Amino acid dipepetide frequency for Polyporus arcularius HHB13444

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.303AlaAla: 10.303 ± 0.049	1.295AlaCys: 1.295 ± 0.014	4.812AlaAsp: 4.812 ± 0.029	5.253AlaGlu: 5.253 ± 0.039	3.418AlaPhe: 3.418 ± 0.026	5.916AlaGly: 5.916 ± 0.03	2.481AlaHis: 2.481 ± 0.019	4.022AlaIle: 4.022 ± 0.026	3.635AlaLys: 3.635 ± 0.026	9.025AlaLeu: 9.025 ± 0.042	1.986AlaMet: 1.986 ± 0.018	2.691AlaAsn: 2.691 ± 0.021	5.987AlaPro: 5.987 ± 0.045	3.599AlaGln: 3.599 ± 0.026	6.438AlaArg: 6.438 ± 0.032	8.084AlaSer: 8.084 ± 0.045	5.553AlaThr: 5.553 ± 0.033	6.071AlaVal: 6.071 ± 0.031	1.335AlaTrp: 1.335 ± 0.012	2.362AlaTyr: 2.362 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.291CysAla: 1.291 ± 0.014	0.32CysCys: 0.32 ± 0.008	0.713CysAsp: 0.713 ± 0.011	0.645CysGlu: 0.645 ± 0.01	0.518CysPhe: 0.518 ± 0.008	1.028CysGly: 1.028 ± 0.013	0.364CysHis: 0.364 ± 0.007	0.692CysIle: 0.692 ± 0.01	0.525CysLys: 0.525 ± 0.009	1.284CysLeu: 1.284 ± 0.014	0.317CysMet: 0.317 ± 0.007	0.403CysAsn: 0.403 ± 0.008	0.927CysPro: 0.927 ± 0.013	0.45CysGln: 0.45 ± 0.009	0.993CysArg: 0.993 ± 0.013	1.116CysSer: 1.116 ± 0.015	0.87CysThr: 0.87 ± 0.014	0.923CysVal: 0.923 ± 0.013	0.222CysTrp: 0.222 ± 0.006	0.367CysTyr: 0.367 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.498AspAla: 5.498 ± 0.033	0.699AspCys: 0.699 ± 0.01	4.383AspAsp: 4.383 ± 0.036	4.343AspGlu: 4.343 ± 0.033	2.038AspPhe: 2.038 ± 0.018	4.175AspGly: 4.175 ± 0.025	1.285AspHis: 1.285 ± 0.014	2.845AspIle: 2.845 ± 0.02	1.947AspLys: 1.947 ± 0.018	4.903AspLeu: 4.903 ± 0.029	1.276AspMet: 1.276 ± 0.014	1.439AspAsn: 1.439 ± 0.014	3.698AspPro: 3.698 ± 0.025	1.487AspGln: 1.487 ± 0.014	3.124AspArg: 3.124 ± 0.024	3.867AspSer: 3.867 ± 0.026	2.988AspThr: 2.988 ± 0.022	4.32AspVal: 4.32 ± 0.028	0.938AspTrp: 0.938 ± 0.012	1.493AspTyr: 1.493 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.121GluAla: 5.121 ± 0.034	0.715GluCys: 0.715 ± 0.009	4.268GluAsp: 4.268 ± 0.032	5.142GluGlu: 5.142 ± 0.05	1.801GluPhe: 1.801 ± 0.018	3.645GluGly: 3.645 ± 0.023	1.608GluHis: 1.608 ± 0.015	2.391GluIle: 2.391 ± 0.02	2.687GluLys: 2.687 ± 0.024	5.491GluLeu: 5.491 ± 0.034	1.241GluMet: 1.241 ± 0.014	1.618GluAsn: 1.618 ± 0.016	2.858GluPro: 2.858 ± 0.024	2.187GluGln: 2.187 ± 0.018	4.273GluArg: 4.273 ± 0.033	3.618GluSer: 3.618 ± 0.025	2.938GluThr: 2.938 ± 0.024	3.759GluVal: 3.759 ± 0.024	0.943GluTrp: 0.943 ± 0.012	1.536GluTyr: 1.536 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.365PheAla: 3.365 ± 0.026	0.55PheCys: 0.55 ± 0.009	2.195PheAsp: 2.195 ± 0.02	1.887PheGlu: 1.887 ± 0.017	1.43PhePhe: 1.43 ± 0.018	2.575PheGly: 2.575 ± 0.025	0.9PheHis: 0.9 ± 0.011	1.565PheIle: 1.565 ± 0.015	1.334PheLys: 1.334 ± 0.016	3.345PheLeu: 3.345 ± 0.024	0.736PheMet: 0.736 ± 0.009	1.153PheAsn: 1.153 ± 0.012	2.206PhePro: 2.206 ± 0.02	1.144PheGln: 1.144 ± 0.012	2.076PheArg: 2.076 ± 0.017	2.862PheSer: 2.862 ± 0.022	2.078PheThr: 2.078 ± 0.019	2.592PheVal: 2.592 ± 0.02	0.592PheTrp: 0.592 ± 0.009	0.986PheTyr: 0.986 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.55GlyAla: 5.55 ± 0.03	0.959GlyCys: 0.959 ± 0.014	3.55GlyAsp: 3.55 ± 0.021	3.475GlyGlu: 3.475 ± 0.024	2.395GlyPhe: 2.395 ± 0.02	5.31GlyGly: 5.31 ± 0.039	1.761GlyHis: 1.761 ± 0.02	2.891GlyIle: 2.891 ± 0.025	2.977GlyLys: 2.977 ± 0.026	5.614GlyLeu: 5.614 ± 0.028	1.508GlyMet: 1.508 ± 0.018	1.941GlyAsn: 1.941 ± 0.018	3.699GlyPro: 3.699 ± 0.03	2.276GlyGln: 2.276 ± 0.021	4.513GlyArg: 4.513 ± 0.028	5.515GlySer: 5.515 ± 0.036	4.089GlyThr: 4.089 ± 0.03	4.313GlyVal: 4.313 ± 0.025	1.157GlyTrp: 1.157 ± 0.014	1.845GlyTyr: 1.845 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	2.57HisAla: 2.57 ± 0.023	0.415HisCys: 0.415 ± 0.007	1.466HisAsp: 1.466 ± 0.016	1.376HisGlu: 1.376 ± 0.013	0.932HisPhe: 0.932 ± 0.012	1.849HisGly: 1.849 ± 0.017	0.868HisHis: 0.868 ± 0.015	1.304HisIle: 1.304 ± 0.013	0.864HisLys: 0.864 ± 0.011	2.675HisLeu: 2.675 ± 0.022	0.523HisMet: 0.523 ± 0.008	0.753HisAsn: 0.753 ± 0.01	2.11HisPro: 2.11 ± 0.018	0.818HisGln: 0.818 ± 0.012	1.858HisArg: 1.858 ± 0.016	2.027HisSer: 2.027 ± 0.02	1.568HisThr: 1.568 ± 0.016	1.845HisVal: 1.845 ± 0.019	0.392HisTrp: 0.392 ± 0.009	0.704HisTyr: 0.704 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.062IleAla: 4.062 ± 0.026	0.694IleCys: 0.694 ± 0.012	2.453IleAsp: 2.453 ± 0.021	2.34IleGlu: 2.34 ± 0.023	1.626IlePhe: 1.626 ± 0.016	2.631IleGly: 2.631 ± 0.022	1.148IleHis: 1.148 ± 0.014	1.991IleIle: 1.991 ± 0.021	1.6IleLys: 1.6 ± 0.017	4.143IleLeu: 4.143 ± 0.026	0.867IleMet: 0.867 ± 0.011	1.261IleAsn: 1.261 ± 0.014	3.122IlePro: 3.122 ± 0.02	1.485IleGln: 1.485 ± 0.016	2.782IleArg: 2.782 ± 0.022	3.259IleSer: 3.259 ± 0.022	2.478IleThr: 2.478 ± 0.019	3.101IleVal: 3.101 ± 0.021	0.662IleTrp: 0.662 ± 0.01	1.204IleTyr: 1.204 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.871LysAla: 3.871 ± 0.025	0.45LysCys: 0.45 ± 0.009	2.236LysAsp: 2.236 ± 0.019	2.625LysGlu: 2.625 ± 0.024	1.203LysPhe: 1.203 ± 0.015	2.506LysGly: 2.506 ± 0.023	1.052LysHis: 1.052 ± 0.014	1.632LysIle: 1.632 ± 0.017	2.47LysLys: 2.47 ± 0.029	3.63LysLeu: 3.63 ± 0.026	0.795LysMet: 0.795 ± 0.011	1.197LysAsn: 1.197 ± 0.014	2.327LysPro: 2.327 ± 0.02	1.431LysGln: 1.431 ± 0.015	3.144LysArg: 3.144 ± 0.025	2.616LysSer: 2.616 ± 0.022	2.28LysThr: 2.28 ± 0.021	2.449LysVal: 2.449 ± 0.02	0.626LysTrp: 0.626 ± 0.01	1.147LysTyr: 1.147 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	8.689LeuAla: 8.689 ± 0.042	1.368LeuCys: 1.368 ± 0.014	5.198LeuAsp: 5.198 ± 0.028	5.342LeuGlu: 5.342 ± 0.037	3.277LeuPhe: 3.277 ± 0.025	5.53LeuGly: 5.53 ± 0.032	2.715LeuHis: 2.715 ± 0.023	3.453LeuIle: 3.453 ± 0.027	3.619LeuLys: 3.619 ± 0.026	8.84LeuLeu: 8.84 ± 0.051	1.685LeuMet: 1.685 ± 0.015	2.725LeuAsn: 2.725 ± 0.022	6.608LeuPro: 6.608 ± 0.037	3.722LeuGln: 3.722 ± 0.028	6.952LeuArg: 6.952 ± 0.04	7.778LeuSer: 7.778 ± 0.038	5.203LeuThr: 5.203 ± 0.031	6.014LeuVal: 6.014 ± 0.034	1.298LeuTrp: 1.298 ± 0.015	2.42LeuTyr: 2.42 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	1.864MetAla: 1.864 ± 0.018	0.279MetCys: 0.279 ± 0.007	1.182MetAsp: 1.182 ± 0.014	1.074MetGlu: 1.074 ± 0.012	0.762MetPhe: 0.762 ± 0.012	1.185MetGly: 1.185 ± 0.016	0.591MetHis: 0.591 ± 0.01	0.803MetIle: 0.803 ± 0.01	0.81MetLys: 0.81 ± 0.011	1.907MetLeu: 1.907 ± 0.017	0.47MetMet: 0.47 ± 0.009	0.654MetAsn: 0.654 ± 0.011	1.398MetPro: 1.398 ± 0.016	0.834MetGln: 0.834 ± 0.01	1.465MetArg: 1.465 ± 0.013	2.056MetSer: 2.056 ± 0.018	1.186MetThr: 1.186 ± 0.017	1.211MetVal: 1.211 ± 0.014	0.289MetTrp: 0.289 ± 0.006	0.546MetTyr: 0.546 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.982AsnAla: 2.982 ± 0.026	0.373AsnCys: 0.373 ± 0.008	1.505AsnAsp: 1.505 ± 0.017	1.463AsnGlu: 1.463 ± 0.015	1.082AsnPhe: 1.082 ± 0.013	2.319AsnGly: 2.319 ± 0.022	0.713AsnHis: 0.713 ± 0.01	1.546AsnIle: 1.546 ± 0.016	1.051AsnLys: 1.051 ± 0.015	2.697AsnLeu: 2.697 ± 0.022	0.66AsnMet: 0.66 ± 0.011	0.933AsnAsn: 0.933 ± 0.015	2.069AsnPro: 2.069 ± 0.016	0.878AsnGln: 0.878 ± 0.012	1.564AsnArg: 1.564 ± 0.016	2.032AsnSer: 2.032 ± 0.021	1.761AsnThr: 1.761 ± 0.016	2.222AsnVal: 2.222 ± 0.02	0.458AsnTrp: 0.458 ± 0.009	0.78AsnTyr: 0.78 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	6.661ProAla: 6.661 ± 0.039	0.702ProCys: 0.702 ± 0.011	3.616ProAsp: 3.616 ± 0.026	3.943ProGlu: 3.943 ± 0.025	2.2ProPhe: 2.2 ± 0.019	4.299ProGly: 4.299 ± 0.033	1.782ProHis: 1.782 ± 0.018	2.504ProIle: 2.504 ± 0.019	2.276ProLys: 2.276 ± 0.02	5.559ProLeu: 5.559 ± 0.029	1.155ProMet: 1.155 ± 0.015	1.928ProAsn: 1.928 ± 0.02	7.031ProPro: 7.031 ± 0.074	2.501ProGln: 2.501 ± 0.023	4.418ProArg: 4.418 ± 0.034	7.28ProSer: 7.28 ± 0.051	4.473ProThr: 4.473 ± 0.032	4.24ProVal: 4.24 ± 0.031	0.812ProTrp: 0.812 ± 0.01	1.619ProTyr: 1.619 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.41GlnAla: 3.41 ± 0.023	0.491GlnCys: 0.491 ± 0.008	1.865GlnAsp: 1.865 ± 0.017	2.147GlnGlu: 2.147 ± 0.018	1.188GlnPhe: 1.188 ± 0.016	2.119GlnGly: 2.119 ± 0.019	1.032GlnHis: 1.032 ± 0.014	1.402GlnIle: 1.402 ± 0.014	1.431GlnLys: 1.431 ± 0.017	3.344GlnLeu: 3.344 ± 0.023	0.759GlnMet: 0.759 ± 0.012	1.073GlnAsn: 1.073 ± 0.013	2.425GlnPro: 2.425 ± 0.025	1.777GlnGln: 1.777 ± 0.028	2.6GlnArg: 2.6 ± 0.021	2.763GlnSer: 2.763 ± 0.02	2.076GlnThr: 2.076 ± 0.02	2.11GlnVal: 2.11 ± 0.02	0.585GlnTrp: 0.585 ± 0.009	1.104GlnTyr: 1.104 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	6.296ArgAla: 6.296 ± 0.035	1.035ArgCys: 1.035 ± 0.014	3.641ArgAsp: 3.641 ± 0.026	4.046ArgGlu: 4.046 ± 0.03	2.249ArgPhe: 2.249 ± 0.021	4.135ArgGly: 4.135 ± 0.025	1.9ArgHis: 1.9 ± 0.018	2.94ArgIle: 2.94 ± 0.022	3.183ArgLys: 3.183 ± 0.024	6.25ArgLeu: 6.25 ± 0.033	1.511ArgMet: 1.511 ± 0.016	1.959ArgAsn: 1.959 ± 0.018	4.364ArgPro: 4.364 ± 0.028	2.374ArgGln: 2.374 ± 0.022	6.334ArgArg: 6.334 ± 0.045	5.49ArgSer: 5.49 ± 0.042	4.205ArgThr: 4.205 ± 0.029	4.202ArgVal: 4.202 ± 0.026	1.14ArgTrp: 1.14 ± 0.013	1.814ArgTyr: 1.814 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	7.661SerAla: 7.661 ± 0.041	1.065SerCys: 1.065 ± 0.013	4.272SerAsp: 4.272 ± 0.028	3.861SerGlu: 3.861 ± 0.025	2.893SerPhe: 2.893 ± 0.024	5.508SerGly: 5.508 ± 0.037	2.098SerHis: 2.098 ± 0.021	3.416SerIle: 3.416 ± 0.022	2.927SerLys: 2.927 ± 0.026	7.504SerLeu: 7.504 ± 0.032	1.66SerMet: 1.66 ± 0.016	2.242SerAsn: 2.242 ± 0.02	6.45SerPro: 6.45 ± 0.056	2.868SerGln: 2.868 ± 0.027	5.576SerArg: 5.576 ± 0.036	9.43SerSer: 9.43 ± 0.082	5.687SerThr: 5.687 ± 0.036	5.057SerVal: 5.057 ± 0.029	1.128SerTrp: 1.128 ± 0.012	1.932SerTyr: 1.932 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.467ThrAla: 5.467 ± 0.032	0.852ThrCys: 0.852 ± 0.012	2.829ThrAsp: 2.829 ± 0.021	2.72ThrGlu: 2.72 ± 0.02	2.397ThrPhe: 2.397 ± 0.019	3.866ThrGly: 3.866 ± 0.029	1.593ThrHis: 1.593 ± 0.016	2.759ThrIle: 2.759 ± 0.023	2.031ThrLys: 2.031 ± 0.019	5.84ThrLeu: 5.84 ± 0.031	1.154ThrMet: 1.154 ± 0.013	1.67ThrAsn: 1.67 ± 0.019	4.792ThrPro: 4.792 ± 0.034	1.949ThrGln: 1.949 ± 0.018	3.727ThrArg: 3.727 ± 0.023	5.458ThrSer: 5.458 ± 0.035	4.006ThrThr: 4.006 ± 0.034	4.085ThrVal: 4.085 ± 0.026	0.865ThrTrp: 0.865 ± 0.01	1.607ThrTyr: 1.607 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	5.987ValAla: 5.987 ± 0.031	1.022ValCys: 1.022 ± 0.014	3.924ValAsp: 3.924 ± 0.026	3.878ValGlu: 3.878 ± 0.03	2.512ValPhe: 2.512 ± 0.021	3.958ValGly: 3.958 ± 0.029	1.85ValHis: 1.85 ± 0.017	2.788ValIle: 2.788 ± 0.022	2.596ValLys: 2.596 ± 0.021	6.513ValLeu: 6.513 ± 0.037	1.319ValMet: 1.319 ± 0.014	1.975ValAsn: 1.975 ± 0.019	4.581ValPro: 4.581 ± 0.03	2.466ValGln: 2.466 ± 0.02	4.372ValArg: 4.372 ± 0.028	5.028ValSer: 5.028 ± 0.031	3.635ValThr: 3.635 ± 0.024	4.878ValVal: 4.878 ± 0.031	1.034ValTrp: 1.034 ± 0.014	1.851ValTyr: 1.851 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	1.192TrpAla: 1.192 ± 0.013	0.242TrpCys: 0.242 ± 0.005	0.95TrpAsp: 0.95 ± 0.013	0.869TrpGlu: 0.869 ± 0.012	0.584TrpPhe: 0.584 ± 0.009	0.881TrpGly: 0.881 ± 0.012	0.411TrpHis: 0.411 ± 0.007	0.693TrpIle: 0.693 ± 0.011	0.755TrpLys: 0.755 ± 0.011	1.39TrpLeu: 1.39 ± 0.015	0.376TrpMet: 0.376 ± 0.008	0.563TrpAsn: 0.563 ± 0.009	0.745TrpPro: 0.745 ± 0.011	0.558TrpGln: 0.558 ± 0.008	1.174TrpArg: 1.174 ± 0.012	1.115TrpSer: 1.115 ± 0.014	1.013TrpThr: 1.013 ± 0.012	0.921TrpVal: 0.921 ± 0.012	0.309TrpTrp: 0.309 ± 0.006	0.449TrpTyr: 0.449 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.431TyrAla: 2.431 ± 0.021	0.442TyrCys: 0.442 ± 0.007	1.686TyrAsp: 1.686 ± 0.016	1.411TyrGlu: 1.411 ± 0.015	1.067TyrPhe: 1.067 ± 0.012	1.905TyrGly: 1.905 ± 0.018	0.764TyrHis: 0.764 ± 0.01	1.27TyrIle: 1.27 ± 0.015	0.967TyrLys: 0.967 ± 0.012	2.484TyrLeu: 2.484 ± 0.019	0.572TyrMet: 0.572 ± 0.01	0.908TyrAsn: 0.908 ± 0.01	1.604TyrPro: 1.604 ± 0.018	0.897TyrGln: 0.897 ± 0.01	1.685TyrArg: 1.685 ± 0.016	1.843TyrSer: 1.843 ± 0.018	1.576TyrThr: 1.576 ± 0.015	1.854TyrVal: 1.854 ± 0.017	0.401TyrTrp: 0.401 ± 0.008	0.855TyrTyr: 0.855 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.006

Statistics based on 17473 proteins (6874114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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