Amino acid dipepetide frequency for Nocardioides guangzhouensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.481AlaAla: 19.481 ± 0.204	1.06AlaCys: 1.06 ± 0.027	8.627AlaAsp: 8.627 ± 0.075	7.802AlaGlu: 7.802 ± 0.101	3.554AlaPhe: 3.554 ± 0.056	12.562AlaGly: 12.562 ± 0.115	2.652AlaHis: 2.652 ± 0.05	4.123AlaIle: 4.123 ± 0.06	2.228AlaLys: 2.228 ± 0.051	13.563AlaLeu: 13.563 ± 0.131	2.753AlaMet: 2.753 ± 0.048	1.909AlaAsn: 1.909 ± 0.035	6.136AlaPro: 6.136 ± 0.082	3.189AlaGln: 3.189 ± 0.052	10.051AlaArg: 10.051 ± 0.098	6.223AlaSer: 6.223 ± 0.06	7.775AlaThr: 7.775 ± 0.077	11.876AlaVal: 11.876 ± 0.122	2.143AlaTrp: 2.143 ± 0.043	2.662AlaTyr: 2.662 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.909CysAla: 0.909 ± 0.026	0.107CysCys: 0.107 ± 0.009	0.517CysAsp: 0.517 ± 0.019	0.361CysGlu: 0.361 ± 0.017	0.237CysPhe: 0.237 ± 0.013	0.863CysGly: 0.863 ± 0.027	0.19CysHis: 0.19 ± 0.012	0.168CysIle: 0.168 ± 0.012	0.104CysLys: 0.104 ± 0.008	0.731CysLeu: 0.731 ± 0.022	0.118CysMet: 0.118 ± 0.007	0.136CysAsn: 0.136 ± 0.01	0.501CysPro: 0.501 ± 0.024	0.168CysGln: 0.168 ± 0.011	0.627CysArg: 0.627 ± 0.02	0.45CysSer: 0.45 ± 0.017	0.513CysThr: 0.513 ± 0.021	0.654CysVal: 0.654 ± 0.019	0.118CysTrp: 0.118 ± 0.009	0.162CysTyr: 0.162 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.262AspAla: 8.262 ± 0.085	0.409AspCys: 0.409 ± 0.017	4.86AspAsp: 4.86 ± 0.067	4.557AspGlu: 4.557 ± 0.056	1.67AspPhe: 1.67 ± 0.034	6.697AspGly: 6.697 ± 0.082	1.575AspHis: 1.575 ± 0.032	1.769AspIle: 1.769 ± 0.035	1.094AspLys: 1.094 ± 0.032	7.636AspLeu: 7.636 ± 0.079	0.817AspMet: 0.817 ± 0.025	0.992AspAsn: 0.992 ± 0.026	4.964AspPro: 4.964 ± 0.06	1.891AspGln: 1.891 ± 0.039	5.441AspArg: 5.441 ± 0.054	2.391AspSer: 2.391 ± 0.041	3.004AspThr: 3.004 ± 0.05	6.333AspVal: 6.333 ± 0.069	1.049AspTrp: 1.049 ± 0.025	1.202AspTyr: 1.202 ± 0.03	0.001AspXaa: 0.001 ± 0.001
Glu	7.243GluAla: 7.243 ± 0.095	0.329GluCys: 0.329 ± 0.014	3.178GluAsp: 3.178 ± 0.046	3.4GluGlu: 3.4 ± 0.062	1.418GluPhe: 1.418 ± 0.03	4.389GluGly: 4.389 ± 0.062	1.71GluHis: 1.71 ± 0.038	2.158GluIle: 2.158 ± 0.039	1.28GluLys: 1.28 ± 0.035	6.184GluLeu: 6.184 ± 0.075	1.038GluMet: 1.038 ± 0.028	0.916GluAsn: 0.916 ± 0.027	3.246GluPro: 3.246 ± 0.051	2.214GluGln: 2.214 ± 0.038	5.094GluArg: 5.094 ± 0.07	2.655GluSer: 2.655 ± 0.043	2.944GluThr: 2.944 ± 0.048	5.529GluVal: 5.529 ± 0.073	0.771GluTrp: 0.771 ± 0.022	0.996GluTyr: 0.996 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.576PheAla: 3.576 ± 0.05	0.267PheCys: 0.267 ± 0.014	2.133PheAsp: 2.133 ± 0.037	1.562PheGlu: 1.562 ± 0.036	0.895PhePhe: 0.895 ± 0.03	2.994PheGly: 2.994 ± 0.046	0.615PheHis: 0.615 ± 0.019	0.716PheIle: 0.716 ± 0.022	0.418PheLys: 0.418 ± 0.018	2.795PheLeu: 2.795 ± 0.042	0.411PheMet: 0.411 ± 0.016	0.552PheAsn: 0.552 ± 0.023	1.36PhePro: 1.36 ± 0.029	0.632PheGln: 0.632 ± 0.021	1.907PheArg: 1.907 ± 0.035	1.451PheSer: 1.451 ± 0.033	1.871PheThr: 1.871 ± 0.037	2.738PheVal: 2.738 ± 0.044	0.443PheTrp: 0.443 ± 0.016	0.607PheTyr: 0.607 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.205GlyAla: 10.205 ± 0.088	0.88GlyCys: 0.88 ± 0.028	5.826GlyAsp: 5.826 ± 0.065	5.003GlyGlu: 5.003 ± 0.073	3.028GlyPhe: 3.028 ± 0.046	8.213GlyGly: 8.213 ± 0.086	2.308GlyHis: 2.308 ± 0.045	3.684GlyIle: 3.684 ± 0.047	2.029GlyLys: 2.029 ± 0.04	9.594GlyLeu: 9.594 ± 0.089	1.983GlyMet: 1.983 ± 0.035	1.797GlyAsn: 1.797 ± 0.036	4.799GlyPro: 4.799 ± 0.066	2.573GlyGln: 2.573 ± 0.043	7.565GlyArg: 7.565 ± 0.082	5.397GlySer: 5.397 ± 0.065	5.973GlyThr: 5.973 ± 0.064	7.936GlyVal: 7.936 ± 0.064	1.84GlyTrp: 1.84 ± 0.036	2.166GlyTyr: 2.166 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.655HisAla: 2.655 ± 0.046	0.197HisCys: 0.197 ± 0.011	1.609HisAsp: 1.609 ± 0.039	1.367HisGlu: 1.367 ± 0.03	0.567HisPhe: 0.567 ± 0.018	2.303HisGly: 2.303 ± 0.046	0.743HisHis: 0.743 ± 0.027	0.521HisIle: 0.521 ± 0.02	0.3HisLys: 0.3 ± 0.015	2.546HisLeu: 2.546 ± 0.044	0.295HisMet: 0.295 ± 0.013	0.357HisAsn: 0.357 ± 0.017	1.74HisPro: 1.74 ± 0.035	0.667HisGln: 0.667 ± 0.02	2.069HisArg: 2.069 ± 0.033	0.848HisSer: 0.848 ± 0.023	1.107HisThr: 1.107 ± 0.028	2.164HisVal: 2.164 ± 0.041	0.382HisTrp: 0.382 ± 0.015	0.466HisTyr: 0.466 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.559IleAla: 4.559 ± 0.068	0.272IleCys: 0.272 ± 0.013	2.48IleAsp: 2.48 ± 0.041	2.049IleGlu: 2.049 ± 0.038	0.787IlePhe: 0.787 ± 0.026	3.509IleGly: 3.509 ± 0.06	0.641IleHis: 0.641 ± 0.024	0.883IleIle: 0.883 ± 0.028	0.683IleLys: 0.683 ± 0.023	2.48IleLeu: 2.48 ± 0.048	0.444IleMet: 0.444 ± 0.017	0.658IleAsn: 0.658 ± 0.023	1.682IlePro: 1.682 ± 0.037	0.677IleGln: 0.677 ± 0.019	2.239IleArg: 2.239 ± 0.039	1.649IleSer: 1.649 ± 0.033	2.091IleThr: 2.091 ± 0.039	2.924IleVal: 2.924 ± 0.047	0.415IleTrp: 0.415 ± 0.02	0.565IleTyr: 0.565 ± 0.019	0.001IleXaa: 0.001 ± 0.001
Lys	2.36LysAla: 2.36 ± 0.052	0.091LysCys: 0.091 ± 0.008	1.078LysAsp: 1.078 ± 0.028	0.978LysGlu: 0.978 ± 0.029	0.441LysPhe: 0.441 ± 0.02	1.478LysGly: 1.478 ± 0.035	0.419LysHis: 0.419 ± 0.016	0.681LysIle: 0.681 ± 0.026	0.676LysLys: 0.676 ± 0.033	1.6LysLeu: 1.6 ± 0.039	0.322LysMet: 0.322 ± 0.016	0.408LysAsn: 0.408 ± 0.018	1.13LysPro: 1.13 ± 0.032	0.646LysGln: 0.646 ± 0.023	1.329LysArg: 1.329 ± 0.036	0.94LysSer: 0.94 ± 0.028	1.091LysThr: 1.091 ± 0.032	1.862LysVal: 1.862 ± 0.039	0.219LysTrp: 0.219 ± 0.011	0.39LysTyr: 0.39 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.457LeuAla: 15.457 ± 0.134	0.738LeuCys: 0.738 ± 0.018	7.327LeuAsp: 7.327 ± 0.081	5.418LeuGlu: 5.418 ± 0.074	2.512LeuPhe: 2.512 ± 0.042	9.686LeuGly: 9.686 ± 0.085	2.204LeuHis: 2.204 ± 0.04	2.689LeuIle: 2.689 ± 0.046	1.604LeuLys: 1.604 ± 0.034	11.052LeuLeu: 11.052 ± 0.115	1.647LeuMet: 1.647 ± 0.032	1.434LeuAsn: 1.434 ± 0.032	5.842LeuPro: 5.842 ± 0.057	2.19LeuGln: 2.19 ± 0.035	8.055LeuArg: 8.055 ± 0.081	5.04LeuSer: 5.04 ± 0.067	6.377LeuThr: 6.377 ± 0.062	11.031LeuVal: 11.031 ± 0.11	1.275LeuTrp: 1.275 ± 0.032	1.568LeuTyr: 1.568 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.295MetAla: 2.295 ± 0.042	0.136MetCys: 0.136 ± 0.009	0.907MetAsp: 0.907 ± 0.026	0.78MetGlu: 0.78 ± 0.024	0.521MetPhe: 0.521 ± 0.017	1.378MetGly: 1.378 ± 0.029	0.381MetHis: 0.381 ± 0.014	0.649MetIle: 0.649 ± 0.022	0.381MetLys: 0.381 ± 0.015	1.856MetLeu: 1.856 ± 0.037	0.321MetMet: 0.321 ± 0.014	0.41MetAsn: 0.41 ± 0.015	1.106MetPro: 1.106 ± 0.027	0.449MetGln: 0.449 ± 0.019	1.456MetArg: 1.456 ± 0.031	1.414MetSer: 1.414 ± 0.027	1.697MetThr: 1.697 ± 0.033	1.567MetVal: 1.567 ± 0.035	0.197MetTrp: 0.197 ± 0.01	0.272MetTyr: 0.272 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.183AsnAla: 2.183 ± 0.037	0.146AsnCys: 0.146 ± 0.009	1.08AsnAsp: 1.08 ± 0.029	0.809AsnGlu: 0.809 ± 0.024	0.456AsnPhe: 0.456 ± 0.018	1.752AsnGly: 1.752 ± 0.042	0.399AsnHis: 0.399 ± 0.018	0.616AsnIle: 0.616 ± 0.023	0.349AsnLys: 0.349 ± 0.016	1.769AsnLeu: 1.769 ± 0.039	0.267AsnMet: 0.267 ± 0.014	0.386AsnAsn: 0.386 ± 0.017	1.358AsnPro: 1.358 ± 0.029	0.491AsnGln: 0.491 ± 0.019	1.305AsnArg: 1.305 ± 0.026	0.7AsnSer: 0.7 ± 0.021	1.005AsnThr: 1.005 ± 0.027	1.426AsnVal: 1.426 ± 0.031	0.248AsnTrp: 0.248 ± 0.013	0.385AsnTyr: 0.385 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.584ProAla: 7.584 ± 0.097	0.314ProCys: 0.314 ± 0.015	4.77ProAsp: 4.77 ± 0.06	3.966ProGlu: 3.966 ± 0.063	1.571ProPhe: 1.571 ± 0.032	6.144ProGly: 6.144 ± 0.076	1.263ProHis: 1.263 ± 0.031	1.548ProIle: 1.548 ± 0.03	0.906ProLys: 0.906 ± 0.029	4.74ProLeu: 4.74 ± 0.059	1.12ProMet: 1.12 ± 0.024	0.864ProAsn: 0.864 ± 0.025	3.201ProPro: 3.201 ± 0.062	1.419ProGln: 1.419 ± 0.031	3.885ProArg: 3.885 ± 0.058	3.082ProSer: 3.082 ± 0.052	3.555ProThr: 3.555 ± 0.057	5.338ProVal: 5.338 ± 0.067	0.956ProTrp: 0.956 ± 0.027	1.25ProTyr: 1.25 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.397GlnAla: 3.397 ± 0.052	0.163GlnCys: 0.163 ± 0.01	1.409GlnAsp: 1.409 ± 0.033	1.323GlnGlu: 1.323 ± 0.028	0.676GlnPhe: 0.676 ± 0.021	2.016GlnGly: 2.016 ± 0.038	0.672GlnHis: 0.672 ± 0.023	0.931GlnIle: 0.931 ± 0.023	0.53GlnLys: 0.53 ± 0.022	2.782GlnLeu: 2.782 ± 0.045	0.516GlnMet: 0.516 ± 0.017	0.429GlnAsn: 0.429 ± 0.016	1.736GlnPro: 1.736 ± 0.037	1.131GlnGln: 1.131 ± 0.034	2.47GlnArg: 2.47 ± 0.045	1.161GlnSer: 1.161 ± 0.028	1.307GlnThr: 1.307 ± 0.031	2.868GlnVal: 2.868 ± 0.048	0.418GlnTrp: 0.418 ± 0.017	0.508GlnTyr: 0.508 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.364ArgAla: 9.364 ± 0.091	0.574ArgCys: 0.574 ± 0.02	4.926ArgAsp: 4.926 ± 0.057	4.596ArgGlu: 4.596 ± 0.06	2.311ArgPhe: 2.311 ± 0.04	5.948ArgGly: 5.948 ± 0.069	2.047ArgHis: 2.047 ± 0.04	2.999ArgIle: 2.999 ± 0.047	1.494ArgLys: 1.494 ± 0.032	8.662ArgLeu: 8.662 ± 0.085	1.758ArgMet: 1.758 ± 0.036	1.39ArgAsn: 1.39 ± 0.031	4.598ArgPro: 4.598 ± 0.057	2.3ArgGln: 2.3 ± 0.042	7.948ArgArg: 7.948 ± 0.102	4.436ArgSer: 4.436 ± 0.051	4.873ArgThr: 4.873 ± 0.061	6.715ArgVal: 6.715 ± 0.078	1.458ArgTrp: 1.458 ± 0.031	1.606ArgTyr: 1.606 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.072SerAla: 6.072 ± 0.061	0.409SerCys: 0.409 ± 0.018	2.908SerAsp: 2.908 ± 0.044	2.439SerGlu: 2.439 ± 0.044	1.671SerPhe: 1.671 ± 0.029	5.563SerGly: 5.563 ± 0.067	1.016SerHis: 1.016 ± 0.023	1.644SerIle: 1.644 ± 0.037	0.894SerLys: 0.894 ± 0.026	4.925SerLeu: 4.925 ± 0.06	1.202SerMet: 1.202 ± 0.03	0.975SerAsn: 0.975 ± 0.027	3.08SerPro: 3.08 ± 0.057	1.284SerGln: 1.284 ± 0.03	3.873SerArg: 3.873 ± 0.054	3.055SerSer: 3.055 ± 0.055	3.33SerThr: 3.33 ± 0.051	4.38SerVal: 4.38 ± 0.052	0.949SerTrp: 0.949 ± 0.027	1.234SerTyr: 1.234 ± 0.03	0.001SerXaa: 0.001 ± 0.001
Thr	7.516ThrAla: 7.516 ± 0.079	0.504ThrCys: 0.504 ± 0.019	3.689ThrAsp: 3.689 ± 0.051	3.015ThrGlu: 3.015 ± 0.051	1.895ThrPhe: 1.895 ± 0.036	6.402ThrGly: 6.402 ± 0.073	1.22ThrHis: 1.22 ± 0.027	2.131ThrIle: 2.131 ± 0.036	1.034ThrLys: 1.034 ± 0.032	5.653ThrLeu: 5.653 ± 0.061	1.12ThrMet: 1.12 ± 0.025	1.126ThrAsn: 1.126 ± 0.029	3.797ThrPro: 3.797 ± 0.054	1.325ThrGln: 1.325 ± 0.027	4.256ThrArg: 4.256 ± 0.049	3.481ThrSer: 3.481 ± 0.059	4.109ThrThr: 4.109 ± 0.058	6.032ThrVal: 6.032 ± 0.075	1.094ThrTrp: 1.094 ± 0.032	1.513ThrTyr: 1.513 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	12.89ValAla: 12.89 ± 0.124	0.715ValCys: 0.715 ± 0.022	6.663ValAsp: 6.663 ± 0.067	5.561ValGlu: 5.561 ± 0.061	2.513ValPhe: 2.513 ± 0.046	7.856ValGly: 7.856 ± 0.079	2.09ValHis: 2.09 ± 0.041	2.846ValIle: 2.846 ± 0.042	1.517ValLys: 1.517 ± 0.036	10.474ValLeu: 10.474 ± 0.103	1.525ValMet: 1.525 ± 0.035	1.687ValAsn: 1.687 ± 0.043	5.375ValPro: 5.375 ± 0.064	2.137ValGln: 2.137 ± 0.039	7.319ValArg: 7.319 ± 0.075	4.574ValSer: 4.574 ± 0.059	6.225ValThr: 6.225 ± 0.072	10.67ValVal: 10.67 ± 0.127	1.227ValTrp: 1.227 ± 0.029	1.467ValTyr: 1.467 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.669TrpAla: 1.669 ± 0.036	0.172TrpCys: 0.172 ± 0.011	0.877TrpAsp: 0.877 ± 0.025	0.756TrpGlu: 0.756 ± 0.024	0.597TrpPhe: 0.597 ± 0.021	1.114TrpGly: 1.114 ± 0.028	0.378TrpHis: 0.378 ± 0.015	0.535TrpIle: 0.535 ± 0.019	0.319TrpLys: 0.319 ± 0.014	1.924TrpLeu: 1.924 ± 0.037	0.307TrpMet: 0.307 ± 0.015	0.35TrpAsn: 0.35 ± 0.017	0.829TrpPro: 0.829 ± 0.023	0.529TrpGln: 0.529 ± 0.018	1.411TrpArg: 1.411 ± 0.033	1.065TrpSer: 1.065 ± 0.025	1.027TrpThr: 1.027 ± 0.025	1.335TrpVal: 1.335 ± 0.036	0.387TrpTrp: 0.387 ± 0.017	0.334TrpTyr: 0.334 ± 0.016	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.69TyrAla: 2.69 ± 0.041	0.152TyrCys: 0.152 ± 0.011	1.749TyrAsp: 1.749 ± 0.033	0.95TyrGlu: 0.95 ± 0.025	0.622TyrPhe: 0.622 ± 0.021	1.931TyrGly: 1.931 ± 0.037	0.381TyrHis: 0.381 ± 0.016	0.396TyrIle: 0.396 ± 0.018	0.3TyrLys: 0.3 ± 0.013	2.18TyrLeu: 2.18 ± 0.04	0.209TyrMet: 0.209 ± 0.012	0.352TyrAsn: 0.352 ± 0.015	0.992TyrPro: 0.992 ± 0.025	0.531TyrGln: 0.531 ± 0.017	1.704TyrArg: 1.704 ± 0.036	0.891TyrSer: 0.891 ± 0.026	1.036TyrThr: 1.036 ± 0.029	1.954TyrVal: 1.954 ± 0.04	0.327TyrTrp: 0.327 ± 0.016	0.429TyrTyr: 0.429 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4817 proteins (1549698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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