Amino acid dipepetide frequency for Propioniferax innocua

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.314AlaAla: 15.314 ± 0.206	1.001AlaCys: 1.001 ± 0.033	7.992AlaAsp: 7.992 ± 0.105	8.684AlaGlu: 8.684 ± 0.121	3.307AlaPhe: 3.307 ± 0.073	10.377AlaGly: 10.377 ± 0.137	2.654AlaHis: 2.654 ± 0.051	4.831AlaIle: 4.831 ± 0.093	2.836AlaLys: 2.836 ± 0.07	11.604AlaLeu: 11.604 ± 0.15	3.292AlaMet: 3.292 ± 0.066	2.229AlaAsn: 2.229 ± 0.053	5.725AlaPro: 5.725 ± 0.11	3.762AlaGln: 3.762 ± 0.074	7.962AlaArg: 7.962 ± 0.132	6.594AlaSer: 6.594 ± 0.097	6.663AlaThr: 6.663 ± 0.096	9.598AlaVal: 9.598 ± 0.133	1.798AlaTrp: 1.798 ± 0.053	1.941AlaTyr: 1.941 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.949CysAla: 0.949 ± 0.035	0.117CysCys: 0.117 ± 0.017	0.564CysAsp: 0.564 ± 0.026	0.487CysGlu: 0.487 ± 0.029	0.284CysPhe: 0.284 ± 0.02	0.945CysGly: 0.945 ± 0.034	0.208CysHis: 0.208 ± 0.015	0.334CysIle: 0.334 ± 0.019	0.104CysLys: 0.104 ± 0.01	0.684CysLeu: 0.684 ± 0.03	0.166CysMet: 0.166 ± 0.014	0.179CysAsn: 0.179 ± 0.012	0.505CysPro: 0.505 ± 0.029	0.242CysGln: 0.242 ± 0.02	0.616CysArg: 0.616 ± 0.027	0.52CysSer: 0.52 ± 0.025	0.519CysThr: 0.519 ± 0.027	0.667CysVal: 0.667 ± 0.03	0.109CysTrp: 0.109 ± 0.01	0.146CysTyr: 0.146 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.765AspAla: 8.765 ± 0.131	0.376AspCys: 0.376 ± 0.024	4.507AspAsp: 4.507 ± 0.105	4.893AspGlu: 4.893 ± 0.094	1.788AspPhe: 1.788 ± 0.048	5.709AspGly: 5.709 ± 0.105	1.649AspHis: 1.649 ± 0.054	2.472AspIle: 2.472 ± 0.057	1.213AspLys: 1.213 ± 0.046	6.477AspLeu: 6.477 ± 0.083	1.165AspMet: 1.165 ± 0.045	0.988AspAsn: 0.988 ± 0.032	4.521AspPro: 4.521 ± 0.091	1.948AspGln: 1.948 ± 0.053	4.292AspArg: 4.292 ± 0.083	2.747AspSer: 2.747 ± 0.069	2.988AspThr: 2.988 ± 0.061	5.493AspVal: 5.493 ± 0.088	0.848AspTrp: 0.848 ± 0.036	1.069AspTyr: 1.069 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.45GluAla: 7.45 ± 0.113	0.461GluCys: 0.461 ± 0.025	3.241GluAsp: 3.241 ± 0.075	3.721GluGlu: 3.721 ± 0.082	1.96GluPhe: 1.96 ± 0.043	4.794GluGly: 4.794 ± 0.092	1.833GluHis: 1.833 ± 0.049	2.97GluIle: 2.97 ± 0.067	1.847GluLys: 1.847 ± 0.062	6.552GluLeu: 6.552 ± 0.09	1.447GluMet: 1.447 ± 0.041	1.594GluAsn: 1.594 ± 0.044	3.983GluPro: 3.983 ± 0.106	2.733GluGln: 2.733 ± 0.062	5.264GluArg: 5.264 ± 0.099	3.245GluSer: 3.245 ± 0.062	3.302GluThr: 3.302 ± 0.073	5.197GluVal: 5.197 ± 0.083	0.979GluTrp: 0.979 ± 0.034	1.172GluTyr: 1.172 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.635PheAla: 3.635 ± 0.081	0.338PheCys: 0.338 ± 0.02	2.273PheAsp: 2.273 ± 0.047	1.784PheGlu: 1.784 ± 0.045	0.996PhePhe: 0.996 ± 0.043	3.384PheGly: 3.384 ± 0.086	0.705PheHis: 0.705 ± 0.029	1.262PheIle: 1.262 ± 0.049	0.524PheLys: 0.524 ± 0.029	2.662PheLeu: 2.662 ± 0.064	0.584PheMet: 0.584 ± 0.028	0.733PheAsn: 0.733 ± 0.032	1.342PhePro: 1.342 ± 0.038	0.781PheGln: 0.781 ± 0.03	1.698PheArg: 1.698 ± 0.047	1.613PheSer: 1.613 ± 0.047	2.151PheThr: 2.151 ± 0.046	2.524PheVal: 2.524 ± 0.063	0.5PheTrp: 0.5 ± 0.026	0.53PheTyr: 0.53 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.264GlyAla: 9.264 ± 0.128	0.853GlyCys: 0.853 ± 0.037	5.188GlyAsp: 5.188 ± 0.086	5.47GlyGlu: 5.47 ± 0.103	3.19GlyPhe: 3.19 ± 0.078	7.748GlyGly: 7.748 ± 0.125	2.116GlyHis: 2.116 ± 0.051	4.239GlyIle: 4.239 ± 0.085	2.344GlyLys: 2.344 ± 0.06	8.88GlyLeu: 8.88 ± 0.125	2.411GlyMet: 2.411 ± 0.059	1.919GlyAsn: 1.919 ± 0.052	4.419GlyPro: 4.419 ± 0.09	2.992GlyGln: 2.992 ± 0.071	6.566GlyArg: 6.566 ± 0.083	5.277GlySer: 5.277 ± 0.094	5.376GlyThr: 5.376 ± 0.087	7.914GlyVal: 7.914 ± 0.109	1.75GlyTrp: 1.75 ± 0.055	2.027GlyTyr: 2.027 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.62HisAla: 2.62 ± 0.055	0.219HisCys: 0.219 ± 0.017	1.689HisAsp: 1.689 ± 0.054	1.43HisGlu: 1.43 ± 0.042	0.655HisPhe: 0.655 ± 0.027	2.296HisGly: 2.296 ± 0.057	0.759HisHis: 0.759 ± 0.035	0.93HisIle: 0.93 ± 0.032	0.38HisLys: 0.38 ± 0.021	2.423HisLeu: 2.423 ± 0.054	0.46HisMet: 0.46 ± 0.022	0.485HisAsn: 0.485 ± 0.023	1.605HisPro: 1.605 ± 0.05	0.727HisGln: 0.727 ± 0.031	1.98HisArg: 1.98 ± 0.06	1.068HisSer: 1.068 ± 0.04	1.296HisThr: 1.296 ± 0.043	2.056HisVal: 2.056 ± 0.052	0.347HisTrp: 0.347 ± 0.021	0.492HisTyr: 0.492 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.806IleAla: 5.806 ± 0.103	0.477IleCys: 0.477 ± 0.022	3.497IleAsp: 3.497 ± 0.063	2.929IleGlu: 2.929 ± 0.068	1.096IlePhe: 1.096 ± 0.037	4.535IleGly: 4.535 ± 0.088	0.919IleHis: 0.919 ± 0.035	1.94IleIle: 1.94 ± 0.063	0.926IleLys: 0.926 ± 0.037	3.363IleLeu: 3.363 ± 0.075	0.885IleMet: 0.885 ± 0.038	1.07IleAsn: 1.07 ± 0.039	2.258IlePro: 2.258 ± 0.048	0.987IleGln: 0.987 ± 0.035	2.55IleArg: 2.55 ± 0.056	2.418IleSer: 2.418 ± 0.061	2.988IleThr: 2.988 ± 0.071	3.847IleVal: 3.847 ± 0.074	0.493IleTrp: 0.493 ± 0.028	0.749IleTyr: 0.749 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.553LysAla: 2.553 ± 0.072	0.136LysCys: 0.136 ± 0.013	1.345LysAsp: 1.345 ± 0.048	1.239LysGlu: 1.239 ± 0.05	0.553LysPhe: 0.553 ± 0.024	1.798LysGly: 1.798 ± 0.053	0.556LysHis: 0.556 ± 0.027	1.057LysIle: 1.057 ± 0.039	0.977LysLys: 0.977 ± 0.058	1.918LysLeu: 1.918 ± 0.052	0.544LysMet: 0.544 ± 0.029	0.625LysAsn: 0.625 ± 0.028	1.434LysPro: 1.434 ± 0.059	0.884LysGln: 0.884 ± 0.038	1.665LysArg: 1.665 ± 0.048	1.303LysSer: 1.303 ± 0.042	1.323LysThr: 1.323 ± 0.046	2.089LysVal: 2.089 ± 0.06	0.269LysTrp: 0.269 ± 0.018	0.485LysTyr: 0.485 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.458LeuAla: 12.458 ± 0.163	0.756LeuCys: 0.756 ± 0.033	6.49LeuAsp: 6.49 ± 0.088	5.41LeuGlu: 5.41 ± 0.095	2.596LeuPhe: 2.596 ± 0.071	8.967LeuGly: 8.967 ± 0.133	2.136LeuHis: 2.136 ± 0.057	4.091LeuIle: 4.091 ± 0.088	1.9LeuLys: 1.9 ± 0.047	9.025LeuLeu: 9.025 ± 0.162	2.276LeuMet: 2.276 ± 0.056	1.846LeuAsn: 1.846 ± 0.05	5.334LeuPro: 5.334 ± 0.082	2.636LeuGln: 2.636 ± 0.065	6.815LeuArg: 6.815 ± 0.102	4.817LeuSer: 4.817 ± 0.073	6.442LeuThr: 6.442 ± 0.09	8.46LeuVal: 8.46 ± 0.114	1.29LeuTrp: 1.29 ± 0.045	1.446LeuTyr: 1.446 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.79MetAla: 2.79 ± 0.057	0.176MetCys: 0.176 ± 0.014	1.167MetAsp: 1.167 ± 0.037	1.158MetGlu: 1.158 ± 0.037	0.723MetPhe: 0.723 ± 0.034	2.096MetGly: 2.096 ± 0.05	0.478MetHis: 0.478 ± 0.02	1.102MetIle: 1.102 ± 0.036	0.595MetLys: 0.595 ± 0.027	2.174MetLeu: 2.174 ± 0.054	0.538MetMet: 0.538 ± 0.026	0.674MetAsn: 0.674 ± 0.031	1.461MetPro: 1.461 ± 0.051	0.696MetGln: 0.696 ± 0.031	1.612MetArg: 1.612 ± 0.047	1.657MetSer: 1.657 ± 0.041	1.874MetThr: 1.874 ± 0.042	2.079MetVal: 2.079 ± 0.051	0.306MetTrp: 0.306 ± 0.018	0.409MetTyr: 0.409 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.482AsnAla: 2.482 ± 0.06	0.179AsnCys: 0.179 ± 0.013	1.319AsnAsp: 1.319 ± 0.044	1.28AsnGlu: 1.28 ± 0.042	0.607AsnPhe: 0.607 ± 0.028	1.984AsnGly: 1.984 ± 0.05	0.57AsnHis: 0.57 ± 0.029	0.952AsnIle: 0.952 ± 0.036	0.49AsnLys: 0.49 ± 0.024	2.024AsnLeu: 2.024 ± 0.047	0.468AsnMet: 0.468 ± 0.024	0.535AsnAsn: 0.535 ± 0.032	1.765AsnPro: 1.765 ± 0.055	0.697AsnGln: 0.697 ± 0.032	1.548AsnArg: 1.548 ± 0.051	1.034AsnSer: 1.034 ± 0.039	1.28AsnThr: 1.28 ± 0.042	1.611AsnVal: 1.611 ± 0.053	0.288AsnTrp: 0.288 ± 0.018	0.424AsnTyr: 0.424 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.972ProAla: 5.972 ± 0.106	0.322ProCys: 0.322 ± 0.022	4.273ProAsp: 4.273 ± 0.097	4.985ProGlu: 4.985 ± 0.106	1.512ProPhe: 1.512 ± 0.045	5.596ProGly: 5.596 ± 0.121	1.374ProHis: 1.374 ± 0.043	2.097ProIle: 2.097 ± 0.055	1.363ProLys: 1.363 ± 0.049	4.62ProLeu: 4.62 ± 0.072	1.289ProMet: 1.289 ± 0.036	1.224ProAsn: 1.224 ± 0.036	2.648ProPro: 2.648 ± 0.093	1.907ProGln: 1.907 ± 0.058	3.452ProArg: 3.452 ± 0.078	3.341ProSer: 3.341 ± 0.091	3.899ProThr: 3.899 ± 0.134	4.919ProVal: 4.919 ± 0.084	1.014ProTrp: 1.014 ± 0.041	1.001ProTyr: 1.001 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.708GlnAla: 3.708 ± 0.084	0.211GlnCys: 0.211 ± 0.016	1.404GlnAsp: 1.404 ± 0.052	1.744GlnGlu: 1.744 ± 0.043	0.82GlnPhe: 0.82 ± 0.035	2.43GlnGly: 2.43 ± 0.062	0.792GlnHis: 0.792 ± 0.032	1.611GlnIle: 1.611 ± 0.045	0.761GlnLys: 0.761 ± 0.038	2.903GlnLeu: 2.903 ± 0.068	0.826GlnMet: 0.826 ± 0.029	0.781GlnAsn: 0.781 ± 0.034	1.938GlnPro: 1.938 ± 0.07	1.579GlnGln: 1.579 ± 0.075	2.676GlnArg: 2.676 ± 0.062	1.476GlnSer: 1.476 ± 0.04	1.678GlnThr: 1.678 ± 0.045	2.869GlnVal: 2.869 ± 0.065	0.566GlnTrp: 0.566 ± 0.028	0.714GlnTyr: 0.714 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.63ArgAla: 7.63 ± 0.114	0.649ArgCys: 0.649 ± 0.03	3.95ArgAsp: 3.95 ± 0.067	4.425ArgGlu: 4.425 ± 0.078	2.399ArgPhe: 2.399 ± 0.055	5.394ArgGly: 5.394 ± 0.095	1.885ArgHis: 1.885 ± 0.052	3.553ArgIle: 3.553 ± 0.067	1.536ArgLys: 1.536 ± 0.048	7.111ArgLeu: 7.111 ± 0.111	1.918ArgMet: 1.918 ± 0.047	1.538ArgAsn: 1.538 ± 0.046	3.874ArgPro: 3.874 ± 0.07	2.194ArgGln: 2.194 ± 0.056	6.869ArgArg: 6.869 ± 0.127	3.952ArgSer: 3.952 ± 0.069	4.08ArgThr: 4.08 ± 0.07	5.745ArgVal: 5.745 ± 0.089	1.274ArgTrp: 1.274 ± 0.04	1.38ArgTyr: 1.38 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.145SerAla: 6.145 ± 0.093	0.456SerCys: 0.456 ± 0.024	3.383SerAsp: 3.383 ± 0.071	3.131SerGlu: 3.131 ± 0.074	1.738SerPhe: 1.738 ± 0.05	5.839SerGly: 5.839 ± 0.09	1.168SerHis: 1.168 ± 0.037	2.242SerIle: 2.242 ± 0.054	1.228SerLys: 1.228 ± 0.043	4.887SerLeu: 4.887 ± 0.084	1.47SerMet: 1.47 ± 0.046	1.186SerAsn: 1.186 ± 0.038	3.066SerPro: 3.066 ± 0.066	1.565SerGln: 1.565 ± 0.051	3.551SerArg: 3.551 ± 0.059	3.282SerSer: 3.282 ± 0.075	3.528SerThr: 3.528 ± 0.066	4.637SerVal: 4.637 ± 0.08	0.898SerTrp: 0.898 ± 0.033	1.022SerTyr: 1.022 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.673ThrAla: 6.673 ± 0.088	0.55ThrCys: 0.55 ± 0.032	3.828ThrAsp: 3.828 ± 0.066	3.684ThrGlu: 3.684 ± 0.077	1.948ThrPhe: 1.948 ± 0.061	5.826ThrGly: 5.826 ± 0.092	1.398ThrHis: 1.398 ± 0.038	2.698ThrIle: 2.698 ± 0.06	1.332ThrLys: 1.332 ± 0.042	5.657ThrLeu: 5.657 ± 0.086	1.311ThrMet: 1.311 ± 0.038	1.292ThrAsn: 1.292 ± 0.05	4.443ThrPro: 4.443 ± 0.132	1.716ThrGln: 1.716 ± 0.049	3.803ThrArg: 3.803 ± 0.075	3.491ThrSer: 3.491 ± 0.063	3.855ThrThr: 3.855 ± 0.085	5.255ThrVal: 5.255 ± 0.095	1.051ThrTrp: 1.051 ± 0.033	1.169ThrTyr: 1.169 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.275ValAla: 10.275 ± 0.123	0.735ValCys: 0.735 ± 0.03	5.903ValAsp: 5.903 ± 0.097	5.431ValGlu: 5.431 ± 0.082	2.537ValPhe: 2.537 ± 0.066	7.229ValGly: 7.229 ± 0.098	1.925ValHis: 1.925 ± 0.047	4.059ValIle: 4.059 ± 0.08	1.692ValLys: 1.692 ± 0.053	8.534ValLeu: 8.534 ± 0.125	1.973ValMet: 1.973 ± 0.05	1.849ValAsn: 1.849 ± 0.048	4.66ValPro: 4.66 ± 0.078	2.338ValGln: 2.338 ± 0.057	5.722ValArg: 5.722 ± 0.086	4.645ValSer: 4.645 ± 0.083	5.751ValThr: 5.751 ± 0.097	8.35ValVal: 8.35 ± 0.117	1.211ValTrp: 1.211 ± 0.041	1.271ValTyr: 1.271 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.71TrpAla: 1.71 ± 0.047	0.16TrpCys: 0.16 ± 0.014	0.732TrpAsp: 0.732 ± 0.027	0.76TrpGlu: 0.76 ± 0.035	0.662TrpPhe: 0.662 ± 0.03	1.178TrpGly: 1.178 ± 0.041	0.38TrpHis: 0.38 ± 0.023	0.679TrpIle: 0.679 ± 0.028	0.336TrpLys: 0.336 ± 0.019	1.816TrpLeu: 1.816 ± 0.06	0.406TrpMet: 0.406 ± 0.023	0.428TrpAsn: 0.428 ± 0.026	0.774TrpPro: 0.774 ± 0.035	0.569TrpGln: 0.569 ± 0.027	1.279TrpArg: 1.279 ± 0.043	0.974TrpSer: 0.974 ± 0.032	0.91TrpThr: 0.91 ± 0.034	1.276TrpVal: 1.276 ± 0.038	0.394TrpTrp: 0.394 ± 0.025	0.273TrpTyr: 0.273 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.966TyrAla: 1.966 ± 0.052	0.173TyrCys: 0.173 ± 0.013	1.165TyrAsp: 1.165 ± 0.035	1.1TyrGlu: 1.1 ± 0.039	0.647TyrPhe: 0.647 ± 0.028	1.816TyrGly: 1.816 ± 0.056	0.414TyrHis: 0.414 ± 0.024	0.614TyrIle: 0.614 ± 0.031	0.368TyrLys: 0.368 ± 0.019	1.878TyrLeu: 1.878 ± 0.049	0.333TyrMet: 0.333 ± 0.023	0.362TyrAsn: 0.362 ± 0.024	1.051TyrPro: 1.051 ± 0.04	0.536TyrGln: 0.536 ± 0.025	1.435TyrArg: 1.435 ± 0.05	0.968TyrSer: 0.968 ± 0.035	1.08TyrThr: 1.08 ± 0.036	1.507TyrVal: 1.507 ± 0.049	0.308TyrTrp: 0.308 ± 0.021	0.413TyrTyr: 0.413 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2528 proteins (847396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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