Amino acid dipepetide frequency for Xenorhabdus cabanillasii JM26

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.197AlaAla: 7.197 ± 0.109	0.93AlaCys: 0.93 ± 0.027	4.272AlaAsp: 4.272 ± 0.057	5.546AlaGlu: 5.546 ± 0.087	3.078AlaPhe: 3.078 ± 0.057	6.259AlaGly: 6.259 ± 0.096	1.555AlaHis: 1.555 ± 0.038	5.722AlaIle: 5.722 ± 0.084	4.114AlaLys: 4.114 ± 0.074	9.141AlaLeu: 9.141 ± 0.115	2.232AlaMet: 2.232 ± 0.043	3.187AlaAsn: 3.187 ± 0.055	2.717AlaPro: 2.717 ± 0.046	3.45AlaGln: 3.45 ± 0.063	4.081AlaArg: 4.081 ± 0.069	4.574AlaSer: 4.574 ± 0.069	4.006AlaThr: 4.006 ± 0.059	5.496AlaVal: 5.496 ± 0.077	0.968AlaTrp: 0.968 ± 0.029	2.287AlaTyr: 2.287 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.815CysAla: 0.815 ± 0.028	0.191CysCys: 0.191 ± 0.014	0.618CysAsp: 0.618 ± 0.021	0.615CysGlu: 0.615 ± 0.023	0.487CysPhe: 0.487 ± 0.019	0.942CysGly: 0.942 ± 0.032	0.413CysHis: 0.413 ± 0.019	0.67CysIle: 0.67 ± 0.024	0.414CysLys: 0.414 ± 0.022	1.076CysLeu: 1.076 ± 0.033	0.22CysMet: 0.22 ± 0.013	0.411CysAsn: 0.411 ± 0.019	0.484CysPro: 0.484 ± 0.02	0.6CysGln: 0.6 ± 0.024	0.605CysArg: 0.605 ± 0.024	0.731CysSer: 0.731 ± 0.027	0.514CysThr: 0.514 ± 0.019	0.657CysVal: 0.657 ± 0.024	0.193CysTrp: 0.193 ± 0.012	0.44CysTyr: 0.44 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.062AspAla: 4.062 ± 0.061	0.593AspCys: 0.593 ± 0.023	2.659AspAsp: 2.659 ± 0.049	3.529AspGlu: 3.529 ± 0.058	2.231AspPhe: 2.231 ± 0.041	3.597AspGly: 3.597 ± 0.071	1.009AspHis: 1.009 ± 0.032	4.378AspIle: 4.378 ± 0.056	3.111AspLys: 3.111 ± 0.058	4.788AspLeu: 4.788 ± 0.066	1.339AspMet: 1.339 ± 0.034	2.661AspAsn: 2.661 ± 0.055	2.096AspPro: 2.096 ± 0.039	1.685AspGln: 1.685 ± 0.039	2.353AspArg: 2.353 ± 0.051	3.023AspSer: 3.023 ± 0.043	2.661AspThr: 2.661 ± 0.05	3.294AspVal: 3.294 ± 0.064	0.838AspTrp: 0.838 ± 0.027	1.959AspTyr: 1.959 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.523GluAla: 4.523 ± 0.068	0.621GluCys: 0.621 ± 0.021	2.446GluAsp: 2.446 ± 0.05	3.637GluGlu: 3.637 ± 0.07	2.108GluPhe: 2.108 ± 0.046	3.301GluGly: 3.301 ± 0.064	1.582GluHis: 1.582 ± 0.037	4.321GluIle: 4.321 ± 0.057	4.292GluLys: 4.292 ± 0.072	6.629GluLeu: 6.629 ± 0.081	1.678GluMet: 1.678 ± 0.04	3.05GluAsn: 3.05 ± 0.051	2.08GluPro: 2.08 ± 0.043	3.885GluGln: 3.885 ± 0.069	3.697GluArg: 3.697 ± 0.067	3.368GluSer: 3.368 ± 0.048	3.107GluThr: 3.107 ± 0.05	3.477GluVal: 3.477 ± 0.065	0.844GluTrp: 0.844 ± 0.024	1.818GluTyr: 1.818 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.955PheAla: 2.955 ± 0.054	0.587PheCys: 0.587 ± 0.023	2.494PheAsp: 2.494 ± 0.051	2.018PheGlu: 2.018 ± 0.05	1.765PhePhe: 1.765 ± 0.048	2.925PheGly: 2.925 ± 0.055	0.863PheHis: 0.863 ± 0.027	2.948PheIle: 2.948 ± 0.056	1.65PheLys: 1.65 ± 0.04	3.418PheLeu: 3.418 ± 0.063	1.025PheMet: 1.025 ± 0.033	2.064PheAsn: 2.064 ± 0.041	1.559PhePro: 1.559 ± 0.035	1.246PheGln: 1.246 ± 0.033	1.874PheArg: 1.874 ± 0.047	3.398PheSer: 3.398 ± 0.061	2.305PheThr: 2.305 ± 0.044	2.442PheVal: 2.442 ± 0.056	0.587PheTrp: 0.587 ± 0.024	1.427PheTyr: 1.427 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.994GlyAla: 4.994 ± 0.082	0.885GlyCys: 0.885 ± 0.034	3.419GlyAsp: 3.419 ± 0.076	4.186GlyGlu: 4.186 ± 0.062	2.944GlyPhe: 2.944 ± 0.055	4.845GlyGly: 4.845 ± 0.089	1.618GlyHis: 1.618 ± 0.039	5.347GlyIle: 5.347 ± 0.071	4.441GlyLys: 4.441 ± 0.071	6.5GlyLeu: 6.5 ± 0.085	2.013GlyMet: 2.013 ± 0.041	2.997GlyAsn: 2.997 ± 0.068	1.599GlyPro: 1.599 ± 0.035	2.83GlyGln: 2.83 ± 0.062	3.566GlyArg: 3.566 ± 0.056	3.959GlySer: 3.959 ± 0.061	3.585GlyThr: 3.585 ± 0.059	4.766GlyVal: 4.766 ± 0.077	1.077GlyTrp: 1.077 ± 0.035	2.741GlyTyr: 2.741 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.649HisAla: 1.649 ± 0.039	0.385HisCys: 0.385 ± 0.019	1.155HisAsp: 1.155 ± 0.029	1.171HisGlu: 1.171 ± 0.033	1.087HisPhe: 1.087 ± 0.028	1.612HisGly: 1.612 ± 0.04	0.797HisHis: 0.797 ± 0.034	1.618HisIle: 1.618 ± 0.035	0.99HisLys: 0.99 ± 0.032	2.375HisLeu: 2.375 ± 0.047	0.524HisMet: 0.524 ± 0.02	0.981HisAsn: 0.981 ± 0.032	1.216HisPro: 1.216 ± 0.033	1.293HisGln: 1.293 ± 0.037	1.245HisArg: 1.245 ± 0.034	1.515HisSer: 1.515 ± 0.036	1.122HisThr: 1.122 ± 0.031	1.263HisVal: 1.263 ± 0.035	0.419HisTrp: 0.419 ± 0.019	1.011HisTyr: 1.011 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.212IleAla: 6.212 ± 0.083	0.818IleCys: 0.818 ± 0.028	3.937IleAsp: 3.937 ± 0.059	4.259IleGlu: 4.259 ± 0.064	2.544IlePhe: 2.544 ± 0.052	4.831IleGly: 4.831 ± 0.076	1.434IleHis: 1.434 ± 0.034	4.489IleIle: 4.489 ± 0.084	3.601IleLys: 3.601 ± 0.062	6.141IleLeu: 6.141 ± 0.087	1.489IleMet: 1.489 ± 0.04	3.605IleAsn: 3.605 ± 0.059	3.19IlePro: 3.19 ± 0.059	2.576IleGln: 2.576 ± 0.043	3.589IleArg: 3.589 ± 0.062	5.038IleSer: 5.038 ± 0.06	4.252IleThr: 4.252 ± 0.066	4.031IleVal: 4.031 ± 0.063	0.803IleTrp: 0.803 ± 0.026	2.11IleTyr: 2.11 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.317LysAla: 4.317 ± 0.064	0.369LysCys: 0.369 ± 0.019	2.51LysAsp: 2.51 ± 0.046	3.302LysGlu: 3.302 ± 0.063	1.539LysPhe: 1.539 ± 0.039	3.345LysGly: 3.345 ± 0.065	1.108LysHis: 1.108 ± 0.029	3.638LysIle: 3.638 ± 0.061	3.334LysLys: 3.334 ± 0.065	5.358LysLeu: 5.358 ± 0.067	1.451LysMet: 1.451 ± 0.037	2.849LysAsn: 2.849 ± 0.059	2.266LysPro: 2.266 ± 0.044	2.722LysGln: 2.722 ± 0.052	2.821LysArg: 2.821 ± 0.05	3.193LysSer: 3.193 ± 0.051	3.082LysThr: 3.082 ± 0.052	3.254LysVal: 3.254 ± 0.051	0.578LysTrp: 0.578 ± 0.024	1.539LysTyr: 1.539 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	9.214LeuAla: 9.214 ± 0.106	1.194LeuCys: 1.194 ± 0.033	5.444LeuAsp: 5.444 ± 0.076	5.721LeuGlu: 5.721 ± 0.08	4.297LeuPhe: 4.297 ± 0.072	6.503LeuGly: 6.503 ± 0.087	2.258LeuHis: 2.258 ± 0.048	6.59LeuIle: 6.59 ± 0.094	5.243LeuLys: 5.243 ± 0.073	10.934LeuLeu: 10.934 ± 0.16	2.634LeuMet: 2.634 ± 0.047	4.811LeuAsn: 4.811 ± 0.069	5.368LeuPro: 5.368 ± 0.081	4.257LeuGln: 4.257 ± 0.071	5.408LeuArg: 5.408 ± 0.074	8.124LeuSer: 8.124 ± 0.089	6.162LeuThr: 6.162 ± 0.096	6.168LeuVal: 6.168 ± 0.087	1.196LeuTrp: 1.196 ± 0.034	2.833LeuTyr: 2.833 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.403MetAla: 2.403 ± 0.046	0.203MetCys: 0.203 ± 0.011	1.179MetAsp: 1.179 ± 0.027	1.36MetGlu: 1.36 ± 0.03	0.874MetPhe: 0.874 ± 0.026	1.705MetGly: 1.705 ± 0.042	0.42MetHis: 0.42 ± 0.018	1.609MetIle: 1.609 ± 0.039	1.503MetLys: 1.503 ± 0.036	2.786MetLeu: 2.786 ± 0.049	0.805MetMet: 0.805 ± 0.029	1.193MetAsn: 1.193 ± 0.032	1.245MetPro: 1.245 ± 0.03	1.093MetGln: 1.093 ± 0.033	1.295MetArg: 1.295 ± 0.034	1.8MetSer: 1.8 ± 0.04	1.631MetThr: 1.631 ± 0.033	1.624MetVal: 1.624 ± 0.035	0.217MetTrp: 0.217 ± 0.014	0.567MetTyr: 0.567 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.31AsnAla: 3.31 ± 0.057	0.464AsnCys: 0.464 ± 0.021	2.315AsnAsp: 2.315 ± 0.048	2.53AsnGlu: 2.53 ± 0.041	1.581AsnPhe: 1.581 ± 0.038	3.248AsnGly: 3.248 ± 0.062	1.097AsnHis: 1.097 ± 0.03	3.514AsnIle: 3.514 ± 0.064	2.584AsnLys: 2.584 ± 0.046	4.176AsnLeu: 4.176 ± 0.056	1.129AsnMet: 1.129 ± 0.035	2.441AsnAsn: 2.441 ± 0.047	2.178AsnPro: 2.178 ± 0.046	2.184AsnGln: 2.184 ± 0.054	2.397AsnArg: 2.397 ± 0.04	2.8AsnSer: 2.8 ± 0.045	2.494AsnThr: 2.494 ± 0.052	2.633AsnVal: 2.633 ± 0.054	0.577AsnTrp: 0.577 ± 0.024	1.634AsnTyr: 1.634 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.559ProAla: 3.559 ± 0.06	0.372ProCys: 0.372 ± 0.018	2.864ProAsp: 2.864 ± 0.053	3.567ProGlu: 3.567 ± 0.055	1.828ProPhe: 1.828 ± 0.042	2.513ProGly: 2.513 ± 0.044	0.996ProHis: 0.996 ± 0.031	2.551ProIle: 2.551 ± 0.046	1.883ProLys: 1.883 ± 0.039	4.549ProLeu: 4.549 ± 0.069	0.977ProMet: 0.977 ± 0.028	1.708ProAsn: 1.708 ± 0.037	1.482ProPro: 1.482 ± 0.037	1.774ProGln: 1.774 ± 0.048	1.626ProArg: 1.626 ± 0.038	2.307ProSer: 2.307 ± 0.044	2.079ProThr: 2.079 ± 0.05	3.475ProVal: 3.475 ± 0.06	0.54ProTrp: 0.54 ± 0.02	1.311ProTyr: 1.311 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.019GlnAla: 4.019 ± 0.064	0.464GlnCys: 0.464 ± 0.021	1.953GlnAsp: 1.953 ± 0.04	2.581GlnGlu: 2.581 ± 0.056	1.715GlnPhe: 1.715 ± 0.036	2.992GlnGly: 2.992 ± 0.062	1.272GlnHis: 1.272 ± 0.038	2.893GlnIle: 2.893 ± 0.055	2.383GlnLys: 2.383 ± 0.046	5.225GlnLeu: 5.225 ± 0.09	1.027GlnMet: 1.027 ± 0.028	1.813GlnAsn: 1.813 ± 0.037	2.076GlnPro: 2.076 ± 0.044	3.422GlnGln: 3.422 ± 0.083	2.763GlnArg: 2.763 ± 0.057	2.748GlnSer: 2.748 ± 0.051	2.232GlnThr: 2.232 ± 0.048	2.932GlnVal: 2.932 ± 0.051	0.736GlnTrp: 0.736 ± 0.025	1.462GlnTyr: 1.462 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.604ArgAla: 3.604 ± 0.058	0.557ArgCys: 0.557 ± 0.022	2.626ArgAsp: 2.626 ± 0.048	3.406ArgGlu: 3.406 ± 0.066	2.388ArgPhe: 2.388 ± 0.044	3.033ArgGly: 3.033 ± 0.052	1.539ArgHis: 1.539 ± 0.037	3.628ArgIle: 3.628 ± 0.061	2.696ArgLys: 2.696 ± 0.053	5.82ArgLeu: 5.82 ± 0.075	1.379ArgMet: 1.379 ± 0.034	2.293ArgAsn: 2.293 ± 0.048	1.996ArgPro: 1.996 ± 0.043	3.007ArgGln: 3.007 ± 0.055	2.972ArgArg: 2.972 ± 0.062	2.803ArgSer: 2.803 ± 0.046	2.442ArgThr: 2.442 ± 0.047	3.111ArgVal: 3.111 ± 0.056	0.805ArgTrp: 0.805 ± 0.031	2.13ArgTyr: 2.13 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.105SerAla: 5.105 ± 0.074	0.667SerCys: 0.667 ± 0.024	3.357SerAsp: 3.357 ± 0.053	3.794SerGlu: 3.794 ± 0.06	2.611SerPhe: 2.611 ± 0.046	5.21SerGly: 5.21 ± 0.077	1.566SerHis: 1.566 ± 0.035	4.101SerIle: 4.101 ± 0.055	2.876SerLys: 2.876 ± 0.051	7.065SerLeu: 7.065 ± 0.09	1.54SerMet: 1.54 ± 0.034	2.535SerAsn: 2.535 ± 0.05	2.749SerPro: 2.749 ± 0.051	3.041SerGln: 3.041 ± 0.058	3.321SerArg: 3.321 ± 0.06	4.109SerSer: 4.109 ± 0.066	3.175SerThr: 3.175 ± 0.049	4.336SerVal: 4.336 ± 0.066	0.899SerTrp: 0.899 ± 0.03	2.102SerTyr: 2.102 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.429ThrAla: 4.429 ± 0.056	0.509ThrCys: 0.509 ± 0.019	2.871ThrAsp: 2.871 ± 0.05	3.307ThrGlu: 3.307 ± 0.056	1.965ThrPhe: 1.965 ± 0.042	4.284ThrGly: 4.284 ± 0.069	1.283ThrHis: 1.283 ± 0.034	3.484ThrIle: 3.484 ± 0.058	2.217ThrLys: 2.217 ± 0.045	6.508ThrLeu: 6.508 ± 0.088	1.069ThrMet: 1.069 ± 0.034	1.983ThrAsn: 1.983 ± 0.039	2.921ThrPro: 2.921 ± 0.05	2.37ThrGln: 2.37 ± 0.044	2.575ThrArg: 2.575 ± 0.047	3.164ThrSer: 3.164 ± 0.056	2.875ThrThr: 2.875 ± 0.063	3.707ThrVal: 3.707 ± 0.057	0.619ThrTrp: 0.619 ± 0.024	1.521ThrTyr: 1.521 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.327ValAla: 5.327 ± 0.077	0.705ValCys: 0.705 ± 0.026	3.408ValAsp: 3.408 ± 0.055	3.777ValGlu: 3.777 ± 0.07	2.544ValPhe: 2.544 ± 0.047	4.131ValGly: 4.131 ± 0.063	1.245ValHis: 1.245 ± 0.032	4.734ValIle: 4.734 ± 0.063	3.271ValLys: 3.271 ± 0.054	6.32ValLeu: 6.32 ± 0.078	1.913ValMet: 1.913 ± 0.047	2.917ValAsn: 2.917 ± 0.063	2.589ValPro: 2.589 ± 0.049	2.235ValGln: 2.235 ± 0.043	3.123ValArg: 3.123 ± 0.051	4.518ValSer: 4.518 ± 0.062	3.841ValThr: 3.841 ± 0.061	4.338ValVal: 4.338 ± 0.068	0.771ValTrp: 0.771 ± 0.025	1.834ValTyr: 1.834 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.832TrpAla: 0.832 ± 0.026	0.163TrpCys: 0.163 ± 0.01	0.615TrpAsp: 0.615 ± 0.024	0.658TrpGlu: 0.658 ± 0.024	0.581TrpPhe: 0.581 ± 0.026	0.802TrpGly: 0.802 ± 0.028	0.398TrpHis: 0.398 ± 0.019	0.742TrpIle: 0.742 ± 0.021	0.612TrpLys: 0.612 ± 0.023	1.963TrpLeu: 1.963 ± 0.042	0.355TrpMet: 0.355 ± 0.018	0.509TrpAsn: 0.509 ± 0.02	0.555TrpPro: 0.555 ± 0.022	1.08TrpGln: 1.08 ± 0.03	0.83TrpArg: 0.83 ± 0.025	0.835TrpSer: 0.835 ± 0.029	0.446TrpThr: 0.446 ± 0.019	0.831TrpVal: 0.831 ± 0.032	0.194TrpTrp: 0.194 ± 0.013	0.36TrpTyr: 0.36 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.285TyrAla: 2.285 ± 0.043	0.415TyrCys: 0.415 ± 0.019	1.727TyrAsp: 1.727 ± 0.048	1.499TyrGlu: 1.499 ± 0.035	1.387TyrPhe: 1.387 ± 0.034	2.235TyrGly: 2.235 ± 0.047	0.975TyrHis: 0.975 ± 0.03	1.97TyrIle: 1.97 ± 0.041	1.361TyrLys: 1.361 ± 0.033	3.583TyrLeu: 3.583 ± 0.059	0.713TyrMet: 0.713 ± 0.023	1.278TyrAsn: 1.278 ± 0.036	1.594TyrPro: 1.594 ± 0.039	1.959TyrGln: 1.959 ± 0.048	2.094TyrArg: 2.094 ± 0.045	2.155TyrSer: 2.155 ± 0.042	1.649TyrThr: 1.649 ± 0.039	1.707TyrVal: 1.707 ± 0.039	0.5TyrTrp: 0.5 ± 0.021	1.077TyrTyr: 1.077 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4375 proteins (1251180 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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