Amino acid dipepetide frequency for Halobacterium phage phiH (Bacteriophage phi-H)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.477AlaAla: 9.477 ± 1.475
0.661AlaCys: 0.661 ± 0.204
8.264AlaAsp: 8.264 ± 0.717
7.383AlaGlu: 7.383 ± 0.84
1.928AlaPhe: 1.928 ± 0.315
7.989AlaGly: 7.989 ± 0.825
1.708AlaHis: 1.708 ± 0.274
4.848AlaIle: 4.848 ± 0.424
3.196AlaLys: 3.196 ± 0.479
7.273AlaLeu: 7.273 ± 1.02
2.975AlaMet: 2.975 ± 0.906
2.81AlaAsn: 2.81 ± 0.401
2.59AlaPro: 2.59 ± 0.324
2.59AlaGln: 2.59 ± 0.485
4.628AlaArg: 4.628 ± 0.431
6.667AlaSer: 6.667 ± 0.742
6.006AlaThr: 6.006 ± 0.686
7.163AlaVal: 7.163 ± 1.093
1.322AlaTrp: 1.322 ± 0.249
1.598AlaTyr: 1.598 ± 0.303
0.0AlaXaa: 0.0 ± 0.0
Cys
0.441CysAla: 0.441 ± 0.163
0.055CysCys: 0.055 ± 0.057
0.826CysAsp: 0.826 ± 0.263
0.551CysGlu: 0.551 ± 0.16
0.165CysPhe: 0.165 ± 0.131
0.992CysGly: 0.992 ± 0.226
0.551CysHis: 0.551 ± 0.197
0.331CysIle: 0.331 ± 0.142
0.331CysLys: 0.331 ± 0.136
0.496CysLeu: 0.496 ± 0.158
0.11CysMet: 0.11 ± 0.089
0.331CysAsn: 0.331 ± 0.138
0.551CysPro: 0.551 ± 0.167
0.165CysGln: 0.165 ± 0.097
0.551CysArg: 0.551 ± 0.201
0.551CysSer: 0.551 ± 0.168
0.551CysThr: 0.551 ± 0.183
0.826CysVal: 0.826 ± 0.211
0.22CysTrp: 0.22 ± 0.106
0.165CysTyr: 0.165 ± 0.13
0.0CysXaa: 0.0 ± 0.0
Asp
9.697AspAla: 9.697 ± 1.215
0.606AspCys: 0.606 ± 0.195
11.625AspAsp: 11.625 ± 1.116
9.587AspGlu: 9.587 ± 0.84
2.204AspPhe: 2.204 ± 0.49
9.146AspGly: 9.146 ± 0.78
2.314AspHis: 2.314 ± 0.441
4.298AspIle: 4.298 ± 0.405
1.488AspLys: 1.488 ± 0.292
8.099AspLeu: 8.099 ± 0.705
1.543AspMet: 1.543 ± 0.331
2.149AspAsn: 2.149 ± 0.387
5.069AspPro: 5.069 ± 0.655
2.975AspGln: 2.975 ± 0.445
5.399AspArg: 5.399 ± 0.638
5.344AspSer: 5.344 ± 0.597
4.904AspThr: 4.904 ± 0.509
8.32AspVal: 8.32 ± 0.646
1.267AspTrp: 1.267 ± 0.267
2.865AspTyr: 2.865 ± 0.385
0.0AspXaa: 0.0 ± 0.0
Glu
8.209GluAla: 8.209 ± 0.775
0.937GluCys: 0.937 ± 0.255
7.824GluAsp: 7.824 ± 0.817
9.366GluGlu: 9.366 ± 1.086
3.802GluPhe: 3.802 ± 0.457
5.234GluGly: 5.234 ± 0.576
1.928GluHis: 1.928 ± 0.422
5.124GluIle: 5.124 ± 0.561
3.802GluLys: 3.802 ± 0.638
8.099GluLeu: 8.099 ± 0.816
2.094GluMet: 2.094 ± 0.361
3.085GluAsn: 3.085 ± 0.413
4.408GluPro: 4.408 ± 0.569
3.802GluGln: 3.802 ± 0.423
5.179GluArg: 5.179 ± 0.625
4.904GluSer: 4.904 ± 0.634
6.391GluThr: 6.391 ± 0.648
6.612GluVal: 6.612 ± 0.623
1.818GluTrp: 1.818 ± 0.312
2.92GluTyr: 2.92 ± 0.427
0.0GluXaa: 0.0 ± 0.0
Phe
2.314PheAla: 2.314 ± 0.401
0.165PheCys: 0.165 ± 0.093
3.306PheAsp: 3.306 ± 0.494
3.691PheGlu: 3.691 ± 0.442
0.606PhePhe: 0.606 ± 0.173
1.873PheGly: 1.873 ± 0.303
0.386PheHis: 0.386 ± 0.13
0.937PheIle: 0.937 ± 0.222
0.441PheLys: 0.441 ± 0.136
1.488PheLeu: 1.488 ± 0.277
0.22PheMet: 0.22 ± 0.119
0.771PheAsn: 0.771 ± 0.189
1.377PhePro: 1.377 ± 0.216
1.433PheGln: 1.433 ± 0.285
1.653PheArg: 1.653 ± 0.319
1.267PheSer: 1.267 ± 0.244
1.763PheThr: 1.763 ± 0.337
1.598PheVal: 1.598 ± 0.316
0.771PheTrp: 0.771 ± 0.211
0.275PheTyr: 0.275 ± 0.118
0.0PheXaa: 0.0 ± 0.0
Gly
5.62GlyAla: 5.62 ± 1.016
0.661GlyCys: 0.661 ± 0.176
8.43GlyAsp: 8.43 ± 0.725
7.713GlyGlu: 7.713 ± 0.732
1.928GlyPhe: 1.928 ± 0.281
6.997GlyGly: 6.997 ± 0.787
1.598GlyHis: 1.598 ± 0.271
3.251GlyIle: 3.251 ± 0.505
1.983GlyLys: 1.983 ± 0.432
6.171GlyLeu: 6.171 ± 0.842
1.598GlyMet: 1.598 ± 0.264
2.259GlyAsn: 2.259 ± 0.385
2.645GlyPro: 2.645 ± 0.433
3.03GlyGln: 3.03 ± 0.412
3.967GlyArg: 3.967 ± 0.707
5.179GlySer: 5.179 ± 0.512
4.628GlyThr: 4.628 ± 0.471
4.848GlyVal: 4.848 ± 0.465
1.543GlyTrp: 1.543 ± 0.321
2.369GlyTyr: 2.369 ± 0.384
0.0GlyXaa: 0.0 ± 0.0
His
1.543HisAla: 1.543 ± 0.334
0.386HisCys: 0.386 ± 0.16
2.755HisAsp: 2.755 ± 0.358
1.873HisGlu: 1.873 ± 0.373
0.551HisPhe: 0.551 ± 0.143
1.983HisGly: 1.983 ± 0.335
0.716HisHis: 0.716 ± 0.17
0.606HisIle: 0.606 ± 0.213
0.386HisLys: 0.386 ± 0.167
2.039HisLeu: 2.039 ± 0.343
0.11HisMet: 0.11 ± 0.071
0.606HisAsn: 0.606 ± 0.206
1.157HisPro: 1.157 ± 0.274
0.386HisGln: 0.386 ± 0.183
2.204HisArg: 2.204 ± 0.395
1.047HisSer: 1.047 ± 0.236
0.826HisThr: 0.826 ± 0.218
1.873HisVal: 1.873 ± 0.324
0.22HisTrp: 0.22 ± 0.098
0.771HisTyr: 0.771 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
4.959IleAla: 4.959 ± 0.526
0.331IleCys: 0.331 ± 0.113
5.675IleAsp: 5.675 ± 0.567
5.124IleGlu: 5.124 ± 0.461
0.882IlePhe: 0.882 ± 0.252
3.085IleGly: 3.085 ± 0.419
0.771IleHis: 0.771 ± 0.244
1.212IleIle: 1.212 ± 0.24
0.882IleLys: 0.882 ± 0.162
2.479IleLeu: 2.479 ± 0.446
0.661IleMet: 0.661 ± 0.156
1.157IleAsn: 1.157 ± 0.269
2.204IlePro: 2.204 ± 0.373
1.873IleGln: 1.873 ± 0.374
2.424IleArg: 2.424 ± 0.312
3.306IleSer: 3.306 ± 0.454
2.92IleThr: 2.92 ± 0.375
2.865IleVal: 2.865 ± 0.377
0.386IleTrp: 0.386 ± 0.15
0.716IleTyr: 0.716 ± 0.185
0.0IleXaa: 0.0 ± 0.0
Lys
2.59LysAla: 2.59 ± 0.336
0.275LysCys: 0.275 ± 0.114
1.708LysAsp: 1.708 ± 0.307
2.039LysGlu: 2.039 ± 0.39
0.882LysPhe: 0.882 ± 0.192
2.204LysGly: 2.204 ± 0.3
0.661LysHis: 0.661 ± 0.202
0.937LysIle: 0.937 ± 0.208
1.322LysLys: 1.322 ± 0.324
2.149LysLeu: 2.149 ± 0.314
0.716LysMet: 0.716 ± 0.218
1.047LysAsn: 1.047 ± 0.258
1.763LysPro: 1.763 ± 0.282
1.157LysGln: 1.157 ± 0.249
2.094LysArg: 2.094 ± 0.344
1.818LysSer: 1.818 ± 0.456
2.7LysThr: 2.7 ± 0.378
0.992LysVal: 0.992 ± 0.225
0.22LysTrp: 0.22 ± 0.113
1.047LysTyr: 1.047 ± 0.261
0.0LysXaa: 0.0 ± 0.0
Leu
8.209LeuAla: 8.209 ± 0.836
0.992LeuCys: 0.992 ± 0.216
7.438LeuAsp: 7.438 ± 0.605
8.871LeuGlu: 8.871 ± 0.824
1.267LeuPhe: 1.267 ± 0.275
6.171LeuGly: 6.171 ± 1.143
1.433LeuHis: 1.433 ± 0.277
3.03LeuIle: 3.03 ± 0.416
2.314LeuLys: 2.314 ± 0.303
6.226LeuLeu: 6.226 ± 0.659
0.661LeuMet: 0.661 ± 0.222
2.479LeuAsn: 2.479 ± 0.325
3.361LeuPro: 3.361 ± 0.401
2.534LeuGln: 2.534 ± 0.42
4.683LeuArg: 4.683 ± 0.714
5.565LeuSer: 5.565 ± 0.762
5.399LeuThr: 5.399 ± 0.462
4.904LeuVal: 4.904 ± 0.398
1.047LeuTrp: 1.047 ± 0.273
1.708LeuTyr: 1.708 ± 0.281
0.0LeuXaa: 0.0 ± 0.0
Met
2.039MetAla: 2.039 ± 0.333
0.055MetCys: 0.055 ± 0.058
1.763MetAsp: 1.763 ± 0.753
0.992MetGlu: 0.992 ± 0.184
0.275MetPhe: 0.275 ± 0.123
0.882MetGly: 0.882 ± 0.225
0.441MetHis: 0.441 ± 0.166
0.606MetIle: 0.606 ± 0.245
0.606MetLys: 0.606 ± 0.178
0.937MetLeu: 0.937 ± 0.248
0.165MetMet: 0.165 ± 0.108
0.661MetAsn: 0.661 ± 0.193
0.826MetPro: 0.826 ± 0.218
0.716MetGln: 0.716 ± 0.233
0.882MetArg: 0.882 ± 0.206
2.259MetSer: 2.259 ± 0.275
2.479MetThr: 2.479 ± 0.319
0.937MetVal: 0.937 ± 0.224
0.11MetTrp: 0.11 ± 0.064
0.331MetTyr: 0.331 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
2.59AsnAla: 2.59 ± 0.415
0.275AsnCys: 0.275 ± 0.117
2.7AsnAsp: 2.7 ± 0.328
2.755AsnGlu: 2.755 ± 0.483
0.826AsnPhe: 0.826 ± 0.262
2.645AsnGly: 2.645 ± 0.444
1.047AsnHis: 1.047 ± 0.284
1.212AsnIle: 1.212 ± 0.313
0.441AsnLys: 0.441 ± 0.143
2.204AsnLeu: 2.204 ± 0.348
0.606AsnMet: 0.606 ± 0.184
0.992AsnAsn: 0.992 ± 0.259
2.7AsnPro: 2.7 ± 0.437
1.212AsnGln: 1.212 ± 0.248
2.259AsnArg: 2.259 ± 0.374
1.157AsnSer: 1.157 ± 0.235
1.983AsnThr: 1.983 ± 0.45
2.259AsnVal: 2.259 ± 0.376
0.275AsnTrp: 0.275 ± 0.125
0.551AsnTyr: 0.551 ± 0.197
0.0AsnXaa: 0.0 ± 0.0
Pro
4.077ProAla: 4.077 ± 0.484
0.275ProCys: 0.275 ± 0.122
5.785ProAsp: 5.785 ± 0.72
5.124ProGlu: 5.124 ± 0.562
1.818ProPhe: 1.818 ± 0.256
2.865ProGly: 2.865 ± 0.369
0.826ProHis: 0.826 ± 0.263
1.543ProIle: 1.543 ± 0.268
1.157ProLys: 1.157 ± 0.288
3.251ProLeu: 3.251 ± 0.528
0.606ProMet: 0.606 ± 0.141
1.212ProAsn: 1.212 ± 0.344
2.149ProPro: 2.149 ± 0.364
1.322ProGln: 1.322 ± 0.277
3.196ProArg: 3.196 ± 0.554
2.975ProSer: 2.975 ± 0.452
3.416ProThr: 3.416 ± 0.516
2.81ProVal: 2.81 ± 0.511
0.551ProTrp: 0.551 ± 0.194
1.763ProTyr: 1.763 ± 0.375
0.0ProXaa: 0.0 ± 0.0
Gln
3.196GlnAla: 3.196 ± 0.643
0.11GlnCys: 0.11 ± 0.076
1.873GlnAsp: 1.873 ± 0.304
3.085GlnGlu: 3.085 ± 0.414
1.047GlnPhe: 1.047 ± 0.228
2.204GlnGly: 2.204 ± 0.304
0.992GlnHis: 0.992 ± 0.25
1.983GlnIle: 1.983 ± 0.315
0.882GlnLys: 0.882 ± 0.205
3.691GlnLeu: 3.691 ± 0.445
1.102GlnMet: 1.102 ± 0.305
1.157GlnAsn: 1.157 ± 0.299
1.873GlnPro: 1.873 ± 0.299
1.267GlnGln: 1.267 ± 0.304
2.149GlnArg: 2.149 ± 0.348
2.59GlnSer: 2.59 ± 0.293
2.755GlnThr: 2.755 ± 0.606
1.653GlnVal: 1.653 ± 0.308
0.441GlnTrp: 0.441 ± 0.124
0.716GlnTyr: 0.716 ± 0.185
0.0GlnXaa: 0.0 ± 0.0
Arg
4.683ArgAla: 4.683 ± 0.503
0.716ArgCys: 0.716 ± 0.218
5.675ArgAsp: 5.675 ± 0.699
5.785ArgGlu: 5.785 ± 0.561
2.094ArgPhe: 2.094 ± 0.24
3.802ArgGly: 3.802 ± 0.448
1.873ArgHis: 1.873 ± 0.298
3.085ArgIle: 3.085 ± 0.44
1.598ArgLys: 1.598 ± 0.274
5.014ArgLeu: 5.014 ± 0.517
1.433ArgMet: 1.433 ± 0.326
1.433ArgAsn: 1.433 ± 0.271
2.645ArgPro: 2.645 ± 0.409
2.259ArgGln: 2.259 ± 0.38
5.675ArgArg: 5.675 ± 0.728
3.526ArgSer: 3.526 ± 0.474
3.912ArgThr: 3.912 ± 0.459
3.747ArgVal: 3.747 ± 0.488
0.771ArgTrp: 0.771 ± 0.279
1.377ArgTyr: 1.377 ± 0.278
0.0ArgXaa: 0.0 ± 0.0
Ser
5.51SerAla: 5.51 ± 0.922
0.386SerCys: 0.386 ± 0.164
5.179SerAsp: 5.179 ± 0.699
5.179SerGlu: 5.179 ± 0.603
1.267SerPhe: 1.267 ± 0.239
5.675SerGly: 5.675 ± 0.69
1.047SerHis: 1.047 ± 0.275
2.975SerIle: 2.975 ± 0.535
2.369SerLys: 2.369 ± 0.433
4.132SerLeu: 4.132 ± 0.615
1.047SerMet: 1.047 ± 0.221
2.59SerAsn: 2.59 ± 0.444
2.534SerPro: 2.534 ± 0.291
2.865SerGln: 2.865 ± 0.434
4.132SerArg: 4.132 ± 0.53
3.581SerSer: 3.581 ± 0.609
5.234SerThr: 5.234 ± 0.697
4.242SerVal: 4.242 ± 0.428
1.267SerTrp: 1.267 ± 0.266
1.267SerTyr: 1.267 ± 0.276
0.0SerXaa: 0.0 ± 0.0
Thr
6.887ThrAla: 6.887 ± 1.22
0.551ThrCys: 0.551 ± 0.164
5.95ThrAsp: 5.95 ± 0.544
6.391ThrGlu: 6.391 ± 0.663
1.653ThrPhe: 1.653 ± 0.363
5.069ThrGly: 5.069 ± 0.604
0.882ThrHis: 0.882 ± 0.249
3.691ThrIle: 3.691 ± 0.43
1.928ThrLys: 1.928 ± 0.29
5.895ThrLeu: 5.895 ± 0.59
0.937ThrMet: 0.937 ± 0.2
2.59ThrAsn: 2.59 ± 0.425
3.581ThrPro: 3.581 ± 0.543
1.708ThrGln: 1.708 ± 0.303
2.7ThrArg: 2.7 ± 0.405
3.471ThrSer: 3.471 ± 0.557
4.077ThrThr: 4.077 ± 0.423
6.446ThrVal: 6.446 ± 0.647
0.551ThrTrp: 0.551 ± 0.224
1.708ThrTyr: 1.708 ± 0.316
0.0ThrXaa: 0.0 ± 0.0
Val
6.226ValAla: 6.226 ± 0.83
0.771ValCys: 0.771 ± 0.206
8.43ValAsp: 8.43 ± 0.752
6.446ValGlu: 6.446 ± 0.574
1.873ValPhe: 1.873 ± 0.371
4.242ValGly: 4.242 ± 0.514
1.873ValHis: 1.873 ± 0.325
2.645ValIle: 2.645 ± 0.436
2.039ValLys: 2.039 ± 0.337
5.069ValLeu: 5.069 ± 0.593
0.882ValMet: 0.882 ± 0.23
2.259ValAsn: 2.259 ± 0.374
3.636ValPro: 3.636 ± 0.576
1.763ValGln: 1.763 ± 0.284
4.408ValArg: 4.408 ± 0.537
4.683ValSer: 4.683 ± 0.932
4.848ValThr: 4.848 ± 0.624
5.014ValVal: 5.014 ± 0.525
0.882ValTrp: 0.882 ± 0.205
2.204ValTyr: 2.204 ± 0.353
0.0ValXaa: 0.0 ± 0.0
Trp
0.937TrpAla: 0.937 ± 0.212
0.165TrpCys: 0.165 ± 0.093
0.992TrpAsp: 0.992 ± 0.259
0.937TrpGlu: 0.937 ± 0.256
0.606TrpPhe: 0.606 ± 0.164
0.882TrpGly: 0.882 ± 0.267
0.386TrpHis: 0.386 ± 0.156
0.882TrpIle: 0.882 ± 0.218
0.441TrpLys: 0.441 ± 0.138
1.653TrpLeu: 1.653 ± 0.382
0.22TrpMet: 0.22 ± 0.122
0.496TrpAsn: 0.496 ± 0.181
0.551TrpPro: 0.551 ± 0.171
0.606TrpGln: 0.606 ± 0.196
0.937TrpArg: 0.937 ± 0.187
1.433TrpSer: 1.433 ± 0.239
0.937TrpThr: 0.937 ± 0.217
0.771TrpVal: 0.771 ± 0.219
0.275TrpTrp: 0.275 ± 0.112
0.386TrpTyr: 0.386 ± 0.14
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.873TyrAla: 1.873 ± 0.266
0.386TyrCys: 0.386 ± 0.146
2.7TyrAsp: 2.7 ± 0.384
2.645TyrGlu: 2.645 ± 0.367
0.661TyrPhe: 0.661 ± 0.186
2.479TyrGly: 2.479 ± 0.44
0.606TyrHis: 0.606 ± 0.194
0.716TyrIle: 0.716 ± 0.19
0.716TyrLys: 0.716 ± 0.224
1.928TyrLeu: 1.928 ± 0.376
0.22TyrMet: 0.22 ± 0.131
0.606TyrAsn: 0.606 ± 0.145
1.102TyrPro: 1.102 ± 0.207
1.157TyrGln: 1.157 ± 0.266
1.983TyrArg: 1.983 ± 0.345
1.157TyrSer: 1.157 ± 0.255
0.937TyrThr: 0.937 ± 0.236
2.314TyrVal: 2.314 ± 0.392
0.551TyrTrp: 0.551 ± 0.158
0.606TyrTyr: 0.606 ± 0.225
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 96 proteins (18151 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski