Amino acid dipepetide frequency for Phragmitibacter flavus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.575AlaAla: 10.575 ± 0.121
0.893AlaCys: 0.893 ± 0.025
5.049AlaAsp: 5.049 ± 0.055
6.029AlaGlu: 6.029 ± 0.074
3.549AlaPhe: 3.549 ± 0.047
7.796AlaGly: 7.796 ± 0.118
1.806AlaHis: 1.806 ± 0.037
4.839AlaIle: 4.839 ± 0.059
4.387AlaLys: 4.387 ± 0.058
10.023AlaLeu: 10.023 ± 0.093
2.552AlaMet: 2.552 ± 0.046
3.392AlaAsn: 3.392 ± 0.069
4.462AlaPro: 4.462 ± 0.069
3.42AlaGln: 3.42 ± 0.052
5.274AlaArg: 5.274 ± 0.072
5.959AlaSer: 5.959 ± 0.075
5.79AlaThr: 5.79 ± 0.088
6.633AlaVal: 6.633 ± 0.076
1.442AlaTrp: 1.442 ± 0.029
2.076AlaTyr: 2.076 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.778CysAla: 0.778 ± 0.024
0.141CysCys: 0.141 ± 0.01
0.46CysAsp: 0.46 ± 0.017
0.521CysGlu: 0.521 ± 0.019
0.387CysPhe: 0.387 ± 0.015
0.831CysGly: 0.831 ± 0.027
0.333CysHis: 0.333 ± 0.011
0.415CysIle: 0.415 ± 0.014
0.263CysLys: 0.263 ± 0.011
1.023CysLeu: 1.023 ± 0.025
0.193CysMet: 0.193 ± 0.01
0.255CysAsn: 0.255 ± 0.014
0.451CysPro: 0.451 ± 0.019
0.299CysGln: 0.299 ± 0.012
0.587CysArg: 0.587 ± 0.019
0.521CysSer: 0.521 ± 0.017
0.387CysThr: 0.387 ± 0.016
0.632CysVal: 0.632 ± 0.022
0.16CysTrp: 0.16 ± 0.009
0.265CysTyr: 0.265 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.077AspAla: 5.077 ± 0.053
0.42AspCys: 0.42 ± 0.017
2.809AspAsp: 2.809 ± 0.051
3.674AspGlu: 3.674 ± 0.057
2.425AspPhe: 2.425 ± 0.038
4.949AspGly: 4.949 ± 0.07
1.427AspHis: 1.427 ± 0.033
2.599AspIle: 2.599 ± 0.049
1.994AspLys: 1.994 ± 0.038
5.656AspLeu: 5.656 ± 0.055
0.999AspMet: 0.999 ± 0.02
1.711AspAsn: 1.711 ± 0.046
3.047AspPro: 3.047 ± 0.054
2.033AspGln: 2.033 ± 0.036
3.098AspArg: 3.098 ± 0.047
2.864AspSer: 2.864 ± 0.044
2.641AspThr: 2.641 ± 0.045
3.405AspVal: 3.405 ± 0.049
1.068AspTrp: 1.068 ± 0.027
1.538AspTyr: 1.538 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
6.141GluAla: 6.141 ± 0.09
0.424GluCys: 0.424 ± 0.019
2.909GluAsp: 2.909 ± 0.048
3.828GluGlu: 3.828 ± 0.067
2.349GluPhe: 2.349 ± 0.041
4.537GluGly: 4.537 ± 0.068
1.307GluHis: 1.307 ± 0.032
3.34GluIle: 3.34 ± 0.046
3.284GluLys: 3.284 ± 0.056
6.133GluLeu: 6.133 ± 0.078
1.61GluMet: 1.61 ± 0.032
2.044GluAsn: 2.044 ± 0.036
2.673GluPro: 2.673 ± 0.042
2.325GluGln: 2.325 ± 0.041
3.836GluArg: 3.836 ± 0.057
3.395GluSer: 3.395 ± 0.048
3.275GluThr: 3.275 ± 0.045
4.72GluVal: 4.72 ± 0.064
0.994GluTrp: 0.994 ± 0.026
1.265GluTyr: 1.265 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.76PheAla: 3.76 ± 0.043
0.481PheCys: 0.481 ± 0.018
2.62PheAsp: 2.62 ± 0.036
2.42PheGlu: 2.42 ± 0.043
1.789PhePhe: 1.789 ± 0.035
3.44PheGly: 3.44 ± 0.053
0.912PheHis: 0.912 ± 0.025
1.972PheIle: 1.972 ± 0.033
1.465PheLys: 1.465 ± 0.03
3.793PheLeu: 3.793 ± 0.05
0.77PheMet: 0.77 ± 0.022
1.548PheAsn: 1.548 ± 0.038
1.759PhePro: 1.759 ± 0.034
1.326PheGln: 1.326 ± 0.029
2.255PheArg: 2.255 ± 0.043
2.636PheSer: 2.636 ± 0.04
2.585PheThr: 2.585 ± 0.041
2.756PheVal: 2.756 ± 0.042
0.656PheTrp: 0.656 ± 0.021
1.113PheTyr: 1.113 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
6.844GlyAla: 6.844 ± 0.123
0.819GlyCys: 0.819 ± 0.025
4.347GlyAsp: 4.347 ± 0.078
4.652GlyGlu: 4.652 ± 0.064
3.454GlyPhe: 3.454 ± 0.043
7.51GlyGly: 7.51 ± 0.153
1.759GlyHis: 1.759 ± 0.033
4.416GlyIle: 4.416 ± 0.058
4.029GlyLys: 4.029 ± 0.057
7.711GlyLeu: 7.711 ± 0.075
2.189GlyMet: 2.189 ± 0.043
3.285GlyAsn: 3.285 ± 0.104
2.741GlyPro: 2.741 ± 0.042
2.773GlyGln: 2.773 ± 0.044
4.543GlyArg: 4.543 ± 0.062
5.493GlySer: 5.493 ± 0.103
5.363GlyThr: 5.363 ± 0.158
5.688GlyVal: 5.688 ± 0.072
1.508GlyTrp: 1.508 ± 0.034
2.183GlyTyr: 2.183 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.199HisAla: 2.199 ± 0.031
0.255HisCys: 0.255 ± 0.012
1.253HisAsp: 1.253 ± 0.029
1.363HisGlu: 1.363 ± 0.031
1.092HisPhe: 1.092 ± 0.027
1.981HisGly: 1.981 ± 0.033
0.855HisHis: 0.855 ± 0.027
1.033HisIle: 1.033 ± 0.024
0.605HisLys: 0.605 ± 0.02
2.705HisLeu: 2.705 ± 0.046
0.391HisMet: 0.391 ± 0.016
0.643HisAsn: 0.643 ± 0.019
1.641HisPro: 1.641 ± 0.035
1.03HisGln: 1.03 ± 0.025
1.479HisArg: 1.479 ± 0.032
1.304HisSer: 1.304 ± 0.031
1.101HisThr: 1.101 ± 0.026
1.387HisVal: 1.387 ± 0.031
0.445HisTrp: 0.445 ± 0.018
0.688HisTyr: 0.688 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.276IleAla: 5.276 ± 0.059
0.518IleCys: 0.518 ± 0.019
2.972IleAsp: 2.972 ± 0.048
3.325IleGlu: 3.325 ± 0.044
1.944IlePhe: 1.944 ± 0.033
4.207IleGly: 4.207 ± 0.065
1.289IleHis: 1.289 ± 0.025
2.609IleIle: 2.609 ± 0.04
2.031IleLys: 2.031 ± 0.034
4.722IleLeu: 4.722 ± 0.045
0.879IleMet: 0.879 ± 0.023
2.118IleAsn: 2.118 ± 0.063
2.633IlePro: 2.633 ± 0.051
1.74IleGln: 1.74 ± 0.033
2.829IleArg: 2.829 ± 0.049
3.27IleSer: 3.27 ± 0.051
3.363IleThr: 3.363 ± 0.071
3.308IleVal: 3.308 ± 0.047
0.628IleTrp: 0.628 ± 0.021
1.259IleTyr: 1.259 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.145LysAla: 4.145 ± 0.059
0.274LysCys: 0.274 ± 0.014
2.364LysAsp: 2.364 ± 0.043
2.677LysGlu: 2.677 ± 0.051
1.445LysPhe: 1.445 ± 0.032
2.99LysGly: 2.99 ± 0.051
1.004LysHis: 1.004 ± 0.025
2.167LysIle: 2.167 ± 0.04
2.373LysLys: 2.373 ± 0.05
4.323LysLeu: 4.323 ± 0.063
1.107LysMet: 1.107 ± 0.028
1.594LysAsn: 1.594 ± 0.033
2.682LysPro: 2.682 ± 0.055
1.481LysGln: 1.481 ± 0.034
2.579LysArg: 2.579 ± 0.046
2.641LysSer: 2.641 ± 0.042
2.587LysThr: 2.587 ± 0.039
3.087LysVal: 3.087 ± 0.053
0.614LysTrp: 0.614 ± 0.02
0.786LysTyr: 0.786 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
10.504LeuAla: 10.504 ± 0.105
1.024LeuCys: 1.024 ± 0.029
5.497LeuAsp: 5.497 ± 0.054
5.926LeuGlu: 5.926 ± 0.072
3.701LeuPhe: 3.701 ± 0.056
7.625LeuGly: 7.625 ± 0.074
2.455LeuHis: 2.455 ± 0.043
5.152LeuIle: 5.152 ± 0.051
4.535LeuLys: 4.535 ± 0.066
10.813LeuLeu: 10.813 ± 0.111
2.384LeuMet: 2.384 ± 0.046
3.845LeuAsn: 3.845 ± 0.069
5.769LeuPro: 5.769 ± 0.072
3.759LeuGln: 3.759 ± 0.053
6.592LeuArg: 6.592 ± 0.079
6.597LeuSer: 6.597 ± 0.06
6.426LeuThr: 6.426 ± 0.086
7.033LeuVal: 7.033 ± 0.072
1.464LeuTrp: 1.464 ± 0.039
2.08LeuTyr: 2.08 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.286MetAla: 2.286 ± 0.047
0.162MetCys: 0.162 ± 0.009
1.12MetAsp: 1.12 ± 0.028
1.409MetGlu: 1.409 ± 0.035
0.757MetPhe: 0.757 ± 0.021
1.76MetGly: 1.76 ± 0.036
0.487MetHis: 0.487 ± 0.015
1.172MetIle: 1.172 ± 0.028
1.389MetLys: 1.389 ± 0.032
2.325MetLeu: 2.325 ± 0.042
0.684MetMet: 0.684 ± 0.023
0.935MetAsn: 0.935 ± 0.024
1.364MetPro: 1.364 ± 0.029
0.868MetGln: 0.868 ± 0.022
1.559MetArg: 1.559 ± 0.037
1.562MetSer: 1.562 ± 0.034
1.393MetThr: 1.393 ± 0.03
1.765MetVal: 1.765 ± 0.036
0.252MetTrp: 0.252 ± 0.013
0.244MetTyr: 0.244 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.577AsnAla: 3.577 ± 0.075
0.274AsnCys: 0.274 ± 0.014
1.841AsnAsp: 1.841 ± 0.046
1.822AsnGlu: 1.822 ± 0.03
1.458AsnPhe: 1.458 ± 0.036
3.425AsnGly: 3.425 ± 0.102
0.932AsnHis: 0.932 ± 0.023
1.832AsnIle: 1.832 ± 0.05
1.105AsnLys: 1.105 ± 0.028
3.873AsnLeu: 3.873 ± 0.073
0.597AsnMet: 0.597 ± 0.018
1.476AsnAsn: 1.476 ± 0.063
2.395AsnPro: 2.395 ± 0.046
1.429AsnGln: 1.429 ± 0.032
2.067AsnArg: 2.067 ± 0.034
2.179AsnSer: 2.179 ± 0.062
2.345AsnThr: 2.345 ± 0.084
2.272AsnVal: 2.272 ± 0.054
0.579AsnTrp: 0.579 ± 0.019
0.991AsnTyr: 0.991 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
5.104ProAla: 5.104 ± 0.086
0.326ProCys: 0.326 ± 0.013
3.405ProAsp: 3.405 ± 0.057
3.71ProGlu: 3.71 ± 0.047
1.925ProPhe: 1.925 ± 0.035
4.19ProGly: 4.19 ± 0.059
1.19ProHis: 1.19 ± 0.027
2.269ProIle: 2.269 ± 0.037
2.153ProLys: 2.153 ± 0.046
4.799ProLeu: 4.799 ± 0.066
1.289ProMet: 1.289 ± 0.03
1.92ProAsn: 1.92 ± 0.038
3.01ProPro: 3.01 ± 0.072
1.871ProGln: 1.871 ± 0.031
2.305ProArg: 2.305 ± 0.039
3.27ProSer: 3.27 ± 0.054
3.188ProThr: 3.188 ± 0.049
3.887ProVal: 3.887 ± 0.061
0.837ProTrp: 0.837 ± 0.028
1.086ProTyr: 1.086 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.439GlnAla: 3.439 ± 0.054
0.287GlnCys: 0.287 ± 0.012
1.48GlnAsp: 1.48 ± 0.032
1.795GlnGlu: 1.795 ± 0.034
1.424GlnPhe: 1.424 ± 0.027
2.529GlnGly: 2.529 ± 0.039
0.94GlnHis: 0.94 ± 0.026
2.0GlnIle: 2.0 ± 0.036
1.666GlnLys: 1.666 ± 0.035
3.799GlnLeu: 3.799 ± 0.055
0.889GlnMet: 0.889 ± 0.024
1.372GlnAsn: 1.372 ± 0.035
2.158GlnPro: 2.158 ± 0.034
1.871GlnGln: 1.871 ± 0.052
2.692GlnArg: 2.692 ± 0.043
2.407GlnSer: 2.407 ± 0.039
2.231GlnThr: 2.231 ± 0.043
2.475GlnVal: 2.475 ± 0.04
0.682GlnTrp: 0.682 ± 0.022
0.758GlnTyr: 0.758 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
4.893ArgAla: 4.893 ± 0.057
0.564ArgCys: 0.564 ± 0.019
3.287ArgAsp: 3.287 ± 0.044
4.141ArgGlu: 4.141 ± 0.068
2.662ArgPhe: 2.662 ± 0.046
3.953ArgGly: 3.953 ± 0.046
1.517ArgHis: 1.517 ± 0.033
3.271ArgIle: 3.271 ± 0.045
2.516ArgLys: 2.516 ± 0.044
6.614ArgLeu: 6.614 ± 0.078
1.607ArgMet: 1.607 ± 0.037
1.934ArgAsn: 1.934 ± 0.033
2.6ArgPro: 2.6 ± 0.04
2.368ArgGln: 2.368 ± 0.041
4.277ArgArg: 4.277 ± 0.062
3.471ArgSer: 3.471 ± 0.05
2.778ArgThr: 2.778 ± 0.038
4.208ArgVal: 4.208 ± 0.052
1.148ArgTrp: 1.148 ± 0.031
1.585ArgTyr: 1.585 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.9SerAla: 5.9 ± 0.067
0.531SerCys: 0.531 ± 0.018
3.197SerAsp: 3.197 ± 0.043
3.282SerGlu: 3.282 ± 0.046
2.538SerPhe: 2.538 ± 0.038
5.957SerGly: 5.957 ± 0.119
1.387SerHis: 1.387 ± 0.028
3.219SerIle: 3.219 ± 0.051
2.444SerLys: 2.444 ± 0.045
6.38SerLeu: 6.38 ± 0.064
1.527SerMet: 1.527 ± 0.034
2.28SerAsn: 2.28 ± 0.063
3.371SerPro: 3.371 ± 0.057
2.126SerGln: 2.126 ± 0.032
3.492SerArg: 3.492 ± 0.051
4.48SerSer: 4.48 ± 0.085
3.88SerThr: 3.88 ± 0.07
4.065SerVal: 4.065 ± 0.06
0.941SerTrp: 0.941 ± 0.025
1.529SerTyr: 1.529 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
5.641ThrAla: 5.641 ± 0.088
0.41ThrCys: 0.41 ± 0.016
2.902ThrAsp: 2.902 ± 0.05
2.91ThrGlu: 2.91 ± 0.044
2.506ThrPhe: 2.506 ± 0.045
5.477ThrGly: 5.477 ± 0.135
1.347ThrHis: 1.347 ± 0.028
3.208ThrIle: 3.208 ± 0.079
2.085ThrLys: 2.085 ± 0.035
6.905ThrLeu: 6.905 ± 0.123
1.123ThrMet: 1.123 ± 0.024
2.187ThrAsn: 2.187 ± 0.074
3.708ThrPro: 3.708 ± 0.058
2.034ThrGln: 2.034 ± 0.04
3.101ThrArg: 3.101 ± 0.046
3.785ThrSer: 3.785 ± 0.069
4.053ThrThr: 4.053 ± 0.111
4.142ThrVal: 4.142 ± 0.074
0.933ThrTrp: 0.933 ± 0.027
1.435ThrTyr: 1.435 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
6.638ValAla: 6.638 ± 0.078
0.683ValCys: 0.683 ± 0.023
3.739ValAsp: 3.739 ± 0.046
4.597ValGlu: 4.597 ± 0.071
2.852ValPhe: 2.852 ± 0.046
5.238ValGly: 5.238 ± 0.076
1.394ValHis: 1.394 ± 0.029
3.696ValIle: 3.696 ± 0.057
3.051ValLys: 3.051 ± 0.051
7.055ValLeu: 7.055 ± 0.077
1.761ValMet: 1.761 ± 0.033
2.464ValAsn: 2.464 ± 0.06
3.428ValPro: 3.428 ± 0.047
2.244ValGln: 2.244 ± 0.038
3.992ValArg: 3.992 ± 0.056
4.305ValSer: 4.305 ± 0.06
4.23ValThr: 4.23 ± 0.068
5.51ValVal: 5.51 ± 0.071
1.022ValTrp: 1.022 ± 0.028
1.57ValTyr: 1.57 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.086TrpAla: 1.086 ± 0.028
0.177TrpCys: 0.177 ± 0.011
0.804TrpAsp: 0.804 ± 0.024
0.878TrpGlu: 0.878 ± 0.028
0.664TrpPhe: 0.664 ± 0.021
0.955TrpGly: 0.955 ± 0.027
0.416TrpHis: 0.416 ± 0.015
0.815TrpIle: 0.815 ± 0.023
0.844TrpLys: 0.844 ± 0.027
1.953TrpLeu: 1.953 ± 0.043
0.555TrpMet: 0.555 ± 0.02
0.692TrpAsn: 0.692 ± 0.019
0.684TrpPro: 0.684 ± 0.023
0.819TrpGln: 0.819 ± 0.023
1.173TrpArg: 1.173 ± 0.033
1.016TrpSer: 1.016 ± 0.026
0.932TrpThr: 0.932 ± 0.027
1.003TrpVal: 1.003 ± 0.027
0.36TrpTrp: 0.36 ± 0.016
0.299TrpTyr: 0.299 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.081TyrAla: 2.081 ± 0.036
0.239TyrCys: 0.239 ± 0.012
1.382TyrAsp: 1.382 ± 0.032
1.432TyrGlu: 1.432 ± 0.028
1.135TyrPhe: 1.135 ± 0.029
1.959TyrGly: 1.959 ± 0.037
0.693TyrHis: 0.693 ± 0.019
0.895TyrIle: 0.895 ± 0.026
0.699TyrLys: 0.699 ± 0.023
2.575TyrLeu: 2.575 ± 0.04
0.385TyrMet: 0.385 ± 0.014
0.773TyrAsn: 0.773 ± 0.029
1.157TyrPro: 1.157 ± 0.029
1.078TyrGln: 1.078 ± 0.025
1.663TyrArg: 1.663 ± 0.034
1.372TyrSer: 1.372 ± 0.035
1.343TyrThr: 1.343 ± 0.033
1.494TyrVal: 1.494 ± 0.033
0.394TyrTrp: 0.394 ± 0.016
0.753TyrTyr: 0.753 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4729 proteins (1763432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski