.458LeuAsn: 4.458 ± 0.089
5.672LeuPro: 5.672 ± 0.098
3.477LeuGln: 3.477 ± 0.103
5.999LeuArg: 5.999 ± 0.105
9.389LeuSer: 9.389 ± 0.15
5.331LeuThr: 5.331 ± 0.11
5.788LeuVal: 5.788 ± 0.116
1.167LeuTrp: 1.167 ± 0.057
4.566LeuTyr: 4.566 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
1.469MetAla: 1.469 ± 0.058
0.15MetCys: 0.15 ± 0.017
0.824MetAsp: 0.824 ± 0.039
1.673MetGlu: 1.673 ± 0.055
0.54MetPhe: 0.54 ± 0.032
1.402MetGly: 1.402 ± 0.047
0.257MetHis: 0.257 ± 0.02
1.021MetIle: 1.021 ± 0.045
1.713MetLys: 1.713 ± 0.052
1.594MetLeu: 1.594 ± 0.062
0.304MetMet: 0.304 ± 0.025
0.627MetAsn: 0.627 ± 0.042
0.811MetPro: 0.811 ± 0.036
0.551MetGln: 0.551 ± 0.03
0.875MetArg: 0.875 ± 0.042
0.959MetSer: 0.959 ± 0.042
0.772MetThr: 0.772 ± 0.037
1.194MetVal: 1.194 ± 0.05
0.148MetTrp: 0.148 ± 0.017
0.381MetTyr: 0.381 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
1.532AsnAla: 1.532 ± 0.053
0.374AsnCys: 0.374 ± 0.029
0.871AsnAsp: 0.871 ± 0.046
1.872AsnGlu: 1.872 ± 0.064
2.667AsnPhe: 2.667 ± 0.078
1.48AsnGly: 1.48 ± 0.053
0.548AsnHis: 0.548 ± 0.034
2.481AsnIle: 2.481 ± 0.076
2.282AsnLys: 2.282 ± 0.077
5.894AsnLeu: 5.894 ± 0.117
0.542AsnMet: 0.542 ± 0.035
0.974AsnAsn: 0.974 ± 0.049
2.465AsnPro: 2.465 ± 0.069
1.147AsnGln: 1.147 ± 0.052
1.46AsnArg: 1.46 ± 0.05
1.587AsnSer: 1.587 ± 0.056
1.384AsnThr: 1.384 ± 0.057
1.574AsnVal: 1.574 ± 0.061
0.479AsnTrp: 0.479 ± 0.032
1.543AsnTyr: 1.543 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.242ProAla: 2.242 ± 0.07
0.457ProCys: 0.457 ± 0.03
2.026ProAsp: 2.026 ± 0.063
5.24ProGlu: 5.24 ± 0.108
2.918ProPhe: 2.918 ± 0.082
2.822ProGly: 2.822 ± 0.075
0.981ProHis: 0.981 ± 0.04
2.421ProIle: 2.421 ± 0.068
2.965ProLys: 2.965 ± 0.075
5.567ProLeu: 5.567 ± 0.097
0.679ProMet: 0.679 ± 0.035
1.119ProAsn: 1.119 ± 0.04
1.959ProPro: 1.959 ± 0.067
1.693ProGln: 1.693 ± 0.057
1.67ProArg: 1.67 ± 0.056
2.494ProSer: 2.494 ± 0.07
1.605ProThr: 1.605 ± 0.059
3.142ProVal: 3.142 ± 0.077
0.45ProTrp: 0.45 ± 0.026
2.045ProTyr: 2.045 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
2.185GlnAla: 2.185 ± 0.061
0.228GlnCys: 0.228 ± 0.024
1.167GlnAsp: 1.167 ± 0.05
2.553GlnGlu: 2.553 ± 0.07
0.909GlnPhe: 0.909 ± 0.039
2.013GlnGly: 2.013 ± 0.064
0.287GlnHis: 0.287 ± 0.024
2.282GlnIle: 2.282 ± 0.076
2.958GlnLys: 2.958 ± 0.092
2.094GlnLeu: 2.094 ± 0.062
0.49GlnMet: 0.49 ± 0.029
1.014GlnAsn: 1.014 ± 0.042
0.896GlnPro: 0.896 ± 0.05
0.517GlnGln: 0.517 ± 0.04
1.655GlnArg: 1.655 ± 0.054
1.223GlnSer: 1.223 ± 0.044
1.175GlnThr: 1.175 ± 0.052
1.675GlnVal: 1.675 ± 0.051
0.183GlnTrp: 0.183 ± 0.016
0.651GlnTyr: 0.651 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.652ArgAla: 3.652 ± 0.093
0.542ArgCys: 0.542 ± 0.033
2.42ArgAsp: 2.42 ± 0.068
5.143ArgGlu: 5.143 ± 0.105
2.501ArgPhe: 2.501 ± 0.068
3.182ArgGly: 3.182 ± 0.075
0.703ArgHis: 0.703 ± 0.036
3.975ArgIle: 3.975 ± 0.089
3.789ArgLys: 3.789 ± 0.076
5.327ArgLeu: 5.327 ± 0.103
0.842ArgMet: 0.842 ± 0.043
1.455ArgAsn: 1.455 ± 0.054
1.926ArgPro: 1.926 ± 0.059
0.896ArgGln: 0.896 ± 0.044
2.317ArgArg: 2.317 ± 0.075
1.95ArgSer: 1.95 ± 0.053
1.802ArgThr: 1.802 ± 0.056
3.46ArgVal: 3.46 ± 0.079
0.454ArgTrp: 0.454 ± 0.034
1.682ArgTyr: 1.682 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.268SerAla: 4.268 ± 0.105
0.591SerCys: 0.591 ± 0.033
1.845SerAsp: 1.845 ± 0.052
4.165SerGlu: 4.165 ± 0.093
3.713SerPhe: 3.713 ± 0.091
3.988SerGly: 3.988 ± 0.097
0.943SerHis: 0.943 ± 0.038
3.487SerIle: 3.487 ± 0.09
3.901SerLys: 3.901 ± 0.107
7.629SerLeu: 7.629 ± 0.126
0.949SerMet: 0.949 ± 0.035
1.391SerAsn: 1.391 ± 0.064
2.897SerPro: 2.897 ± 0.08
2.038SerGln: 2.038 ± 0.067
2.062SerArg: 2.062 ± 0.067
3.287SerSer: 3.287 ± 0.095
2.1SerThr: 2.1 ± 0.069
2.539SerVal: 2.539 ± 0.069
0.47SerTrp: 0.47 ± 0.033
2.051SerTyr: 2.051 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
2.642ThrAla: 2.642 ± 0.078
0.535ThrCys: 0.535 ± 0.03
1.588ThrAsp: 1.588 ± 0.061
2.898ThrGlu: 2.898 ± 0.07
2.759ThrPhe: 2.759 ± 0.084
3.686ThrGly: 3.686 ± 0.08
0.885ThrHis: 0.885 ± 0.037
2.833ThrIle: 2.833 ± 0.086
2.665ThrLys: 2.665 ± 0.069
6.268ThrLeu: 6.268 ± 0.125
0.622ThrMet: 0.622 ± 0.038
1.207ThrAsn: 1.207 ± 0.052
2.477ThrPro: 2.477 ± 0.069
1.366ThrGln: 1.366 ± 0.046
1.633ThrArg: 1.633 ± 0.062
2.465ThrSer: 2.465 ± 0.075
2.002ThrThr: 2.002 ± 0.071
2.047ThrVal: 2.047 ± 0.061
0.381ThrTrp: 0.381 ± 0.027
1.704ThrTyr: 1.704 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
3.711ValAla: 3.711 ± 0.095
0.716ValCys: 0.716 ± 0.047
2.736ValAsp: 2.736 ± 0.07
4.953ValGlu: 4.953 ± 0.115
3.189ValPhe: 3.189 ± 0.082
3.415ValGly: 3.415 ± 0.092
0.842ValHis: 0.842 ± 0.034
4.891ValIle: 4.891 ± 0.099
5.34ValLys: 5.34 ± 0.106
6.61ValLeu: 6.61 ± 0.113
1.082ValMet: 1.082 ± 0.043
2.141ValAsn: 2.141 ± 0.065
2.391ValPro: 2.391 ± 0.067
1.149ValGln: 1.149 ± 0.05
2.712ValArg: 2.712 ± 0.07
3.795ValSer: 3.795 ± 0.089
2.353ValThr: 2.353 ± 0.066
4.029ValVal: 4.029 ± 0.108
0.475ValTrp: 0.475 ± 0.03
2.058ValTyr: 2.058 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.591TrpAla: 0.591 ± 0.034
0.099TrpCys: 0.099 ± 0.014
0.506TrpAsp: 0.506 ± 0.034
1.05TrpGlu: 1.05 ± 0.044
0.493TrpPhe: 0.493 ± 0.029
0.71TrpGly: 0.71 ± 0.038
0.161TrpHis: 0.161 ± 0.018
0.775TrpIle: 0.775 ± 0.037
0.777TrpLys: 0.777 ± 0.04
1.012TrpLeu: 1.012 ± 0.043
0.215TrpMet: 0.215 ± 0.019
0.347TrpAsn: 0.347 ± 0.025
0.249TrpPro: 0.249 ± 0.026
0.343TrpGln: 0.343 ± 0.026
0.437TrpArg: 0.437 ± 0.028
0.379TrpSer: 0.379 ± 0.03
0.302TrpThr: 0.302 ± 0.022
0.544TrpVal: 0.544 ± 0.033
0.117TrpTrp: 0.117 ± 0.016
0.351TrpTyr: 0.351 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.071TyrAla: 2.071 ± 0.06
0.363TyrCys: 0.363 ± 0.031
1.42TyrAsp: 1.42 ± 0.05
2.732TyrGlu: 2.732 ± 0.082
2.593TyrPhe: 2.593 ± 0.074
2.474TyrGly: 2.474 ± 0.084
0.752TyrHis: 0.752 ± 0.033
2.286TyrIle: 2.286 ± 0.078
2.584TyrLys: 2.584 ± 0.068
5.77TyrLeu: 5.77 ± 0.107
0.546TyrMet: 0.546 ± 0.03
1.276TyrAsn: 1.276 ± 0.053
2.101TyrPro: 2.101 ± 0.069
1.53TyrGln: 1.53 ± 0.053
1.715TyrArg: 1.715 ± 0.053
1.852TyrSer: 1.852 ± 0.062
1.594TyrThr: 1.594 ± 0.065
1.879TyrVal: 1.879 ± 0.054
0.358TyrTrp: 0.358 ± 0.024
1.785TyrTyr: 1.785 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1771 proteins (553420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski