Amino acid dipepetide frequency for Flavobacterium commune

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.928AlaAla: 4.928 ± 0.099	0.557AlaCys: 0.557 ± 0.027	3.571AlaAsp: 3.571 ± 0.076	4.089AlaGlu: 4.089 ± 0.069	3.279AlaPhe: 3.279 ± 0.061	4.318AlaGly: 4.318 ± 0.094	1.047AlaHis: 1.047 ± 0.031	5.675AlaIle: 5.675 ± 0.09	5.239AlaLys: 5.239 ± 0.078	6.067AlaLeu: 6.067 ± 0.098	1.563AlaMet: 1.563 ± 0.044	4.012AlaAsn: 4.012 ± 0.08	2.022AlaPro: 2.022 ± 0.059	2.59AlaGln: 2.59 ± 0.054	1.919AlaArg: 1.919 ± 0.049	4.214AlaSer: 4.214 ± 0.08	4.212AlaThr: 4.212 ± 0.1	4.578AlaVal: 4.578 ± 0.068	0.662AlaTrp: 0.662 ± 0.026	2.496AlaTyr: 2.496 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.465CysAla: 0.465 ± 0.028	0.119CysCys: 0.119 ± 0.011	0.392CysAsp: 0.392 ± 0.02	0.475CysGlu: 0.475 ± 0.026	0.428CysPhe: 0.428 ± 0.018	0.587CysGly: 0.587 ± 0.03	0.183CysHis: 0.183 ± 0.014	0.604CysIle: 0.604 ± 0.021	0.502CysLys: 0.502 ± 0.025	0.654CysLeu: 0.654 ± 0.027	0.145CysMet: 0.145 ± 0.012	0.464CysAsn: 0.464 ± 0.028	0.367CysPro: 0.367 ± 0.022	0.259CysGln: 0.259 ± 0.015	0.207CysArg: 0.207 ± 0.014	0.602CysSer: 0.602 ± 0.039	0.492CysThr: 0.492 ± 0.038	0.476CysVal: 0.476 ± 0.022	0.087CysTrp: 0.087 ± 0.009	0.307CysTyr: 0.307 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.707AspAla: 3.707 ± 0.065	0.437AspCys: 0.437 ± 0.026	2.49AspAsp: 2.49 ± 0.062	3.356AspGlu: 3.356 ± 0.065	3.704AspPhe: 3.704 ± 0.065	3.677AspGly: 3.677 ± 0.077	0.729AspHis: 0.729 ± 0.028	4.047AspIle: 4.047 ± 0.07	4.336AspLys: 4.336 ± 0.07	5.054AspLeu: 5.054 ± 0.078	0.986AspMet: 0.986 ± 0.033	3.214AspAsn: 3.214 ± 0.067	1.542AspPro: 1.542 ± 0.05	1.502AspGln: 1.502 ± 0.04	1.672AspArg: 1.672 ± 0.04	3.064AspSer: 3.064 ± 0.06	2.525AspThr: 2.525 ± 0.061	3.431AspVal: 3.431 ± 0.074	0.783AspTrp: 0.783 ± 0.029	2.771AspTyr: 2.771 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.441GluAla: 4.441 ± 0.077	0.368GluCys: 0.368 ± 0.025	3.118GluAsp: 3.118 ± 0.049	4.359GluGlu: 4.359 ± 0.094	2.822GluPhe: 2.822 ± 0.059	3.549GluGly: 3.549 ± 0.073	1.013GluHis: 1.013 ± 0.033	5.694GluIle: 5.694 ± 0.091	6.149GluLys: 6.149 ± 0.115	5.808GluLeu: 5.808 ± 0.084	1.568GluMet: 1.568 ± 0.039	4.915GluAsn: 4.915 ± 0.079	1.453GluPro: 1.453 ± 0.039	2.187GluGln: 2.187 ± 0.045	2.18GluArg: 2.18 ± 0.047	3.36GluSer: 3.36 ± 0.056	3.48GluThr: 3.48 ± 0.055	4.061GluVal: 4.061 ± 0.069	0.613GluTrp: 0.613 ± 0.026	2.314GluTyr: 2.314 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.16PheAla: 3.16 ± 0.058	0.468PheCys: 0.468 ± 0.023	3.253PheAsp: 3.253 ± 0.062	3.505PheGlu: 3.505 ± 0.06	2.755PhePhe: 2.755 ± 0.063	3.522PheGly: 3.522 ± 0.06	0.863PheHis: 0.863 ± 0.031	3.742PheIle: 3.742 ± 0.061	3.775PheLys: 3.775 ± 0.064	4.654PheLeu: 4.654 ± 0.081	1.122PheMet: 1.122 ± 0.032	3.249PheAsn: 3.249 ± 0.067	1.873PhePro: 1.873 ± 0.043	1.65PheGln: 1.65 ± 0.043	1.529PheArg: 1.529 ± 0.037	4.135PheSer: 4.135 ± 0.075	2.989PheThr: 2.989 ± 0.057	3.101PheVal: 3.101 ± 0.057	0.635PheTrp: 0.635 ± 0.026	2.184PheTyr: 2.184 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.116GlyAla: 4.116 ± 0.076	0.625GlyCys: 0.625 ± 0.041	3.021GlyAsp: 3.021 ± 0.062	3.473GlyGlu: 3.473 ± 0.071	3.673GlyPhe: 3.673 ± 0.066	4.483GlyGly: 4.483 ± 0.1	1.098GlyHis: 1.098 ± 0.031	5.686GlyIle: 5.686 ± 0.08	5.191GlyLys: 5.191 ± 0.079	5.567GlyLeu: 5.567 ± 0.083	1.585GlyMet: 1.585 ± 0.043	3.864GlyAsn: 3.864 ± 0.079	1.301GlyPro: 1.301 ± 0.039	1.887GlyGln: 1.887 ± 0.045	1.969GlyArg: 1.969 ± 0.05	4.076GlySer: 4.076 ± 0.087	4.283GlyThr: 4.283 ± 0.106	4.232GlyVal: 4.232 ± 0.083	0.803GlyTrp: 0.803 ± 0.029	2.855GlyTyr: 2.855 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	0.95HisAla: 0.95 ± 0.032	0.16HisCys: 0.16 ± 0.012	0.832HisAsp: 0.832 ± 0.027	0.889HisGlu: 0.889 ± 0.026	1.175HisPhe: 1.175 ± 0.037	1.007HisGly: 1.007 ± 0.03	0.452HisHis: 0.452 ± 0.023	1.273HisIle: 1.273 ± 0.034	1.06HisLys: 1.06 ± 0.032	1.654HisLeu: 1.654 ± 0.038	0.26HisMet: 0.26 ± 0.015	0.957HisAsn: 0.957 ± 0.037	0.857HisPro: 0.857 ± 0.03	0.722HisGln: 0.722 ± 0.028	0.56HisArg: 0.56 ± 0.024	1.011HisSer: 1.011 ± 0.027	0.851HisThr: 0.851 ± 0.028	0.791HisVal: 0.791 ± 0.028	0.214HisTrp: 0.214 ± 0.014	0.805HisTyr: 0.805 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.844IleAla: 5.844 ± 0.094	0.661IleCys: 0.661 ± 0.025	4.807IleAsp: 4.807 ± 0.069	5.473IleGlu: 5.473 ± 0.081	3.322IlePhe: 3.322 ± 0.071	5.117IleGly: 5.117 ± 0.084	1.337IleHis: 1.337 ± 0.039	6.14IleIle: 6.14 ± 0.099	6.121IleLys: 6.121 ± 0.094	6.861IleLeu: 6.861 ± 0.096	1.387IleMet: 1.387 ± 0.038	4.923IleAsn: 4.923 ± 0.075	3.396IlePro: 3.396 ± 0.056	2.923IleGln: 2.923 ± 0.057	2.579IleArg: 2.579 ± 0.057	5.842IleSer: 5.842 ± 0.086	4.982IleThr: 4.982 ± 0.111	4.915IleVal: 4.915 ± 0.073	0.77IleTrp: 0.77 ± 0.029	2.875IleTyr: 2.875 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.206LysAla: 5.206 ± 0.084	0.381LysCys: 0.381 ± 0.018	4.358LysAsp: 4.358 ± 0.074	6.048LysGlu: 6.048 ± 0.1	2.951LysPhe: 2.951 ± 0.056	4.845LysGly: 4.845 ± 0.075	1.239LysHis: 1.239 ± 0.036	6.925LysIle: 6.925 ± 0.088	7.173LysLys: 7.173 ± 0.119	6.599LysLeu: 6.599 ± 0.099	2.226LysMet: 2.226 ± 0.048	5.866LysAsn: 5.866 ± 0.099	2.587LysPro: 2.587 ± 0.046	2.687LysGln: 2.687 ± 0.062	2.543LysArg: 2.543 ± 0.056	4.774LysSer: 4.774 ± 0.08	5.082LysThr: 5.082 ± 0.072	4.893LysVal: 4.893 ± 0.075	0.899LysTrp: 0.899 ± 0.029	3.151LysTyr: 3.151 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.028LeuAla: 6.028 ± 0.09	0.71LeuCys: 0.71 ± 0.026	4.746LeuAsp: 4.746 ± 0.074	5.725LeuGlu: 5.725 ± 0.087	4.996LeuPhe: 4.996 ± 0.089	5.688LeuGly: 5.688 ± 0.093	1.502LeuHis: 1.502 ± 0.044	6.816LeuIle: 6.816 ± 0.115	7.639LeuLys: 7.639 ± 0.091	8.333LeuLeu: 8.333 ± 0.123	2.006LeuMet: 2.006 ± 0.05	5.625LeuAsn: 5.625 ± 0.084	3.421LeuPro: 3.421 ± 0.066	3.014LeuGln: 3.014 ± 0.058	2.87LeuArg: 2.87 ± 0.058	6.542LeuSer: 6.542 ± 0.087	5.042LeuThr: 5.042 ± 0.083	5.23LeuVal: 5.23 ± 0.077	0.86LeuTrp: 0.86 ± 0.032	3.235LeuTyr: 3.235 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.556MetAla: 1.556 ± 0.042	0.134MetCys: 0.134 ± 0.011	1.142MetAsp: 1.142 ± 0.036	1.309MetGlu: 1.309 ± 0.036	0.817MetPhe: 0.817 ± 0.026	1.383MetGly: 1.383 ± 0.039	0.343MetHis: 0.343 ± 0.02	1.615MetIle: 1.615 ± 0.037	2.245MetLys: 2.245 ± 0.049	1.908MetLeu: 1.908 ± 0.045	0.564MetMet: 0.564 ± 0.024	1.396MetAsn: 1.396 ± 0.041	0.865MetPro: 0.865 ± 0.032	0.815MetGln: 0.815 ± 0.025	0.832MetArg: 0.832 ± 0.031	1.394MetSer: 1.394 ± 0.033	1.138MetThr: 1.138 ± 0.033	1.265MetVal: 1.265 ± 0.038	0.187MetTrp: 0.187 ± 0.014	0.711MetTyr: 0.711 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.116AsnAla: 4.116 ± 0.07	0.565AsnCys: 0.565 ± 0.041	3.181AsnAsp: 3.181 ± 0.053	3.892AsnGlu: 3.892 ± 0.065	3.172AsnPhe: 3.172 ± 0.062	4.272AsnGly: 4.272 ± 0.086	1.133AsnHis: 1.133 ± 0.039	4.886AsnIle: 4.886 ± 0.07	4.785AsnLys: 4.785 ± 0.081	5.71AsnLeu: 5.71 ± 0.081	1.251AsnMet: 1.251 ± 0.035	4.308AsnAsn: 4.308 ± 0.088	3.134AsnPro: 3.134 ± 0.063	2.633AsnGln: 2.633 ± 0.053	2.102AsnArg: 2.102 ± 0.049	4.231AsnSer: 4.231 ± 0.082	3.891AsnThr: 3.891 ± 0.085	3.67AsnVal: 3.67 ± 0.091	0.912AsnTrp: 0.912 ± 0.028	3.135AsnTyr: 3.135 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	2.257ProAla: 2.257 ± 0.071	0.212ProCys: 0.212 ± 0.013	1.929ProAsp: 1.929 ± 0.042	2.826ProGlu: 2.826 ± 0.052	1.912ProPhe: 1.912 ± 0.045	1.929ProGly: 1.929 ± 0.057	0.563ProHis: 0.563 ± 0.023	2.702ProIle: 2.702 ± 0.053	2.737ProLys: 2.737 ± 0.055	2.904ProLeu: 2.904 ± 0.05	0.763ProMet: 0.763 ± 0.026	2.392ProAsn: 2.392 ± 0.055	0.743ProPro: 0.743 ± 0.031	1.117ProGln: 1.117 ± 0.034	0.894ProArg: 0.894 ± 0.033	2.181ProSer: 2.181 ± 0.046	2.024ProThr: 2.024 ± 0.055	2.473ProVal: 2.473 ± 0.044	0.402ProTrp: 0.402 ± 0.02	1.338ProTyr: 1.338 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.113GlnAla: 2.113 ± 0.048	0.198GlnCys: 0.198 ± 0.013	1.608GlnAsp: 1.608 ± 0.043	2.279GlnGlu: 2.279 ± 0.053	1.853GlnPhe: 1.853 ± 0.043	1.816GlnGly: 1.816 ± 0.044	0.537GlnHis: 0.537 ± 0.024	2.856GlnIle: 2.856 ± 0.055	3.173GlnLys: 3.173 ± 0.063	3.578GlnLeu: 3.578 ± 0.066	0.815GlnMet: 0.815 ± 0.029	2.489GlnAsn: 2.489 ± 0.054	1.037GlnPro: 1.037 ± 0.035	1.454GlnGln: 1.454 ± 0.039	1.161GlnArg: 1.161 ± 0.036	2.078GlnSer: 2.078 ± 0.052	1.999GlnThr: 1.999 ± 0.059	1.758GlnVal: 1.758 ± 0.034	0.421GlnTrp: 0.421 ± 0.019	1.432GlnTyr: 1.432 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.956ArgAla: 1.956 ± 0.05	0.21ArgCys: 0.21 ± 0.015	1.609ArgAsp: 1.609 ± 0.054	2.021ArgGlu: 2.021 ± 0.055	1.769ArgPhe: 1.769 ± 0.041	1.801ArgGly: 1.801 ± 0.05	0.511ArgHis: 0.511 ± 0.025	2.814ArgIle: 2.814 ± 0.051	2.639ArgLys: 2.639 ± 0.059	2.965ArgLeu: 2.965 ± 0.053	0.828ArgMet: 0.828 ± 0.032	2.091ArgAsn: 2.091 ± 0.052	1.004ArgPro: 1.004 ± 0.029	0.975ArgGln: 0.975 ± 0.032	1.069ArgArg: 1.069 ± 0.033	1.733ArgSer: 1.733 ± 0.04	1.715ArgThr: 1.715 ± 0.042	1.917ArgVal: 1.917 ± 0.044	0.414ArgTrp: 0.414 ± 0.021	1.384ArgTyr: 1.384 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.967SerAla: 3.967 ± 0.066	0.73SerCys: 0.73 ± 0.033	3.309SerAsp: 3.309 ± 0.053	3.795SerGlu: 3.795 ± 0.054	3.963SerPhe: 3.963 ± 0.072	4.728SerGly: 4.728 ± 0.099	1.09SerHis: 1.09 ± 0.031	5.236SerIle: 5.236 ± 0.081	5.044SerLys: 5.044 ± 0.078	5.855SerLeu: 5.855 ± 0.088	1.274SerMet: 1.274 ± 0.035	4.116SerAsn: 4.116 ± 0.08	2.094SerPro: 2.094 ± 0.05	2.255SerGln: 2.255 ± 0.049	2.104SerArg: 2.104 ± 0.042	4.224SerSer: 4.224 ± 0.091	3.526SerThr: 3.526 ± 0.064	4.101SerVal: 4.101 ± 0.072	0.771SerTrp: 0.771 ± 0.029	2.843SerTyr: 2.843 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.497ThrAla: 4.497 ± 0.122	0.303ThrCys: 0.303 ± 0.019	3.338ThrAsp: 3.338 ± 0.091	3.316ThrGlu: 3.316 ± 0.057	2.909ThrPhe: 2.909 ± 0.057	3.955ThrGly: 3.955 ± 0.085	0.944ThrHis: 0.944 ± 0.036	5.242ThrIle: 5.242 ± 0.108	4.097ThrLys: 4.097 ± 0.064	5.119ThrLeu: 5.119 ± 0.076	0.981ThrMet: 0.981 ± 0.034	3.83ThrAsn: 3.83 ± 0.085	2.572ThrPro: 2.572 ± 0.068	2.022ThrGln: 2.022 ± 0.054	1.469ThrArg: 1.469 ± 0.039	3.641ThrSer: 3.641 ± 0.067	3.92ThrThr: 3.92 ± 0.123	4.042ThrVal: 4.042 ± 0.108	0.598ThrTrp: 0.598 ± 0.033	2.322ThrTyr: 2.322 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	4.442ValAla: 4.442 ± 0.073	0.54ValCys: 0.54 ± 0.024	3.416ValAsp: 3.416 ± 0.065	3.692ValGlu: 3.692 ± 0.07	3.583ValPhe: 3.583 ± 0.065	3.672ValGly: 3.672 ± 0.077	0.912ValHis: 0.912 ± 0.035	4.81ValIle: 4.81 ± 0.08	4.58ValLys: 4.58 ± 0.062	5.911ValLeu: 5.911 ± 0.082	1.266ValMet: 1.266 ± 0.043	3.723ValAsn: 3.723 ± 0.069	2.207ValPro: 2.207 ± 0.044	1.838ValGln: 1.838 ± 0.04	1.874ValArg: 1.874 ± 0.043	4.445ValSer: 4.445 ± 0.065	3.844ValThr: 3.844 ± 0.139	4.319ValVal: 4.319 ± 0.075	0.66ValTrp: 0.66 ± 0.026	2.373ValTyr: 2.373 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.717TrpAla: 0.717 ± 0.028	0.11TrpCys: 0.11 ± 0.011	0.674TrpAsp: 0.674 ± 0.028	0.75TrpGlu: 0.75 ± 0.028	0.575TrpPhe: 0.575 ± 0.024	0.753TrpGly: 0.753 ± 0.029	0.217TrpHis: 0.217 ± 0.013	0.779TrpIle: 0.779 ± 0.029	0.896TrpLys: 0.896 ± 0.03	0.979TrpLeu: 0.979 ± 0.032	0.31TrpMet: 0.31 ± 0.017	0.815TrpAsn: 0.815 ± 0.032	0.279TrpPro: 0.279 ± 0.019	0.465TrpGln: 0.465 ± 0.023	0.42TrpArg: 0.42 ± 0.019	0.698TrpSer: 0.698 ± 0.024	0.676TrpThr: 0.676 ± 0.036	0.636TrpVal: 0.636 ± 0.026	0.164TrpTrp: 0.164 ± 0.013	0.458TrpTyr: 0.458 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.57TyrAla: 2.57 ± 0.057	0.325TyrCys: 0.325 ± 0.018	2.235TyrAsp: 2.235 ± 0.041	2.179TyrGlu: 2.179 ± 0.046	2.508TyrPhe: 2.508 ± 0.047	2.687TyrGly: 2.687 ± 0.062	0.765TyrHis: 0.765 ± 0.032	2.733TyrIle: 2.733 ± 0.049	3.05TyrLys: 3.05 ± 0.057	3.848TyrLeu: 3.848 ± 0.064	0.719TyrMet: 0.719 ± 0.029	2.731TyrAsn: 2.731 ± 0.054	1.545TyrPro: 1.545 ± 0.041	1.66TyrGln: 1.66 ± 0.043	1.471TyrArg: 1.471 ± 0.036	2.778TyrSer: 2.778 ± 0.054	2.446TyrThr: 2.446 ± 0.077	2.22TyrVal: 2.22 ± 0.048	0.517TyrTrp: 0.517 ± 0.023	1.913TyrTyr: 1.913 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3082 proteins (1113438 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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