Amino acid dipepetide frequency for Sphingobacterium alimentarium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.062AlaAla: 5.062 ± 0.094	0.587AlaCys: 0.587 ± 0.025	3.866AlaAsp: 3.866 ± 0.061	4.415AlaGlu: 4.415 ± 0.086	3.219AlaPhe: 3.219 ± 0.054	4.561AlaGly: 4.561 ± 0.075	1.363AlaHis: 1.363 ± 0.037	5.603AlaIle: 5.603 ± 0.093	4.93AlaLys: 4.93 ± 0.076	6.776AlaLeu: 6.776 ± 0.094	1.666AlaMet: 1.666 ± 0.045	3.638AlaAsn: 3.638 ± 0.061	1.933AlaPro: 1.933 ± 0.041	3.036AlaGln: 3.036 ± 0.059	2.397AlaArg: 2.397 ± 0.054	4.348AlaSer: 4.348 ± 0.072	3.602AlaThr: 3.602 ± 0.06	4.547AlaVal: 4.547 ± 0.066	0.701AlaTrp: 0.701 ± 0.029	2.838AlaTyr: 2.838 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.468CysAla: 0.468 ± 0.025	0.131CysCys: 0.131 ± 0.011	0.345CysAsp: 0.345 ± 0.018	0.376CysGlu: 0.376 ± 0.021	0.357CysPhe: 0.357 ± 0.019	0.602CysGly: 0.602 ± 0.027	0.177CysHis: 0.177 ± 0.015	0.566CysIle: 0.566 ± 0.023	0.466CysLys: 0.466 ± 0.023	0.654CysLeu: 0.654 ± 0.025	0.184CysMet: 0.184 ± 0.014	0.393CysAsn: 0.393 ± 0.019	0.326CysPro: 0.326 ± 0.022	0.276CysGln: 0.276 ± 0.015	0.287CysArg: 0.287 ± 0.018	0.47CysSer: 0.47 ± 0.02	0.428CysThr: 0.428 ± 0.02	0.457CysVal: 0.457 ± 0.022	0.076CysTrp: 0.076 ± 0.008	0.315CysTyr: 0.315 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.595AspAla: 3.595 ± 0.058	0.377AspCys: 0.377 ± 0.02	2.58AspAsp: 2.58 ± 0.056	3.553AspGlu: 3.553 ± 0.069	3.23AspPhe: 3.23 ± 0.061	3.508AspGly: 3.508 ± 0.057	0.989AspHis: 0.989 ± 0.031	4.518AspIle: 4.518 ± 0.068	4.389AspLys: 4.389 ± 0.067	5.319AspLeu: 5.319 ± 0.074	1.329AspMet: 1.329 ± 0.033	2.971AspAsn: 2.971 ± 0.055	1.793AspPro: 1.793 ± 0.04	1.726AspGln: 1.726 ± 0.041	2.263AspArg: 2.263 ± 0.045	2.976AspSer: 2.976 ± 0.054	2.555AspThr: 2.555 ± 0.045	3.428AspVal: 3.428 ± 0.059	0.753AspTrp: 0.753 ± 0.031	2.627AspTyr: 2.627 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.346GluAla: 4.346 ± 0.079	0.326GluCys: 0.326 ± 0.017	3.334GluAsp: 3.334 ± 0.057	4.952GluGlu: 4.952 ± 0.093	2.66GluPhe: 2.66 ± 0.051	3.564GluGly: 3.564 ± 0.059	1.229GluHis: 1.229 ± 0.036	5.212GluIle: 5.212 ± 0.077	5.392GluLys: 5.392 ± 0.082	6.183GluLeu: 6.183 ± 0.086	1.504GluMet: 1.504 ± 0.034	3.934GluAsn: 3.934 ± 0.071	1.605GluPro: 1.605 ± 0.038	2.675GluGln: 2.675 ± 0.057	2.855GluArg: 2.855 ± 0.068	3.407GluSer: 3.407 ± 0.06	2.965GluThr: 2.965 ± 0.048	4.213GluVal: 4.213 ± 0.059	0.686GluTrp: 0.686 ± 0.026	2.403GluTyr: 2.403 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.249PheAla: 3.249 ± 0.057	0.419PheCys: 0.419 ± 0.021	3.1PheAsp: 3.1 ± 0.052	3.091PheGlu: 3.091 ± 0.056	2.575PhePhe: 2.575 ± 0.058	3.502PheGly: 3.502 ± 0.057	0.924PheHis: 0.924 ± 0.029	3.607PheIle: 3.607 ± 0.068	3.154PheLys: 3.154 ± 0.059	4.36PheLeu: 4.36 ± 0.082	1.134PheMet: 1.134 ± 0.031	2.873PheAsn: 2.873 ± 0.061	1.71PhePro: 1.71 ± 0.035	1.655PheGln: 1.655 ± 0.04	1.859PheArg: 1.859 ± 0.045	3.549PheSer: 3.549 ± 0.065	2.756PheThr: 2.756 ± 0.053	3.132PheVal: 3.132 ± 0.06	0.551PheTrp: 0.551 ± 0.026	2.003PheTyr: 2.003 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.347GlyAla: 4.347 ± 0.075	0.53GlyCys: 0.53 ± 0.025	3.158GlyAsp: 3.158 ± 0.063	3.49GlyGlu: 3.49 ± 0.066	3.29GlyPhe: 3.29 ± 0.054	4.378GlyGly: 4.378 ± 0.08	1.215GlyHis: 1.215 ± 0.037	5.445GlyIle: 5.445 ± 0.093	4.959GlyLys: 4.959 ± 0.073	6.028GlyLeu: 6.028 ± 0.085	1.668GlyMet: 1.668 ± 0.038	3.488GlyAsn: 3.488 ± 0.065	1.314GlyPro: 1.314 ± 0.04	2.174GlyGln: 2.174 ± 0.048	2.578GlyArg: 2.578 ± 0.059	3.798GlySer: 3.798 ± 0.064	3.662GlyThr: 3.662 ± 0.064	4.299GlyVal: 4.299 ± 0.072	0.814GlyTrp: 0.814 ± 0.028	3.084GlyTyr: 3.084 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.193HisAla: 1.193 ± 0.038	0.188HisCys: 0.188 ± 0.013	0.912HisAsp: 0.912 ± 0.033	1.037HisGlu: 1.037 ± 0.03	1.074HisPhe: 1.074 ± 0.033	1.123HisGly: 1.123 ± 0.035	0.525HisHis: 0.525 ± 0.024	1.716HisIle: 1.716 ± 0.044	1.228HisLys: 1.228 ± 0.032	1.993HisLeu: 1.993 ± 0.041	0.408HisMet: 0.408 ± 0.022	1.014HisAsn: 1.014 ± 0.034	0.967HisPro: 0.967 ± 0.031	0.859HisGln: 0.859 ± 0.026	0.828HisArg: 0.828 ± 0.027	1.147HisSer: 1.147 ± 0.031	1.132HisThr: 1.132 ± 0.032	1.046HisVal: 1.046 ± 0.03	0.227HisTrp: 0.227 ± 0.015	0.931HisTyr: 0.931 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.039IleAla: 6.039 ± 0.076	0.67IleCys: 0.67 ± 0.027	4.617IleAsp: 4.617 ± 0.07	5.043IleGlu: 5.043 ± 0.074	3.463IlePhe: 3.463 ± 0.064	5.152IleGly: 5.152 ± 0.073	1.524IleHis: 1.524 ± 0.037	5.839IleIle: 5.839 ± 0.089	5.366IleLys: 5.366 ± 0.071	7.185IleLeu: 7.185 ± 0.101	1.516IleMet: 1.516 ± 0.042	4.468IleAsn: 4.468 ± 0.071	3.331IlePro: 3.331 ± 0.061	3.022IleGln: 3.022 ± 0.054	3.016IleArg: 3.016 ± 0.052	5.346IleSer: 5.346 ± 0.063	4.15IleThr: 4.15 ± 0.065	4.866IleVal: 4.866 ± 0.079	0.71IleTrp: 0.71 ± 0.028	2.94IleTyr: 2.94 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.865LysAla: 4.865 ± 0.077	0.321LysCys: 0.321 ± 0.018	4.261LysAsp: 4.261 ± 0.067	5.489LysGlu: 5.489 ± 0.081	2.898LysPhe: 2.898 ± 0.052	4.44LysGly: 4.44 ± 0.066	1.386LysHis: 1.386 ± 0.034	5.553LysIle: 5.553 ± 0.084	5.509LysLys: 5.509 ± 0.096	6.346LysLeu: 6.346 ± 0.075	1.929LysMet: 1.929 ± 0.041	4.463LysAsn: 4.463 ± 0.062	2.456LysPro: 2.456 ± 0.048	2.771LysGln: 2.771 ± 0.061	2.913LysArg: 2.913 ± 0.059	4.595LysSer: 4.595 ± 0.071	3.865LysThr: 3.865 ± 0.06	4.544LysVal: 4.544 ± 0.073	0.774LysTrp: 0.774 ± 0.029	3.146LysTyr: 3.146 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	6.798LeuAla: 6.798 ± 0.085	0.789LeuCys: 0.789 ± 0.031	5.229LeuAsp: 5.229 ± 0.075	5.696LeuGlu: 5.696 ± 0.083	4.844LeuPhe: 4.844 ± 0.086	5.992LeuGly: 5.992 ± 0.086	1.838LeuHis: 1.838 ± 0.044	6.963LeuIle: 6.963 ± 0.092	6.941LeuLys: 6.941 ± 0.082	9.26LeuLeu: 9.26 ± 0.136	2.287LeuMet: 2.287 ± 0.048	5.316LeuAsn: 5.316 ± 0.084	3.798LeuPro: 3.798 ± 0.071	3.802LeuGln: 3.802 ± 0.066	3.797LeuArg: 3.797 ± 0.07	6.876LeuSer: 6.876 ± 0.09	5.106LeuThr: 5.106 ± 0.068	5.462LeuVal: 5.462 ± 0.069	0.864LeuTrp: 0.864 ± 0.03	3.549LeuTyr: 3.549 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.702MetAla: 1.702 ± 0.046	0.151MetCys: 0.151 ± 0.013	1.304MetAsp: 1.304 ± 0.032	1.498MetGlu: 1.498 ± 0.035	0.892MetPhe: 0.892 ± 0.027	1.504MetGly: 1.504 ± 0.041	0.46MetHis: 0.46 ± 0.02	1.51MetIle: 1.51 ± 0.039	1.965MetLys: 1.965 ± 0.04	2.224MetLeu: 2.224 ± 0.05	0.638MetMet: 0.638 ± 0.027	1.393MetAsn: 1.393 ± 0.04	0.903MetPro: 0.903 ± 0.032	0.956MetGln: 0.956 ± 0.029	1.056MetArg: 1.056 ± 0.032	1.501MetSer: 1.501 ± 0.039	1.181MetThr: 1.181 ± 0.033	1.344MetVal: 1.344 ± 0.037	0.209MetTrp: 0.209 ± 0.015	0.756MetTyr: 0.756 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.814AsnAla: 3.814 ± 0.059	0.345AsnCys: 0.345 ± 0.02	2.727AsnAsp: 2.727 ± 0.061	3.299AsnGlu: 3.299 ± 0.057	2.817AsnPhe: 2.817 ± 0.053	3.604AsnGly: 3.604 ± 0.068	1.031AsnHis: 1.031 ± 0.032	4.661AsnIle: 4.661 ± 0.065	4.16AsnLys: 4.16 ± 0.066	5.334AsnLeu: 5.334 ± 0.082	1.345AsnMet: 1.345 ± 0.04	3.597AsnAsn: 3.597 ± 0.067	2.733AsnPro: 2.733 ± 0.052	2.19AsnGln: 2.19 ± 0.052	2.369AsnArg: 2.369 ± 0.051	3.628AsnSer: 3.628 ± 0.058	3.288AsnThr: 3.288 ± 0.059	3.243AsnVal: 3.243 ± 0.056	0.757AsnTrp: 0.757 ± 0.029	2.61AsnTyr: 2.61 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.31ProAla: 2.31 ± 0.052	0.199ProCys: 0.199 ± 0.013	1.998ProAsp: 1.998 ± 0.044	2.637ProGlu: 2.637 ± 0.056	1.811ProPhe: 1.811 ± 0.044	1.88ProGly: 1.88 ± 0.046	0.739ProHis: 0.739 ± 0.031	2.783ProIle: 2.783 ± 0.053	2.292ProLys: 2.292 ± 0.049	3.126ProLeu: 3.126 ± 0.053	0.762ProMet: 0.762 ± 0.028	2.086ProAsn: 2.086 ± 0.04	0.774ProPro: 0.774 ± 0.031	1.461ProGln: 1.461 ± 0.037	1.083ProArg: 1.083 ± 0.033	2.255ProSer: 2.255 ± 0.048	2.127ProThr: 2.127 ± 0.043	2.301ProVal: 2.301 ± 0.047	0.356ProTrp: 0.356 ± 0.02	1.488ProTyr: 1.488 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.581GlnAla: 2.581 ± 0.05	0.165GlnCys: 0.165 ± 0.013	2.039GlnAsp: 2.039 ± 0.042	2.654GlnGlu: 2.654 ± 0.057	1.713GlnPhe: 1.713 ± 0.04	2.192GlnGly: 2.192 ± 0.05	0.916GlnHis: 0.916 ± 0.027	2.971GlnIle: 2.971 ± 0.059	2.915GlnLys: 2.915 ± 0.052	3.876GlnLeu: 3.876 ± 0.062	0.887GlnMet: 0.887 ± 0.03	2.3GlnAsn: 2.3 ± 0.056	1.13GlnPro: 1.13 ± 0.04	2.038GlnGln: 2.038 ± 0.053	1.671GlnArg: 1.671 ± 0.036	2.263GlnSer: 2.263 ± 0.049	2.061GlnThr: 2.061 ± 0.039	2.295GlnVal: 2.295 ± 0.041	0.416GlnTrp: 0.416 ± 0.022	1.679GlnTyr: 1.679 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.48ArgAla: 2.48 ± 0.056	0.229ArgCys: 0.229 ± 0.015	2.127ArgAsp: 2.127 ± 0.043	2.605ArgGlu: 2.605 ± 0.047	1.994ArgPhe: 1.994 ± 0.047	2.152ArgGly: 2.152 ± 0.054	0.769ArgHis: 0.769 ± 0.03	3.371ArgIle: 3.371 ± 0.059	3.1ArgLys: 3.1 ± 0.06	3.789ArgLeu: 3.789 ± 0.07	1.08ArgMet: 1.08 ± 0.029	2.406ArgAsn: 2.406 ± 0.05	1.349ArgPro: 1.349 ± 0.032	1.505ArgGln: 1.505 ± 0.037	1.647ArgArg: 1.647 ± 0.043	2.227ArgSer: 2.227 ± 0.049	2.141ArgThr: 2.141 ± 0.046	2.445ArgVal: 2.445 ± 0.051	0.498ArgTrp: 0.498 ± 0.022	1.843ArgTyr: 1.843 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.255SerAla: 4.255 ± 0.066	0.577SerCys: 0.577 ± 0.024	3.213SerAsp: 3.213 ± 0.044	3.495SerGlu: 3.495 ± 0.063	3.618SerPhe: 3.618 ± 0.057	4.235SerGly: 4.235 ± 0.074	1.134SerHis: 1.134 ± 0.034	5.154SerIle: 5.154 ± 0.075	4.509SerLys: 4.509 ± 0.07	6.308SerLeu: 6.308 ± 0.081	1.312SerMet: 1.312 ± 0.035	3.696SerAsn: 3.696 ± 0.068	2.148SerPro: 2.148 ± 0.043	2.3SerGln: 2.3 ± 0.043	2.499SerArg: 2.499 ± 0.052	4.447SerSer: 4.447 ± 0.081	3.753SerThr: 3.753 ± 0.067	3.882SerVal: 3.882 ± 0.061	0.683SerTrp: 0.683 ± 0.029	2.806SerTyr: 2.806 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.027ThrAla: 4.027 ± 0.065	0.324ThrCys: 0.324 ± 0.019	3.004ThrAsp: 3.004 ± 0.057	3.166ThrGlu: 3.166 ± 0.055	2.786ThrPhe: 2.786 ± 0.052	3.716ThrGly: 3.716 ± 0.062	1.087ThrHis: 1.087 ± 0.034	4.272ThrIle: 4.272 ± 0.067	3.411ThrLys: 3.411 ± 0.055	5.337ThrLeu: 5.337 ± 0.072	0.996ThrMet: 0.996 ± 0.032	2.796ThrAsn: 2.796 ± 0.054	2.247ThrPro: 2.247 ± 0.046	1.917ThrGln: 1.917 ± 0.042	1.867ThrArg: 1.867 ± 0.041	3.514ThrSer: 3.514 ± 0.056	3.113ThrThr: 3.113 ± 0.063	3.637ThrVal: 3.637 ± 0.059	0.554ThrTrp: 0.554 ± 0.022	2.258ThrTyr: 2.258 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.376ValAla: 4.376 ± 0.079	0.584ValCys: 0.584 ± 0.027	3.664ValAsp: 3.664 ± 0.061	3.987ValGlu: 3.987 ± 0.064	3.031ValPhe: 3.031 ± 0.06	4.141ValGly: 4.141 ± 0.071	1.126ValHis: 1.126 ± 0.032	4.738ValIle: 4.738 ± 0.074	4.19ValLys: 4.19 ± 0.066	6.088ValLeu: 6.088 ± 0.086	1.339ValMet: 1.339 ± 0.036	3.496ValAsn: 3.496 ± 0.063	2.158ValPro: 2.158 ± 0.049	2.21ValGln: 2.21 ± 0.048	2.523ValArg: 2.523 ± 0.047	4.17ValSer: 4.17 ± 0.068	3.21ValThr: 3.21 ± 0.048	4.242ValVal: 4.242 ± 0.063	0.68ValTrp: 0.68 ± 0.025	2.402ValTyr: 2.402 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.716TrpAla: 0.716 ± 0.028	0.098TrpCys: 0.098 ± 0.009	0.641TrpAsp: 0.641 ± 0.026	0.654TrpGlu: 0.654 ± 0.025	0.498TrpPhe: 0.498 ± 0.024	0.754TrpGly: 0.754 ± 0.031	0.227TrpHis: 0.227 ± 0.016	0.779TrpIle: 0.779 ± 0.029	0.799TrpLys: 0.799 ± 0.03	1.045TrpLeu: 1.045 ± 0.035	0.321TrpMet: 0.321 ± 0.018	0.713TrpAsn: 0.713 ± 0.026	0.238TrpPro: 0.238 ± 0.015	0.484TrpGln: 0.484 ± 0.023	0.465TrpArg: 0.465 ± 0.021	0.682TrpSer: 0.682 ± 0.026	0.594TrpThr: 0.594 ± 0.024	0.671TrpVal: 0.671 ± 0.027	0.141TrpTrp: 0.141 ± 0.011	0.455TrpTyr: 0.455 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.867TyrAla: 2.867 ± 0.053	0.344TyrCys: 0.344 ± 0.019	2.36TyrAsp: 2.36 ± 0.047	2.312TyrGlu: 2.312 ± 0.048	2.43TyrPhe: 2.43 ± 0.051	2.719TyrGly: 2.719 ± 0.054	0.886TyrHis: 0.886 ± 0.029	3.0TyrIle: 3.0 ± 0.051	2.847TyrLys: 2.847 ± 0.053	3.978TyrLeu: 3.978 ± 0.063	0.844TyrMet: 0.844 ± 0.029	2.513TyrAsn: 2.513 ± 0.058	1.556TyrPro: 1.556 ± 0.039	1.704TyrGln: 1.704 ± 0.037	1.784TyrArg: 1.784 ± 0.039	2.825TyrSer: 2.825 ± 0.052	2.338TyrThr: 2.338 ± 0.056	2.301TyrVal: 2.301 ± 0.045	0.524TyrTrp: 0.524 ± 0.025	1.971TyrTyr: 1.971 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3405 proteins (1064945 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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